Abstract
Alkaline phosphatase estimations in human serum* are widely used to diagnose physiological or pathological processes involving the skeleton, the hepatobiliary system, or the placenta.1–13 Alkaline phosphatase activities have also been measured in other biological fluids such as urine, saliva, cerebrospinal fluid, and synovial fluid, though the use of such measurements is not as clearly established in clinical medicine as is that of serum alkaline phosphatase. In addition, activities have been estimated in tissues (especially leukocytes), though few clinical decisions are currently based on such tests.
Note: Consult Tables 9.21–9.26 (pages 685–703) for direct referral to sections of this chapter wherein specific problems encountered in the clinical interpretation of alkaline phosphatase measurements are discussed.
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References
Kay, H. D., Phosphatase in growth and disease of bone, Physiol. Rev., 12, 384, 1932.
Bodansky, A., and Jaffe, H. L., Phosphatase studies. III. Serum phosphatase in diseases of the bone: Interpretation and significance, Arch. Intern. Med., 54, 88, 1934.
Sunderman, F. W., Recent advances in the significance and interpretation of phosphatase measurements in disease, Am. J. Gin. Pathol., 12, 404, 1942.
King, E. J., Plasma alkaline phosphatase in disease, Br. Med. Bull., 9, 160, 1953.
Gutman, A. B., Serum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systems: A consideration of the current status, Am. J. Med., 27, 875, 1959.
Stadtman, T. C., Alkaline phosphatase, in: The Enzymes, Vol. 5, 2nd ed. (Boyer, P. D., Lardy, H., and Myrbäck, K., eds.), p. 55, Academic Press, New York, 1961.
Fishman, W. H., and Ghosh, N. E., Isoenzymes of human alkaline phosphatase, in: Advances in Clinical Chemistry, Vol. 10 (Bodansky, O., and Stewart, C. P., eds.), p. 255, Academic Press, New York, 1967.
Posen, S., Alkaline phosphatase, Ann. Intern. Med., 67, 183, 1967.
Kaplan, M. M., Alkaline phosphatase, Gastroenterology, 62, 452, 1972.
Schmidt, E., and Schmidt, F., Diagnosis, control of progress and therapy: Diseases of liver, in: Methods of Enzymatic Analysis 2nd English ed. (Bergmeyer, H. U., ed.), (translated from the 3rd German ed., 1974), pp. 14–30, Academic Press, New York, 1974.
Young, D. S., Pestaner, L. C., and Gibberman, V., Effects of drugs on clinical laboratory tests, Clin. Chem., 21, 246D, 1975.
Posen, S., Lee, C., Vines, R., Kilham, H., Latham, S., and Keefe, J. F., Transient hyperphos-phatasemia of infancy-An insufficiently recognized syndrome, Clin. Chem., 23, 292, 1977.
Schwartz, M. K., Enzyme patterns in cancer, Ann. Clin. Lab. Sci., 7, 99, 1977.
Latner, A. L., and Skillen, A. W., Isoenzymes in Biology and Medicine, pp. 56 and 158, Academic Press, New York, 1968.
Moss, D. W., The heterogeneity of human alkaline phosphatase, in: Enzymes and Isoenzymes, Structure, Properties and Function, Vol. 18 (Shugar, D., ed.) (Proceedings of the 5th Meeting, Prague, July 1968, of the Federation of European Biochemical Societies), p. 227, Academic Press, New York, 1970.
Stolbach, L. L., Krant, M. J., and Fishman, W. H., Ectopic production of an alkaline phosphatase isoenzyme in patients with cancer, N. Engl. J. Med., 281, 757, 1969.
Ectopic alkaline-phosphatase production by tumours (editorial), Lancet, 2, 1236, 1969.
Wilkinson, J. H., Isoenzymes, 2nd ed., p. 239, J. B. Lippincott, Philadelphia, 1970.
Laurence, D. J. R., and Neville, A. M., Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: A review, ifr. J. Cancer, 26, 335, 1972.
Ustegui-Gomez, M., Yeager, F. M., and Fernandez de Castro, A., A sensitive immunochemical method for the determination of the Regan isoenzyme in serum, Cancer Res. 33, 1574, 1973.
Fishman, W. H., Perspectives on alkaline phosphatase isoenzymes, Am. J. Med., 56, 617, 1974.
Cadeau, B. J., Blackstein, M. E., and Malkin, A., Increased incidence of placenta-like alkaline phosphatase activity in breast and genitourinary cancer, Cancer Res., 34, 729, 1974.
Hørder, M., and Tryding, N., Unpublished data from a letter dated March 11, 1977.
Munan, L., Kelly, A., and Petitclerc, C., Population serum enzyme patterns: Age-sex depen-dencies, Clin. Biochem., 9, 7, 1976.
Olsen, D. M., Kane, R. L., and Proctor, P. H., A controlled trial of multiphasic screening, N. Engl. J. Med., 294, 925, 1976.
Amador, E., Health and normality, J. Am. Med. Assoc., 232, 953, 1975.
Sunderman, F. W., Jr., Current concepts of 201cnormal values,201c 201creference values201c and 201cdiscrimination values201c in clinical chemistry, Clin. Chem., 21, 1873, 1975.
Alstrom, T., Grasbeck, R., Hjelm, M., and Skandsen, S., Recommendations concerning the collection of reference values in clinical chemistry and activity report, Scand. J. Clin. Lab. Invest., 35 (Suppl. 144), 1975.
Grasbeck, R., Siest, G., Wilding, P., Williams, G. Z., and Whitehead, T. P., Provisional recommendation on the theory of reference values (1978). Part 1. The concept of reference values (Stage 2, Draft 1), Expert panel on the Theory of Reference Values, Committee on Standards, IFCC, Gin. Chim. Acta, 87, 461F–465F, 1978.
Siest, G., Reference Values in Human Chemistry, S. Karger, Basel, 1973.
Williams, G. Z., The nature and use of individual person’s reference limits in clinical chemistry, Scand. J. Clin. Lab. Invest., 29 (Suppl. 126 ), 19. 3, 1972.
Winkel, P., Lyngbye, J., and Jorgensen, K., The normal region-A multivariate problem, Scand. J. Clin. Lab. Invest., 30, 339, 1972.
Martin, H. F., Gudzinowicz, B. J., and Fanger, H., Alkaline phosphatase, in: Normal Values in Clinical Chemistry: A Guide to Statistical Analysis of Laboratory Data, Vol. 2 (Schwartz, M. K., ed.), p. 347, Marcel Dekker, New York, 1975.
Elveback, L. R., Guillier, C. L., and Keating, F. R., Jr., Health, normality, and the ghost of Gauss, J. Am. Med. Assoc., 211, 69, 1970.
Roberts, L. B., The normal ranges with statistical analysis for seventeen blood constituents, Gin. Chim. Acta, 16, 69, 1967.
O’Halloran, M. W., Studley-Ruxton, J., and Wellby, M. L., A comparison of conventionally derived normal ranges with those obtained from patients’ results, Clin. Chim. Acta, 27, 35, 1970.
Werner, M., Tolls, R. E., Hultin, J. V., and Mellecker, J., Influence of sex and age on the normal range of eleven serum constituents, Z. Klin. Chem. Klin. Biochem., 8, 105, 1970.
Keating, F. R., Jr., Jones, J. D., Elveback, L. R., and Randall, R. V., The relation of age and sex to distribution of values in healthy adults of serum calcium, inorganic phosphorous, magnesium, alkaline phosphatase, total proteins, albumin, and blood urea, J. Lab. Gin. Med., 73, 825, 1969.
Eastman, J. R., and Bixler, D., Serum alkaline phosphatase: Normal values by sex and age, Clin. Chem., 23, 1769, 1977.
Levin, G. E., McPherson, C. K., Fraser, P. M., and Baron, D. N., Long-term variation in plasma activities of aspartate transaminase and alkaline phosphatase in health, Gin. Sci., 44, 185, 1973.
Grams, R. R., Johnson, E. A., and Benson, E. S., Laboratory data analysis system. Section III. Multivariate normality, Am. J. Gin. Pathol., 58, 188, 1972.
Posen, S., Turnover of circulating enzymes, Gin. Chem., 16, 71, 1970.
Hoffman, R. G., Statistics in the practice of medicine, J. Am. Med. Assoc., 185, 864, 1963.
Best, W. R., Mason, C. C., Barron, S. S., and Shephard, H. G., Validation of procedure for setting normal limits on basis of total laboratory experience, Gin. Chim. Acta, 28, 127, 1970.
Harris, E. K., Effect of intra- and inter-individual variation on the appropriate use of normal ranges, Gin. Chem., 20, 1535, 1974.
Lo, J. S., and Kellen, J. A., A proposal for a more uniform output in laboratory data, Gin. Chim. Acta, 41, 239, 1972.
Gerstbrein, H. L., and Lederer, W. H., Uniform presentation of enzyme determinations (letter to the editor), J. Am. Med. Assoc., 227, 325, 1974.
Lederer, W. H., and Gerstbrein, H. L., Expressing results of enzyme assays (letter to the editor), Gin. Chem., 20, 916, 1974.
Whitaker, K. B., Whitby, L. G., and Moss, D. W., Activities of bone and liver alkaline phosphatases in serum in health and disease, Gin. Chim. Acta, 80, 209, 1977.
Petitclerc, C., Quantitative fractionation of alkaline phosphatase isoenzymes according to their thermostability, Gin. Chem., 22, 42, 1976.
O’Carroll, D., Statland, B. E., Steele, B. W., and Burke, M. D., Chemical inhibition method for alkaline phosphatase isoenzymes in human serum, Am. J. Gin. Pathol., 63, 564, 1975.
Nerenberg, S. T., and Pogojeff, G., Laboratory diagnosis of specific organ diseases by means of combined serum isoenzyme patterns, Am. J. Clin. Pathol., 51, 429, 1969.
Nerenberg, S. T., and Pogojeff, G., A new rapid technic of tissue extraction for isoenzyme studies in normal and diseased tissues, Am. J. Gin. Pathol., 51, 95, 1969.
Warnes, T. W., Hine, P. M., and Kay, G. H., Serum alkaline phsophatase isoenzymes in liver disease, Gut, 13, 853, 1972.
Skillen, A. W., and Pierides, A. M., Serum gamma glutamyl transferase and alkaline phosphatase activities in epileptics receiving anticonvulsant therapy, Clin. Chim. Acta, 72, 245, 1976.
Dixon, M., and Paterson, C. R., Posture and the composition of plasma, Gin. Chem., 24, 824, 1978.
Fleisher, G. A., Eickelberg, E. S., and Elveback, L. R., Alkaline phosphatase activity in the plasma of children and adolescents, Gin. Chem., 23, 469, 1977.
Breuer, J., and Stucky, W., Enzymaktivitäten in Serum und Plasma von Mensch, Hund und Ratte sowie deren Veränderungen beim Aufbewahren des Blutes, Z. Klin. Chem. Klin. Biochem., 13, 355, 1975.
Statland, B. E., Winkel, P., and Bokelund, H., Factors contributing to intra-individual variation of serum constituents. 2. Effects of exercise and diet on variation of serum constituents in healthy subjects, Gin. Chem., 19, 1380, 1973.
Statland, B. E., Bokelund, H., and Winkel, P., Factors contributing to intra-individual variation of serum constituents. 4. Effects of posture and tourniquet application on variation of serum constituents in healthy subjects, Gin. Chem., 20, 1513, 1974.
Radcliff, F. J., Baume, P. E., and Jones, W. O., Effect of venous stasis and muscular exercise on total serum calcium concentration, Lancet, 2, 1249, 1962.
Bowers, G. N., Jr., Bergmeyer, H. U., and Moss, D. W., Provisional recommendation (1974) on IFCC methods for the measurement of catalytic concentration of enzymes (International Federation of Clinical Chemistry, Committee on Standards, Expert Panel on Enzymes), Gin. Chim. Acta, 61, F11 (following p. 238), 1975 (also reprinted in Gin. Chem., 22, 384, 1975 ).
Bowers, G. N., Jr., The acceptability of enzyme methods, in: Quality Control in Ginical Chemistry (Anido, G., Rosalki, S. B., van Kampen, E. J., and Rubin, M., eds.), p. 441, Walter de Gruyter, Berlin and New York, 1975.
Bowers, G. N., Jr., Standardization efforts in clinical enzymology, Gin. Chem., 22, 1142, 1976.
International Union of Pure and Applied Chemistry and International Union of Biochemistry, Enzyme Nomenclature: Recommendations (1972) of the International Union of Pure and Applied Chemistry and the International Union of Biochemistry, Elsevier, Amsterdam, 1973.
Gundersen, H. J., and Amdisen, A., The electrophoretic pattern of alkaline phosphatase in schizophrenic females under long-term treatment with neuroleptic drugs and in young and old healthy women, Scand. J. Clin. Lab. Invest., 24, 173, 1969.
Burnett, V., Baker, R. K., and Wallach, S., Primary hypophosphatemic rickets in an elderly woman, Arch. Intern. Med., 131, 581, 1973.
Deren, J. J., Williams, L. A., Muench, H., Chalmers, T., and Zamcheck, N., Comparative study of four methods of determining alkaline phosphatase, N. Engl. J. Med., 270, 1277, 1964.
Gradwohl, R. B. H., Clinical Laboratory Methods and Diagnosis: A Textbook on Laboratory Procedures with Their Interpretation, Vol. 2, 3rd ed., p. 308, C. V. Mosby, St. Louis, 1943.
Laurent, B., and Norberg, B., Phosphatase assay in serum with p-nitrophenyl phosphate as substrate, Scand. J. Gin. Lab. Invest., 12, 154, 1960.
Gelb, D., West, M., and Zimmerman, H. J., The relationship of Bodansky to the King- Armstrong method for the determination of the serum alkaline phosphatase, Am. J. Gin. Pathol., 38, 198, 1962.
Klein, B., Read, P. A., and Babson, A. L., Rapid method for the quantitative determination of serum alkaline phosphatase, Gin. Chem., 6, 269, 1960.
Bowers, G. N., Jr., Kelly, M. L., and McComb, R. B., Continuous spectrophotometry measurement of serum alkaline phosphatase activity: Relative molecular activity and sensitivity of nine self-indicating phenolic substrates in 2-amino-2-methyl-l-propanol buffer, Gin. Chem., 13, 608, 1967.
Schwartz, M. K., Kessler, G., and Bodansky, O., Comparison of serum alkaline phosphatase activities determined with sodium beta glycerophosphate and sodium phenylphosphate as substrates, Am. J. Gin. Pathol, 33, 275, 1960.
Tietz, N. W., Woodrow, D., and Woodrow, B., A comparative study of the Bodansky and the Bessey Lowry Brock methods for alkaline phosphatase in serum, Clin. Chim. Acta., 15, 365, 1967.
Statland, B. E., Nishi, H. N., and Young, P. S., Serum alkaline phosphatase: Total activity and isoenzyme determinations made by use of the centrifugal fast analyzer, Clin. Chem., 18, 1468, 1972.
Eaton, R. H., Plasma alkaline phosphatase assay: Interconversion of results by two methods, Gin. Chem., 23, 2148, 1977.
Kay, H. D., Plasma phosphatase. I. Method of determining some properties of the enzyme, J. Biol. Chem., 89, 235, 1930.
Smith, J., and Maizels, M., The plasma phosphatase in rickets and scurvy,Proc. R. Soc. Med., 25, 705, 1932.
Roberts, W. M., Blood phosphatase and the van den Bergh reaction and the differentiation of the several types of jaundice, Br. Med. J., 1, 734, 1933.
Stearns, G., and Warweg, E., Studies on phosphorus of blood. I. The partition of phosphorus in whole blood and serum, the serum calcium and plasma phosphatase from birth to maturity, J. Biol Chem., 100, 749, 1933.
Meranze, T., Meranze, D. R., and Rothman, M. M., Blood phosphatase in pregnancy, Am. J. Obstet. Gynecol, 33, 444, 1937.
Mulay, A. S., and Hurwitz, S., Normal plasma phosphatase values (Jenner-Kay method), J. Lab. Clin. Med., 23, 1117, 1938.
Vermehren, E., Variationen im Phosphatasegehalt des Plasmas im Anschluss an die verschiedenen Lebsensalter, Acta Med. Scand., 100, 244, 1939.
Pimenta, N., Fosfatase sanguinea. II. Estudo das taxas encontradas em individuos normais, Hospital (Rio De Janeiro), 18, 11, 1940.
Klasmer, R., Serum phosphatase activity and clinical rickets in children in Jerusalem, Am. J. Dis. Child., 67, 348, 1944.
Von Sydow, G., A study of the development of rickets in premature infants, Acta Paediatr. Scand., 33 (Suppl. 2), 122, 1946.
Heredia, J. L., Fosfatasemia y fosfatemia durante el parto y en el cordon umbilical en el momento de nacer, Obstet. Ginecol. Lat.-Am., 6, 345, 1948.
Harrison, A. P., Roderuck, C., Lesher, M., Kaucher, M., Moyer, E. Z., Lameck, W., and Beach, E. F., Nutritional status of children. VIII. Blood serum alkaline phosphatase, J. Am. Diet. Assoc., 24, 503, 1948.
Bessey, O. A., and Lowry, O. H., Nutritional assay of 1,200 New York State school children, Division of Nutrition and Physiology, The Public Health Research Institute of the City of New York, 1948.
Barnes, D. J., and Munks, B., Serum phosphatase, calcium and phosphorus values in infancy, Proc. Soc. Exp. Biol Med., 44, 327, 1949.
Clark, L. C., Jr., and Beck, E., Plasma 201calkaline201c phosphatase activity. I. Normative data for growing children, J. Pediatr., 36, 335, 1950.
Speert, H., Graff, S., and Graff, A. M., Serum phosphatase relations in mother and fetus, Am. J. Obstet. Gynecol, 59, 148, 1950.
Clark, L. C., Jr., Beck, E., and Shock, N. W., Serum alkaline phosphatase in middle and old age, J. Gerontol, 6, 7, 1951.
Lapan, B., and Friedman, M. M., A comparative study of fetal and maternal serum enzyme levels, J. Lab. Gin. Med., 54, 417, 1959.
Christiansson, G., and Josephson, B., A study of the enzyme pattern in children and newborn infants, Acta Paediatr., 49, 626, 1960.
Heino, A. E., and Jokipii, S. G., Serum alkaline phosphatase levels in the aged, Ann. Med. Intern. Fenn., 51, 105, 1962.
Dent, E. C., and Harper, C. M., Plasma-alkaline-phosphatase in normal adults and in patients with primary hyperparathyroidism, Lancet, 1, 559, 1962.
Gautier, E., Gautier, R., and Richterich R., Valeur diagnostique d’anomalies d’activités enz matiques du sérum en pédiatrie. I. Valeurs normales et influence des corticosteroides, Helv. Paediatr. Acta, 17, 415, 1962.
Meade, B. W., and Rosalki, S. B., Serum enzyme activity in normal pregnancy and the newborn, J. Obstet. Gynaecol. Br. Emp., 70, 693, 1963.
Henrotte, J. G., Heuse, G. A., and Jaeger, G., Variations of serum alkaline phosphatase and plasma uric acid during child’s growth, Arch. Int. Physiol. Biochim., 72, 599, 1964.
Klaassen, C. H. L., and Siertsema, L. H., De invloed van de leeftijd op de alkalische-fosfatase- waarde in het serum, Ned. Tudschr. Geneeskd., 108, 1433, 1964.
Kitchener, P. N., Neale, F. C., Posen, S., and Woods, J. B., Alkaline phosphatase in maternal and fetal sera at term and during the puerperium, Am. J. Clin. Pathol., 44, 654, 1965.
Reddemann, H., and Weinke, I., Die Aktivität der alkalischen Serumphosphatase bei Frühge-borenen, Z. Kinderheilkd., 99, 91, 1967.
Tandon, G. S., Teotia, S. P. S., and Rastogi, A. N., A study of serum alkaline phosphatase in healthy Indians, Indian J. Physiol. Pharmacol., 11, 15, 1967
De Wijn, J. F., Growth and chemical growth of adolescent boys related to physique and somatotype, Helv. Pediatr. Acta, 20, 497, 1965.
Izquierdo, J. M., Ferrerò, J., Romeo, D., Badia, J. L. S., and Vigil, E. R., Capillary blood potassium, chloride, sodium, calcium, phosphorus and alkaline phosphatase in the newborn, Clin. Chim. Acta, 30, 343, 1970.
O’Kell, R. T., and Elliott, J. R., Development of normal values for use in multitest biochemical screening of sera, Clin. Chem., 16, 161, 1970.
Sereny, G., and McLaughlin, L., Serum alkaline phosphatase values in normal adolescents, Can. Med. Assoc. J., 102, 1400, 1970.
Adams, P., Davies, G. T., and Sweetnam, P., Osteoporosis and the effects of ageing on bone mass in elderly men and women, Q. J. Med., 39, 601, 1970.
Fomon, S. J., Filer, L. J., Jr., Thomas, L. N., and Rogers, R. R., Growth and serum chemical values of normal breastfed infants, Acta Paediatr. Scand. (Suppl.), 202, 1, 1970.
Stephen, J. M. L., and Stephenson, P., Alkaline phosphatase in normal infants, Arch. Dis. Child., 46, 185, 1971.
Swan, C. H. J., and Cooke, W. T., Nutritional osteomalacia in immigrants in an urban community, Lancet, 2, 456, 1971.
Willital, G. H., Verhalten der alkalischen Serumphosphatase bei gesunden Neugeborenen, Säuglingen und Kindern,Med. Welt, 10, 378, 1971.
Wilding, P., Rollason, J. G., and Robinson, D., Patterns of change for various biochemical constituents detected in well population screening, Gin. Chim. Acta, 41, 375, 1972.
Reed, A. H., Cannon, D. C., Winkelman, J. W., Bhasin, Y. P., Henry, R. J., and Pileggi, V. J., Estimation of normal ranges from a controlled sample survey. I. Sex and age related influence on the SMA 12/60 screening group of tests, Gin. Chem., 18, 57, 1972.
Round, J. M., Plasma calcium, magnesium, phosphorus, and alkaline phosphatase levels in normal British schoolchildren,Br. Med. J., 3, 137, 1973.
Bowyer, R. C., Curnow, D. H., and Stenhouse, N. S., The second Busselton adult population survey (1969): Twelve biochemical variables,Pathology, 5, 197, 1973.
Arnaud, S. B., Goldsmith, R. S., Stickler, G. B., McCall, J. T., and Arnaud, C. D., Serum parathyroid hormone and blood minerals: Interrelationship in normal children, Pediatr. Res., 7, 485, 1973.
Tiisala, R., Jarvinen, L., Takkunen, R., and Hallman, N., Alkaline phosphatase in the serum of Finnish children,,4««. Paediatr. Fenn., 7, 85, 1961.
Hodkinson, H. M., and McPherson, C. K., Alkaline phosphatase in a geriatric inpatient population, Age Ageing, 2, 28, 1973.
Cooke, W. T., Swan, C. H. J., Asquith, P., Melikian, V., and McFeely, W. E., Serum alkaline phosphatase and rickets in urban schoolchildren,ifr. Med. J., 1, 324, 1973.
Goldberg, D. M., and Winfield, D. A., Relationship of serum enzyme activities to demographic variables in a healthy population, Gin. Chim. Acta, 54, 357, 1974.
Sharland, D. E., Alkaline phosphatase: The isoenzyme pattern in the elderly and changes in total serum levels with age, Gin. Chim. Acta, 56, 187, 1974.
Statland, B. E., Discussion (alkaline phosphatase), in: Proceedings of the Second International Symposium on Clinical Enzymology (Tietz, N. W., Weinstock, A., and Rodgerson, D. O., eds.), p. 67, American Association for Clinical Chemists, Washington D. C., 1976.
Shinowara, G. Y., Jones, L. M., and Reinhart, H. L., The estimation of serum inorganic phosphate and 201cacid201c and 201calkaline201c phosphatase activity, J. Biol. Chem., 142, 921, 1942.
Lundsteen, E., and Vermehren, E., Micro-methods for the estimation of phosphatases in blood plasma and inorganic phosphorus in blood, C. R. Trav. Lab. Carlsberg Ser. Chim., 21, 147, 1936.
Zuckerman, H., Sadovsky, E., and Kallner, B., Serum alkaline phosphatase in pregnancy and Puerperium, Obstet. Gynecol., 25, 819, 1965.
Hilderbrand, D. C., Fahim, Z., James, E., and Fahim, M., Ceruloplasmin and alkaline phosphatase levels in cord serum of term, preterm and physiologically jaundiced neonates, Am. J. Obstet. Gynecol., 118, 950, 1974.
Posen, S., Cornish, C. J., Hörne, M., and Saini, P. K., Placental alkaline phosphatase and pregnancy,, Ann. N. Y. Acad. Sci., 166, 733, 1969.
Bessey, O. A., Lowry, O. H., and Brock, M. J., A method for the rapid determination of alkaline phosphatase with 5 cubic millimeters of serum, J. Biol. Chem., 164, 321, 1946.
Bodansky, A., Phosphatase studies. II. Determination of serum phosphatase: Factors influencing accuracy of determination, J. Biol. Chem., 101, 93, 1933.
King, E. J., and Armstrong, A. R., Convenient method for determining serum and bile phosphatase activity, Can. Med. Assoc. J., 31, 376, 1934.
McComb, R. B., and Bowers, G. N., Jr., Study of optimum buffer conditions for measuring alkaline phosphatase activity in human serum, Clin. Chem., 18, 97, 1972.
German Society for Clinical Chemistry, Recommendations: Standard method for determination of alkaline phosphatase (AP) activity, Z. Klin. Chem. Klin. Biochem., 10, 290, 1972.
Scandinavian Society for Clinical Chemistry and Clinical Physiology, Committee on Enzymes, Recommended methods for the determination of four enzymes in blood, Scand. J. Clin. Lab. Invest., 33, 291, 1974.
Watney, P. J. M., Chance, G. W., Scott, P., and Thompson, J. M., Maternal factors in neonatal hypocalcaemia: A study in three ethnic groups, Br. Med. J., 2, 432, 1971.
Vermehren, E., Plasmaphosphatase während der Gravidität und der Laktation, Acta Med. Scand., 100, 254, 1939.
Ford, J. A., Davidson, D. C., Mcintosh, W. B., Fybe, W. M., and Dunnigan, M. G., Neonatal rickets in Asian immigrant population, Br. Med. J., 3, 211, 1973.
Healy, P. J., Isoenzymes of alkaline phosphatase in serum of lambs and ewes, Res. Vet. Sci., 19, 120, 1975.
Healy, P. J., Serum alkaline phosphatase in the newborn lamb, Clin. Chim. Acta, 33, 437, 1971.
Healy, P. J., and Mclnnes, P., Serum alkaline phosphatase activity in relation to live-weight of lambs, Res. Vet. Sci., 18, 157, 1975.
Asanti, R., Hultin, H., and Visakorpi, J. K., Serum alkaline phosphatase in healthy infants: Occurrence of abnormally high values without known cause, Ann. Paediatr. Fenn., 12, 139, 1965.
Talbot, N. B., Hoeffel, G., Schwachman, H., and Tuohy, E. L., Serum phosphatase as an aid in the diagnosis of cretinism and juvenile hypothyroidism, Am. J. Dis. Child., 62, 273, 1941.
Sandstead, H. H., Shukry, A. S., Prasad, A. S., Gabr, M. K., Hifney, A. E., Mokhtar, N., and Darby, W. J., Kwashiorkor in Egypt. 1. Clinical and biochemical studies,with special reference to plasma zinc and serum lactic dehydrogenase, Am. J. Gin. Nutr., 17, 15, 1965.
Schwartz, R., Alkaline phosphatase activity of the serum of kwashiorkor, J. Gin. Pathol., 9, 33, 1956.
Cooke, W. T., Asquith, P., Ruck, N., Melikian, V., and Swan, C. H. J., Rickets, growth and alkaline phosphatase in urban adolescents, Med. J., 2, 293, 1974.
Bennett, D. L., Ward, M. S., and Daniel, W. A., Jr., The relationship of serum alkaline phosphatase concentrations to sex maturity ratings in adolescents, J. Pediatr., 88, 633, 1976.
Kantero, R. L., Wide, L., and Widholm, O., Endocrine changes before and after the menarche. II. Serum levels of growth hormone and alkaline phosphatase and urinary excretion of 17 ketosteroids and 17 hydroxy corticosteroids, Acta Obstet. Gynecol. Scand., 54, 1, 1975.
