Genetic Control of Antibody Responses to Myeloma Proteins of Mice
Immunoglobulins of the mouse are polymorphic and the polymorphism is ascribable in part to allelism of the structural genes for the immunoglobulin heavy chain constant regions (CH genes). The existence of allotypic forms of mouse immunoglobulin has permitted the establishment of the genetic relationship between the CH genes for different classes of immunoglobulins (Potter and Lieberman, 1967a,b) and also the determination of the linkage between CH genes and the genes controlling the variable regions of immunoglobulin heavy chains (VH genes) (Blomberg et al, 1972; Sher and Cohn, 1972; Eichmann, 1972; Pawlak et al, 1973). More recently, it has become clear that the immunoglobulins constitute a set of antigens that are of particular value in the identification and linkage analysis of genes controlling immune responses (Lieberman and Humphrey, 1971, 1972; Lieberman et al, 1972). The latter genes are referred to as immune response (Ir) genes.
KeywordsAntibody Response Genetic Control Congenic Strain Myeloma Protein Idiotypic Determinant
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