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Antigen-Binding Receptors on Lymphocytes

  • Joseph M. Davie
  • William E. Paul

Abstract

The concept that activation of immunocompetent cells by antigen depends upon the presence of specific antigen-binding receptors on the cell surface has been central to immunologic theory since it was originally proposed by Paul Ehrlich (1900). Direct evidence for the existence of such receptors has been amassed in recent years. In particular, it has been demonstrated that in nonimmunized animals, rare lymphocytes will bind a given substance to their surface and that the frequency of such cells increases upon immunization (Naor and Sulitzeanu, 1967; Byrt and Ada, 1969; Davie and Paul, 1971; Humphrey and Keller, 1970; Davie et al, 1971a).

Keywords

Surface Immunoglobulin Mouse Spleen Cell Tolerant Mouse Clonal Selection Theory Nonimmune Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Joseph M. Davie
    • 1
    • 2
  • William E. Paul
    • 3
  1. 1.Department of PathologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of MicrobiologyWashington University School of MedicineSt. LouisUSA
  3. 3.Laboratory of Immunology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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