Munan, L., Kelly, A., Petitclerc, C., and Billon, B., Associations with body weight of selected chemical constituents in blood: Epidemiologic data., Gin. Chem., 24, 772, 1978.
Tuba, J., Cantor, M. M., and Siemens, H., Phosphatases and inorganic phosphorus in normal human serum, J. Lab. Gin. Med., 32, 194, 1947.
Marsh, W. H., Fingerhut, B., and Kirsch, E., Adaptation of an alkaline phosphatase method for automatic colorimetric analysis, Gin. Chem, 5, 119, 1959.
Morgenstern, S., Kessler, G., Auerbach, J., Flor, R. V., and Klein, B., An automated p-nitrophenylphosphate serum alkaline phosphatase procedure for the Auto Analyzer, Gin. Chem., 11, 876, 1965.
Sewell, S., Serum acid and alkaline phosphatase values in the adult male, Am. J. Med. Sci., 240, 593, 1960.
Pickrell, J. A., Schlüter, S. J., Belasich, J. J., Stewart, E. V., Meyer, J., Hobbs, C. H., and Jones, R. K., Relationship of age of normal dogs to blood serum constituents and reliability of measured single values, Am. J. Vet. Res., 35, 897, 1974.
Bodansky, A., and Jaffe, H. L., Effects of diet and fasting on plasma phosphatase, Proc. Soc. Exp. Biol. Med., 29, 199, 1931.
Bodansky, A., Phosphatase studies. 6. Non-osseous origins of serum phosphatase: Its increase after ingestion of carbohydrates, J. Biol. Chem., 104, 473, 1934.
Weil, L., and Russell, M. A., Studies on plasma phosphatase activity in relation to fat metabolism in rats, J. Biol. Chem., 136, 9, 1940.
Gould, B. S., Studies on the source of serum phosphatase: The nature of the increased serum phosphatase in rats after fat feeding, Arch. Biochem., 4, 175, 1944.
Jackson, S. H., The effect of food ingestion on intestinal and serum alkaline phosphatase in rats, J. Biol. Chem., 198, 553, 1952.
Taylor, J. D., Madsen, N. B., and Tuba, J., The effects of some dietary derived lipids and fat soluble vitamins on rat serum tributyrinase and alkaline phosphatase, Can. J. Med. Sci., 30, 308, 1952.
Tuba, J., Cantor, M. M., and Richards, A. G., The relationship between serum alkaline phosphatase and dietary essential amino acids, Can. J. Res., 27, 25, 1949.
Tuba, J., and Madsen, N. B., The relationship of dietary factors to rat serum alkaline phosphatase. 2. The effect of total food consumption, methionine, choline, and vitamin B12 in normal and alloxan diabetic adult rats, Can. J. Med. Sci., 30, 18, 1952.
Saini, P. K., and Posen, S., The origin of serum alkaline phosphatase in the rat, Biochim. Biophys. Acta, 177, 50, 1969.
Breuer, J., and Kieser, H., Der Einfluss des Füttern auf klinisch-chemische Parameter im Serum der Ratte, Z. Klin. Chem. Klin. Biochem., 13, 401, 1975.
Moss, D. W., Heterogeneity of human intestinal alkaline phosphatase, Nature (London), 200, 1206, 1963.
Moss, D. W., Properties of alkaline phosphatase fractions in extracts of human small intestine, Biochem. J., 94, 458, 1965.
Tan It-Koon and Moss, D. W., The estimation of intestinal alkaline phosphatase in human blood serum, Gin. Chim. Acta, 25, 117, 1969.
Sukumaran, M., and Bloom, W. L., Influence of diet on serum alkaline phosphatase in rats and men,Proc. Soc. Exp. Biol. Med., 84, 631, 1953.
Fishman, W. H., Inglis, N. I., and Krant, M. J., Serum alkaline phosphatase of intestinal origin in patients with cancer and with cirrhosis of the liver, Clin. Chim. Acta, 12, 298, 1965.
Keiding, N. R., Intestinal alkaline phosphatase in human lymph and serum, Scand. J. Gin. Med. Invest., 18, 134, 1966.
Langman, M. J. S., Leuthold, E., Robson, E. B., Harris, J., Luffman, J. E., and Harris, H., Influence of diet on the 201cintestinal201c component of serum alkaline phosphatase in people of different ABO blood groups and secretor status, Nature (London), 212, 41, 1966.
Kleerekoper, M., Hörne, M., Cornish, C. J., and Posen, S., Serum alkaline phosphatase after fat ingestion: An immunological study, Clin. Sci., 38, 339, 1970.
Walker, B. A., Eze, L. C., Tweedie, M. C. K., and Price-Evans, D. A., The influence of ABO blood groups, secretory status and fat ingestion on serum alkaline phosphatase, Clin. Chim. Acta, 35, 433, 1971.
Statland, B. E., Winkel, P., and Bokelund, H., Serum alkaline phosphatase after fatty meals: The effect of substrates on the assay procedure, Clin. Chim. Acta, 49, 299, 1974.
Steinmetz, J., Panek, E., Sourieau, F., and Siest, G., Influence of food intake on biological parameters, in: Reference Values in Human Chemistry (G. Siest, ed.), p. 193, S. Karger, Basel, 1973.
Irwin, M. I., and Staton, A. J., Dietary wheat starch and sucrose: Effect on levels of five enzymes in blood serum of young adults, Am. J. Clin. Nutr., 22, 701, 1969.
Statland, B. E., Winkel, P., and Bokelund, H., Factors contributing to intra-individual variation of serum constituents: 1. Within-day variation of serum constituents in healthy subjects, Clin. Chem., 19, 1374, 1973.
Landau, W., and Schlamowitz, M., Studies of factors related to the differentiation of alkaline phosphatases derived from several tissues, Arch. Biochem. Biophys., 95, 474, 1961.
Haije, W. G., Influence of buffer conditions on the activities of some isoenzymes of alkaline phosphatase in the serum, Clin. Chim. Acta, 48, 23, 1973.
Katchman, B. J., and Zipf, R. E., Correlation between triglycerides and glutamic-pyruvic transaminase in men on high-fat diets, Clin. Chem, 16, 118, 1970.
Williams, M. L., Rose, C. S., Morrow, G., III, Sloan, S. E., and Barness, L. A., Calcium and fat absorption in neonatal period, Am. J. Clin. Nutr., 23, 1322, 1970.
Waterlow, J. C., and Stephen, J. M. L., Enzymes and the assessment of protein nutrition, Proc. Nutr.Soc., 28, 234, 1969.
Dean, R. F. A., and Schwartz, R., The serum chemistry in uncomplicated kwashiorkor, J. Nutr., 7, 131, 1953.
Edozien, J. C., Enzymes in serum in kwashiorkor, Pediatrics, 27, 325, 1961.
Viteri, F., Behar, M., Arroyave, G., and Scrimshaw, N. S., Clinical aspects of protein malnutrition, in: Mammalian Protein Metabolism, Vol. 2 (Munro, H. N., and Allison, J. B., eds.), p. 523, Academic Press, New York, 1964.
Ramalingaswami, V., Sriramachari, S., and Patwardhan, V. N., Liver injury in protein malnutrition, Indian. Med. Sci., 8, 433, 1954.
Ireland, P., and Fordtran, J. S., Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion, J. Clin. Invest., 52, 2672, 1973.
Paunier, L., Radde, I. C., Kooh, S. W., Conen, P. E., and Fraser, D., Primary hypomagnesemia with secondary hypocalcemia in an infant,Pediatrics, 385, 1968.
Zimmet, P., Breidahl, H. D., and Nayler, W. G., Plasma ionized calcium in hypomagnesaemia, Br. Med. J., 1, 622, 1968.
Tufts, E. V., and Greenberg, D. M., The biochemistry of magnesium deficiency. I. Chemical changes resulting from magnesium deprivation, J. Biol. Chem., 122, 693, 1938.
Heaton, F. W., Effect of magnesium deficiency on plasma alkaline phosphatase activity, Nature (London), 207, 1292, 1965.
Pimstone, B., Eisenberg, E., and Stallone, W., Decrease in serum alkaline phosphatase activity produced by magnesium depletion in rats,Ptoc. Soc. Exp. Biol. Med., 123, 201, 1966.
Bussell, N. E., Vogel, J. J., and Levy, B. M., Magnesium deficiency. II. Isoenzymes of serum alkaline phosphatase in acute magnesium deficiency, Proc. Soc. Exp. Biol. Med., 145, 574, 1974.
Lotz, M., Ney, R., Bartter, F. C., and Smith, H., Osteomalacia and debility resulting from phosphorus depletion, Trans. Assoc. Am. Physicians, 77, 281, 1964.
Miller, W. L., Meyer, W. J., and Bartter, F. C., Intermittent hyperphosphatemia, polyuria, and seizures–a new familial disorder, J. Pediatr., 86, 233, 1975.
Lai, C. C., Singer, L., and Armstrong, W. O., Effects of fluoride on phosphatase activity and ash content of metaphyseal bone of the rat, Clin. Orthop., 100, 387, 1974.
Smith, M. C., and Lantz, E. M., The effect of fluorine upon the phosphatase content of plasma, bones and teeth of albino rats, J. Biol. Chem., 112, 303, 1935.
Weidmann, S. M., Weatherell, J. A., and Whitehead, R. G., The effect of fluoride on the chemical composition and calcification of bone, J. Pathol. Bacteriol., 78, 435, 1959.
Rosenquist, J., Effects of supply and withdrawal of fluoride: Experimental studies on growing and adult rabbits. 4. Serum alkaline phosphatase isoenzymes, Acta Pathol. Microbiol. Scand. Sect. A, 81, 645, 1973.
Riekstniece, E., Myers, H. M., and Glass, L. E., In vivo effects of sodium fluoride on serum proteins and enzymes as studied with starch gel electrophoresis, Arch. Oral Biol., 10, 107, 1965.
Luoma, H., Helminen, S. K. J., Ranta, H., Rytomaa, I., and Meurman, J. H., Relationships between the fluoride and magnesium concentrations in drinking water and some components in serum related to cardiovascular diseases in men from four rural districts in Finland, Scand. J. Clin. Lab. Invest., 32, 217, 1973.
Ferguson, D. B., Effects of low doses of fluoride on serum proteins and a serum enzyme in man,Nature (London) New Biol., 231, 159, 1971.
Srikantia, S. G., and Siddiqui, A. H., Metabolic studies in skeletal fluorosis, Clin. Sci., 28, 477, 1965.
Kay, H. D., Plasma phosphatase. II. The enzyme in disease, particularly in bone disease, J. Biol. Chem., 89, 249, 1930.
Bodansky, A., and Jaffe, H. L., Phosphatase studies. V. Serum phosphatase as a criterion of the severity and rate of healing of rickets, Am. J. Dis. Child., 48, 1268, 1934.
Youmans, J. B., Patton, E. W., Sutton, W. R., Kern, R., and Steinkamp, R., Surveys of nutrition of populations. 4. The vitamin D and calcium nutrition of a rural population in Middle Tennesses, Am. J. Public Health, 34, 1049, 1944.
Adamson, J. D., Jolliffe, N., Kruse, H. D., Lowry, O. H., Moore, P. E., Piatt, B. S., Sebrell, W. H., Tice, J. W., Tisdall, F. F., Wilder, R. M., and Zamecnik,P. C., Medical survey of nutrition in Newfoundland, Can. Med. Assoc. J., 52, 227, 1945.
Lester, E., Skinner, R. K., and Wills, M. R., Seasonal variation in serum 25-hydroxyvitamin D in the elderly in Britain, Lancet, 1, 979, 1977.
Hodkinson, H. M., Staton, B. R., Round, P., and Morgan, C., Sunlight, vitamin D, and osteo-malacia of the elderly, Lancet, 1, 910, 1973.
Wills, M. R., Day, R. C., Phillips, J. B., and Bateman, E. C., Phytic acid and nutritional rickets in immigrants, Lancet, 1, 111, 1972.
Holmes, A. M., Enoch, B. A., Taylor, J. L., and Jones, M. E., Occult rickets and osteomalacia amongst the Asian immigrant population, Q. J. Med., 42, 125, 1973.
Truhlar, J., Drekter, L., McGuire, G., and Falk, K. G., The phosphatase actions of tissues of normal and rachitic rats, J. Biol. Chem., 127, 345, 1939.
Gould, B. S., and Schwachman, H., Bone and tissue phosphatase in experimental scurvy and studies on the source of serum phosphatase, Am. J. Physiol., 135, 485, 1942.
Harrer, C. J., and King, C. G., Ascorbic acid deficiency and enzyme activity in guinea pig tissues, J. Biol. Chem., 138, 111, 1941.
Voelker, R. W., and Carlton, W. W., Effect of ascorbic acid on copper deficiency in miniature swine, Am. J. Vet. Res., 30, 1825, 1969.
Kurz, D., and Eyring, E. J., Effects of vitamin C on osteogenesis imperfecta, Pediatrics, 54, 56, 1974.
Thannhauser, S. J., Reichel, M., Grattan, J. F., and Maddock, S. J., Studies on serum phosphatase activity. II. The effect of experimental total biliary obstruction on serum phosphatase activation in dogs and cats, J. Biol. Chem., 121, 709, 1937.
King, E. S., and Delory, G. E., Ascorbic acid and phosphatase activity, Biochem. J., 32, 1157, 1938.
MacPherson, A., Moon, F. E., and Voss, R. C., Some effects of feeding young steers on a diet deficient in both cobalt and copper. Br. Vet. J., 129, 414, 1973.
Van Dommelen, C. K. V., and Klaassen, C. H. L., Cyanocobalamin-dependent depression of the serum alkaline phosphatase level in patients with pernicious anemia, N. Engl. J. Med., 271, 541, 1964.
Jeffrey, F. E., and Abelmann, W. H., Recovery from proved Shoshin beriberi, Am, J. Med., 50, 123, 1971.
Muenter, M. D., Perry, H. O., and Ludwig, J., Chronic vitamin A intoxication in adults: Hepatic, neurologic and dermatologic complications, Am. J. Med., 50, 129, 1971.
Stimson, W. H., Vitamin A intoxication in adults: Report of a case with a summary of the literature, TV. Engl J. Med., 265, 369, 1961.
Gerber, A., Raab, A. P., and Sobel, A. E., Vitamin A poisoning in adults with description of a case, Am. J. Med., 16, 729, 1954.
Pease, C. N., Focal retardation and arrestment of growth of bones due to vitamin A intoxication, J. Am. Med. Assoc., 182, 980, 1962.
Jowsey, J., and Riggs, B. L., Bone changes in a patient with hypervitaminosis A, J. Clin. Endocrinol Me tab., 28, 1833, 1968.
Fisher, G., and Skillern, P. G., Hypercalcemia due to hypervitaminosis A, J. Am. Med. Assoc., 227, 1413, 1974.
Frame, B., Jackson, C. E., Reynolds, W. A., and Umphrey, J. E., Hypercalcemia and skeletal effects in chronic hypervitaminosis A, Ann. Intern. Med., 80, 44, 1974.
Russell, R. M., Boyer, J. L., Bagheri, S. A., and Hruban, Z., Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites, N. Engl J. Med., 291, 435, 1974.
Leelaprute, V., Boonpucknavig, V., Bhamarapravati, N., and Weerapradist, W., Hypervitaminosis A in rats: Varying responses due to different forms, doses and routes of administration, Arch. Pathol, 96, 5, 1973.
Clark, L., Seawright, A. A., and Gartner, R. J. W., Longbone abnormalities in kittens following vitamin A administration, J. Comp. Pathol, 80, 113, 1970.
Lease, J. G., Effect of histidine on tibia alkaline phosphatase of chicks fed zinc-deficient sesame meal diets, J. Nutr., 102, 1323, 1972.
Starcher, B., and Kratzer, F. H., Effect of zinc on bone alkaline phosphatase in turkey poults, J. Nutr., 79, 18, 1963.
Vallee, B. L., Biochemistry, physiology and pathology of zinc, Physiol Rev., 39, 443, 1959.
Miller, W. J., Pitts, W. J., Clifton, C. M., and Morton, J. D., Effects of zinc deficiency per se on feed efficiency, serum alkaline phosphatase, zinc in skin, behavior, greying and other measurements in the Holstein calf, J. Dairy Sci., 48, 1329, 1965.
Burch, R. E., Williams, R. V., Hahn, H. K. J., Jetton, M. M., and Sullivan, J. F., Serum and tissue enzyme activity and trace-element content in response to zinc deficiency in the pig, Clin. Chem., 21, 568, 1975.
Luecke, R. W., Hoefer, J. A., Brammell, W. S., and Thorp, F., Jr., Mineral interrelationship in parakeratosis of swine, J. Anim. Sci., 15, 347, 1956.
Luecke, R. W., Hoefer, J. A., Brammell, W. S., and Schmidt, D. A., Calcium and zinc in para-keratosis of swine, J. Anim. Sci., 16, 3, 1957.
Moynahan, E. J., Acrodermatitis enteropathica: A lethal inherited human zinc-deficiency disorder, Lancet, 2, 399, 1974.
Neldner, K. H., and Hambidge, K. M., Zinc therapy of acrodermatitis enteropathica, N. Engl J. Med., 292, 879, 1975.
Carter, J. P., Grivetti, L. E., Davis, J. T., Nasiff, S., Mansour, A., Mousa, W. A., Atta, A.-E.-D., Patwardhan, V. W., Moneim, M. A., Abdou, I. A., and Darby, W. J., Growth and sexual development of adolescent Egyptian village boys: Effects of zinc, iron, and placebo supplementation, Am. J. Clin. Nutr., 22, 59, 1969.
Prasad, A. S., Miale, A., Farid, Z., Sandstead, H. H., Schulert, A. R., and Darby, W. J., Biochemical studies on dwarfism, hypogonadism and anemia, Arch. Intern. Med., 111, 401, 1963.
Danks, D. M., Campbell, P. E., Stevens, B. J., Mayne, V., and Cartwright, E., Menkes’s kinky hair syndrome: An inherited defect in copper absorption with widespread effects, Pediatrics, 50, 188, 1972.
Danks, D. M., Personal communication, 1976.
Crosby, W. H., Likhite, V. V., O’Brien, J. E., and Forman, D., Serum iron levels in ostensibly normal people, J. Am. Med. Assoc., 227, 310, 1974.
Britton, W. M., and Hill, C. H., Effects of copper and cadmium on zinc deficient chicks, Fed Proc. Fed. Am. Soc. Exp. Biol, 23, 133, 1964.
Burger, F. J., Malan, J., and Bester, P., The effect of hyperthermia on serum enzymes’ activity, S. Afr. Med. J., 44, 899, 1970.
Szadkowski, D., Ehrhardt, H. P., Schaller, K. H., and Lehnert, G., Der Zinc- und Kupferspiegel im Serum hitzeadaptierter Schwerarbeiter, Int. Arch. Gewerbapathol. Gewerbehyg., 25, 202, 1969.
Morimoto, T., Shiraki, K., Inoue, T., and Yoshimura, H., Seasonal variation of water and electrolyte in serum with respect to homeostasis, Jpn. J. Physiol., 19, 801, 1969.
De Moor, P., Stein, F., Claes, J. H., De Baene, J., and Joossens, J. V. J., Factors related to the between-person variation in the transcortin activity of normal adults, Clin. Chim. Acta, 30, 311, 1970.
Kanis, J. A., Brown, P., Fitzpatrick, K., Hibbert, D. J., Horn, D. B., Nairn, I. M., Shirling, D., Strong, J. A., and Walton, H. J., Anorexia nervosa: A clinical, psychiatric, and laboratory study, Q. J. Med., 43, 321, 1974.
Moxley, R. T., Pozefsky, T., and Lockwood, D. H., Protein nutrition and liver disease after jejunoileal bypass for morbid obesity, N. Engl. J. Med., 290, 921, 1974.
Brown, R. G., O’Leary, J. P., and Woodward, E. R., Hepatic effects of jejunoileal bypass for morbid obesity, Am. J. Surg., 127, 53, 1974.
Bradley, E. M., Bellamy, H. M., Knudsen, K. B., and Lecocq, F. R., Impairment of biliary transport as a cause of sulfbromophthalein retention in fasting men, Metabolism, 18, 675, 1969.
Galteau, M. M., and Siest, G., Variation of plasmatic enzymes produced by exercise, in: Reference Values in Human Chemistry (Siest, G., ed.), p. 223, S. Karger, Basel, 1973.
Sarin, R. C., Hazards of prolonged bed-rest: Clinical, biochemical and blood coagulation studies, Indian J. Med. Sci., 26, 301, 1972.
Hantman, D. A., Vogel, J. M., Donaldson, C. L., Friedman, R., Goldsmith, R. S., and Hulley, S. B., Attempts to prevent disuse osteoporosis by treatment with calcitonin, longitudinal compression and supplementary calcium and phosphate, J. Clin. Endocrinol. Metab., 36, 845, 1973.
Hulley, S. B., Vogel, J. M., Donaldson, C. J., Bayers, J. H., Friedman, R. J., and Rosen, S. N., The effect of supplemental oral phosphate on the bone mineral changes during prolonged bed rest, J. Gin. Invest., 50, 2506, 1971.
King, S. W., Statland, B. E., and Savory, J., The effect of a short burst of exercise on activity values of enzymes in sera of healthy young men, Clin. Chim. Acta, 72, 211, 1976.
Riley, W. S., Pyke, F. S., Roberts, A. D., and England, S. F., The effects of long-distance running on some biochemical variables, Clin. Chim. Acta, 65, 83, 1975.
Lutwak, L., Whedon, G. D., Lachance, P. A., Reid, J. M., and Lipscomb, H. S., Mineral, elec-trolyte and nitrogen balance studies of the Gemini-VII fourteen-day orbital space flight, J. Clin. Endocrinol., 29, 1140, 1969.
Alexander, W. C., Leach, C. S., and Fischer, C. L., Clinical biochemistry, in: Biomedical Results of Apollo (Johnson, R. S., Dietlein, L. F., and Berry, C. A., eds.), p. 185, National Aeronautics and Space Administration, Washington, D.C., 1975.
Leach, C. S., and Rambaut, P. C., Biochemical observations of long duration manned orbital spaceflight, J. Am. Med. Women’s Assoc., 30, 153, 1975.
Leach, C. S., Personal communication, 1976.
Billings, C. E., Brashear, R. E., Bason, R., and Mathews, D. K., Medical observations during 20 days at 3,800 meters, Arch. Environ. Health, 18, 987, 1969.
Martin, K. J., Gray, S. P., and Nichols, G., Effect of a short simulated dive on selected blood constituents in mm, Aerosp. Med., 44, 516, 1973.
Allcroft, W. M., and Folley, S. J., Observations on the serum phosphatase of cattle and sheep, Biochem. J., 35, 254, 1941.
Keiding, N. R., Mechanisms of phosphohydrolase transport and of homeostasis, Ann. N. Y. Acad. Sci., 166, 511, 1969.
Young, D. S., Harris, E. K., and Cotlove, E., Biological and analytical components of variation in long-term studies of serum constituents in normal subjects. IV. Results of a study designed to eliminate long-term analytic deviations, Clin. Chem., 17, 403, 1971.
Statland, B. E., and Winkel, P., The use of a patient’s baseline values as a subject-specific reference interval: An alternative definition of normality, Presented at the First Inter American Symposium on Quality Control, Key Biscayne, Florida, April 9, 1976 (sponsored by DADE, Division of American Hospital Supply, Miami, Florida 33152 ).
Statland, B. E., Winkel, P., and Killings worth, L. M., Factors contributing to intra-individual variation of serum constituents. 6. Physiological day-to-day variation in concentrations of 10 specific proteins in sera of healthy subjects, Clin, Chem., 22, 1635, 1976.
Pickup, J. F., Harris, E. K., Kearns, M., and Brown, S. S., Intra-individual variation of some serum constituents and its relevance to population-based reference ranges, Clin. Chem., 23, 842, 1977.
Bowers, G. N., Jr., and McComb, R. B., A continuous spectrophotometry method for measuring the activity of serum alkaline phosphatase, Clin. Chem., 12, 70, 1966.
Bowers, G. N., Jr., and McComb, R. B., Measurement of total alkaline phosphatase activity in human serum, Clin. Chem. (201cSelected Methods201c section), 21, 1988, 1975.
Bowers, G. N., Jr., Burnett, R. W., and McComb, R. B., Preparation and use of human serum control materials for monitoring precision in clinical chemistry, Gin. Chem., 21, 1830, 1975.
Burnett, R. W., Accurate estimation of standard deviations for quantitative methods used in clinical chemistry, Clin. Chem., 21, 1935, 1975.
Bowers, G. N., Jr., Unpublished, 1977.
Kanabrocki, E. L., Scheving, L. E., Halberg, F., Brewer, R. L., and Bird, T. J., Orcadian variations in presumably healthy men under conditions of peace-time army reserve unit training, Space Life Sci., 4, 258, 1973.
Cotlove, E., Harris, E. K., and Williams, G. Z., Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. III. Physiological and medical implications, Clin. Chem., 16, 1028, 1970.
Hosenfeld, D., and Schröter, E., Concerning the question of individual constancy and individual specificity of three serum enzyme activities (serum Cholinesterase E.C. 3.1.1.8, ceruloplasmin E.C. 1.10.3.2, and alkaline phosphatase E.C. 3.1.3.1), Humangenetik, 9, 38, 1970.
Zaidman, J., Discussion in Section 1: Economics of laboratory utilization, in: Logic and Economics of Ginical Laboratory Use (Benson, E. S., and Rubin, M., eds.), p. 71, Elsevier, New York, 1978.
Rang, M., The Ulysses syndrome, Can. Med. Assoc. J., 106, 122, 1972.
Bach, U., Das Verhalten der alkalischen Serumphosphatase bei Frühgeborenen, Rachitikern und Spasmophilen, Z. Zinderheilkd., 74, 593, 1954.
Guedeke, M., Bestaat er hyperfosfatasemia van voorbijgaande aard?, Maandschr. Kinder- geneeskd., 40, 46, 1972.
Posen, S., Neale, F. C., and Clubb, J. S., Heat inactivation in the study of human alkaline phosphatases, Intern. Med., 62, 1234, 1965.
Posen, S., Kleerekoper, M., and Cornish, C., Serum alkaline phosphatase in the diagnosis of metabolic bone disorders, in: Clinical Aspects of Metabolic Bone Disease (Frame, E., Parfitt, A. M., and Duncan, H., eds.), p. 74, Excerpta Medica, Amsterdam, 1973.
Kind, P. R. N., and King, E. J., Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine, J. Clin. Pathol., 7, 322, 1954.
Neale, F. C., Clubb, J. S., and Posen, S., Artificial elevation of the serum alkaline phosphatase concentration (letter to the editor),Med. J. Aust., 2, 684, 1963.
Mahy, B. W. J., Rowson, K. E. K., and Parr, C. W., Studies on mechanisms of action of Riley virus. IV. The reticuloendothelial system and impaired plasma enzyme clearance in infected mice, J. Exp. Med., 125, 277, 1967.
Wieme, R. L., More on transient hyperphosphatasemia in infancy-an insufficiently recognized syndrome (letter), Clin. Chem., 24, 520, 1978.
Budinger, J. M., and Weller, C., Normal ranges of 340 physicians, in: Advances in Automated Analysis (Technicon International Congress of 1969), Vol. 3, p. 23, Mediad, White Plains, New York, 1970.
Craig, J. L., and Bartholomew, M. D., Blood profile ranges by age decades in 7,337 male employees, in: Advances in Automated Analysis (Technicon International Congress of 1969), Vol. 3, p. 105, Mediad, White Plains, New York, 1970.
Kaplow, S. L., A histochemical procedure for localizing and evaluating alkaline phosphatase activity in smears of blood and marrow, Blood, 10, 1023, 1955.
Systematized Nomenclature of Pathology, 1st ed., College of American Pathologists, Chicago, 1965.
Spiro, H. M., Visceral viewpoints: The tools of our trade-Some comments on disease and disorder, N. Engl J. Med., 292, 575, 1975.
Johnson, W. C., and Menne, H. L., Localization of alkaline phosphatase in skin of man and certain animals, J. Histochem. Cytochem., 16, 514, 1968.
