Histocompatibility Systems, Immune Response, and Disease in Man

  • Peter J. Morris


Over the last few years there has been an explosion of interest in the possible association of disease with the major histocompatibility system of man, HL-A. This interest arose first as a result of the demonstration of a linkage between susceptibility of mice to leukemia and H-2 (the major histocompatibility system in the mouse) and second as a result of the more recently demonstrated linkages between the genetic control of certain immune responses in mice and guinea pigs and the major histocompatibility systems of those two species. The human studies have been beset with difficulties attributable mainly to the serological difficulties associated with the determination of certain specificities of the HL-A system as well as the complex nature of many of the diseases investigated.


Infectious Mononucleosis Mixed Lymphocyte Reaction Histocompatibility Antigen Tissue Antigen Immune Response Gene 


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Peter J. Morris
    • 1
  1. 1.Tissue Transplantation Laboratories and Department of SurgeryUniversity of Melbourne, Royal Melbourne HospitalMelbourneAustralia

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