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Improving the Microbial Production of Amino Acids: From Conventional Approaches to Recent Trends

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Abstract

Variable industrial strains have been applied in the fermentation of bulk amino acids. Strain discovery and evolution, process optimization are traditional approaches to improve the yield and efficiency of the bio-production process, hence to compete with chemical or enzymatic process in amino acids production. With the fast development of bioengineering and synthetic biology, the strains can be rationally engineered to achieve better performance and gain the capacity in the fermentation of broader range of amino acids, especially for value-added amino acids. This proposed review aims to summarize traditional and recent strains in the microbial production of amino acids, characterize their metabolic pathways and present potential objectives for rational evolution. In addition, this proposed review prospect the recent opportunities and challenges in the microbial production of value-added amino acids (rare amino acids, non-canonical amino acids, and unnatural amino acids).

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Acknowledgements

The present study was supported by Shandong Province Natural Science Foundation (ZR2015BM011), Technology Development Project of Shandong Province (2016GSF 121013), National Natural Science Foundation (21978311), Open Subject of Zibo Research Platform in Gene Editing and Cell Application (2019GECA011).

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  1. The authors contribute equally to the study.

Authors and Affiliations

  1. State Key Laboratory Base of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China

    Guoqing Zhang, Xueni Ren, Xiuhong Liang, Yaqun Wang & Huibin Zou

  2. CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China

    Dexin Feng, Mo Xian & Huibin Zou

  3. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Qilu Medical University, Zibo, 255213, China

    Yujun Zhang

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  1. Guoqing Zhang
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Zhang, G., Ren, X., Liang, X. et al. Improving the Microbial Production of Amino Acids: From Conventional Approaches to Recent Trends. Biotechnol Bioproc E 26, 708–727 (2021). https://doi.org/10.1007/s12257-020-0390-1

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