Fisher, I., and Glick, D., Histochemistry. XIX. Localization of alkaline phosphatase in normal and pathological human skin, Proc. Soc. Exp. Biol Med., 66, 14, 1947.
Kopf, A. W., The distribution of alkaline phosphatase in normal and pathologic skin, Arch. Determatol., 75, 1, 1957.
Loewenthal, L. J. A., and Politzer, W. M., Alkaline phosphatase in human eccrine sweat, Nature (London), 195, 902, 1962.
Loewenthal, L. J. A., and Hins, S. C., Phosphomonoesterases in eccrine sweat and their localization after prolonged sweating, Dermatologia (Basel), 126, 311, 1963.
Graham, J. H., Johnson, W. C., and Helwig, E. B. (eds.), Dermal Pathology, p. 99, Harper & Row, New York, 1972.
Serri, F., Montagna, W., and Haber, W. M., Studies of skin of fetus and the child: The distribution of alkaline phosphatase in the skin of the fetus, Arch. Dermatol, 87, 234, 1963.
Hewitt, J., and Guigon, M., Histoenzymological study of dermal vessels in normal and pathological skin, Br. J. Dermatol., 82, 364, 1970.
Kawakatsu, K., and Mori, M., Histochemical evaluation of enzymatic activities in human squamous-cell cancer, Cancer Res., 23, 539, 1963.
Girard, C., Johnson, W. C., and Graham, J. H., Cutaneous angiosarcoma, Cancer, 26, 868, 1970.
Chapel, H. M., and Batchelor, J. R., Rosette inhibition test in severely burned patients, Br. Med. J., 4, 385, 1973.
Arturson, G., and Beckman, L., Serum isozyme variations in clinical burns: Alterations in naphthylamidase and alkaline phosphatase, Scand. J. Plast. Reconstr. Surg., 1, 81, 1967.
Robinson, H. M., Jr., and Stone, J. H., Exanthem due to diphenylhydantoin therapy, Arch. Dermatol, 101, 462, 1970.
Hahn, T. J., Hendin, B. A., Scharp, C. R., Boisseau, V. C., and Haddad, J. G., Jr., Serum 25- hydroxycalciferol levels and bone mass in children on chronic anticonvulsant therapy, N. Engl J. Med., 292, 550, 1975.
Hahn, T. J., Hendin, B. A., Scharp, C. R., and Haddad, J. G., Jr., Effects of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults, TV. Engl J. Med., 287, 900, 1972.
Leard, S. E., Greer, W. E. R., and Kaufman, J. C., Hepatitis, exfoliative dermatitis and abnormal bone marrow occurring during tridione therapy, W. Engl J. Med., 240, 962, 1949.
Blume, R. S., and Wolff, S. M., The Chediak-Higashi syndrome: Studies in four patients and review of the literature, Medicine (Baltimore), 51, 247, 1972.
Hosli, P., Griscelli, C., and Good, R. A., Chediak-Higashi syndrome. I. Biochemical abnormality and prospects for prenatal diagnosis, Monogr. Hum. Genet., 9, 126, 1978.
Aronsen, K. F., Gundersen, J., and Haeger, K. H. M., Leg ulcers and liver function tests, Angiology, 23, 111, 1972.
Marks, J., Studies with 47Ca in patients with calcinosis cutis, Br. J. Dermatol, 82, 1, 1970.
Anderson, D. C., Stewart, W. K., and Piercy, D. M., Calcifying panniculitis with fat and skin necrosis in a case of uraemia with autonomous hyperparathyroidism, Lancet, 2, 323, 1968.
Reynolds, T. B., Denison, E. K., and Frankl, H., Primary biliary cirrhosis with scleroderma, Raynaud’s phenomenon and telangiectasia: New syndrome, Am. J. Med., 50, 302, 1971.
Case records of the Massachusetts General Hospital, Case 28-1965, N. Engl. J. Med., 272, 1340, 1965.
Wilson, R. H., McCormick, W. E., Tatum, C. F., and Creech, J. L., Occupational acroosteolysis, J. Am. Med. Assoc., 201, 577, 1967.
Makk, L., Creech, J. L., Whelan, J. G., and Johnson, M. N., Liver damage and angiosarcoma in vinyl chloride workers: A systematic detection program, J. Am Med. Assoc., 230, 64, 1974.
Mitsudo, S. M., Chronic idopathic hyperphosphatasia associated with pseudoxanthoma elasticum, J. Bone Joint Surg., 53-A, 303, 1971.
Milstoc, M., An unusual anatomo-pathologic aspect of a case with pseudoxanthoma elasticum, Dis. Chest, 55, 431, 1969.
Gordon, M., and Johnson, W. C., Histopathology and histochemistry of psoriasis. 1. The active lesions and clinically normal skin, Arch. Dermatol., 95, 402, 1967.
Schuster, S., Watson, A. J., and Marks, J., Small intestine in psoriasis, Br. Med. J., 3, 458, 1967.
Preger, L., Maibach, H. I., Osborne, R. B., Shapiro, H. A., and Lee, J. C., On the question of psoriatic enteropathy, Arch. Dermatol., 102, 151, 1970.
Dahl, M. G. C., Gregory, M. M., and Scheuer, P. J., Liver damage due to methotrexate in patients with psoriasis, Br. Med. J., 1, 625, 1971.
Spiro, J. M., and Demis, D. J., Treatment of psoriasis with minute divided oral doses of methotrexate, Arch. Dermatol., 99, 459, 1969.
McDonald, C. J., and Bertino, J. R., Parenteral methotrexate in psoriasis: A report on the efficacy and toxicity of long-term intermittent treatment, Arch. Dermatol., 100, 655, 1969.
Noojin, R. O., Bradford, L. G., and Osment, L. S., Monitoring methotrexate therapy in psoriasis, Arch. Dermatol., 101, 646, 1970.
Nagy-Vezekenyi, K., Die Behandlung der Psoriasis mit Gricin, Z. Hautkr., 44, 269, 1969.
Mutter, R. D., Tannenbaum, M., and Ultmann, J. E., Systemic mast cell disease, Ann. Intern. Med., 59, 887, 1963.
Barer, M., Peterson, L. F. A., Dahlin, D. C., Winkelmann, R. K., and Stewart, J. R., Mastocytosis with osseous lesions resembling metastatic malignant lesions in bone, J. Bone Joint Surg., 50A, 142, 1968.
Hirschman, S. Z., Feingold, M., and Boylen, G., Mercury in house paint as a cause of acrodynia: Effect of therapy with N-acetyl-DL-penicillamine, N. Engl J. Med., 269, 889, 1963.
Nadler, H. L., Inouye, T., Justice, P., and Hsia, D. Y. Y., Enzymes in cultivated human fibroblasts derived from patients with Down’s syndrome (mongolism), Nature (London), 213, 1261, 1967.
Cox, R. P., Regulation of alkaline phosphatase in skin fibroblast cultures from patients with mongolism, Exp. Cell Res., 37, 690, 1965.
Fanger, H., and Barker, B. E., Histochemistry of breast diseases. 1. Phosphatases, Arch. Pathol., 67, 293, 1959.
Fanger, H., and Barker, B. E., Capillaries of normal and diseased breast, Arch. Pathol., 69, 67, 1960.
Pakdaman, P., and Stein, A. A., Enzyme histochemical studies on surgically resected breasts, Arch. Surg., 86, 593, 1963.
Pretlow, T. G., Dow, S. R., Murad, T. M., and Jones, J., Separation of acinar cells from lactat- ing mammary gland using velocity sedimentation in an isokinetic gradient of Ficoll in tissue culture medium, Am. J. Pathol., 76, 95, 1974.
Jensen, H., Gynecomastia: Enzyme histochemical and histological investigations with a correlation of enzyme activities in gynecomastia and fibro-adenomatosis, Acta Pathol. Microbiol. Scand. Sect. A, 81, 543, 1973.
Murad, T. M., A proposed histochemical and electron microscopic classification of human breast cancer according to cell of origin, Cancer, 27, 288, 1971.
Drennan, J. M., Alkaline phosphatase in breast carcinomas, Br. J. Surg., 39, 458, 1952.
Jensen, H., and Schiodt, T., Stromal response in breast carcinoma and fibroadenomatosis, estimated by the aid of the alkaline phosphatase activity, Acta Pathol Microbiol Scand. Sect. A, 79, 321, 1971.
Chowdhury, S. R., Haider, K., and Chaudhuri, N., Alkaline phosphatase activity during preg-nancy and puerperium in Indian women, Indian J. Med. Sci., 19, 493, 1965.
Posen, S., Unpublished, 1974.
Galasko, C. S., Skeletal metastases and mammary cancer, Ann. R. Coll. Surg. Engl., 50, 3, 1972.
Woodard, H. Q., Escher, G. C., and Farrow, J. H., Changes in blood chemistry of patients with disseminated carcinoma of the breast during endocrine therapy, Cancer, 7, 744, 1954.
Anglesio, E., Calciati, A., and Pianarosa, M., Changes of calcium, phosphorus, citrate and alkaline phosphatases in metastatic breast cancer, Helv. Med. Acta, 30, 116, 1963.
Lee, C. A., and Lloyd, H. M., Bone collagen and calcium metabolism in normocalcemic and hypercalcemic patients with breast cancer, Cancer, 27, 1099, 1971.
Galasko, C. S., The detection of skeletal metastases from carcinoma of the breast, Surg. Gynecol. Obstet., 132, 1019, 1971.
Cowan, R. J., and Young, K. A., Evaluation of serum alkaline phosphatase determination in patients with positive bone scans, Cancer, 32, 887, 1973.
Galasko, C. S. B., Hypercalcaemia in carcinoma of the breast, Proc. R. Soc. Med., 62, 487, 1969.
Griboff, S. I., Herrman, J. B., Smelin, A., and Moss, J., Hypercalcemia secondary to bone metastases from carcinoma of the breast. I. Relationship between serum calcium and alkaline phosphatase values, J. Clin. Endocrinol Metab., 14, 378, 1954.
Jaffe, H. L., Tumors and Tumorous Conditions of Bones and Joints, Lea & Febiger, Philadelphia, 1958.
Nathanson, L., and Fishman, W. H., New observations on the Regan isoenzyme of alkaline phosphatase in cancer patients, Cancer, 27, 1388, 1971.
Coombes, R. C., Powles, T. J., Gazet, J. C., Ford, H. T., Sloane, J. P., Laurence, D. J. R., and Neville, A. M., Biochemical markers in human breast cancer, Lancet, 7, 132, 1977.
Berndt, G., and Stender, H. S., Die Östrogen-Gestagen-Kombinations-behandlung des metastasierenden Mammakarzinoms mit SH834, Dtsch. Med. Wochenschr., 95, 2399, 1970.
Ditzel, J., Jordal, R., and Riskaer, N., Total urinary hydroxyproline excretion before and after hypophysectomy in patients with bone metastases from breast carcinoma, Acta Endocrinol., 59, 353, 1968.
Wachstein, M., Alkaline phosphatase activity in normal and abnormal human blood and bone marrow cells, J. Lab. Clin. Med., 31, 1, 1946.
Wachstein, M., Renal phosphatase in choline deflcinecy, Arch. Pathol., 38, 297, 1944.
Takamatsu, H., Histologische und biochemische Studien liber die Phosphatase: Histochemische Untersuchungsmethodik der Phosphatase und deren Verteilung in verschiedenen Organen und Gewerben, Trans. Soc. Pathol Jpn., 29, 492, 1939.
Gomori, G., Microtechnical demonstration of phosphatase in tissue sections, Proc. Soc. Exp. Biol. Med., 42, 23, 1939.
Kaplow, L. S., Leukocyte alkaline phosphatase in disease, Crit. Rev. Clin. Lab. Sci., 2, 243, 1971.
Kaplow, L. S., Leukocyte alkaline phosphatase cytochemistry: Applications and methods, Ann. N. Y. Acad. Sci, 155, 911, 1968.
Kaplow, L. S., Alkaline phosphatase activity in peripheral blood lymphocytes, Arch. Pathol., 88, 69, 1969.
Yarrison, G., Mertens, B. F., and Mathies, J. C., New diagnostic use of bone marrow acid and alkaline phosphatase, Am. J. Clin. Pathol., 66, 667, 1976.
Lie-Injo, L. E., Alkaline phosphatase activity of the leukocytes in animals, Nature (London), 204, 191, 1964.
Whitt, J., Evaluation of a histochemical method for determining leukocyte alkaline phosphatase activity and a discussion of normal values in adults and newborns, Am. J. Med. Technol., 29, 169, 1963.
Hayhoe, F. G. J., and Quaglino, D., Cytochemical demonstration and measurement of leucocyte alkaline phosphatase activity in normal and pathological states by a modified azo-dye coupling technique, Br. J. Haematol., 4, 375, 1958.
Sherwood, L. M., and Kendall, R. E., A histochemical study of leukocyte alkaline phosphatase in health and disease, Hartford Hosp. Bull., 14 (December), 18, 1959.
Ray, P. K., and Pinkerton, P. H., Leukocyte alkaline phosphatase: The effect of age and sex, Acta Haematol., 42, 18, 1969.
Rosner, F., Lee, S. L., Schultz, F. S., and Gorfien, P. C., The regulation of leukocyte alkaline phosphatase, Ann. N. Y. Acad. Sci., 155, 902, 1968.
Pralle, H., Schnellbacher, E., and Loffler, H., Alkaline phosphatase in human erythrocytes: A new hereditary disorder, in: Erythrocytes, Thrombocytes, Leukocytes: Recent Advances in Membrane and Metabolic Research (IInd International Symposium), p. 189, Geo. Thieme, Stuttgart, 1973.
Van der Ploeg, M., and Van Duijn, P., Cytophotometric determination of alkaline phosphatase activity of individual neutrophilic leukocytes with a biochemically calibrated model system, J. Histochem. Cytochem., 16, 693, 1968.
Diamant, Y. Z., Sadovsky, E., and Gal, A., Evaluation of the leukocyte alkaline phosphatase activity: Comparison of the biochemical and cytochemical assay, Clin. Chim. Acta, 34, 73, 1971.
Halbrecht, I., and Shabtay, F., Leukocyte alkaline phosphatase activity in pre-term, term and post-term infants, Isr. J. Med. Sci., 8, 1956, 1972.
O’Kell, R. T., Leukocyte alkaline phosphatase in the infant, Ann. N. Y. Acad. Sci., 155, 980, 1968.
Sadovsky, E., Matz, D., Diamant, Y. Z., and Polishuk, W. Z., Leukocyte alkaline phosphatase in the newborn, Biol. Neonate, 27, 96, 1975.
Pritchard, J. A., Leukocyte phosphatase activity in pregnancy, J. Lab. Clin. Med., 50, 432, 1957.
Polishuk, W. Z., Diamant, Y. Z., Zuckerman, H., and Sadovsky, E., Leukocyte alkaline phosphatase in pregnancy and the puerperium,, Am. J. Obstet. Gynecol., 107, 604, 1970.
Beal, R. W., Read, W. M. F., and Turvey, P. A., Neutrophil alkaline phosphatase in pregnancy, Clin. Pathol., 20, 749, 1967.
Rosner, F., and Lee, S. L., Endocrine relationships of leukocyte alkaline phosphatase, Blood, 25, 356, 1965.
Macaraeg, P. V. J., Jr., Connell, E., and Bianchine, J. K., Neutrophil alkaline phosphatase activity: Effect of certain oral contraceptive hormones, Arch. Intern. Med., 122, 412, 1968.
Sachs, E. S., Van der Ploeg, M., Van Gelderen, H. H., and Schaberg, A., Alkaline phosphatase activity in leukocytes of patients with trisomy G normal mosaicism, Am. J. Clin. Pathol., 54, 699, 1970.
Alter, A. A., and Lee, S. L., Leukocyte alkaline phosphatase in the 21-trisomy (Down’s) syn-drome, Ann. N. Y. Acad. Sci., 155, 1023, 1968.
Alter, A. A., Lee, S. L., Pourfar, M., and Dobkin, G., Studies of leukocyte alkaline phosphatase in mongolism: A possible chromosome marker, Blood, 22, 165, 1963.
King, M. J., Gillis, E. M., and Baikie, A. G., Alkaline phosphatase activity of polymorphs in mongolism, Lancet, 2, 1302, 1962.
O’Sullivan, M. A., and Pryles, C. V., A comparison of leukocyte alkaline phosphatase determinations in 200 patients with mongolism and in 200 201cfamilial201c controls, N. Engl. J. Med., 268, 1168, 1963.
Coburn, S. P., and Seidenberg, M., Leukocyte pyridoxal phosphate and alkaline phosphatase in Down’s syndrome and other retardates, Am. J. Clin. Nutr., 22, 1197, 1969.
Trubowitz, S., Kirman, D., and Masek, B., The leukocyte alkaline phosphatase in mongolism, Lancet, 2, 486, 1962.
Bottomley, R. H., Lovig, C. A., Holt, R., and Griffin, M. J., Comparison of alkaline phosphatase from human normal and leukemic leukocytes, Cancer Res., 29, 1866, 1969.
Lyons, R. B., Weaver, D. D., and Beck, J. H., Isoenzymes of human leukocyte alkaline phosphatase, Ann. N. Y. Acad. Sci., 155, 948, 1968.
Valentine, W. N., and Beck, W. S., Biochemical studies on leucocytes. I. Phosphatase activity in health, leucocytosis and myelocytic leucemia, J. Lab. Clin. Med., 38, 39, 1951.
Wiltshaw, E., and Moloney, W. C., Histochemical and biochemical studies on leukocyte alkaline phosphatase activity, Blood, 10, 1120, 1955.
Trubowitz, S., Feldman, D., Morgenstern, S. W., and Hunt, V. M., The isolation, purification and some properties of the alkaline phosphatase of human leukocytes, Biochem. J., 80, 369, 1961.
McCoy, E. E., Park, J., and England, J., A fluorometric assay and properties of leucocyte alkaline phosphatase, Clin. Chim. Acta, 12, 453, 1965.
Avila, J. L., and Convit, J., Studies on human polymorphonuclear leukocyte enzymes. 1. Assay of acid hydrolases and other enzymes, Biochim. Biophys. Acta, 293, 397, 1973.
Shih, L. Y., and Hsia, D. Y. Y., Enzymes in Down’s syndrome, Lancet, 1, 155, 1966. 3
Ansell, B. F., and Scott, R. B., Platelet alkaline phosphatase: Normal values and variations in myeloproliferative syndromes, Proc. Soc. Exp. Biol. Med., 130, 1119, 1969.
Levy, R. N., Sawitsky, A., Florman, A. L., and Rubin, E., Fatal aplastic anemia after hepatitis: Report of five cases, N. Engl. J. Med., 273, 1118, 1965.
Schwarz, E., Baehner, R. L., and Diamond, L. K., Aplastic anemia following hepatitis, Pediatrics, 37, 681, 1966.
Sanchez-Medal, L., Gomez-Leal, A., Duarte, L., and Rico, M. G., Anabolic androgenic steroids in the treatment of acquired aplastic anemia, Blood, 34, 283, 1969.
Allen, D. M., Fine, M. H., Necheles, T. F., and Dameshek, W., Oxymetholone therapy in aplastic anemia, Blood, 32, 83, 1968.
McCredie, K. B., Oxymetholone in refractory anaemia, Br. J. Haematol., 17, 265, 1969.
Storb, R., Thomas, E. D., Buckner, C. D., Clift, R. A., Johnson, F. L., Fefer, A., Glucksberg, H., Giblett, E. R., Lerner, K. G., and Neiman, P., Allogeneic marrow grafting for treatment of aplastic anemia, Blood, 43, 157, 1974.
Barrett-Connor, E., Cholelithiasis in sickle cell anemia, Am. J. Med., 45, 889, 1968.
Green, T. W., Conley, C. L., and Berthrong, M., The liver in sickle cell anemia, Bull Johns Hopkins Hosp., 92, 99, 1953.
Hargrove, M. D., Jr., Marked increase in serum bilirubin in sickle cell anemia: A report of 6 patients, Am. J. Dig. Dis., 15, 437, 1970.
Rosenblate, H. J., Eisenstein, R., and Holmes, A. W., The liver in sickle cell anemia: A clinical- pathologic study, Arch. Pathol, 90, 235, 1970.
Brody, J. I., Ryan, W. N., and Haidar, M. A., Serum alkaline phosphatase in sickle cell anemia, J. Am. Med. Assoc., 232, 738, 1975.
Rosner, F., and Karayalcin, G., Decreased leukocyte alkaline phosphatase activity in sickle cell anemia, Ann. Intern. Med., 80, 668, 1974.
Wajima, T., and Kraus, A. P., Low leukocyte alkaline phosphatase activity in sickle cell anemia, J. Lab. Clin. Med., 72, 980, 1968.
Wajima, T., and Kraus, A. P., Leukocyte alkaline phosphatase in sickle-cell anemia, N. Engl. J. Med., 295, 918, 1975.
Janis, M. G., Leukocyte alkaline phosphatase in sickle-cell disease, N. Engl J. Med., 294, 163, 1976.
Phillips, S. M., and Silvers, N. P., Glucose-6 phosphate dehydrogenase deficiency, infectious hepatitis, acute hemolysis and renal failure, Ann. Intern. Med., 70, 99, 1970.
Tanaka, K. R., Valentine, W. N., and Miwa, S., Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia, Blood, 19, 267, 1962.
Valentine, W. N., Hsieh, H.-S., Paglia, D. E., Anderson, H. M., Baughan, M. A., Jaffe, E. R., and Garson, O. M., Hereditary hemolytic anemia associated with phosphoglycerate kinase deficiency in erythrocytes and leukocytes, M Engl. J. Med., 280, 528, 1969.
Tanaka, K. R., Valentine, W. N., and Fredricks, R. E., Diseases or clinical conditions associated with low leukocyte alkaline phosphatase, N. Engl. J. Med., 262, 912, 1960.
Mitus, W. J., Mednicoff, I. B., and Dameshek, W., Alkaline phosphatase of mature neutrophils in various 201cpolycythemias,201c N. Engl. J. Med., 260, 1131, 1959.
Kondo, T., Hasegawa, M., Ootsuki, M., Inoue, E., and Baba, S., Peculiar alkaline phosphatase isoenzyme observed in serum of polycythemia vera, Igaku No Ayumi, 88, 422, 1974 (cited from Chem. Abstr., 81, 10598n, 1974 ).
Santer, M. A., Waldmann, T. A., and Fallon, H. J., Erythrocytosis and hyperlipemia as mani-festations of hepatic carcinoma, Arch. Intern. Med., 120, 735, 1967.
Baxter, M. F., and Reinfrank, R. F., Electrophoretic patterns of human leukocyte alkaline phosphatase in polycythemia vera, Blood, 37, 512, 1971.
Rosenblum, D., and Petzold, S. J., Granulocyte alkaline phosphatase: Studies of purified enzymes from normal subjects and patients with polycythemia vera, Clin. Invest., 52, 1665, 1973.
Trubowitz, S., and Miller, W. L., Electrophoretic heterogeneity of leukocyte alkaline phosphatase in normal man and in patients with polycythemia vera, Proc. Soc. Exp. Biol. Med., 123, 187, 1966.
Stein, J. A., and Tschudy, D. P., Acute intermittent porphyria: A clinical and biological study of 46 patients, Medicine (Baltimore), 49, 1, 1970.
Hellmann, E. S., Tschudy, D. P., and Bartter, F. C., Abnormal electrolyte and water metabolism in acute intermittent porphyria, Am. J. Med., 32, 734, 1962.
Nielson, B., and Thorn, N. A., Transient excess urinary excretion of antidiuretic material in acute intermittent porphyria with hyponatremia and hypomagnesemia, Am. J. Med., 38, 345, 1965.
Kaplow, L. S., and Beck, R. E., Leukocyte alkaline phosphatase response to surgical stress, Surg. Gynecol. Obstet., 119, 97, 1964.
Wyllie, R. G., Neutrophil alkaline phosphatase response to acute inflammation, Australas. Ann. Med., 11, 118, 1962.
Valentine, W. N., Follette, J. H., Solomon, D. H., and Reynolds, J., The relationship of leukocyte alkaline phosphatase to 201cstress,201c to ACTH, and to adrenal 17-OH corticosteroids, J. Lab. Clin. Med., 49, 723, 1957.
Berg, B., and Brandt, L., A syndrome of anaemia thrombocytopenia and subnormal granulo-cyte function in elderly patients, Scand. J. Haematol., 10, 161, 1973.
Strauss, R. G., Bove, K. E., Jones, J. F., Mauer, A. M., and Fulginiti, V. A., An anomaly of neutrophil morphology with impaired function, N. Engl. J. Med., 290, 478, 1974.
Pedersen, B., and Hayhoe, F. G. J., Cellular changes in chronic myeloid leukemia, Br. J. Haematol., 21, 251, 1971.
Pedersen, B., The blastic crisis of chronic myeloid leukemia: Acute transformation of a pre- leukaemic condition ?, Br. J. Haematol., 25, 141, 1973.
O’Riordan, M. L., Robinson, J. A., Buckton, K. E., and Evans, H. J., Distinguishing between the chromosomes involved in Down’s syndrome (trisomy 21) and chronic myeloid leukaemia (Ph1) by fluorescence, Nature (London), 230, 167, 1971.
Caspersson, T., Gahrton, G., Lindsten, J., and Zech, L., Identification of the Philadelphia chromosome as a number 22 by quinacrine mustard fluorescence analysis, Exp. Cell Res., 63, 238, 1970.
Rundle, A. T., and Atkin, J., Serum alkaline phosphatase isoenzymes in Down’s syndrome, Am. J. Ment. Defic., 75, 613, 1971.
Robinson, J. C., Pierce, J. E., and Goldstein, D. P., Leukocyte alkaline phosphatase: Electrophoretic variants associated with chronic myelogenous leukemia, Science, 150, 58, 1965.
Cory, J. G., and Whitford, T. W., Jr., Alkaline phosphatase activity in virus-induced murine leukemia, Biochem. Med., 5, 465, 1971.
Mitus, W. J., Bergna, L. J., Mednicoff, I. B., and Dameshek, W., Alkaline phosphatase of mature neutrophils in chronic forms of the myeloproliferative syndrome, Am. J. Clin. Pathol, 30, 285, 1958.
Koler, R. D., Seaman, A. J., Osgood, E. E., and Vanbellinghen, P., Myeloproliferative diseases, Am. J. Clin. Pathol., 30, 295, 1958.
Teplitz, R. L., Rosen, R. B., and Teplitz, M. R., Granulocytic leukaemia, Philadelphia chromo-some, and leucocyte alkaline phosphatase, Lancet, 2, 418, 1964.
Krauss, S., The Philadelphia chromosome and leukocyte alkaline phosphatase in chronic myelocytic leukemia and related disorders, Ann. N. Y. Acad. Sci., 155, 983, 1968.
Pedersen, B., and Hayhoe, F. G. J., Relation between phagocytic activity and alkaline phospha-tase content of neutrophils in chronic myeloid leukaemia, Br. J. Haematol., 21, 251, 1971.
Woodard, H. Q., and Craver, L. F., Serum phosphatase in the lymphomatoid diseases, J. Clin. Invest., 19, 1, 1940.
Pouya, Y., Gaguik, H., and Baghdassarian, A., Serum alkaline phosphatase activity in leukaemia, Acta Biochim. Iran., 2, 76, 1963.
Neumann, H., Wilson, K. J., Hauck-Granoth, R., and Haran-Ghera, N., A comparative bio-chemical study of alkaline phosphatases in normal and leukemic mice, Cancer Res., 31, 1695, 1971.
Kronfield, S. J., and Reynolds, T. B., Leukemia and hypercalcemia: Report of a case and review of the literature, N. Engl. J. Med., 271, 399, 1964.
Benvenisti, D. S., Sherwood, L. M., and Heinemann, H. O., Hypercalcemic crisis in acute leukemia, Am. J. Med., 46, 976, 1969.
Jordan, G. W., Serum calcium and phosphorus abnormalities in leukemia, Am J. Med., 41, 381, 1966.
Neumann, H., Moran, E. M., Russell, R. M., and Rosenberg, I. H., Distinct alkaline phosphatase in serum of patients with lymphatic leukemia and infectious mononucleosis, Science, 186, 151, 1974.
Chabner, B. A., Haskell, C. M., and Canellos, G. P., Destructive bone lesions in chronic granulocytic leukemia, Medicine CBaltimore), 48, 401, 1969.
Ballard, H. S., and Marcus, A. J., Hypercalcemia in chronic myelogenous leukemia, N. Engl. J. Med., 282, 663, 1970.
Franseen, C. C., Simmons, C. C., and McLean, R., The phosphatase determination in the differential diagnosis of bone lesions, Surg. Gynecol. Obstet., 68, 1038, 1939.
Martin, N. H., The immunoglobulins: A review, J. Clin. Pathol., 22, 117, 1969.
Dillman, C. E., Jr., and Silverstein, M. N., Alkaline phosphatase in multiple myeloma, Am. J. Med. Set, 249, 445, 1965.
Adams, W. S., Ailing, E. L., and Lawrence, J. S., Multiple myeloma: Its clinical and laboratory diagnosis with emphasis on electrophoretic abnormalities, Am. J. Med., 6, 141, 1949.
Anonymous (Working Party of 20), Report on the first myelomatosis trial Part I. Analysis of presenting features of prognostic importance, J. Haematol., 24, 123, 1973.
Kyle, R. A., Multiple myeloma: Review of 869 cases, Mayo Clin. Proc., 50, 29, 1975.
Thomas, F. B., Clausen, K. P., and Greenberger, N. J., Liver disease in multiple myeloma, Arch. Intern. Med., 132, 195, 1973.
Horn, M. E., Knapp, M. S., Page, F. T., and Walker, W. H. C., Adult Fanconi syndrome and multiple myelomatosis, J. Clin. Pathol., 22, 414, 1969.
Costanza, D. J., and Smoler, M., Multiple myeloma with the Fanconi syndrome: Study of a case, with electron microscopy of the kidney, Am. J. Med., 34, 125, 1963.
Afonja, A. O., and Baron, D. N., Plasma alkaline phosphatase isoenzymes in hepatobiliary disease, J. Clin. Pathol., 21, 916, 1974.
Pygott, F., Paget’s disease of bone: The radiological incidence, Lancet, 2, 1170, 1957.
Posen, S., Studies in human alkaline phosphatase, M.D. thesis, University of Adelade, 1966.
Kabat, E. A., and Furth, J., Histochemical study of the distribution of alkaline phosphatase in various normal and neoplastic tissues, Am. J. Pathol., 11, 303, 1941.
Newman, W., Feigin, I., Wolf, A., and Kabat, E. A., Histochemical studies on tissue enzymes. IV. Distribution of some enzyme systems which liberate phosphate at pH 9.2 as determined with various substrates and inhibitors: Distribution of three groups of enzymes, Am. J. Pathol., 26, 257, 1950.
Pietroni, R. G., An unusual tumor of the spleen associated with a high serum alkaline phospha-tase, Guy’sHosp. Rep., 119, 379, 1970.
Fredrickson, D. S., and Sloan, H. R., Glucosyl ceramide lipidoses: Gaucher’s disease, in: The Metabolic Basis of Inherited Disease (Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., eds.), p. 730, McGraw-Hill, New York, 1972.
Edlin, P., Kepler, W. E., and Knabe, G. W., Gaucher’s disease, Gastroenterology, 28, 120, 1955.
McKelvie, I. J., and Edwards, L. R., Gaucher’s disease: Report of a case, Med. J. Aust., 2, 297, 1969.
Chang-Lo, M., Yam, L. T., and Rubenstone, A. I., Gaucher’s disease: Review of the literature and report of twelve new cases, Am. J. Med. Sci., 254, 303, 1967.
Gomori, G., Distribution of phosphatase in normal organs and tissues, J. Cell. Comp. Physiol., 77, 71, 1941.
Braunstein, H., Freiman, D. G., and Gall, E. A., A histochemical study of the enzymatic activity of lymph nodes. I. The normal and hyperplastic lymph node, Cancer, 11, 829, 1958.
Braunstein, H., Freiman, D. G., Thomas, W., Jr., and Gall, E. A., A histochemical study of the enzymic activity of lymph nodes. III. Granulomatous and primary neoplastic conditions of lymphoid tissue, Cancer, 15, 139, 1962.
Cohn, C., and Lidman, B. I., Hepatitis without jaundice in infectious mononucleosis, J. Clin. Invest., 25, 145, 1946.
Gall, E. A., Serum phosphatase and other tests of liver function in infectious mononucleosis, Am. J. Gin. Pathol., 17, 529, 1947.
Berk, J. E., Shay, H., Ritter, J. A., and Siplet, H., Infectious mononucleosis and infectious hepatitis: Studies bearing on certain resemblances and differences, Gastroenterology, 11, 658, 1948.
Jordan, W. S., Jr., and Albright, R. W., Liver function tests in infectious mononucleosis, J. Lab. Gin. Med., 35, 688, 1950.
Wormer, D. C., Martin, W. J., and Wollaeger, E. E., Infectious mononucleosis with jaundice and abdominal pain as presenting complaints: Report of a case, Ann. Intern. Med., 45, 718, 1956.
Barondess, J. A., and Erie, H., Serum alkaline phosphatase activity in hepatitis of infectious mononucleosis, Am. J. Med., 29, 43, 1960.
Futterweit, W., Serum alkaline phosphatase activity in infectious mononucleosis: A clinical study of fifty-five cases, Arch. Intern. Med., 108, 253, 1961.
Kilpatrick, Z. M., Structural and functional abnormalities of liver in infectious mononucleosis, Arch. Intern. Med., 117, 47, 1966.
Shuster, F., and Ognibene, A. J., Dissociation of serum bilirubin and alkaline phosphatase in infectious mononucleosis, J. Am. Med. Assoc., 209, 267, 1969.
McMahon, J. M., Elliott, C. W., and Green, R. C., Infectious mononucleosis complicated by hepatic coma,,4m. J. Gastroenterol., 51, 200, 1969.
Boughton, C. R., Glandular fever: A study of a hospital series in Sydney, Med. J. Aust., 2, 529, 1970.
Madigan, N. P., Newcomer, A. D., Campbell, D. C., and Taswell, H. F., Intense jaundice in infectious mononucleosis, Mayo Gin. Proc., 48, 857, 1973.
Palva, T., Raunio, V., and Nousiainen, R., Alkaline and acid phosphatase activity in sarcoid lymph nodes, Acta Pathol. Microbiol Scand., Sect. A, 81, 577, 1973.
Rosenberg, S. A., Diamond, H. D., Jaslowitz, B., and Craver, L. F., Lymphosarcoma: A review of 1269 cases, Medicine CBaltimore), 40, 31, 1961.
Symmers, D. Lymphoid diseases: Hodgkin’s granuloma, giant follicular lymphadenopathy, lymphoid leukemia, lymphosarcoma, and gastrointestinal pseudoleukemia, Arch. Pathol., 45, 73, 1948.
Bouroncle, B. A., Old, J. W., Jr., and Vazques, A. G., Pathogenesis of jaundice in Hodgkin’s disease, Arch. Intern. Med., 110, 872, 1962.
Levitan, R., Diamond, H. D., and Craver, L. F., Jaundice in Hodgkin’s disease, Am. J. Med., 30, 99, 1961.
Brensilver, H. L., and Kaplan, M. M., Significance of elevated liver alkaline phosphatase in serum, Gastroenterology, 68, 1556, 1975.
Aisenberg, A. C., Kaplan, M. M., Rieder, S. V., and Goldman, J. M., Serum alkaline phospha-tase at the onset of Hodgkin’s disease, Cancer, 26, 318, 1970.
Levine, P. H., Abnormal blood chemistry values in Hodgkin’s disease: Lack of correlation with staging of disease, J. Am. Med. Assoc., 220, 1734, 1972.
Johnson, R. E., Thomas, L. B., Johnson, S. K., and Johnston, G. S., Correlation between abnormal baseline liver tests and long-term clinical course in Hodgkin’s disease, Cancer, 33, 1123, 1974.
Grozdea, J., and Corberand, J., Lymphocyte cytochemistry, Lancet, 2, 1319, 1972.
Mann, R. B., Jaffe, E. S., Braylan, R. C., Nanba, K., Frank, M. M., Ziegler, J. L., and Bernard, C. W., Non-endemic Burkitt’s lymphoma: A B-cell tumor related to germinal centers, M Engl. J. Med., 295, 685, 1976.
Robison, R., The possible significance of hexosephosphoric esters in ossification, Biochem. J., 17, 286, 1923.
Robison, R., and Soames, K. M., The possible significance of hexosephosphoric esters in ossification. Part II. The phosphoric esterase of ossifying cartilage, Biochem. J., 18, 740, 1924.
Gomori, G., Calcification and phosphatase, Am. J. Pathol., 19, 197, 1943.
Gomori, G., Histochemical specificity of phosphatases, Proc. Soc. Exp. Biol. Med., 70, 7, 1949.
Teaford, M. E., and White, A. A., Alkaline phosphatase and osteogenesis in vitro, Proc. Soc. Exp. Biol. Med., 117, 541, 1964.
Timmer, J., Hadders, H. N., Hardonk, M. J., and Koudstaal, J., An experimental investigation into the development of callus and induced bone tumours in mice studied by histological and enzyme histochemical methods, Br. J. Cancer, 22, 422, 1968.
Pritchard, J. J., Cytological and histochemical study of bone and cartilage formation in rat, J.Anat., 86, 259, 1952.
Göthlin, G., and Ericsson, J. L. E., Fine structural localization of alkaline phosphomono-esterase in the fracture callus of the rat, Isr. J. Med. Sci., 7, 488, 1971.
Granda, J. L., and Posner, A. S., Distribution of four hydrolases in the epiphyseal plate, Clin. Orthop. Relat. Res., 74, 269, 1971.
Messer, H. H., Armstrong, W. D., and Singer, L., Influence of calcitonin on bone phosphatases and phosphate release in organ culture, Proc. Soc. Exp. Biol. Med., 143, 690, 1973.
Matsuzawa, T., and Anderson, H. C., Phosphatases of epiphyseal cartilage studied by electron microscopic cytochemicalmethods, J. Histochem. Cytochem., 19, 801, 1971.
Kay, H. D., Plasma phosphatase in osteitis deformans and in other diseases of bone, Br. J. Exp. Pathol., 10, 253, 1929.
Posen, S., Cornish, C., and Kleerekoper, M., Alkaline phosphatase and metabolic bone disease, in: Metabolic Bone Disease (Avioli, L. V., and Krane, S. M., eds.), p. 141, Academic Press, New York, 1977.
Bourne, G. H., The Biochemistry and Physiology of Bone, Vol. 2, 2nd ed., p. 79, Academic Press, New York, 1972.
Kerkhoff, J. F., A rapid serum screening test for increased osteoblastic activity, Clin. Chim. Acta, 22, 231, 1968.
Barak, Y., Osteoblasts and osteoclasts in bone marrow aspirated from children with rickets, Acta Paediatr. Scand., 59, 363, 1970.
Cerda, J. J., Toskes, P. P., Shopa, N. A., and Wilkinson, J. H., The relationship of the serum alkaline phosphatase to urinary hydroxyproline excretion in liver and bone diseases, Clin. Chim. Acta, 27, 437, 1970.
Klein, L., Lafferty, F. W., Pearson, O. H. and Curtiss, P. H., Correlation of urinary hydroxyl-proline, serum alkaline phosphatase and skeletal calcium turnover, Metabolism, 13, 212, 1964.
Khairi, M. R. A., Wellman, H. N., Robb, J. A., and Johnston, C. C., Paget’s disease of bone (osteitis deformans): Symptomatic lesions and bone scan,, Ann. Intern. Med., 79, 348, 1973.
Schwartz, M. K., Enzymes in cancer, Clin. Chem., 19, 10, 1973.
Shifrin, L. Z., Correlation of serum alkaline phosphatase with bone formation rates, Clin. Orthop. Relat. Res., 70, 212, 1970.
Woodward, H. Q., and Marcove, R. C., A comparison of the chemistry of blood from bone and peripheral veins, Gin. Orthop., 66, 254, 1969.
Posen, S., Kleerekoper, M., Ingham, J. P., and Hirshorn, J. E., Parathyroid hormone assay in clinical decision-making, Br. Med. J., 1, 16, 1976.
Posen, S., Unpublished, 1975.
Patton, R. B., Spectacular elevations of serum alkaline phosphatase: Clinical and pathological correlation, Henry Ford Hosp. Med. J., 18, 211, 1970.
Woodard, H. Q., Long-term studies on the blood chemistry in Paget’s disease of bone, Cancer, 12, 1226, 1959.
Gutman, A. B., Gutman, E. B., and Kasabach, H. H., Serum phosphatase activity in seventeen cases of osteoporosis circumscripta of the skull, Proc. Soc. Exp. Biol. Med., 33, 295, 1935.
Gutman, A. B., Tyson, T. L., and Gutman, E. B., Serum calcium, inorganic phosphorus and phosphatase activity in hyperparathyroidism, Paget’s disease, multiple myeloma and neoplastic disease of the bones, Arch. Intern. Med., 57, 319, 1936.
Kasabach, H. H., and Gutman, A. B., Osteoporosis circumscripta of the skull and Paget’s disease: Fifteen new cases and a review of the literature, Am. J. Roentgenol., 37, 577, 1937.
Nagant de Deuxchaisnes, C., and Krane, S. M., Paget’s disease of bone: Clinical and metabolic observations, Medicine (Baltimore), 43, 233, 1964.
Barry, H. C., Fractures of the femur in Paget’s disease of bone in Australia, J. Bone Joint Surg., 49-A, 1359, 1967.
Porretta, C. A., Dahlin, D. C., and Janes, J. M., Sarcoma in Paget’s disease of bone, J. Bone Joint Surg., 39A, 1314, 1957.
Peacock, A. C., Reed, R. A., and Highsmith, E. M., Ethanol fractionation of human serum alkaline phosphatase, Clin. Chim. Acta, 8, 914, 1963.
Horne, M., Cornish, C. J., and Posen, S., The use of urea denaturation in the identification of human alkaline phosphatases, J. Lab. Gin. Med., 72, 905, 1968.
Fitzgerald, M. X. M., Fennelly, J. J., and McGeeney, K., The value of differential alkaline phosphatase thermostability in clinical diagnosis, Am. J. Clin. Pathol., 57, 194, 1969.
Fritsche, H. A., Jr., and Adams-Park, H. R., Cellulose acetate electrophoresis of alkaline phosphatase isoenzymes in human serum and tissue, Clin. Chem., 18, 417, 1972.
Sussman, H. H., Source of the increased serum alkaline phosphatase in Paget’s disease, Clin. Chim. Acta, 21, 121, 1970.
Ryan, W. G., Schwartz, T. B., and Northrop, G., Experiences in the treatment of Paget’s disease of bone with mithramycin, J. Am. Med. Assoc., 213, 1153, 1970.
Lebbin, D., Ryan, W. G., and Schwartz, T. B., Outpatient treatment of Paget’s disease of bone with mithramycin, Ann. Intern. Med., 81, 635, 1974.
Haddad, J. G., Jr., Birge, S. J., and Avioli, L. V., Effects of prolonged thyrocalcitonin administration on Paget’s disease of bone, N. Engl. J. Med., 283, 549, 1970.
Bell, N. H., Avery, S., and Johnston, C. C., Jr., Effects of calcitonin in Paget’s disease and polyostotic fibrous dysplasia, J. Clin. Endocrinol. Metab., 31, 283, 1970.
Woodhouse, N. J. Y., Reiner, M., Bordier, P., Kalu, D. N., Fisher, M., Foster, G. V., Joplin, G. F., and Maclntyre, I., Human calcitonin in the treatment of Paget’s bone disease, Lancet, 1, 1139, 1971.
Kanis, J. A., Horn, D. B., Scott, R. D. M., and Strong, J. A., Treatment of Paget’s disease of bone with synthetic salmon calcitonin, Br. Med. J., 3, 727, 1974.
Plehwe, W. E., Hudson, J., Clifton-Bligh, P., and Posen, S., Porcine calcitonin in the treatment of Paget’s disease of bone: Experience with 32 patients, Med. J. Aust., 1, 577, 1977.
Martin, T. J., Jerums, G., Melick, R. A., Xipell, J. M., and Arnott, R., Clinical, biochemical and histological observations on the effect of porcine calcitonin in Paget’s disease of bone, Aust. N. Z.J. Med., 1, 36, 1977.
Rojanasathit, S., Rosenberg, E., and Haddad, J. G., Jr., Paget’s bone disease: Response to human calcitonin in patients resistant to salmon calcitonin, Lancet, 2, 1412, 1974.
Smith, R., Russell, R. G. G., and Bishop, M., Diphosphonates and Paget’s disease of bone, Lancet, 1, 945, 1971.
Altman, R. D., Johnston, C. C., Khairi, M. R. A., Wellman, H., Serafini, A. N., and Sankey, R. R., Influence of disodium etidronate on clinical and laboratory manifestations of Paget’s disease of bone (osteitis deformans), N. Engl. J. Med., 289, 1379, 1973.
Khairi, M. R. A., Johnston, C. C., Altman, R. D., Wellman, H. N., Serafini, A. N., and Sankey, R. R., Treatment of Paget disease of bone (osteitis deformans): Results of a one-year study with sodium etidronate, J. Am. Med. Assoc., 230, 562, 1974.
Bodansky, A., and Jaffe, H. L., Plasma phosphatase in experimental hyperparathyroidism, J.Biol. Chem., 92, 16, 1931.
Klendshoj, N. C., and Koepf, G. F., Serum phosphatase activity in hyperparathyroidism, J. Clin. Endocrinol., 3, 351, 1943.
Pridgen, W. R., Richardson, R. L., Chappell, F. W., and Pridgen, S. A., Primary hyperparathyroidism: Diagnosis and surgical management, South. Med J., 62, 503, 1969.
Keating, F. R., Jr., The clinical problem of primary hyperparathyroidism, Med Clin. North Am., 54, 511, 1970.
Fraser, P., Healy, M., Rose, N., and Watson, L., Discriminant functions in differential diagnosis of hypercalcaemia, Lancet, 1, 1314, 1971.
Pratley, S. K., Posen, S., and Reeve, T. S., Primary hyperparathyroidism: Experience with 60 patients, Med. J. Aust., 1, 421, 1973.
Genant, H. K., Heck, L. L., Lanzl, L. H., Rossmann, K., Horst, J. V., and Paloyan, E., Primary hyperparathyroidism: A comprehensive study of clinical, biochemical and radiographic manifestations, Radiology, 109, 513, 1973.
Latimer, R. G., Rees, V. L., and Peterson, C. N., Hypercalcemic crisis treated with inorganic phosphate solution, Am. J. Surg., 116, 669, 1968.
Goldbloom, R. B., Gillis, D. A., and Prasad, M., Hereditary parathyroid hyperplasia: A surgical emergency of early infancy, Pediatrics, 49, 514, 1972.
Zisman, E., Buckle, R. M., Deftos, L. J., Aurbach, G. D., Morton, D. L., Bartter, F. C., and Potts, J. T., Production of parathyroid hormone by metastatic parathyroid carcinoma, Am. J. Med., 45, 619, 1968.
Johnson, R. D., and Conn, J. W., Hyperparathyroidism with a prolonged period of normocalcemia, J. Am. Med. Assoc., 210, 2063, 1969.
Frame, B., Foroozanfar, F., and Patton, R. B., Normocalcemic primary hyperparathyroidism with osteitis fibrosa, Ann. Intern. Med., 73, 253, 1970.
Utley, J. R., and Black, W. C., Hyperparathyroidism: A clinicopathologic evaluation, Am. J. Surg., 114, 788, 1967.
Pyrah, L. N., Hodgkinson, A., and Anderson, C. K., Primary hyperparathyroidism, Br. J. Surg., 53, 245, 1966.
Lloyd, H. M., Primary hyperparathyroidism: An analysis of the role of the parathyroid tumor, Medicine (Baltimore), 47, 53, 1968.
Becker, F. O., and Tausk, K., Radiologically evident functioning mediastinal parathyroid adenoma, Chest, 58, 79, 1970.
Gleason, D. C., and Potchen, E. J., The diagnosis of hyperparathyroidism, Radiol Clin. North Am., 5, 211, 1967.
Forland, M., Strandjord, N. M., Paloyan, E., and Cox, A., Bone density studies in primary hyperparathyroidism, Arch. Intern. Med., 122, 236, 1968.
Smith, R., Dissociation between changes in urinary total hydroxyproline and plasma alkaline phosphatase after removal of parathyroid tumor, Clin. Chim. Acta, 23, 421, 1969.
Gründig, E., Czitober, H., and Maruna, R. F. L., Primärer Hyperparathyreoidismus. I. Vergleichende biochemische Untersuchungen der 201Csauren201C und 201Calkalischen201C Phosphatasen bei Hyperparathyreoidismus, Clin. Chim. Acta, 30, 331, 1970.
Kleerekoper, M., Ingham, J. P., McCarthy, S. W., and Posen, S., Parathyroid hormone assay in primary hyperparathyroidism: Experiences with a radioimmunoassay based on commercially available reagents, Clin. Chem., 20, 369, 1974.
Vaishnava, H., and Rizvi, S. N. A., Primary hyperparathyroidism associated with nutritional osteomalacia, Am. J. Med., 46, 640, 1969.
Davies, D. R., Dent, C. E., and Willcox, A., Hyperparathyroidism and steatorrhoea, Br. Med. J., 2, 1133, 1956.
Thomas, W. C., Jr., and Fry, R. M., Parathyroid adenomas in chronic rickets, Am. J. Med., 49, 404, 1970.
Martin, M. M., Barr, A. B., and Howe, J. S., Coexisting hyperparathyroidism and Paget’s disease, Arch. Intern. Med., 114, 482, 1964.
Judd, D. R., Heimburger, I., and Johnston, C., Parathyroid adenoma, Ann. Surg., 164, 1077, 1966.
Posen, S., Clifton-Bligh, P., and Wilkinson, M. R., Paget’s disease of bone and hyperparathyroidism: Coexistence or causal relationship?, Calcif. Tissue Res., 26, 107, 1978.
Torsti, P., and Lamberg, B.-A., Coexisting hyperthyroidism and hyperparathyroidism, Acta Med. Scand., 174, 115, 1963.
Bryant, L. R., Wulsin, J. H., and Altemeier, W. A., Hyperparathyroidism and hyperthyroidism, Ann. Surg., 159, 411, 1964.
Ogburn, P. L., and Black, B. M., Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid: Report of four cases, Proc. Staff Meet. Mayo Clin., 31, 295, 1956.
Steiner, A. L., Goodman, A. D., and Powers, S. R., Study of a kindred with pheochromo-cytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing’s disease: Multiple endocrine neoplasia, type 2, Medicine (Baltimore), 47, 371, 1968.
Snapper, I., Yarvis, J. J., Freund, H. R., and Goldberg, A. F., Hyperparathyroidism in identical twins one of whom suffered concomitantly of Boeck’s sarcoidosis,Metabolism, 7, 671, 1958.
Ehrig, U., and Wilson, D. R., Fibrous dysplasia of bone and primary hyperparathyroidism, Ann. Intern. Med., 77, 234, 1972.
Cohen, R. D., and Vince, F. P., Pseudohypoparathyroidism with raised plasma alkaline phosphatase, Arch. Dis. Child., 44, 96, 1969.
Keiser, H. R., Gill, J. R., Sjoerdsma, A., and Bartter, F. G, Relation between urinary hydroxyl-proline and parathyroid function, J. Clin. Invest., 43, 1073, 1964.
Harris, O. D., Warner, M., and Cooke, W. T., Serum alkaline phosphatase in adult coeliac disease, Gut, 10, 655, 1969.
Garrick, R., Ireland, A. W., and Posen, S., Bone abnormalities after gastric surgery: A prospective histological study, Ann. Intern. Med., 75, 221, 1971.
Anonymous, Dietary osteomalacia, Lancet, 1, 1037, 1969.
Morgan, D. B., Hunt, G., and Paterson, C. R., The osteomalacia syndrome after stomach operations, Q. J. Med., 39, 395, 1970.
Eddy, R. L., Metabolic bone disease after gastrectomy, Am. J. Med., 50, 442, 1971.
Melvin, K. E. W., Hepner, G. W., Bordier, P., Neale, G., and Joplin, G. F., Calcium metabolism and bone pathology in adult coeliac disease, Q. J. Med., 39, 83, 1970.
Hossain, M., The osteomalacia syndrome after colocystoplasty: A cure with sodium bicarbonate alone, Br. J. Urol., 42, 243, 1970.
Dent, C. E., and Smith, R., Nutritional osteomalacia, Q. J. Med., 38, 195, 1969.
Arnstein, A. R., Frame, B., and Frost, H. M., Recent progress in osteomalacia and rickets, Ann. Intern. Med., 67, 1296, 1967.
Salassa, R. M., Jowsey, J., and Arnaud, C. P., Hypophosphatemic osteomalacia associated with 201Cnonendocrine201C tumors, N. Engl. J. Med., 283, 65, 1970.
Dent, C. E., Rickets (and osteomalacia), nutritional and metabolic (1919-1969), Proc. R. Soc. Med., 63, 401, 1970.
Demuth, F., Über Phosphatstoffwechsel. II., Biochem. Z., 166, 162, 1925.
Barnes, D. J., and Carpenter, M. D., A comparative study in the diagnosis and treatment of rickets with observations of the normal and abnormal serum phosphatase, J. Pediatr., 10, 596, 1937.
Ireland, A. W., Clubb, J. S., Neale, F. C., Posen, S., and Reeve, T. S., The calciferol requirements of patients with surgical hypoparathyroidism, Ann Intern. Med., 69, 81, 1968.
Saville, P. D., Biochemistry and radiologic diagnosis of bone disease, Radiol Clin. North Am., 8, 207, 1970.
Rosin, A. J., Clinical features and detection of osteomalacia in the elderly,Postgrad. Med. J., 46, 131, 1910.
Khalifa, A. S., Mourad, K. A. H., Khattab, A. K., Sallam, M. S., and Hosny, S., Repeated doses of vitamin D in rickets, J. Trop. Med. Hyg., 74, 66, 1971.
Begum, A., and Pereira, S. M., Calcium balance studies on children accustomed to low calcium intakes, Br. J. Nutr., 23, 905, 1969.
Arthur, A. B., and Weston, H. J., Rickets in the welfare state, N. Z. Med. J., 70, 29, 1969.
Anonymous, Rickets in Greece: A surprisingly high prevalence in this land of sunshine, Nutr. Rev., 27, 51, 1969.
Ewen, L. M., Separation of alkaline phosphatase isoenzymes and evaluation of the clinical usefulness of this determination, Am. J. Clin. Pathol., 61, 142, 1974.
Parfitt, A. M., Hypophosphatemic vitamin D refractory rickets and osteomalacia, Orthop. Clin. North Am., 3, 653, 1972.
Harris, W. H., and Heaney, R. P., Skeletal renewal and metabolic bone disease, N. Engl. J. Med., 280, 193, 1969.
Chalmers, J., Barclay, A., Davison, A. M., Macleod, D. A. D., and Williams, D. A., Quantitative measurements of osteoid in health and disease, Clin. Orthop. Relat. Res., 63, 196, 1969.
Jenkins, D. H. R., Roberts, J. G., Webster, D., and Williams, E. O., Osteomalacia in elderly patients with fracture of the femoral neck, J. Bone Joint Surg., 55B, 575, 1973.
Richards, I. D. G., Hamilton, F. M. W., Taylor, E. C., Sweet, E. M., Bremner, E., and Price, H., A search for sub-clinical rickets in Glasgow children, Scot. Med. J., 13, 291, 1968.
Ng, S. H., The search for pre-clinical rickets, Gin Sci., 38, 11P, 1970.
Clark, F., Simpson, W., and Young, J. R., Osteomalacia in immigrants from the Indian subcontinent in Newcastle upon Tyne, Proc. R. Soc. Med., 65, 478, 1972.
Groen, J. J., Eshchar, J., Ben-Ishay, D., Alkan, W. J., and Ben Assa, B. I., Osteomalacia among the Bedouin of the Negev desert, Arch. Intern. Med., 116, 195, 1965.
Gray, J. D., and Carter, F. S., The early diagnosis of rickets, Arch. Dis. Child., 24, 189, 1949.
Lichtmann, M. A., Miller, D. R., Cohen, J., and Waterhouse, C., Reduced red cell glycolysis, 2,3-diphosphoglycerate and adenosine triphosphate concentration, and increased hemoglobin- oxygen affinity caused by hypophosphatemia, Ann. Intern. Med., 74, 562, 1911.
Mahony, J. F., Hayes, J. M., Lugham, J. P., and Posen, S., Hypophosphataemic osteomalacia in patients receiving haemodialysis, Br. Med. J., 3, 142, 1976.
Dent, C. E., and Winter, C. S., Osteomalacia due to phosphate depletion from excessive aluminum hydroxide ingestion, Br. Med. J., 1, 551, 1974.
Bloom, W. L., and Flinchum, D., Osteomalacia with pseudofractures caused by the ingestion of aluminum hydroxide, J. Am. Med. Assoc., 174, 1327, 1960.
Melick, R. A., and Benson, J. A., Jr., Osteomalacia following partial gastrectomy, N. Engl J. Med., 260, 976, 1959.
Thompson, G. R., Watts, J. M., Neale, G., and Booth, C. C., Detection of vitamin-D deficiency after partial gastrectomy, Lancet, 1, 623, 1966.
Pulvertaft, C. N., Luffman, J. E., Robson, E. B., Harris, H., and Langman, M. J. S., Isoenzymes of alkaline phosphatase in patients operated upon for peptic ulcer, Lancet, 1, 237, 1967.
Bostròm, H., Edgren, B., Nilsonne, U., and Wester, P. O., Metabolic and orthopedic treatment of a case of adult nonfamilial hypophosphatemia with severe osteomalacia, Acta Orthop. Scand., 39, 238, 1968.
Ingham, J. P., Stewart, J. H., and Posen, S., Quantitative skeletal histology in untreated end- stage renal failure, Br. Med. J., 2, 745, 1973.
Paterson, C. R., and Losowsky, M. S., The bones in chronic liver disease, Scand. J. Gastroenterol., 2, 293, 1967.
Atkinson, M., Nordin, B. E. C., and Sherlock, S., Malabsorption and bone disease in prolonged obstructive jaundice, Q. J. Med., 25, 299, 1956.
Mandelbaum, H., and Kane, L. J., Dilantin sodium poisoning: Report of a case with dermatitis exfoliativa, pyrexia and hepatic and splenic enlargement, Arch. Neurol Psychiatry, 45, 769, 1941.
Finkelman, I., and Arieff, A. J., Untoward effects of phenytoin sodium in epilepsy, J. Am. Med. Assoc., 118, 1209, 1942.
Kruse, R., Osteopathienbei antiepileptischer Langzeittherapie, Monatschr. Kinderheilkd., 116, 378, 1968.
Dent, C. E., Richens, A., Rowe, D. J., and Stamp, T. C. B., Osteomalacia with long-term anticonvulsant therapy in epilepsy, Br. Med. J., 4, 69, 1970.
Richens, A., and Rowe, D. J. F., Disturbance of calcium metabolism by anticonvulsant drugs, Br. Med. J., 4, 13, 1970.
Genuth, S. M., Klein, L., Rabinovich, S., and King, K. C., Osteomalacia accompanying chronic anticonvulsant therapy, J. Clin. Endocrinol. Metab., 35, 378, 1972.
Tolman, K. G., Jubiz, W., Sannella, J. J., Madsen, J. A., Belsey, R. E., Goldsmith, R. S., and Freston, J. W., Osteomalacia associated with anticonvulsant drug therapy in mentally retarded children, Pediatrics, 56, 45, 1975.
Crosley, C. J.; Chee, C., and Berman, P. H., Rickets associated with long-term anticonvulsant therapy in a pediatric out-patient population, Pediatrics, 56, 52, 1975.
Lifshitz, F., and Maclaren, N. K., Vitamin D-dependent rickets in institutionalized mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients, J. Pediatr., 83, 612, 1973.
Andreasen, P. B., Lyngbye, J., and Trolle, E., Abnormalities in liver function tests during long- term diphenylhydantoin therapy in epileptic out-patients, Acta Med. Scand., 194, 261, 1973.
Christiansen, C., Rødbro, P., and Lund, M., Incidence of anticonvulsant osteomalacia and effect of vitamin D: Controlled therapeutic trial, Br. Med. J., 4, 695, 1973.
Hunter, J., Maxwell, J. D., Stewart, D. A., Parsons, V., and Williams, R., Altered calcium metabolism in epileptic children on anticonvulsants, Br. Med. J., 4, 202, 1971.
Ingham, J. P., and Posen, S., Unpublished, 1975.
Rosalki, S. B., Gamma-glutamyl transpeptidase, in: Advances in Clinical Chemistry (Bodansky, O., and Latner, A. L., eds), p. 53, Academic Press, New York, 1975.
Villareale, M., Gould, L. V., Wasserman, R. H., Barr, A., Chiroff, R. T., and Bergstrom, W. H., Diphenylhydantoin: Effects on calcium metabolism in the chick, Science, 183, 671, 1974.
Livingston, S., Berman, W., and Pauli, L. L., Anticonvulsant drugs and vitamin D metabolism, J. Am. Med. Assoc., 224, 1634, 1973.
Pollack, J. A., Schiller, A. L., and Crawford, J. D., Rickets and myopathy cured by removal of a nonossifying fibroma of bone, Pediatrics, 52, 364, 1973.
Evans, D. J., and Azzoparki, J. G., Distinctive tumors of bone and soft tissue causing acquired D-resistant osteomalacia, Lancet, 1, 353, 1972.
Wyman, A. L., Paradinas, F. J., and Daly, J. R., Hypophosphataemic osteomalacia associated with a malignant tumour of the tibia: Report of a case, J. Clin. Pathol., 30, 328, 1977.
Balsan, S., Guivarch, J., Dartois, A. M., and Royer, P., Rachitisme vitamino-resistant associé à une neurofibromatose probable chez an enfant, Arch. Fr. Pediatr., 24, 609, 1967.
Emmerson, B. T., “Ouch-ouch” disease: The osteomalacia of cadmium nephropathy, Ann. Intern. Med., 73, 854, 1970.
Friberg, L., Piscator, M., and Nordberg, G., Cadmium in the Environment, p. 112, Chemical Rubber Co. Press, Cleveland, Ohio, 1971.
Itokawa, Y., Abe, T., Tabei, R., and Tanaka, S., Renal and skeletal lesions in experimental cadmium poisoning: Histological and biochemical approaches, A rch. Environ. Health, 28, 149, 1974.
Chisolm, J. J., Jr., Harrison, H. C., Eberlein, W. R., and Harrison, H. E., Amino-aciduria, hypo-phosphatasemia, and rickets in lead poisoning: Study of a case, AMA, Am. J. Dis. Child., 89, 159, 1955.
Beam, A. G., Wilson’s disease: An inborn error of metabolism with multiple manifestations, Am. J. Med., 22, 747, 1957.
Finby, N., and Beam, A. G., Roentgenographic abnormalities of the skeletal system in Wilson’s disease (hepatolenticular degeneration), Am. J. Roentgenol. Radium Ther. Nucl. Med., 79, 603, 1958.
Lavelle, M. L., Fanconi’s syndrome, Proc. R. Soc. Med., 5 7, 592, 1964.
Scheinberg, I. H., and Sternlieb, I., The liver in Wilson’s disease, Gastroenterology, 37, 550, 1959.
Morgan, H. G., Stewart, W. K., Lowe, K. G., Stowers, J. M., and Johnstone, J. H., Wilson’s disease and the Fanconi syndrome, Q. J. Med., 31, 361, 1962.
Mclntyre, N., Clink, H. M., Levi, A. J., Cumings, J. N., and Sherlock, S., Hemolytic anemia in Wilson’s disease, N. Engl J. Med., 276, 439, 1967.
Albright, F., Butler, A. M., and Bloomberg, E., Rickets resistant to vitamin D therapy, Am. J. Dis. Child., 54, 529, 1937.
Glorieux, F. H., Scriver, C. R., Reade, T. M., Goldman, H., and Rosenborough, A., Use of phosphatase and vitamin D to prevent dwarfism and rickets in X-linked hypophosphatemia, N. Engl. J. Med., 287, 481, 1972.
Scriver, C. R., Vitamin D dependency, Pediatrics, 45, 361, 1970.
Hamilton, R., Harrison, J., Fraser, D., Radde, I., Morecki, R., and Paunier, L., The small intestine in Vitamin D dependent rickets, Pediatrics, 45, 364, 1970.
Dent, C. E., and Stamp, T. C. B., Hypophosphataemic osteomalacia presenting in adults, Q. J. Med., 40, 303, 1971.
Stickler, G. B., Beabout, J. W., and Riggs, B. L., Vitamin D resistant rickets: Clinical experience with 41 typical familial hypophosphatemic patients and 2 atypical nonfamilial cases, Mayo Clin. Proc., 45, 197, 1970.
Chan, A. M., Lynch, M. J. G., Bailey, J. D., Ezrin, C., and Fraser, D., Hypothyroidism in cys- tinosis: A clinical, endocrinologie and histologic study involving sixteen patients with cystino- sis, Am. J. Med., 48, 678, 1970.
Crawhall, J. G., Lietman, P. S., Schneider, J. A., and Seegmiller, J. E., Cystinosis: Plasma cystine and cysteine concentrations and the effect of D-penicillamine and dietary treatment, Am. J. Med., 44, 330, 1968.
Lee, D. B. N., Drinkard, J. P., Rosen, V. J., and Gonick, H. C., The adult Fanconi syndrome: Observations on etiology, morphology, renal function and mineral metabolism in three patients, Medicine (Baltimore), 51, 107, 1972.
Anonymous, Hypophosphataemic osteomalacia in adults, Lancet, 1, 1343, 1971.
McNair, S. L., and Stickler, G. B., Growth in familial hypophosphatemic vitamin-D-resistant rickets, TV. Engl. J. Med., 281, 511, 1969.
Paunier, L., Kooh, S. W., Conen, P. E., Gibson, A. A. M., and Fraser, D., Renal function and histology after long-term vitamin D therapy of vitamin D refractory rickets, J. Pediatr., 75, 833. 1968.
Smith, R., and Dick, M., The effect of vitamin D and phosphate on urinary total hydroxypro-line excretion in adult-presenting ‘Vitamin D resistant’ type I renal tubular osteomalacia, Clin. Sci., 35, 575, 1968.
Earp, H. S., Ney, R. L., Gitelman, H. J., Richman, R., and DeLuca, H. F., Effects of 25- hydroxycholecalciferol in patients with familial hypophosphatemia and vitamin-D-resistant rickets, N. Engl. J. Med., 283, 627, 1970.
Clayton, B. E., and Patrick, A. D., Use of dimercaprol or penicillamine in the treatment of cystinosis, Lancet, 2, 909, 1961.
Stickler, G. B., Familial hypophosphatemic vitamin D resistant rickets: The neonatal period and infancy, Acta Paediatr. Scand., 58, 213, 1969.
Schoen, E. J., and Reynolds, J. B., Severe familial hypophosphatemic rickets: Normal growth following early treatment, Am. J. Dis. Child., 120, 58, 1970.
Kleerekoper, M., Coffey, R., Greco, T., Nichols, S., Cooke, N., Murphy, W., and Avioli, L. V., Hypercalcemic hyperparathyroidism in hypophosphatemic rickets, J. Clin. Endocrinol., 45, 86, 1977.
Ingham, J. P., Kleerekoper, M., Stewart, J. H., and Posen, S., Symptomatic skeletal disease in non-terminal renal failure, Med. J. Aust., 1, 873, 1974.
Stanbury, S. W., Bone disease in uremia, Am. J. Med., 44, 714, 1968.
Kaye, M., Recognition of osteodystrophy in chronic uremia, Am. J. Med. Sci., 261, 182, 1971.
Massry, S. G., Coburn, J. W., Popovtzer, M. M., Shinaberger, J. H., Maxwell, M. H., and Kleeman, C. R., Secondary hyperparathyroidism in chronic renal failure, Arch. Intern. Med., 124, 431. 1969.
Parfitt, A. M., Renal osteodystrophy, Orthop. Clin. North Am., 3, 681, 1972.
Parfitt, A. M., The quantitative approach to bone morphology: A critique of current methods and their interpretation, in: Clinical Aspects of Metabolic Bone Disease, (Frame, B., Parfitt, A. M., and Duncan, H., eds.), p. 86, Excerpta Medica, Amsterdam, 1973.
O’Riordan, J. L., Page, J., Kerr, D. N., Walls, J., Moorhead, J., Crockett, R. E., Franz, H., and Ritz, E., Hyperparathyroidism in chronic renal failure and dialysis osteodystrophy, Q. J. Med., 39, 359, 1970.
Kim, D., Bell, N. H., Bundesen, W., Putong, P., Simon, N. M., Walker, C., and Del Greco, F., Renal osteodystrophy in course of periodic dialysis for chronic uremia, Trans. Am. Soc. Artificial Intern. Organs, 14, 367, 1968.
Fournier, A. E., Johnson, W. J., Taves, D. R., Beabout, J. W., Arnaud, C. D., and Goldsmith, R. S., Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. I. Association of bone disease with potentially etiologic factors, J. Clin. Invest., 50, 592, 1971.
Alfrey, A. C., Jenkins, D., Groth, C. G., Schorr, W. S., Gecelter, L., and Ogden, D. A., Resolution of hyperparathyroidism, renal osteodystrophy and metastatic calcification after renal homotransplantation, N. Engl. J. Med., 279, 1349, 1968.
Tannen, R. L., Regal, E. M., Dunn, M. J., and Schrier, R. W., Vasopressin-resistant hyposthenuria in advanced chronic renal disease, N. Engl. J. Med., 280, 1135, 1969.
Goldstein, D. A., Oda, Y., Kurokawa, K., and Massry, S. G., Blood levels of 24 hydroxy- vitamin D in nephrotic syndrome: Studies in 26 patients, Ann. Intern. Med., 87, 664, 1977.
Haussler, M. R., and McCain, T. A., Basic and clinical concepts related to Vitamin D metabolism and action (second of two parts), N. Engl. J. Med., 297, 1041, 1977.
Brickman, A. S., Coburn, J. W., Massry, S. G., and Norman, A. W., 1,25-Dihydroxy-vitamin D in normal man and patients with renal failure, Ann. Intern. Med., 80, 161, 1974.
Massry, S. G., Coburn, J. W., Lee, D. B. N., Jowsey, J., and Kleeman, C. R., Skeletal resistance to parathyroid hormone in renal failure: Studies in 105 subjects, Ann. Intern. Med., 78, 357, 1973.
Mason, R. S., and Posen, S., Unpublished, 1978.
McComb, R. B., Testerman, N., Unpublished, 1970.
Wong, N., McKenzie, D., Henderson, A. R., and Linton, A. L., Does haemoconcentration account for the changes in serum enzyme activities following haemodialysis?, Clin. Chim. Acta, 56, 105, 1974.
Binswanger, U., Sherrard, D., Rich, C., and Curtis, F. K., Dialysis bone disease: A quantitative histologic study,Nephron, 12, 1, 1973.
Denney, J. D., Sherrard, D. J., Nelp, W. B., Chesnut, C. H., Ill, and Baylink, D. J., Total body calcium and long-term calcium balance in chronic renal disease, J. Lab. Clin. Med., 82, 226 1973.
Katz, A. I., Hampers, C. I., and Merrill, J. P. Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure: Analysis of 195 patients with observations of the effects of chronic dialysis, kidney transplanatation and subtotal parathyroidectomy, Medicine (Baltimore), 48, 333, 1969.
Meyrier, A., Marsac, J., and Richet, G., The influence of a high calcium carbonate intake on bone disease in patients undergoing hemodialysis, Kidney Int., 4, 146, 1973.
Potter, D. E., Wilson, C. J., and Ozonoff, M. B., Hyperparathyroid bone disease in children undergoing long-term hemodialysis: Treatment with vitamin D, J. Pediatr., 85, 60, 1974.
Schimke, R. N., Hereditary renal-retinal dysplasia, Ann. Intern. Med., 70, 735, 1969.
Senior, B., Familial renal-retinal dystrophy, Am. J. Dis. Child., 125, 442, 1973.
Kaye, M., Chatterjee, G., Cohen, G. F., and Sagar, S., Arrest of hyperparathyroid bone disease with dihydrotachysterol in patients undergoing chronic hemodialysis, Ann. Intern. Med., 73, 225, 1970.
De Broe, M. E., Bosteels, V., and Wieme, R. J., Increased intestinal alkaline phosphatase in serum of patients on maintenance haemodialysis, Lancet, 1, 753, 1974.
Walker, A. W., Intestinal alkaline phosphatase in serum of patients on maintenance haemodialysis, Clin. Chim. Acta, 55, 399, 1974.
David, D. S., Sakai, S., Granda, J., Cheigh, J. S., Riggio, R. R., Stenzel, K. H., and Rubin, A. L., Role of pyrophosphate in renal osteodystrophy, Trans. Am. Soc. Artificial Intern. Organs, 19, 440, 1973.
Schwartz, G. H., David, D. S., Riggio, R. R., Saville, P. D., Whitsell, J. C., Stenzel, K. H., and Rubin, A. L., Hypercalcemia after renal transplantation,,4m. J. Med., 49, 42, 1970.
Mcintosh, D. A., Peterson, E. W., and McPhaul, J. J., Jr., Autonomy of parathyroid function after renal homotransplantation, Ann. Intern. Med., 65, 900, 1966.
Kleerekoper, M., Ibels, L. S., Ingham, J. P., McCarthy, S. W., Mahony, J. F., Stewart, J. H., and Posen, S., Hyperparathyroidism after renal transplantation, Br. Med. J., 3, 680, 1975.
Ibels, L. S., Alfrey, A. C., Huffer, W. E., and Weil, R., Aseptic necrosis of bone following renal transplantation: Experience in 194 transplant recipients and review of the literature, Medicine (Baltimore), 57, 25, 1978.
Ireland, P., Rashid, A., Von Lichtenberg, F., Cavallo, T., and Merrill, J. P., Liver disease in kidney transplant patients receiving azathioprine, Arch. Intern. Med., 132, 29, 1973.
Barzel, U.S., Osteoporosis, Grune and Stratton, New York, 1970.
Munck, O., Osteoporosis due to malabsorption of calcium responding favourably to large doses of vitamin D1, Q. J. Med., 33, 209, 1964.
Jowsey, J., Riggs, B. L., Kelly, P. J., and Hoffman, D. L., Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosis, Am. J. Med., 53, 43, 1972.
Bartter, F. C., Osteoporosis, Am. J. Med., 22, 191, 1957.
Teitelbaum, S. L., Rosenberg, E. M., Richardson, C. A., and Avioli, L. V., Histological studies of bone from normocalcemic post-menopausal osteoporotic patients with increased circulating parathyroid hormone, J. Clin. Endocrinol. Metab., 42, 531, 1976.
Riggs, B. L., Jowsey, J., Kelley, P. J., Jones, D. J., and Maher, F. T., Effect of sex hormones on bone in primary osteoporosis, J. Clin. Invest., 48, 1065, 1969.
Lafferty, F. W., Spencer, G. E., Jr., and Pearson, O. H., Effects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis, Am. J. Med., 36, 514, 1964.
Cohn, S. H., Dombrowski, C. S., Hauser, W., and Atkins, H. L., Effects of fluoride on calcium metabolism in osteoporosis, Am. J. Clin. Nutr., 24, 20, 1971.
Manzke, E., Rawley, R., Vose, G., Roginsky, M., Rader, J. I., and Baylink, D. J., Effect of fluoride therapy on nondialyzable urinary hydroxyproline, serum alkaline phosphatase, parathyroid hormone and 25-hydroxyvitamin D,Metab. Clin. Exp., 26, 1005, 1977.
Jowsey, J., and Johnson, K. A., Juvenile osteoporosis: Bone findings in seven patients, J. Pediatr., 57, 511, 1972.
Cloutier, M. D., Hayles, A. B., Riggs, B. L., Jowsey, J., and Bickel, W. H., Juvenile osteoporosis: Report of a case including a description of some metabolic and microradiographic studies, Pediatrics, 40, 649, 1967.
Dent, C. E., and Friedman, M., Idiopathic juvenile osteoporisis, Q. J. Med., 34, 111, 1965.
Child, J. A., and Smith, I. E., Lymphoma presenting as “idiopathic” juvenile osteoporosis, Br. Med. J., 7, 720, 1975.
Reed, R. J., Fibrous dysplasia of bone, Arch. Pathol., 75, 480, 1963.
Albright, F., Butler, A. M., Hampton, A. D., and Smith, P., Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation, and endocrine dysfunction, with precocious puberty in females,M Engl. J. Med., 216, 727, 1937.
Benedict, P. H., Endocrine features in Albright’s syndrome (fibrous dysplasia of bone), Metabolism, 77, 30, 1962.
Ramsey, H. E., Strong, E. W., and Frazell, E. L., Fibrous dysplasia of the craniofacial bones, Am. J. Surg., 116, 542, 1968.
Jeffree, G. M., Enzymes in fibroblastic lesions: A histochemical and quantitative survey of alkaline and acid phosphatase, β-glucuronidase, non-specific esterase and leucine aminopepti-dase in benign and malignant fibroblastic lesions of bone and soft tissue, J. Bone Joint Surg., 54B, 535, 1972.
Firat, D., and Stutzman, L., Fibrous dysplasia of the bone: Review of twenty-four cases, Am. J. Med., 44, 421, 1968.
Andrews, B. S., Podolsky, S., and Posen, S., Thyrotrophin in Albright’s syndrome with hyperthyroidism, Ann. Intern. Med., 81, 561, 1974.
Huvos, A. G., Higinbotham, N. L., and Miller, T. R., Bone sarcomas arising in fibrous dysplasia, Bone Joint Surg., 54A, 1047, 1972.
Fischer, J. A., Bollinger, A., Lichtlen, P., and Wellauer, J., Fibrous dysplasia of the bone and high cardiac output, Am. J. Med., 49, 140, 1970.
Mcintosh, H. D., Miller, D. E., Gleason, W. L., and Goldner, J. L., The circulatory dynamics of polyostotic fibrous dysplasia, Am. J. Med., 32, 393, 1962.
Dent, C. E., and Gertner, J. M., Hypophosphataemic osteomalacia in fibrous dysplasia, Q. J. Med., 45, 411, 1976.
Gegick, C. G., Danowski, T. S., Khurana, R. C., Vidalon, C., Nolan, S., Stephan, T., Chae, S., and Wingard, L., Hyperostosis frontalis interna and hyperphosphatasemia, Ann. Intern. Med., 79, 71, 1973.
Bakwin, H., Golden, A., and Fox, S., Familial osteoectasia with macrocranium,, Am. J. Roentgenol Radium Ther. Nucl. Med., 91, 609, 1964.
Jett, S., and Frost, H. M., Tetracycline-based measurements of the bone dynamics in the rib of a girl with hyperphosphatasia, Henry Ford Hosp. Med. J., 16, 325, 1968.
Eyring, E. J., and Eisenberg, E., Congenital hyperphosphatasia: A clinical, pathological, and biochemical study of two cases, J. Bone Joint Surg., 50A, 1099, 1968.
Thompson, R. C., Jr., Gaull, G. E., Horowitz, S. J., and Schenk, R. K., Hereditary hyperphosphatasia: Studies of three siblings, Am. J. Med., 47, 209, 1969.
Clausen, J., Dyggve, H. V., and Melchior, J. C., Chemical and enzymic studies of a family with skeletal abnormalities associated with mental retardation, Clin. Chim. Acta, 29, 197, 1970.
Desai, M. P., Joshi, N. C., and Shah, K. N., Chronic idiopathic hyperphosphatasia in an Indian child,,4m. J. Dis. Child., 126, 626, 1973.
Gomes, W. J., and Hunter, J. L. P., Mental retardation, cataracts, and unexplained hyperphosphatasia,,Arch. Dis. Child., 45, 726, 1970.
Mabry, C. C., Bautista, A., Kirk, R. F. H., Dubilier, L. D., Braunstein, H., and Koepke, J. A., Familial hyperphosphatasia with mental retardation, seizures and neurologic deficits, J. Pediatr., 77, 14, 1970.
Rathburn, J. C., Hypophosphatasia, a new developmental anomaly, Am. J. Dis. Child., 75, 822, 1948.
Bartter, F. C., Hypophosphatasia, in: The Metabolic Basis of Inherited Disease, 3rd ed. (Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., eds.), Chapt. 51, McGraw-Hill, New York, 1972.
Currarino, G., Neuhauser, E. B. D., Reyersbach, G. C., and Sobel, E. H., Hypophosphatasia, Am. J. Roentgenol., 78, 392, 1957.
Fraser, D., Hypophosphatasia, Am. J. Med., 22, 730, 1957.
Birtwell, W. M., Riggs, B. L., Peterson, L. F. A., and Jones, J. D., Hypophosphatasia in an adultere, Arch. Intern. Med., 120, 90, 1967.
McCance, R. A., Fairweather, D. V. I., Barrett, A. M., and Morrison, A. B., Genetic, clinical, biochemical and pathological features of hypophosphatasia, Q. J. Med., 25, 523, 1956.
Pimstone, B., Eisenberg, E., and Silverman, S., Hypophosphatasia: Genetic and dental studies, Ann. Intern. Med., 65, 722, 1966.
Fraser, D., and Yendt, F. R., Metabolic abnormalities in hypophosphatasia, J. Dis. Child., 90, 552, 1955.
McCance, R. A., Morrison, A. B., and Dent, C. E., The excretion of phosphoethanolamine and hypophosphatasia, Lancet, 1, 131, 1955.
Russell, R. G. G., Excretion of inorganic pyrophosphate in hypophosphatasia, Lancet, 2, 461, 1965.
Schneider, R. W., and Corcoran, A. C., Familial nephrogenic osteopathy due to excessive tubular reabsorption of inorganic phosphate: A new syndrome and novel mode of relief, J. Lab. Clin. Med., 36, 985, 1950 (abstract).
Harris, H., and Robson, E. B., A genetical study of ethanolamine phosphate excretion in hypo-phosphatasia, Ann. Hum. Genet.,23, All, 1959.
Schlesinger, B., Luder, J., and Bodian, M., Rickets with alkaline phosphatase deficiency: An osteoblastic dysplasia, Arch. Dis. Child., 30, 265, 1955.
Hòsli, P., and Rudd, N., Alkaline phosphatase induction in fibroblast cultures: Prenatal diagnosis and carrier detection in hypophosphatasia, Hum. Hered.,Part IV, 1, 1978.
Hosli, P., Quantitative assays of enzyme activity in single cells: Early prenatal diagnosis of genetic disorders, Clin. Chem., 23, 1476, 1977.
Inglis, N. R., Fishman, L., Stolbach, L. L., Warshaw, J. B., and Fishman, W. H., A comparison of chyle isoenzymes of alkaline phosphatase in chyle and hypophosphatasemic sera, Clin. Chim. Acta, 38, 67, 1972.
Newton, M. A., A distinctive fraction of alkaline phosphatase in health and disease, J. Clin. Pathol., 79, 491, 1966.
Warshaw, J. B., Littlefield, J. W., Fishman, W. H., Inglis, N. R., and Stolbach, L. L., Serum alkaline phosphatase in hypophosphatasia, J. Clin. Invest., 50, 2137, 1971.
Scaglione, P. R., and Lucey, J. F., Further observations on hypophosphatasia, Am. J. Dis. Child., 92, 493, 1956.
Kretchmer, N., Stone, M., and Bauer, C., Hereditary enzymatic effects as illustrated by hypo-phosphatasia, Ann. N. Y. Acad. Sci., 75, 279, 1958.
Brydon, W. G., Crofton, P. M., Smith, A. F., Barr, D. G. D., and Harkness, R. A., Hypophosphatasia: Enzyme studies in cultured cells and tissues, Biochem. Soc. Trans., 3, 927, 1975.
Heizer, W. D., and Laster, L., Peptide hydrolase activities of the mucosa of the human small intestine, J. Clin. Invest., 48, 210, 1969.
Danovitch, S. H., Baer, P. N., and Laster, L., Intestinal alkaline phosphatase activity in familial hypophosphatasia, N. Engl. J. Med., 278, 1253, 1968.
Sorensen, E., and Flodgaard, H., Adult hypophosphatasia, Acta Med. Scand., 197, 357, 1975.
Gorodischer, R., Davidson, R. G., Mosovich, L. L., and Yaffe, S. J., Hypophosphatasia: A developmental anomaly of alkaline phosphatase, Pediatr, Res., 10, 650, 1976.
Rudd, N. J., Nuskin M., Hoar, D. I., Benzie, R., and Doran, T. A., Prenatal diagnosis of hypo-phosphatasia, N. Engl J. Med., 295, 146, 1976.
Beisel, W. R., Benjamin, N., and Austen, K. F., Absence of leukocyte alkaline phosphatase activity in hypophosphatasia, Blood, 14, 975, 1959.
Korner, N. H., Distribution of alkaline phosphatase in the serum proteins in hypophosphatasia, J. Clin. Pathol., 15, 200, 1962.
Reilly, B. J., Leeming, J. M., and Fraser, D., Craniosynostosis in the rachitic spectrum, J. Pediatr., 64, 396, 1964.
Bongiovanni, A. M., Album, M. M., Root, A. W., Hope, J. W., Marino, J., and Spencer, D. M.,Studies in hypophosphatasia and response to high phosphate intake, Am. J. Med. Sci. 255, 163, 1968.
Bethune, J. E., and Dent, C. E., Hyophosphatasia in the adult, Am. J. Med., 28, 615, 1960.
Scriver, C. R., and Cameron, D., Pseudohypophosphatasia, N. Engl. J. Med., 281, 604, 1969.
Caniggia, A., Stuart, C., and Guideri, R., Fragilitas ossium hereditaria tarda, Acta. Med. Scand. Suppl., 340, 1, 1958.
Banta, J. V., Schreiber, R. R., and Kulik, W. J., Hyperplastic callus formation in osteogenesis imperfecta simulating osteosarcoma, J. Bone Joint Surg., 53, 115, 1971.
Klenerman, L., Ockenden, B. G., and Townsend, A. C., Osteosarcoma occurring in osteogenesis imperfecta: Report of two cases, J. Bone Joint Surg., 49B, 314, 1967.
Amstutz, H. C., Multiple osteogenic sarcomata-metastatic or multicentric? Report of two cases and review of literature, Cancer, 24, 923, 1969.
Ophuls, W., A Statistical Survey of Three Thousand Autopsies, Stanford University Press, 1926.
Lee, E. S., and Mackenzie, D. H., Osteosarcoma: A study of the value of preoperative megavolt- age radiotherapy, Br. J. Surg., 51, 252, 1964.
McKenna, R. J., Schwinn, C. P., Soong, K. Y., and Higinbotham, N. L., Sarcomata of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma and sarcomata arising in abnormal bone): An analysis of 552 cases, J. Bone Joint Surg., 48A, 1, 1966.
Gomori, G., Study of enzymes in tissue section, Am. J. Clin. Pathol., 16, 347, 1946.
Monis, B., and Rutenburg, A. M., Alkaline phosphatase activity in neoplastic and inflammatory tissues of man,Cancer, 13, 538, 1960.
Mori, M., Fukuda, M., Tsukamoto, S., Takeda, M., Arita, J., and Morishita, M., Enzyme histochemistry of osteogenic saicoma, chondrosarcoma and giant cell lesions in jawbones, Oral Surg. Oral Med. Oral Pathol., 26, 103, 1968.
Cade, S., Maclagan, N. F., and Townsend, R. F., Serum phosphatase in cases of bone tumour, Lancet, 1, 1074, 1940.
Dahlin, D. C., and Coventry, M. B., Osteogenic sarcoma: A study of six hundred cases, J. Bone Joint Surg., 49A, 101, 1967.
Brozmanova, E., and Skrovina, B., Serum alkaline phosphatase in malignant bone tumors osteosarcoma, chondrosarcoma, fibrosarcoma, E wing’s sarcoma), Neoplasma, 20, 419, 1973.
Cornish, C., Studies on human bone alkaline phosphatase, M.Sc. thesis, University of Sydney, Australia, 1975.
Jeffree, G. M., and Price, C. N. G., Bone tumours and their enzymes: A study of the phosphatases, non-specific esterases and beta-glucuronidase of osteogenic and cartilaginous tumours, fibroblastic and giant-cell lesions, J. Bone Joint Surg., 47B, 120, 1965.
Yabsley, R. H., and Harris, W. R., Solitary eosinophilic granuloma of a vertebral body causing paraplegia: Report of a case, J. Bone Joint Surg., 48A, 1570, 1966.
Schajowicz, F., and Cabrini, R. L., Histochemical studies of bone in normal and pathological conditions with special reference to alkaline phosphatase, glycogen and mucopolysaccharides, J. Bone Joint Surg., 36B, 414, 1954.
Case records of the Massachusetts General Hospital, Case 44452, N. Engl. J. Med., 259, 934, 1958.
Case records of the Massachusetts General Hospital, Case 38–1965,N. Engl. J. Med., 273, 494, 1965.
Sharma, S. M., and Quinn, J. L., Sensitivity of 18F bone scans in the search for metastases, Surg. Gynecol. Obstet., 135, 536, 1972.
Pistenma, D. A., McDougall, I. R., and Kriss, J. P., Screening for bone metastases: Are only scans necessary?, J. Am. Med. Assoc., 231, 46, 1975.
Raskin, P., McClain, C. J., and Medsger, T. A., Hypocalcemia associated with metastatic bone disease: A retrospective study, Arch. Intern. Med., 132, 539, 1973.
Wallis, L. A., Asch, T., and Maisel, B. W., Diffuse skeletal hemangiomatosis: Report of two cases and review of the literature, Am. J. Med., 37, 545, 1964.
Enriquez, P., Dahlin, D. C., Hayles, A. B., and Henderson, E. D., Histiocystosis X: A clinical study, Mayo Clin. Proc., 42, 88, 1967.
Avioli, L. V., Lasersohn, J. C., and Lopresti, J. M., Histocystosis X (Schüller-Christian disease): A clinic-pathological survey, review of ten patients and the results of prednisone therapy, Medicine (Baltimore), 42, 119, 1963.
Simmons, C. C., and Franseen, C. C., The diagnostic value of phosphatase determinations in the study of bone tumors, Ann. Surg., 102, 555, 1935.
Lutwak, L., Myositis ossificans progressiva: Mineral, metabolic, and radioactive calcium studies on the effects of hormones, Am. J. Med., 37, 269, 1964.
Furman, R., Nicholas, J. J., and Jivoff, L., Elevation of the serum alkaline phosphatase coincident with ectopic-bone formation in paraplegic patients, J. Bone Joint Surg., 52A, 1131, 1970.
Nicholas, J. J., Ectopic bone formation in patients with spinal cord injury, Arch. Phys. Med. Rehabil., 54, 354, 1973.
Cheney, W. D., Aero-osteolysis, Am. J. Roentgenol., 94, 595, 1965.
Shurtleff, D. B., Sparkes, R. S., Clawson, D. K., Guntheroth, W. G., and Mottet, N. K., Hereditary osteolysis with hypertension and nephropathy, J. Am. Med. Assoc., 188, 363, 1964.
Hodkinson, H. M., Fracture of the femoral neck in the elderly: Assessment of the role of osteomalacia, Gerontol. Clin., 13, 153, 1971.
Botterell, E. H., and King, E. J., Phosphatase in fractures, Lancet, 1, 1267, 1935.
Durst, J., Flasch, A., Eggstein, M., Geisbe, H. and Probst, H., Ein Beitrag zur Pathogenese der traumatischen Fettembolie. I. Das Verhalten der Plasmaenzyme, Med. Welt, 47, 2808, 1967.
Urist, M. R., and Johnson, R. W., Calcification and ossification. IV. The healing of fractures in in man under clinical conditions, J. Bone Joint Surg., 25, 375, 1943.
Gudmundson, C., and Semb, H., Enzyme studies of fractures with normal and delayed union, Acta Orthop. Scand., 42, 18, 1971.
Nilsson, B. E., and Westlin, N. E., The plasma concentration of alkaline phosphatase, phosphorus and calcium following femoral neck fracture, Acta Orthop. Scand., 43, 564, 1972.
Clinicopathologic conference: Fat embolism, Am. J. Med., 51, 258, 1971.
Case records of the Massachusetts General Hospital, Case 37-1963, N. Engl. J. Med., 268, 1240, 1963.
Hunsberger, A., and Ferguson, L. K., Variations in phosphatase and inorganic phosphorus in serum during fracture repair, Arch. Surg., 24, 1052, 1932.
Wray, J. B., The biochemical characteristics of the fracture hematoma in man, Surg. Gynecol. Obstet., 130, 847, 1970.
Waldvogel, F. A., Medoff, G., and Swartz, M. N., Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects, N. Engl. J. Med., 282, 198, 1970.
Case records of the Massachusetts General Hospital, Case 28-1971,TV. Engl. J. Med., 285, 166, 1971.
Cabanela, M. E., Sim, F. H., Beabout, J. W., and Dahlin, D. C., Osteomyelitis appearing as neoplasms: A diagnostic problem, Arch. Surg., 109, 68, 1974.
Cabenela, M. E., Personal communication, 1976.
McKusick, V. A., and Scott, C. I., A nomenclature for constitutional disorders of bone, / Bone Joint Surg., 53A, 918, 1971.
Macdessi, J. J., Kozlowski, K., and Posen, S., Spondyloepiphyseal dysplasia: Report of two “new” variants in two different families, Pediatr. Radiol., 7, 220, 1978.
Johnston, C. C., Lavy, N., Lord, T., Velios, F., Merritt, A. D., and Deiss, W. P., Jr., Osteo¬petrosis: A clinical genetic, metabolic and morphologic study of the dominantly inherited, benign form,Medicine (Baltimore), 47, 149, 1968.
Hinkel, C. L., and Beiler, D. D., Osteopetrosis in adults, Am. J. Roentgenol., 74, 46, 1955.
Thiersch, J. B., Contribution to the radiology and pathology of transmissible avian osteopetrosis, Radiology, 51, 100, 1948.
Gluck, J., and Miller, J. J., Familial osteolysis of the carpal and tarsal bones, J. Pediatr., 81, 506, 1972.
Van Buchem, F. S. P., Hadders, H. N., Hansen, J. F., and Woldring, M. G., Hyperostosis corticalis generalisata, Am. J. Med., 33, 387, 1962.
Beighton, P., Durr, L., and Hamersma, H., The clinical features of sclerosteosis: A review of the manifestations in twenty-five affected individuals,, Ann. Intern. Med., 84, 393, 1976.
Burgert, E. O., Dower, J. C., and Tauxe, W. N., A new syndrome–Aregenerative anemia, mal-absorption (celiac) dyschondroplasia and hyperphosphatasemia, J. Pediatr., 67, 111, 1965 (abstract).
Von Wowern, N., Cherubism, Int. J. Oral Surg., 1, 240, 1972.
Nagamine, M., and Ohkuma, S., Serum alkaline phosphatase isoenzymes linked to immunoglobulin G, Gin. Chim. Acta, 65, 39, 1975.
McCarty, D. J., Solomon, S. D., Warnock, M. L., and Paloyan, E., Inorganic pyrophosphate concentrations in the synovial fluid of arthritic patients, J. Lab. Gin. Med., 78, 216, 1971.
Bunch, T. W., Hunder, G. G., McDuffie, F. C., O’Brien, P. C., and Markowitz, H., Synovial fluid complement determination as a diagnostic aid in inflammatory joint disease, Mayo Gin. Proc., 49, 715, 1974.
Lehman, M. A., Kream, J., and Brogna, D., Acid and alkaline phosphatase activity in the serum and synovial fluid of patients with arthritis, J. Bone Joint Surg., 46A, 1732, 1964.
Watson, E. M., The effect of adrenal cortical extract on the serum phosphatase in chronic arthritis, Endocrinology, 27, 521, 1940.
Chalmers, T. M., Clinical experience with ibuprofen in the treatment of rheumatoid arthritis, Ann. Rheum. Dis., 28, 513, 1969.
Kendall, M. J., Cockel, R., Becker, J., and Hawkins, C. F., Raised serum alkaline phosphatase in rheumatoid disease: An index of liver dysfunction ?, Ann. Rheum. Dis., 29, 537, 1970.
Rich, R. R., and Johnson, J. S., Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis, Arthritis Rheum., 16, 1, 1973.
Seaman, W. E., and Plotz, P. H., Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers, Arthritis Rheum., 19, 155, 1976.
Maddison, P. J., and Bacon, P. A., Vitamin D deficiency, spontaneous fractures and osteopenia in rheumatoid arthritis, Br. Med. J., 4, 433, 1974.
Kendall, M. J., Lawrence, D. S., Shuttleworth, G. R., and Whitfield, A. G. W., Haematology and biochemistry of ankylosing spondylitis, Br Med. J., 2, 235, 1973.
Webb, J., Whaley, K., MacSween, R. N. M., Nuki, G., Dick, W. C., and Buchanan, W. W., Liver disease in rheumatoid arthritis and Sjogren’s syndrome, Ann. Rheum. Dis., 34, 70, 1975.
Russell, A. S., Sturge, R. A., and Smith, M. A., Serum transaminases during salicylate therapy, Br. Med. J., 2, 428, 1971.
Acheson, E. D., An association between ulcerative colitis, regional enteritis, and ankylosing spondylitis, Q. J. Med., 29, 489, 1960.
McCarty, D. J., Kohn, N. N., and Faires, J. S., The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: The “pseudogout syndrome”, Ann. Intern. Med., 56, 711, 1962.
Phelps, P., and Hawker, C. D., Serum parathyroid hormone levels in patients with calcium pyrophosphate crystal deposition disease (chondrocalcinosis, pseudogout), Arthritis Rheum., 16, 590, 1973.
Hamilton, E., Williams, R., Barlow, K. A., and Smith, P. M., The arthropathy of idiopathic haemochromatosis, Q. J. Med., 37, 111, 1968.
Russell, R. G., Bisaz, S., Fleisch, H., Currey, H. L. F., Rubinstein, H. M., Dietz, A. A., Boussina, I., Micheli, A., and Fallet, G., Inorganic pyrophosphate in plasma, urine, and synovial fluid of patients with pyrophosphate arthropathy (chondrocalcinosis or pseudogout), Lancet, 2, 899, 1970.
Yaron, M., Zurkowski, P., Weiser, H. I., Yust, I., Goldschmied, A., and Hermann, E., Pseudogout with low values of alkaline phosphatase in the synovial fluid, Ann. Intern. Med., 73, 751, 1970.
Yaron, M., Yust, I., and Zurkowski, P., Alkaline phosphatase in pseudogout (letter), Lancet, 2, 651, 1969.
Machtey, I., Pyrophosphate arthropathy (letter), Lancet, 1, 654, 1971.
Franck, W. A., Bress, N. M., Singer, S. R., and Krane, S. M., Rheumatic manifestations of Paget’s disease of bone, Am. J. Med., 56, 592, 1974.
Kanof, A., Aronson, S. M., and Volk, B. W., Arthrogryposes: A clinical and pathological study of three cases, Pediatrics, 17, 532, 1956.
Shariff, F. K., Horoupian, D., and Greenlaw, R. K., Arthrogryposis multiplex congenita, Gin. Orthop., 94, 263, 1973.
Wittman, W., and Fellingham, S. A., Unusual hip disease in remote part of Zuhiimd,Lancet, 1, 842, 1966.
Burger, F. J., Elphinstone, C. D., Fellingham, S. A., Grey, P. C., and Hogewind, Z. A., Mseleni joint disease: Biochemical survey, S. Afr. Med. J., 47, 2331, 1973.
Kar, N. C., and Pearson, C. M., Alkaline phosphatase in normal and diseased human muscle, Proc. Soc. Exp. Biol. Med., 141, 4, 1972.
Benitez-Bribiesca, L., and De La Vega, G., Occurrence of alkaline phosphatase-containing muscle fibers after denervation, J. Histochem. Cytochem., 19, 691, 1971.
Smith, B., Changes in the enzyme histochemistry of skeletal muscle during experimental denervation and reinnervation, J Neurol. Neurosurg. Psychiatry, 28, 99, 1965.
Engel, W. K., and Cunningham, G. G., Alkaline phosphatase-positive abnormal muscle fibers of humans, J. Histochem. Cytochem., 18, 55, 1970.
Engel, W. K., and Meltzer, H., Histochemical abnormalities of skeletal muscle in patients with acute psychoses, Science, 168, 273, 1970.
Romanul, F. A., and Bannister, R. G., Localized areas of high alkaline phosphatase activity in the terminal arterial tree, J. Cell Biol., 15, 73, 1962.
Ledwith, J. W., and Whipple, R. J., Myotonia dystrophica: A case report with sex chromatin studies, Ann. Intern. Med., 54, 113, 1961.
White, A. A., and Hess, W. C., Some alterations in serum enzymes in progressive muscular dystrophy, Proc. Soc. Exp. Biol. Med., 94, 541, 1957.
Bethlem, J., Van Gool, J., Hiilsmann, W. C., and Meijer, A. E. F. H., Familial non-progressive myopathy with muscle cramps after exercise: A new disease associated with cores in the muscle fibers, Brain, 89, 569, 1966.
Banker, B. Q., and Victor, M., Dermatomyositis (systemic angiopathy) of childhood, Medicine (Baltimore), 45, 261, 1966.
Fauchald, P., Rygvold, O., and Oystese, B., Temporal arteritis and polymyalgia rheumatica: Clinical and biopsy findings, Ann. Intern. Med., 77, 845, 1972.
Hall, G. H., and Hargreaves, T., Giant-cell arteritis and raised serum-alkaline-phosphatase levels (letter), Lancet, 2, 48, 1972.
Glick, E. N., Raised serum-alkaline-phosphatase levels in polymyalgia rheumatica, Lancet, 2, 328, 1972.
Gibbs, P., Polymyalgia rheumatica and liver disease, Lancet, 1, 351, 1974.
Dixon, A. S. J., Polymyalgia rheumatica and liver disease (letter), Lancet, 1, 178, 1974.
Smith, A. F., Macfie, W. G., and Oliver, M. F., Clofibrate, serum enzymes, and muscle pain, Br. Med. J., 2, 86, 1970.
Hellman, L., Zumoff, B., Kessler, G., Kara, E., Rubin, I. L., and Rosenfeld, R. S., Reduction of serum cholesterol and lipids by ethyl chlorophenoxyisobutyrate, J. Atheroscler. Res., 3, 454, 1963.
Leonard, C. D., and Eichner, E. R., Acute renal failure and transient hypercalcemia in idiopathic rhabdomyolysis, J. Am. Med. Assoc., 211, 1539, 1970.
Robinson, S. F., and Woods, A. H., Heroin induced rhabdomyolysis and acute renal failure: A case report, Ariz. Med., 31, 246, 1974.
Tavill, A. S., Evanson, J. M., Baker, S. B., and Hewitt, V., Idiopathic paroxysmal myoglobinuri with acute renal failure and hypercalcemia, N. Engl. J. Med., 271, 283, 1964.
Turkington, R. W., Delcher, H. K., and Neelon, F. A., Hypercalcemia following acute renal failure, J. Clin. Endocrinol. Metab., 28, 1224, 1968.
Robinson, S. F., and Woods, A. H., Hypercalcemia during recovery from renal failure (letter), N. Engl. J. Med., 292, 535, 1975.
Clinicopathologic exercise: University of Kansas Medical Center College of Health Sciences and Hospital (Scarpelli, D. G., ed.),N. Engl. J. Med., 293, 922, 1975.
Ross, R. S., Iber, F. L., and Harvey, A. M., The serum alkaline phosphatase in chronic infiltrative disease of the liver, Am. J. Med., 21, 850, 1956.
McFarlane, M. G., Patterson, L. M. B., and Robison, R., The phosphatase activity of animal tissues, Biochem. J., 28, 720, 1934.
Herz, F., Kaplan, E., and Fineman, E. L., Regulation of alkaline phosphatase activity in KB cells: Influence of serum, Biochim. Biophys. Acta, 304, 660, 1973.
Herz, F., Alkaline phosphatase in KB cells: Influence of hyperosmolality and prednisolone on enzyme activity and thermostability, Arch. Biochem. Biophys., 158, 223, 1973.
Probert, J. C., Thompson, R. W., and Bagshaw, M. A., Patterns of spread of distant metastases in head and neck cancer, Cancer, 33, 127, 1974.
Papavasiliou, C. G., Pulmonary metastases from cancer of the nasopharynx associated with hypertrophic osteoarthropathy, Br. J. Radiol., 36, 680, 1963.
Hammarsten, J. F., and O’Leary, J., The features and significance of hypertrophic osteoarthropathy, Arch. Intern. Med., 99, 431, 1957.
Rees, H. A., and Wilhams, D. A., Long term steroid therapy in chronic intractable asthma, Br. Med. J., 1, 1575, 1962.
Krokowski, E., and Stressman, E., Röntgenologische Bestimmungen des Mineralisationsgrades der Wirbelsäule von Kranken mit chronischem Bronchialasthma, Klin. Wochenschr., 45, 570, 1967.
Arnoldsson, H., Long-term ACTH and corticosteroid therapy in bronchial asthma: A clinical evaluation, Acta Allergol., 12, Suppl. 6, 1958.
Arman, E., Svanborg, N., Carlstrom, A., and Reizenstein, P., Calcium retention and skeletal calcium uptake in asthmatic subjects treated with glucocorticoids, Acta Allergol., 25, 456, 1970.
Sharp, H. L., Bridges, R. A., Krivit, W., and Freier, E. F., Cirrhosis associated with antitrypsin deficiency: A previously unrecognized inherited disorder, J. Lab. Clin. Med., 73, 934, 1969.
Kumar, P., Lancaster-Smith, M., Cook, P., Stansfeld, A., Clark, M. L., and Dawson, A. M., Alphai antitrypsin deficiency in chronic liver disease, and a report of cirrhosis and emphysema in adult members of a family, Br. Med. J., 1, 366, 1974.
Richman, S. M., Delman, A. J., and Grob, D., Alterations in indices of liver function in congestive heart failure with particular reference to serum enzymes, Am. J. Med., 30, 211, 1961.
Schonell, M. E., Crompton, G. K., Farshall, J. M., and Whitby, L. G., Failure to differentiate pulmonary infarction from pneumonia by biochemical tests, Br. Med. J., 1, 1146, 1966.
Schweppe, H. I., Knowles, J. H., and Kane, L., Lung abcess: An analysis of the Massachusetts General Hospital cases from 1943 through 1956, N. Engl. J. Med., 265, 1039, 1961.
Manfredi, F., Daly, W. J., and Behuke, R. H., Clinical observations of acute Friedländer pneumonia, Ann. Intern. Med., 58, 642, 1963.
Tugwell, P., and Wilhams, A. O., Jaundice associated with lobar pneumonia: A clinical, laboratory and histological study, Q. J. Med., 46, 97, 1977.
Katz, H. L., Sbar, S., and Goldner, M. G., The effect of pneumoperitoneum therapy in pulmonary tuberculosis on liver function, Am. Rev. Tuberc., 65, 589, 1952.
Ban, B., Hepatic damage in chronic pulmonary tuberculosis, Am. Rev. Tuberc., 72, 71, 1955.
Brandt, K., Cathcart, E. S., and Cohen, A. S., A clinical analysis of the course and prognosis of forty-two patients with amyloidosis, Am. J. Med., 44, 955, 1968.
Korn, R. J., Kellow, W. F., Heller, P., Chomet, B., and Zimmerman, H. J., Hepatic involvement in extrapulmonary tuberculosis: Histologic and functional characteristics, Am. J. Med., 27, 60, 1959.
Bowry, S., Chan, C. H., Weiss, H., Katz, S., and Zimmerman, H. J., Hepatic involvement in pulmonary tuberculosis: Histologic and functional characteristics, Am. Rev. Respir. Dis., 101, 941, 1970.
Shai, F., Baker, R. K., Addrizzo, J. R., and Wallach, S., Hypercalcaemia in mycobacterial infections, J. Clin. Endocrinol. Metabol., 34, 251, 1972.
Houk, V. N., and Moser, K. M., Pulmonary cryptococcosis: Must all receive Amphotericin B ?, Ann. Intern. Med., 63, 583, 1965.
Johns, L. E., Jr., Garrison, R. G., and White, T. G., Bronchopleurocutaneous fistula due to infection with Histoplasma capsulatum, Chest, 63, 638, 1973.
Webster, B. H., Bronchopulmonary cryptococcosis, Dis. Chest, 43, 513, 1963.
Riley, E. A., Boeck’s sarcoid: A review based upon a clinical study of fifty-two cases, Am. Rev. Tuberc., 62, 231, 1950.
Case records of the Massachusetts General Hospital, Case 8-1974, N. Engl. J. Med., 290, 504, 1974.
Harrell, G. T., and Fisher, S., Blood chemical changes in Boeck’s sarcoid with particular reference to protein calcium and phosphatase values, J. Clin. Invest., 18, 687, 1939.
Clinicopathologic conference: Wegener’s granulomatosis, Am. J. Med., 35, 384, 1963.
Rubin, E. H., and Lubliner, R., The Hamman-Rich syndrome: Review of the literature and analysis of 15 cases, Medicine (Baltimore), 36, 397, 1957.
Chisholm, J. C., Jr., Traad, E. A., and Gregonis, J. G., Cholesterol pneumonitis, Dis. Chest, 55, 492, 1969.
Sanders, M., Kahan, M., and Sbar, S., Pulmonary alveolar proteinosis: A review of the literature; Report of two cases, Dis. Chest, 42, 437, 1962.
Trujillo, N. P., Nutter, D., and Evans, J. M., The isoenzymes of lactic dehydrogenase. II. Pulmonary embolism, liver disease, the postoperative state, and other medical conditions, Arch. Intern. Med., 119, 333, 1967.
Nikkila, E. A., Serum alkaline phosphatase activity in pulmonary infarction, Scand. J. Clin. Lab. Invest., 11, 405, 1959.
Dijkman, J. H., and Kloppenborg, P. W. C., Increased serum alkaline phosphatase activity in pulmonary infarction, Acta Med. Scand., 180, 273, 1966.
Case records of the Massachusetts General Hospital, Case 5-1965, N. Engl. J. Med., 272, 202, 1965.
Betro, M. G., The significance of increased alkaline phosphatase and lactate dehydrogenase activities coincident with normal serum bilirubin, Gin. Chem., 18, 1427, 1972.
Goodwin, N. J., Castronuovo, J. J., and Friedman, E. A., Recurrent septic pulmonary embolization complicating maintenance hemodialysis, Ann. Intern. Med., 71, 29, 1969.
Weiss, E. B., Earnest, D. L., and Greally, J. F., Goodpasture’s syndrome: Case report with emphasis on pulmonary physiology, Am. Rev. Respir. Dis., 97, 144, 1968.
Ognibene, A. J., and Johnson, D. E. Idiopathic pulmonary hemosiderosis in adults: Report of case and review of literature, Arch. Intern. Med., Ill, 503, 1963.
Gault, M. H., Cohen, M. W., Kahana, L. M., Leelin, F. T., Meakins, J. F., and Aronovitch, M., Serum enzymes in patients with carcinoma of the lung: Lactic acid dehydrogenase, phosphor-hexose isomerase, alkaline phosphatase and glutamic oxalacetic transaminase, Can. Med. Assoc. J., 96, 87, 1967.
Charles, M. A., Claypool, R., Schaaf, M., Rosen, S. W., and Weintraub, R. D., Lung carcinoma associated with production of three placental proteins, Arch. Intern. Med., 132, 427, 1973.
Fishman, W. H., Inglis, N. I., Green, S., Anstiss, C. L., Ghosh, N. K., Reif, A. E., Rustigian, R., Krant, M. J., and Stolbach, L. L., Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer, Nature (London), 219, 697, 1968.
Sussman, H. H., Weintraub, B. D., and Rosen, S. W., Relationship of ectopic placental alkaline phosphatase to ectopic chorionic gonadotropin and placental lactogen: Discordance of three “markers” for cancer, Cancer, 33, 820, 1974.
Turkington, R. W., Goldman, J. K., Ruffner, B. W., and Dobson, J. L., Bronchogenic carcinoma simulating hyperparathyroidism, Cancer, 19, 406, 1966.
Eckhardt, R. E., MacFarland, H. N., Alarie, Y. C. E., and Busey, W. M., The biologic effect from long-term exposure of primates to carbon monoxide, Arch. Environ. Health, 25, 381, 1972.
Schaeppi, U., Phelan, R., Stadnick, S. W., Fleischman, R. W., Heyman, I. A., Ilievsky, V., and Redding, R. A., Pulmonary fibrosis following multiple treatments with bleomycin (NSC-125066) in dogs, Cancer Chemother. Rep., 58, 301, 1974.
Werthamer, S., Penha, P. D., and Amaral, L., Pulmonary lesions induced by chronic exposure to ozone. I. Biochemical alterations, Arch. Environ. Health, 29, 164, 1974.
Ramirez-R., J., and Dowell, A. R., Silo-filler’s disease: Nitrogen dioxide-induced lung injury, Ann. Inter. Med., 74, 569, 1971.
Leach, C. S., Kimzey, S. L., and Nicogossian, A. E., Biochemical changes following exposure to nitrogen tetroxide (N204) upon return from space flight (abstract), Aerospace Medical Association Annual Meeting, 1976.
Feldstein, A. M., Samachson, J., and Spencer, H., Levels of calcium, phosphorus, alkaline phosphatase and protein in effusion fluid and serum in mm, Am. J. Med., 35, 530, 1963.
Nakayama, T., Yoshida, M., and Kitamura, M., L-Leucine sensitive, heat stable alkaline phosphatase isoenzyme detected in a patient with pleuritis carcinomatosa, Clin. Chim. Acta, 30, 546, 1970.
Lubbers, P., Zum Verhalter der alkalischen Ergussphosphatasen bei Serocacarcinosen, Klin. Wochenschr., 35, 590, 1957.
Doust, J. Y., and Kohout, E., Alkaline phosphatase in pleural effusion, Isr. J. Med. Sci., 9, 1588, 1973.
Arvy, L., Généralités sur les artères et leurs enzymes, Arch. Mal. Coeur Vaiss., Suppl. 3, 58, 1968.
Borgers, M., Schaper, J., and Schaper, W., Localization of specific phosphatase activities in canine coronary blood vessels and heart muscle, J. Histochem. Cytochem., 19, 526, 1971.
Anestiadis, B. C., and Russu, S. P., Considérations sur les caractères histoenzymologiques des enzymes hydrolytiques de la paroi des artères au stade initial de l’athérosclérose, Ann. Anat. Pathol., 14, 267, 1969.
Haussier, M., Nagode, L. A., and Rasmussen, H., Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase,Nature (London), 228, 1199, 1970.
Wojcicki, J., Rozewicka, L., and Kadjykow, M., Experimental studies on cobalt cardiopathy, Arch. Immunol. Ther. Exp., 21, 287, 1973.
Ewen, L. M., and Griffiths, J., Patterns of enzyme activity following myocardial infarction and ischemia, Am. J. Gin. Pathol., 56, 614, 1971.
Sherlock, S., The liver in heart failure: Relationship of anatomical, functional and circulatory changes, Br. Heart J., 13, 273, 1951.
Rowan, T., Diagnostic enzymology in myocardial infarction and acute chest pain, Guy’s Hosp. Rep., 119, 221, 1970.
Betro, M. G., Oon, R. C. S., and Edwards, J. B., Gamma-glutamyl transpeptidase and other liver function tests in myocardial infarction and heart failure, Am. J. Gin. Pathol., 60, 697, 1973.
Felder, L., Mund, A., and Parker, J. C., Liver function tests in chronic congestive heart failure, Circulation, 2, 286, 1950.
Case records of the Massachusetts General Hospital, Case 22-1971, N. Engl. J. Med., 284, 1260, 1971.
Cook, U. P., and Carter, N. K., Nonutility of measurement of serum gamma-glutamyl transpeptidase activities in diagnosis of myocardial disease, Gin. Chem., 19, 774, 1973.
Dietz, A. A., Hodges, L. K., and Foxworthy, D. T., Correlation of serum and urine enzyme activity in patients with acute myocardial infarction, Gin. Chem., 13, 359, 1967.
Highman, B., Thompson, E. C., Roshe, J., and Altland, P. D., Serum alkaline phosphatase in dogs with experimental splenic and renal infarcts and with endocarditis, Proc. Soc. Exp. Biol. Med., 95, 109, 1957.
Gault, M. H., and Steiner, G., Serum and urinary enzyme activity after renal infarction, Can. Med. Assoc. J., 93, 1101, 1965.
Case records of the Massachusetts General Hospital, Case 19-1971, N. Engl. J. Med., 284, 1084, 1971.
Wiltse, H. E., Goldbloom, R. B., Antia, A. V., Ottesen, O. E., Rowe, R. D., and Cooke, R. E., Infantile hypercalcemia in twins, N. Engl. J. Med., 275, 1157, 1966.
Garcia, R. E., Friedman, W. F., Kaback, M. M., and Rowe, R. D., Idiopathic hypercalcemia and supravalvular aortic stenosis, N. Engl. J. Med., 271, 111, 1964.
Larmi, T. K. I., and Kârkôlà, P., Liver dysfunction and enzymes during experimental long- term cardiopulmonary by-pass, J. Cardiovasc. Surg., 14, 395, 1973.
Thomas, T. V., Heilbrunn, A., and Lucas, S. R., Biochemical response to cardiopulmonary bypass: Clinical evaluation of disc and bubble oxygenators with and without coronary perfusion, J. Cardiovasc. Surg., 12, 9, 1971.
Pourtois, M., Morphogenesis of primary and secondary palate, in: Developmental Aspects of Oral Biology (Slavkin, H. C., and Bavetta, L. A., eds.), Chapt. 5, p. 95, Academic Press, New York, 1972.
Miles, A. E. W., Structure and Chemical Organization of Teeth, Academic Press, New York, 1967.
Bruckner, R. J., Alkaline phosphatase in pulpal tissue of human teeth, J. Dent. Res., 28, 55, 1949.
Kiguel, E., A study of tooth development and the possible role of alkaline phosphatase, Int. Dent. J., 20, 1, 1970.
Ten Cate, A. R., The distribution of alkaline phosphatase in the human tooth germ, Arch. Oral Biol, 7, 195, 1962.
Provenza, D. V., Oral Histology, Inheritance and Development, Chapt. 8, Lippincott, Philadelphia, 1964.
Gaunt, W. A., and Miles, A. E. W., Fundamentals of tooth morphogenesis, in: Structure and Chemical Organization of Teeth (Miles, A. E. W., ed.), p. 151, Academic Press, New York, 1967.
Symons, N. B. B., Microanatomy and histochemistry of dentinogenesis, in: Structure and Chemical Organization of Teeth (Miles, A. E. W., ed.), p. 292, Academic Press, New York, 1967.
Reeth, E. J., and Butcher, E. O., Microanatomy and histochemistry of amelogenesis, in: Structure and Chemical Organization of Teeth (Miles, A. E. W., ed ), Academic Press, 1967.
Nuki, K., and Bonting, S. L., Quantitative histochemistry of the developing hamster tooth: Alkaline phosphatase and lactic dehydrogenase, J. Histochem. Cytochem., 9, 117, 1961.
Larmas, M., Histochemical studies on phosphatase and arylsulphatase activity in human carious dentine, A eta Odontol. Scand., 26, 357, 1968.
Bowen, W. H., Phosphatase in micro-organisms cultured from carious dentin and calculus, J.Dent. Res.,40,Sil, 1961.
Witkop, C. J. Dental problems of a heritable nature in: Genetics and Dental Health (Witkop, C. J., ed.), Proceedings of an International Symposium held at The National Institutes of Health, Bethesda, Maryland, April 4-6,1961, McGraw-Hill, New York, 1962.
Ishikawa, I., and Cimasoni, G., Alkaline phosphatase in human gingival fluid and its relation to periodontitis, Arch. Oral Biol, 15, 1401, 1970.
Lazzari, E. P., Dental Biochemistry, p. 64, Lea and Febiger, Philadelphia, 1968.
Murata, I., Kawashima, H., and Mori, M., Histochemical study on alkaline phosphatase activity in human neoplasms, Gann, 57, 513, 1966.
Rakhawy, M. T., Phosphatases in the nervous tissue: The nature of the ganglionic nerve cells in the tongue, ActaAnat., 83, 356, 1972.
Oikarinen, V. J., Malström, M., and Gordin, R., Observations on the enzymatic activities in relation to trauma and diseases in the maxillofacial region: A preliminary report, Acta Odontol Scand., 26, 473, 1968.
Ariyan, S., Farber, L. R., Hamilton, B. P., and Papac, R. J., Pseudohyperparathyroidism in head and neck tumors, Cancer, 33, 159, 1974.
Arvy, L., Comparative histoenzymology of the salivary glands, Ann. N. Y. Acad. Sci., 106, 472, 1963.
Kaufmann, F., and Stiebitz, R., Zur Enzymhistochemie der Speicheldrüsentumoren, Acta Histochem., 32, 221, 1969.
Bruce, R. A., and Wertheimer, F. W., Enzyme histochemistry of adenoid cystic carcinoma of minor salivary glands, J. Oral Surg., 25, 30, 1967.
Cutler, L. S., Chaudhry, A. P., and Monies, M., Alkaline phosphatase activity in normal and neoplastic human salivary glands: An ultrastructural study, Arch. Oral Biol., 19, 499, 1974.
Chauncey, H. H., Lionetti, F., Winer, R. A., and Lisanti, V. F., Enzymes of human saliva, I. The determination, distribution, and origin of whole saliva enzymes, J. Dent. Res., 33, 321, 1954.
Nakayama, Y., Ooi, N., and Mishiro, Y., Alkaline and acid phosphatase in saliva with special reference to its behavior in incubated saliva, Igaku To Seibutsugaku, 67, 322, 1963 (cited from Chem. Abstr., 63, 13790b, 1965 ).
Hope, R. M., and Mayo, O., Relationship of human salivary alkaline phosphatase with ABO blood group and secretory status, Austr. J. Exp. Biol. Med. Sci., 47, 235, 1969.
Cornish, C. J., and Posen, S., Human salivary alkaline phosphatase, Clin. Chim. Acta, 20, 387, 1968.
Chauncey, H. H., Henriques, B. L., and Tanzer, J. M., Comparative enzyme activity of saliva from the sheep, hog, dog, rabbit, and human, Arch. Oral Biol., 8, 615, 1963.
Davidson, D., Leibel, B. S., and Berris, B., Asymptomatic parotid gland enlargement in diabetes mellitus, Ann. Intern. Med., 70, 31, 1969.
Bloch, K. J., Buchanan, W. W., Wohl, M. J., and Bunim, J. J., Sjogren’s syndrome: A clinical, pathological and serological study of sixty-two cases, Medicine (Baltimore), 44, 187, 1965.
Alarcon-Segovia, D., Diaz-Jouanen, E., and Fishbein, E., Features of Sjögren’s syndrome in primary biliary cirrhosis,. Ann. Intern. Med., 79, 31, 1973.
Bunim, J. J., Buchanan, W. W., Wertlake, P. T., Sokoloff, L., Bloch, K. J., Beck, J. S., and Alepa, F. P., Clinical pathologic and serologic studies in Sjögren’s syndrome, Ann. Intern. Med., 61, 509, 1964.
Chisholm, M., Ardran, G. M., Callender, S. T., and Wright, R., A follow-up study of patients with post-cricoid webs, Q. J. Med., 40, 409, 1971.
Chisholm, M., Ardran, G. M., Callender, S. T., and Wright, R., Iron deficiency and autoimmunity in post-cricoid webs, Q. J. Med., 40, 421, 1971.
Just-Viera, J. O., and Haight, C., Achalasia and carcinoma of the esophagus, Surg. Gynecol. Obstet., 128, 1081, 1969.
Wychulis, A. R., Woolam, G. L., Andersen, H. A., and Ellis, F. H., Achalasia and carcinoma of the esophagus, J. Am. Med. Assoc., 215, 1638, 1971.
Kock, N. G., Lewin, E., Pettersson, S., and Stener, B., Carcinoma of the thoracic esophagus and cardia: A review of 146 cases, Acta. Chir. Scand., 133, 375, 1967.
Gunnlaugsson, G. H., Wychulis, A. R., Roland, C., and Ellis, F. H., Analysis of the records of 1,657 patients with carcinoma of the esophagus and cardia of the stomach, Surg. Gynecol. Obstet., 130, 997, 1970.
Stemmerman, G. N., and Hayashi, T., Intestinal metaplasia of the gastric mucosa: A gross and microscopic study of its distribution in various states, J. Natl. Cancer Inst., 41, 627, 1968.
Ostrow, J. D., Blanshard, G., and Gray, S. J., Peptic ulcer in primary hyperparathyroidism, Am. J. Med., 29, 769, 1960.
Greider, M. H., Rosai, J., and McGuigan, J. E., The human pancreatic islet cells and their tumors. II. Ulcerogenic and diarrheogenic tumors, Cancer, 33, 1423, 1974.
Yamagata, S., Wakui, K., Sato, S., Ito, K., Sanada, M., Kumada, H., Matsuda, N., Osato, Y., Yanbe, R., and Tadaki, H., Liver function tests in patients with peptic ulcer, TohokuJ. Exp. Med., 90, 355, 1966.
Steigmann, F., and Dolehide, R. A., Corrosive (acid) gastritis: Management of early and late cases, N. Engl. J. Med., 254, 981, 1956.
Ambler, J., Green, A. G., and Pulvertaft, C. N., A study of total serum alkaline phosphatase activity in men following partial gastrectomy, Gut, 11, 255, 1970.
Arman, E., and Reizenstein, P., Studies in the dumping syndrome. IV. Effect of calcium therapy on calcium metabolism and osteopenia in gastrectomized patients, Am. J. Dig. Dis., 14, 153, 1969.
Kennedy, T., Connell, A. M., Love, A. H. G., Macrae, K. D., and Spencer, E. F. A., Selective or truncal vagotomy: Five-year results of double-blind, randomized controlled trial, Br. J. Surg. 60, 944, 1973.
Piper, D. W., Macon, M. L., Broderick, F. L., Fenton, B. H., and Builder, J. E., The diagnosis of gastric carcinoma by the estimation of enzyme activity in gastric juice, Gastroenterology, 45, 614, 1963.
Cederqvist, C., and Nielsen, J., Value of liver function tests in predicting resectability in patients with gastric cancer, Acta Clin. Scan., 139, 656, 1973.
Moog, F., Vire, H. R., and Grey, R. D., The mulitple forms of alkaline phosphatase in the small intestine of the young mouse, Biochem. Biophys. Acta, 113, 336, 1966.
Houghton, S. E., and McCarthy, C. F., The isolation, partial characterization and subfractionation of human intestinal brush borders, Gut, 14, 529, 1973.
Marcus, D. M., The ABO and Lewis blood group system: Immunochemistry, genetics and relation to human disease, N. Engl. J. Med., 280, 994, 1969.
Shreffler, D. C., Relationship of alkaline phosphatase levels in intestinal mucosa to ABO and secretor blood groups, Proc. Soc. Exp. Biol. Med., 123, 423, 1966.
Baraona, E., Pirola, R. C., and Lieber, C. S., Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat, Gastroenterology, 66, 226, 1974.
Welsh, J. D., Zschiesche, 0. M., Anderson, J., and Walker, A., Intestinal disaccharidase activity in celiac sprue (gluten-sensitive enteropathy), Arch. Intern. Med., 123, 33, 1969.
Weiser, M. M., Bolt, R. J., and Pollard, H. M., Isoenzyme patterns of the human gastrointestinal tract in the normal state and in nontropical sprue, J. Lab. Clin. Med., 63, 656, 1964.
Campbell, C. B., Cowen, A. E., McGeary, H. M., and Gaffney, T. J., Mucosal enzyme activity as a quantitative index of early functional improvement in the management of coeliac disease and other small intestinal diseases, Aust. N. Z. J. Med., 2, 220, 1972.
Plotkin, G. R., and Isselbacher, K. J., Secondary disaccharidase deficiency in adult celiac disease (non-tropical sprue) and other malabsorption states, N. Engl. J. Med., 271, 1033, 1964.
Hamilton, J. R., Reilly, B. J., and Morecki, R., Short small intestine associated with malrotation: A newly described congenital cause of intestinal malabsorption, Gastroenterology, 56, 124, 1969.
Gudmand-Hoyer, E., Jarnum, S., and Worning, H., Intestinal disaccharidase activity after Billroth II resection for peptic ulcer, Gut, 10, 451, 1969.
Wall, A. J., Douglas, A. P., Booth, C. C., and Pearse, A. G. E., Response of the jejunal mucosa in adult coeliac disease to oral prednisolone, Gut, 11, 7, 1970.
Agus, S. G., Dolin, R., Wyatt, R. G., Tousimis, A. J., and Northrup, R. S., Acute infectious nonbacterial gastroenteritis: Intestinal histopathology; Histologic and enzymatic alterations during illness produced by the Norwalk agent in mm, Ann. Intern. Med., 79, 80, 1973.
Kuitunen, P., Visakorpi, J. K., Savilathi, E., and Pelkonen, P., Malabsorption syndrome with cow’s milk intolerance: Clinical findings and course in 54 cases, Arch. Dis. Child., 50, 351, 1975.
Warnes, T. W., Hine, P., and Kay, G., Alkaline phosphatase in duodenal juice following secretin and pancreozymin, Gut, 10, 1049, 1969 (abstract).
Ozsoylu, S., and Turhan, O., Alkaline phosphatase activity of duodenal juice in rickets due to vitamin D deficiency, Acta Paediatr. Scand., 60, 337, 1971.
Blomstrand, R., and Werner, B., Alkaline phosphatase activity in human thoracic duct lymph, Acta Chir. Scand., 129, 111, 1965.
Reynoso, G., Elias, E. G., and Mittelman, A., The contribution of the intestinal mucosa to the total serum alkaline phosphatase activity, Am. J. Clin. Pathol, 56, 707, 1971.
Arfors, K. E., Beckman, L., and Lundin, L. G., Genetic variations of human serum phosphatases, Genet. (Basel), 13, 89, 1963.
Langman, M. J. S., ABO blood groups and gastrointestinal function, Gut, 11, 796, 1970.
Denborough, M. A., Prineas, R. J., and Downing, H. J., Serum intestinal alkaline phosphatase, ABO blood groups, secretor status, and lipaemia, Clin. Genet., 2, 347, 1971.
Van Belle, H., DeBroe, M. E., and Wieme, R. J., L-p-Bromotetramisole, a new reagent for use in measuring placental or intestinal isoenzymes of alkaline phosphatase in human serum, Clin. Chem., 23, 454, 1911.
Gupta, M. C., Neale, G., and Dowling, R. H., Liver structure and function following small bowel resection, Gut, 14, 438, 1973.
Keating, J. P., Strominger, D. B., and Poulos, J., Rickets and a medium chain triglyceride diet, J. Pediatr. Surg., 8, 439, 1973.
Drenick, E. J., Simmons, F., and Murphy, J. F., Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small-bowel bypass, N. Engl. J. Med., 282, 829, 1970.
Langman, M. J. S., Banwell, J. G., Stewart, J. S., and Robson, E. B., ABO blood groups, secretor, status, and intestinal alkaline phosphatase concentrations in patients with celiac disease, Gastroenterology, 57, 19, 1969.
Harris, O. D., Cooke, W. T., Thompson, H., and Waterhouse, J. A., Malignancy in adult coeliac disease and idiopathic steatorrhea, Am. J. Med., 42, 899, 1967.
Dent, C. E., Norris, T. S. M., Smith, R., Sutton, R. A. L., and Temperley, J. M., Steatorrhea with striking increase of plasma-alkaline-phosphatase of intestinal origin, Lancet, 1, 1333, 1968.
Dixon, J. A., and Verner, J. L., Enzymes in intestinal strangulation-obstruction, J. Am. Med. Assoc., 200, 1000, 1967.
Lee, Y. T. N., Alkaline phosphatase in intestinal perforation, J. Am. Med. Assoc., 208, 361, 1969.
Dordal, E., Glagov, S., and Kirsner, J. B., Hepatic lesions in chronic inflammatory bowel disease. 1. Clinical correlations with liver biopsy diagnoses in 103 patients, Gastroenterology, 52, 239, 1967.
Perrett, A. D., Higgins, G., Johnston, H. H., Massarella, G. R., Truelove, S. C., and Wright, R., The liver in Crohn’s disease, Q. J. Med., 40, 187, 1971.
Eade, M. N., Cooke, W. T., and Brooke, B. N., Liver disease in Crohn’s colitis: A study of 21 consecutive patients having colectomy, Ann. Intern. Med., 74, 518, 1971.
Booth, S. N., Jamieson, G. C., King, J. P. G., Leonard, J., Oates, G. D., and Dykes, P. W., Carcinoembryonic antigen in management of colorectal carcinoma, Br. Med. J., 4, 183, 1974.
Cantwell, J. D., Kettering, R. F., Carney, J. A., and Ludwig, J., Adenocarcinoma complicating regional enteritis: Report of a case and review of the literature, Gastroenterology, 54, 599, 1968.
Thorson, A. H., Studies on carcinoid disease, Acta Med. Scand. Suppl., 334, 1, 1958.
Sjoerdsma, A., Weissbach, H., and Udenfriend, S., A clinical physiologic and biochemical study of patients with malignant carcinoid (argentaffinoma), Am. J. Med., 20, 520, 1956.
Booth, C. C., Maclntyre, I., and Mollin, D. L., Nutritional problems associated with extensive lesions of the distal small intestine in man, Q. J. Med., 33, 401, 1964.
Melmon, K. L., Sjoerdsma, A., and Mason, D. T., Distinctive clinical and therapeutic aspects of the syndrome associated with bronchial carcinoid tumors, Am. J. Med., 39, 568, 1965.
Melmon, K. L., Sjoerdsma, A., Oates, J. A., and Laston, L., Treatment of malabsorption and diarrhea of the carcinoid syndrome with methysergide, Gastroenterology, 48, 18, 1965.
Stolbach, L., Skillman, J., and Goodman, R., Increase in serum alkaline phosphatase due to Regan isoenzyme in a patient with localized jejunal lymphoma, Arch. Surg., 105, 491, 1972.
Czernobilsky, B., and Tsou, K. C., Adenocarcinoma, adenomas and polyps of the colon: Histochemical study, Cancer, 21, 165, 1968.
Perrett, A. D., Higgins, G., and Johnston, H. H., The liver in ulcerative colitis, Q. J. Med., 40, 211, 1971.
Jalan, K. N., Prescott, R. J., Sircus, W., Card, W. I., McManus, J. P. A., Falconer, C. W. A., Small, W. P., Smith, A. N., and Bruce, J., An experience of ulcerative colitis. II. Short term outcome, Gastroenterology, 59, 589, 1970.
Eade, M. N., Liver disease in ulcerative colitis. I. Analysis of operative liver biopsy in 138 consecutive patients having colectomy, Ann. Intern. Med., 72, 475, 1970.
Streifler, C., Schnitzer, N., and Harell, A., A rare isoenzyme of alkaline phosphatase in 4 patients with ulcerative colitis, Clin. Chim. Acta, 38, 244, 1972.
Qirbi, A. A., and Moss, D. W., Incidence and some properties of an electrophoretically slow form of alkaline phosphatase in sera of patients with diseases of the intestine, Clin. Chim. Acta, 60, 1, 1975.
Eade, M. N., and Cooke, W. T., Hepatobiliary disease associated with ulcerative colitis, Postgrad. Med., 53, 112, 1973.
Mistilis, S. P., Pericholangitis and ulcerative colitis. I. Pathology, etiology and pathogenesis,, Ann. Intern. Med., 63, 1, 1965.
Mistilis, S. P., Skyring, A. P., and Goulston, S. J. M., Periocholangitis and ulcerative colitis. II. Clinical aspects, Ann. Intern. Med., 63, 17, 1965.
Vinnik, I. E., Kern, F., Jr., and Corley, W. D., Serum 5’-nucleotidase and periocholangitis in patients with chronic ulcerative colitis, Gastroenterology, 45, 492, 1963.
Roberts-Thomas, I. C., Strickland, R. G., and Mackay, J. R., Bile duct carcinoma in chronic ulcerative colitis,, Aust. N. Z. J. Med., 3, 264, 1973.
Stillman, A. E., and Stillman, P. L., Hyperphosphatasia and rapid growth following control of ulcerative colitis, Am. J. Dis. Child., 126, 693, 1973.
Maggi, V., and Wyatt, A. P., Observations on an unusual enzyme distribution pattern in the colon of a case of familial polyposis with malignant changes, Gut, 77, 319, 1970.
Klein, U. E., Alkaline phosphatase in liver cirrhosis and rectal cancer, Lancet, 2, 1396, 1968.
Klein, U. E., and Drube, H. C., Enzyme cytochemical and isoenzyme studies of normal and diseased rectal mucosa, Am. J. Proctol., 21, 346, 1970.
Freeman, S., Chen, Y. P., and Ivy, A. C., On the cause of the elevation of serum phosphatase in jaundice, J. Biol Chem., 124, 79, 1938.
Roberts, W. M., Variations in the phosphatase activity of the blood in disease, Br. J. Exp. Pathol, 11, 90, 1930.
Dalgaard, J. B., Serum phosphatase after nephrectomy and bile obstruction in dogs. Acta Physiol Scand., 76, 318, 1949.
Armstrong, A. R., and Banting, F. G., The site of formation of the phosphatase of serum, Can. Med. Assoc. J., 33, 243, 1935.
Dalgaard, J. B., Serum phosphatase after hepatectomy in dogs, Acta Physiol. Scand., 16, 308, 1949.
Gutman, A. B., Olson, K. B., Gutman, E. B., and Flood, C. A., Effects of disease of the liver and biliary tract upon phosphatase activity of the serum, J. Clin. Invest., 19, 129, 1940.
Dalgaard, J. B., Phosphatase in cats with obstructive jaundice, Acta Physiol Scand., 15, 290, 1948.
Dalgaard, J. B., Serum phosphatase in rats with obstructive jaundice,, Acta Physiol Scand., 13, 310, 1947.
Freeman, S., Comparison of effects of hepatectomy and of common bile duct obstruction on serum phosphatase of adult dogs, Am. J. Physiol, 164, 792, 1951.
Oppenheimer, M. I., and Flock, E. V., Alkaline phosphatase levels in the plasma and liver following partial hepatectomy, Am. J. Physiol, 149, 418, 1947.
LeVeen, H. H., Talbot, L. J., Restuccia, M., and Barberio, J. R., Metabolism and excretion of alkaline phosphatase in relation to liver function and determination of maximal secretory rates of liver, J. Lab. Clin. Med., 36, 192, 1950.
Dalgaard, J. B., On the cause of increase in serum phosphatase in obstructive jaundice, Acta Physiol Scand., 22, 200, 1951.
Wang, C. C., and Grossman, M. I., Non-excretion of serum alkaline phosphatase by the liver and pancreas of normal dogs, Am. J. Physiol, 156, 256, 1949.
Polin, S. G., Spellberg, M. A., Teitelman, L., and Okumura, M., The origin of elevation of serum alkaline phosphatase in hepatic disease: An experimental study, Gastroenterology, 42, 431, 1962.
Sebesta, D. G., Bradshaw, F. J., and Prockop, D. J., Source of the elevated serum alkaline phosphatase activity in biliary obstruction: Studies using isolated liver perfusion, Gastroenterology, 47, 166, 1964.
Kaplan, M. M., and Righetti, A. B. B., Induction of rat liver alkaline phosphatase: The mechanism of the serum elevation in bile duct obstruction J. Clin. Invest., 49, 508, 1970.
Righetti, A. B. B., and Kaplan, M. M., The origin of the serum alkaline phosphatase in normal rats, Biochim. Biophys. Acta, 230, 504, 1971.
Righetti, A. B. B., and Kaplan, M. M., Effects of actinomycin D on rat liver alkaline phosphatase, Proc. Soc. Exp. Biol Med., 136, 491, 1971.
Righetti, A. B. B., and Kaplan, M. M., Disparate response of serum and hepatic alkaline phosphatase and 5’-nucleotidase to bile duct obstruction in the rat, Gastroenterology, 62, 1034, 1972.
Righetti, A. B. B., Kaplan, M. M., and Raben, M. S., Properties of rat liver alkaline phosphatase before and after bile duct ligation, Proc. Soc. Exp. Biol Med., 145, 126, 191A.
Kaplan, M. M., Ohkubo, A., and Sze-Tu, D., Increased synthesis of rat liver alkaline phosphatase by bile duct ligation (preprint of publication through personal communications with M. M. Kaplan; also: abstract in Clin. Res., 23, 394A, 1975 ).
Clubb, J. S., Neale, F. C., and Posen, S., The behavior of infused placental alkaline phosphatase in human subjects, J. Lab. Clin. Med., 66, 493, 1965.
Case Records of the Massachusetts General Hospital, Case 38–1978, N. Engl J. Med., 299, 708, 1978.
Kaplan, M. M., and Rogers, L., Separation of human serum-alkaline-phosphatase isoenzymes by polyacrylamide gel electrophoresis, Lancet, 2, 1029, 1969.
Hodson, A. W., Latner, A. L., and Raine, L., Isoenzymes of alkaline phosphatase, Clin. Chim. Acta, 7, 225, 1962.
Wieme, R. J., and De Broe, M. E., De Diagnosticle Betekenis van een “Snelle” Fraktie in het Iso-enzympatronn der Alkalische Fosfatase, Tijdschr. Geneeskd., 28, 468, 1972.
De Broe, M. E., and Wieme, R. J., The cholestatic doublet of alkaline phosphatase: Its origin and clinical significance, in: Isozymes III: Developmental Biology (Markert, C. L., ed.), p. 799, Academic Press, New York, 1975.
De Broe, M. E., Borgers, M., and Wieme, R. J., The separation and characterization of liver plasma membrane fragments circulating in the blood of patients with cholestasis, Clin. Chim. Acta, 59, 368, 1974.
Carruthers, J. S., and Steiner, J. W., Experimental extrahepatic biliary obstruction: Fine structural changes of liver mitochondria, Gastroenterology, 42, 419, 1962.
Biava, C. G., Studies on cholestasis: A re-evaluation of the fine structure of normal human bile canaliculi,Lab. Invest., 13, 840, 1964.
Birns, M., Masek, B. A., and Auerbach, O., The effects of experimental acute biliary obstruction and release on the rat liver: A histochemical study, Am. J. Pathol., 40, 95, 1962.
Goldfischer, S., Arias, I. M., Essner, E., and Novikoff, A. B., Cytochemical and electron microscopic studies of rat liver with reduced capacity to transport conjugated bilirubin, J. Exp. Med., 775, 467, 1962.
Ronchi, G., and Desmet, V., Histochemische Untersuchungen über sogenannte “Lutenzyme bei cholestase” bei extrahepatischer Gallengangsobstruktion der Ratte, Beitr. Pathol., 149, 213, 1973.
Jersky, J., Alkaline phosphatase in auxiliary liver transplatation, Gut, 15, 636, 1974.
Shinkai, K., and Akedo, H., A multienzyme complex in serum of hepatic cancer, Cancer Res., 32, 2307, 1972.
Brocklehurst, D., Lathe, G. H., and Aparicio, S. R., Serum alkaline phosphatase, nucleotide pyrophosphatase, 5’-nucleotidase and lipoprotein-X in cholestasis, Clin. Chim. Acta, 67, 269, 1976.
Brocklehurst, D., Wilde, C. E., and Doar, J. W. H., The incidence and likely origins of serum particulate alkaline phosphatase and lipoprotein-X in liver disease, Clin. Chim. Acta., 88, 509, 1978.
Schenker, S., Balint, J., and Schiff, L., Differential diagnosis of jaundice: Report of a prospective study of 61 proven cases, Am. J. Dig. Dis., 7, 449, 1962.
Becher, K. L., and Stauffer, M. H., Evaluation of concentrations of serum alkaline phosphatase in hepatitis and obstructive jaundice, Am. J. Med. Sci., 243, 222, 1962.
Bodansky, A., and Jaffe, H. L., Phosphatase studies. IV. Serum phosphatase of non-osseous origin: Significance of the variations of serum phosphatase in jaundice, Proc. Soc. Exp. Biol. Med., 31, 107, 1933.
Greene, C. H., Shattuck, H. F., and Kaplowitz, K., The phosphatase content of the blood serum in jaundice, J. Clin. Invest., 7 J, 1079, 1934.
Spiro, H. M., Clinical Gastroenterology, Macmillan, Toronto, 1970.
Dubin, I. N., Sullivan, B. H., Jr., LeGolvan, P. C., and Murphy, L. C., The cholestatic form of viral hepatitis: Experiences with viral hepatitis at Brooke Army Hospital during the years 1951 to 1953, Am. J. Med., 29, 55, 1960.
Sherlock, S., Jaundice, Br. Med. J., 7, 1359, 1962.
Hill, E., and Zieve, L., Discrimination between obstructive and hepatocellular jaundice by means of the commonly used serum tests, Am. J. Clin. Pathol., 27, 6, 1957.
Case records of the Massachusetts General Hospital, Case 36072, N. Engl. J. Med., 242, 261, 1950.
Jorgensen, F., and Madsen, S., Forholdet serum glutaminoxaleddihesyretransaminase og alkalisk fosfatase ved ikterus,Nord. Med., 64, 1587, 1960.
Clermont, R. J., and Chalmers, T. C., The transaminase tests in liver disease, Medicine (Baltimore), 46, 197, 1967.
Abbruzzese, A., and Jeffery, R. L., Marked elevations of serum glutamic oxalacetic transaminase and lactic dehydrogenase activity in chronic extrahepatic biliary disease, Am. J. Dig. Dis., 14, 332, 1969.
Schwartz, M. K., and Bodansky, O., Serum 5’-nucleotidase in patients with cancer, Cancer, 18, 886, 1965.
Hill, P. G., and Sammons, H. G., An assessment of 5’-nucleotidase as a liver function test, Q. J. Med., 36, 457, 1967.
Van der Slik, W., Persijn, J. P., Engelsman, E., and Riethorst, A., Serum 5’-nucleotidase, Clin. Biochem., 3, 59, 1970.
Seitanidis, B., and Moss, D. W., Serum alkaline phosphatase and 5’-nucleotidase levels during normal pregnancy, Clin. Chim. Acta, 25, 183, 1969.
Belfield, A., Serum alkaline phosphatase and 5’-nucleotidase activities in patients with hepatobiliary disease, Clin. Chim. Acta, 37, 525, 1972.
Batsakis, J. G., Kremers, B. J., Thiessen, M. M., and Schilling, J. M., “Biliary tract enzymology”: A comparison of serum alkaline phosphatase, leucine aminopeptidase and 5’-nucleotidase, Am. J. Clin. Pathol., 50, 485, 1968.
Phelan, M. B., Neale, G., and Moss, D. W., Serial studies of serum alkaline phosphatase and 5’- nucleotidase levels in hepatobiliary disease, Clin. Chim. Acta, 32, 95, 1911.
Schwartz, M. K., Biochemical procedures in different forms of cancer, A Jed. Clin. North Am., 55, 613, 1971.
Goldberg, D. M., and Belfield, A., Reciprocal relationship of alkaline phosphatase and 5’- nucleotidase in human bone, Nature (London), 247, 286, 1974.
Van Husen, N., and Gerlach, U., Uber die Aktivitatserhohung der unspezifisch lipoproteidge- bundenen alkalischen Phosphatase im menschlichen Serum, Clin. Chim. Acta, 53, 91, 1974.
Goldberg, D. M., 5’-Nucleotidase: Recent advances in cell biology, methodology and clinical significance, Digestion, 8, 87, 1973.
Schwartz, M. K., Bethune, V. G., and Fleischer, M., Evaluation of serum 5’-nucleotidase, leucine aminopeptidase and glutamyl transpeptidase in patients with cancer, Clin. Chem., 19, 655, 1973 (abstract).
Schwartz, M. K., and Bodansky, O., Lactic dehydrogenase (clinical analysis), in: Methods in Enzymology IX (Colowick, S., Kaplan, N., and Wood, W. A., eds.), p. 294, Academic Press, New York, 1966.
Bodansky, O., and Schwartz, M. K., Phosphohexose isomerase: Clinical aspects, in: Methods in Enzymology IX (Colowick, S., Kaplan, N., and Wood, W. A., eds.), p. 568, Academic Press, New York, 1966.
Cohen, N. N., Potter, H. P., Jr., and Bowers, G. N., Jr., An evaluation of isocitric dehydrogenase in liver disease, Ann. Intern. Med., 55, 604, 1961.
Bowers, G. N., Jr., Potter, H. P., Jr., and Norris, R. F., The prevalence of an increased isocitric dehydrogenase (ICD) activity in a segment of the blood donor population with a low social and economic status, Am. J. Clin. Pathol., 34, 513, 1960.
Bowers, G. N., Jr., and MacDuffle, R. C., Transaminase and isocitric dehydrogenase elevations with liver cell necrosis due to hypoxia and shock, Clin. ChemB, 5, 369, 1959 (abstract).
Jonson, G., and Reichard, H., Ornithine carbamoyl transferase activity in blood plasma in partial obstruction of the common bile duct: Experiments on the dog with a permanent external biliary fistula, Acta Chir. Scand., 126, 123, 1963.
Conolly, W. B., Belzer, F. O., and Dunphy, J. E., Studies in obstructive jaundice, Gut, 10, 623, 1969.
Boone, D. J., and Routh, J. I., A comparison of 5’-nucleotidase (NTP) and gamma-glutamyl transpeptidase (G6TP) as diagnostic for liver disease, Clin. Chem., 19, 656, 1973 (abstract).
Boone, D. J., Routh, J. I., and Schrantz, R., Gamma glutamyl transpeptidase and 5’- nucleotidase: Comparison as diagnostics for hepatic disease, Am. J. Clin. Pathol., 61, 321, 1974.
Whitfield, J. B., Pounder, R. E., Neale, G., and Moss, D. W., Serum 7-glutamyl transpeptidase activity in liver disease, Gut, 13, 702, 1972.
Rosalki, S. B., Rau, D., Lehmann, D., and Prentice, M., Determination of serum gamma- glutamyl transpeptidase and its clinical applications, Ann. Clin. Biochem., 7, 143, 1970.
Rosalki, S. B., Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme- inducing drugs, Lancet, 2, 376, 1971.
Lum, G., and Gambino, S. R., Serum gamma-glutamyl transpeptidase activity as an indicator of disease of liver, pancreas, or bone, Clin. Chem., 18, 358, 1972.
Betro, M. G., Oon, R. C. S., and Edwards, J. B., Gamma-glutamyl transpeptidase in diseases of the liver and bone,, Am. J. Clin. Pathol., 60, 672, 1973.
Szasz, G., A kinetic photometric method for serum gamma-glutamyl transpeptidase, Clin. Chem., 75, 124, 1969.
Aronsen, K. F., Nosslin, B., and Pihl, B., The value of 7 glutamyl transpeptidase as a screen test for liver tumour, Acta Chir. Scand., 17, 136, 1970.
Aronsen, K. F., Hagerstrand, I., Norden, J. G., and Pihl, B., On the cause of the increased activity of alkaline phosphatase and gamma-glutamyl transpeptidase in serum of patients with liver metastases, Acta Chir. Scand., 135, 619, 1969.
Huguet, C., and Azzopardi, O., Valeu du dosage de la 7 glutamyl transpeptidase dans le dépistage des métastases hépatiques, Rev. Med. Fr., 113, 45, 1970.
Delarue, J. C., Sancho, H., Rouesse, J., and Bohoun, C., Determination of gamma glutamyl transpeptidase activity in human serum: Its use in oncology, Biomedicine, 18, 152, 1973.
Dalai, F. R., and Winsten, S., The relation between isoenzymes of gamma glutamyl transpeptidase and leucine aminopeptidase in human serum, Clin. Chem., 19, 655, 1973.
Walker, F. B., IV, Hoblit, D. L., Cunningham, F. G., and Combes, B., Gamma-glutamyl transpeptidase in normal pregnancy, Obstet. Gynecol, 43, 745, 1974.
Williams, H. M., LaMotta, R. V., and Wetstone, H. J., Studies of cholinsterase activity. III. Serum Cholinesterase in obstructive jaundice and neoplastic disease, Gastroenterology, 33, 58, 1957.
Wetstone, H. J., LaMotta, R. V., Bellucci, A., Tennant, R., and White, B. V., Studies of Cholinesterase activity. V. Serum Cholinesterase in patients with carcinoma, Ann. Intern. Med., 52, 102, 1960.
Kim, N. K., Yasmineh, W. G., Freier, E. F., Goldman, A. I., and Theologides, A., Value of alkaline phosphatase, 5’-nucleotidase, 7-glutamyltransferase and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver, Clin. Chem., 23, 2034, 1977.
Turek-Maischeider, M., and Kazum, I., Palliative irradiation for liver metastases, J. Am. Med. Assoc., 252, 628, 1975.
Popper, H., and Schaffner, F., Liver: Structure and Function, McGraw-Hill, New York, 1957.
Schiff, L „Diseases of the Liver, 3rd ed., J. B. Lippincott, Philadelphia, 1972.
Sherlock, S.,Diseasesof the Liver and Biliary System, 4th ed., p. 317, Davis, Philadelphia, 1968.
Bernstein, H. (ed.), Pediatrics, 15th ed., pp. 1682–1685, Appleton-Century-Crofts, New York, 1972.
Gross, R. E., The Surgery of Infancy and Childhood, pp. 508–541, W. B. Saunders, Philadelphia, 1953.
Dunn, P. M., Obstructive jaundice and haemolytic disease of the newborn, Arch. Dis. Child., 38, 54, 1963.
Crigler, J. F., and Najjar, V. A., Congenital familial nonhemolytic jaundice with kernicterus, Pediatrics, 10, 169, 1952.
Zuelzer, W. W., and Stulberg, C. S., Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy: Report of eight cases and isolation of the virus in one case, Am. J. Dis. Child., 83, 421, 1952.
Cooper, L. Z., Green, R. H., Krugman, S., Giles, J. P., and Mirick, J. S., Neonatal thrombocytopenic purpura and other manifestations of rubella contracted in utero, Am. J. Dis. Child., 110, 416, 1965.
Cooper, L. Z., Ziring, P. R., Ockerse, A. B., Fedun, B. A., Kiely, B., and Krugman, S., Rubella: Clinical manifestations and management, A m. J. Dis. Child., 118, 18, 1969.
Bernstein, J., and Brown, A. K., Sepsis and jaundice in early infancy, Pediatrics, 29, 873, 1962.
Hamilton, J. R., and Sass-Kortsak, A., Jaundice associated with severe bacterial infection in young infants, J. Pediatr., 63, 121, 1963.
Zeltzer, P. M., Neerhout, R. C., Fonkalsrud, E. W., and Stiehm, E. R., Differentiation between neonatal hepatitis and biliary atresia by measuring serum alpha-fetoprotein, Lancet, 1, 373, 1974.
Santulli, T. V., Harris, R. C., and Reemtsma, K., Surgical exploration in obstructive jaundice of infancy, Pediatrics, 26, 27, 1960.
Craig, J. M., and Landing, B. H., Form of hepatitis in neonatal period simulating biliary atresia, Arch. Pathol, 54, 321, 1952.
Cassady, G., Morrison, A. B., and Cohen, M. M., Familial “giant-cell hepatitis” in infancy: Clinical, pathological, and genetic studies on a large family, Ama J. Dis. Child., 107, 456, 1964.
deToni, G., and Romano, G., La sindrome de bile spessa nel primo trimestre di vita, Minerva Pediatr., 14, 1429, 1962.
Thaler, M., and Gellis, S., Studies in neonatal hepatitis and biliary atresia, Am. J. Dis. Child., 116, 257, 1968.
deLorimier, A. A., Surgical management of neonatal jaundice, N. Engl. J. Med., 288, 1284, 1973.
Hsia, D. Y., and Gellis, S. S., Prolonged obstructive jaundice in infancy. III. Liver function tests, Am. J. Dis. Child., 85, 13, 1953.
Yu, J. S., Walker-Smith, J. A., and Burnard, E. D., Rickets: A common complication of neonatal hepatitis,Med. J. Aust., 1, 790, 1971.
Bastis-Maounis, B., Matsaniotis, N., and Maounis, F., Serum alkaline phosphatase in infants with obstructive jaundice: Relation to vitamin D supplementation, Pediatrics, 82, 68, 1973.
Kumate, J., Beltrán, F., Benavides, L., and Flores, M. A., Liver function tests in infants with biliary atresia: Report of 30 cases, Pediatrics, 26, 630, 1960.
Krovetz, L. J., Congenital biliary atresia. I. Analysis of thirty cases with particular reference to diagnosis, Surgery, 47, 453, 1960.
Plotkin, S. A., Oski, F. A., Hartnett, E. M., Hervada, A. R., Friedman, S., and Gowing, J., Some recently recognized manifestations of the rubella syndrome, J. Pediatr., 67, 182, 1965.
Suzuki, H., Gilbert, E. F., Anido, V., Jones, B., and Klingberg, W. G., Galactosemia: A report of two fatal cases with giant cell transformation of the liver in one, Arch. Pathol, 82, 602, 1966.
Dubin, I. N., and Johnson, F. B., Chronic idiopathic jaundice with unidentified pigment in liver cells: A new clinicopathologic entity with a report of 12 cases, Medicine (Baltimore), 33, 155, 1954.
Dubin, I. N., Chronic idiopathic jaundice: A review of fifty cases, Am. J. Med., 24, 268, 1958.
Butt, H. R., Anderson, V. E., Foulk, W. T., Baggenstoss, A. H., Schoenfeld, L. J., and Dickson, E. R., Studies of chronic idiopathic jaundice (Dubin-Johnson syndrome). II. Evaluation of a large family with the trait, Gastroenterology, 51, 619, 1966.
Shani, M., Seligsohn, U., and Gilon, E., Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases, Q. J. Med., 39, 549, 1970.
Aagenaes, O., Van der Hagen, C. B., and Refsum, S., Hereditary recurrent intrahepatic cholestasis from birth, Arch. Dis. Child., 43, 646, 1968.
Ware, A. J., Eigenbrodt, E. H., Shorey, J., and Combes, B., Viral hepatitis complicating the Dubin-Johnson syndrome, Gastroenterology, 63, 331, 1972.
Rotor, A. B., Manahan, L., and Florentin, A., Familial nonhemolytic jaundice with direct van den Bergh reaction, Acta Med. Philipp., 5, 37, 1948.
Arias, I. M., Studies of chronic familial non-hemolytic jaundice with conjugated bilirubin in the serum with and without an unidentified pigment in the liver cells, Am. J. Med., 31, 510, 1961.
Gartner, L. M., and Arias, I. M., Pharmacologic and genetic determinants of disordered bilirubin transport and metabolism in the liver, Ann. N. Y. Acad. Sci., 151, 833, 1968.
Schiff, L., Billing, B. H., and Oikawa, Y., Familial non-hemolytic jaundice with conjugated bilirubin in the serum, N. Engl. J. Med., 260, 1315, 1959.
Powell, L. W., Hemingway, E., Billing, B. H., and Sherlock, S., Idopathic unconjugated hyper-bilirubinemia (Gilbert’s syndrome).,N. Engl. J. Med., 277, 1108, 1967.
Foulk, W. T., Butt, H. R., Owen, C. A., Jr., Whitcomb, F. F., Jr., and Mason, H. L., Constitutional hepatic dysfunction (Gilbert’s disease): Its nature, history and related syndromes,Medicine CBaltimore), 38, 25, 1959.
Powell, L. W., Bilirubin metabolism and jaundice with special reference to unconjugated hyper- bilirabinaemia,,Australas. Ann. Med., 16, 343, 1967.
Schmid, R., Hyperbilirubinemia, in: The Metabolic Basis of Inherited Disease, 3rd ed. (Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., eds.), p. 1141, McGraw-Hill, New York, 1972.
Schiff, L., and Billing, B. H., Congenital defects in bilirubin metabolism as seen in the adult, Gastroenterology, 37, 595, 1959.
Brown, N. K., and Smuckler, E. A., Alkaptonuria and Gilbert’s syndrome: Report of two affected siblings and hepatic ultrastructure in one sibling, Am. J. Med., 48, 579, 1970.
Arias, I. M., Gartner, L. M., Cohen, M., Ben-Ezzer, J., and Levi, A. J., Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyltransferase deficiency, Am. J. Med., 47, 395. 1969.
Ertel, I. J., and Newton, W. A., Therapy in congenital hyperbilirubinemia: Phenobarbital and diethylnicotinamide, Pediatrics, 44, 43, 1969.
Karon, M., Imach, D., and Schwartz, A., Effective phototherapy in congenital non-obstructive nonhemolytic jaundice, N. Engl. J. Med., 282, 377, 1970.
Blumenschein, S. D., Kallen, R. J., Storey, B., Natzschka, J. C., Odell, G. B., and Childs, B., Familial nonhemolytic jaundice with late onset of neurological damage, Pediatrics, 42, 786, 1968.
Huang, P. W. H., Rozdilsky, B., Gerrard, J. W., Goluboff, N., and Holman, G. H., Crigler- Najjar syndrome in four of five siblings with postmortem findings in one, Arch. Pathol., 90, 536. 1970.
Arias, I. M., Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults, J. Clin. Invest., 41, 2233, 1962.
Jervis, G. A., Constitutional nonhemolytic hyperbilirubinemia with findings resembling kernic- teius, Arch. Neurol. Psychiatry, 81, 55, 1959.
Sleisenger, M. H., Kahn, I., Barniville, H., Rubin, W., Ben Ezzer, J., and Arias, I. M., Nonhemolytic unconjugated hyperbilirubinemia with hepatic glucuronyl transferase deficiency: A genetic study in four generations, Trans. Assoc. Am. Physicians, 80, 259, 1967.
Juberg, R. C., Holland-Moritz, R. M., Henley, K. S., and Gonzales, C. F., Familial intrahepatic cholestasis with mental and growth retardation, Pediatrics, 38, 819, 1966.
Gray, O. P., and Saunders, R. A., Familial intrahepatic cholestatic jaundice in infancy, Arch. Dis. Child., 41, 320, 1966.
Clayton, R. J., Iber, F. L., Ruebner, B. H., and McKusick, V. A., Byler disease: Fatal familial intrahepatic cholestasis in an Amish kindred, A m. J. Dis. Child., 117, 112, 1969.
Williams, C. N., Kaye, R., Baker, L., Hurwitz, R., and Senior, J. R., Progressive familial cholestatic cirrhosis and bile acid metabolism, J. Pediatr., 81, 493, 1972.
Linarelli, L. G., Williams, C. N., and Phillips, M. J., Byler’s disease: Fatal intrahepatic cholestasis, J Pediatr., 81, 484, 1972.
Odievre, M., Gautier, M., Hadchouel, M., and Alagille, D., Severe familial intrahepatic cholestasis, Arch. Dis. Child., 48, 806, 1973.
LaBerge, C., and Dallaire, L., Genetic aspects of tyrosinemia in the Chicoutimi region, Can. Med. Assoc. J., 97, 1099, 1967.
Scriver, C. R., Silverberg, M., and Clow, C. L., Hereditary tyrosinemia and tyrosyluria: Clinical report of four patients, Can. Med. Assoc. J., 97, 1047, 1967.
Sass-Kortsak, A., Ficici, S., Paunier, L., Kooh, S. W., Fraser, D., and Jackson, S. H., Secondary metabolic derangements in patients with tyrosyluria, Can. Med. Assoc. J., 97, 1079, 1967.
Holston, J. L., Levy, H. L., Tomlin, G. A., Atkins, R. J., Patton, T. H., and Hosty, H. S., Tyrosinosis: A patient without liver or renal diseasq, Pediatrics, 48, 393, 1971.
Louis, W. J., Pitt, D. D., and Davies, H., Biochemical studies in a patient with “tyrosinosis,” Aust. N. Z. J. Med., 4, 281, 1974.
Shih, V. E., Levy, H. L., Karolkewicz, V., Houghton, S., Efron, M. L., Isselbacher, K. J., Beutler, E., and MacCready, R. A., Galactosemia screening in Massachusetts, N. Engl. J. Med., 284, 753, 1971.
Thalhammer, O., Gitzelmann, R., and Pantlischko, M., Hypergalactosemia and galactosuria due to galactokinase deficiency in a newborn, Pediatrics, 42, 441, 1968.
Hsia, D. Y. Y., and Walker, F. A., Variability in the clinical manifestations of galactosemia, J.Pediatr., 59, 872, 1961.
Smetana, H. F., and Olen, E., Hereditary galactose disease, Am. J. Clin. Pathol., 38, 3, 1962.
Monteleone, J. A., Beutler, E., Monteleone, P. L., Utz, C. L., and Casey, E. C., Cataracts, galactosuria and hypergalactosemia due to galactokinase deficiency in a child, A m. J. Med., 50, 403, 1971.
Dahlqvist, A., Gamstorp, I., and Madsen, H., A patient with hereditary galactokinase deficiency, Acta Paediatr. Scand., 59, 669, 1970.
McAdams, A. J., Hug, G., and Bove, K. E., Glycogen storage disease, types I to X: Criteria for morphologic diagnosis, Hum. Pathol., 5, 463, 1974.
Howell, R. R., the glycogen storage diseases, in: The Metabolic Basis of Inherited Disease, 3rd ed. (Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., eds.), p. 249, McGraw- Hill, New York, 1972.
Posen, S., Glycogen storage disease with unusual renal lesions: Report of a case with autopsy and enzyme studies, Australas. Ann. Med., 6, 238, 1957.
Holling, H. E., Gout and glycogen storage disease, Ann. Intern. Med., 58, 654, 1963.
Brante, G., Kaijser, K., and Óckerman, P. A., Glycogenosis type I (lack of glucose-6-phos- phatase) in four siblings, Acta Paediatr. Scand. Suppl., 157, 1, 1964.
Brombacher, P. J., Van Creveld, S., Damme, J. P., Huijing, F., and Ploem, J. E., A report on two adult patients with glycogen storage disease, Acta Med. Scand., 176, 269, 1964.
diSant’Agnese, P. A., Diseases of glycogen storage with special reference to the cardiac type of generalized glycogenosis, Ann. N. Y. Acad. Sci., 72, 439, 1959.
Smith, J., Zellweger, H., and Afifi, A. K., Muscular form of glycogenosis, type II (Pompe), Neurology, 17, 537, 1967.
Engel, A. G., and Dale, A. J. D., Autophagic glycogenosis of late onset with mitochondrial abnormalities: Light and electron microscopic observations, Mayo Clin. Proc., 43, 233, 1968.
Starzl, T. E., Marchioro, T. L., Sexton, A. W., Illingworth, B., Waddell, W. R., Faris, T. D., and Herrmann, T. J., The effect of portacaval transposition on carbohydrate metabolism: Experimental and clinical observations, Surgery, 57, 687, 1965.
Moses, S. W., Levin, S., Chayoth, R., and Steinitz, K., Enzyme induction in a case of glycogen storage disease, Pediatrics, 38, 111, 1966.
Sidbury, J. B., Jr., Mason, J., Burns, W. B., Jr., and Ruebner, B. H., Type IV glycogenosis: Report of a case proven by characterization of glycogen and studied at necropsy, Bull. Johns HopkinsHosp., Ill, 157, 1962.
Reed, G. B., Dixon, J. F. P., Neustein, H. B., Donnell, G. N., and Landing, B. H., Type IV glycogenosis: Patient with absence of a branching enzyme alpha-l,4-glucan:alpha-l,4-glucan 6-glycosyl transferase, Lab. Invest., 19, 546, 1968.
Grunfeld, J. P., Ganeval, D., Chanard, J., Fardeau, M., and Dreyfus, J. C., Acute renal failure in McArdle’s disease: Report of two cases, N. Engl. J. Med., 286, 1237, 1972.
Hug, G., Garancis, J. C., Schubert, W. K., and Kaplan, S., Glycogen storage disease types II, III, VIII and IX: A biochemical and electron microscopic analysis, Am. J. Dis. Child., Ill, 457, 1966.
Hug, G., Schubert, W. K., and Chuck, G., Deficient activity of dephosphophosphorylase kinase and accumulation of glycogen in the liver, J. Clin. Invest., 48, 704, 1969.
Jubiz, W., and Rallison, M. L., Diphenylhydantoin treatment of glycogen storage disease, Arch. Intern. Med., 134, 418, 1974.
Froesch, E. R., Essential fructosuria and hereditary fructose intolerance, in: The Metabolic Basis of Inherited Disease, 3rd ed. ( Stanbury, J. B., Wyngaarden, J. B., and Frederickson, D. S., eds.), p. 131, McGraw-Hill, New York, 1972.
Cornblath, M., Rosenthal, I. M., Reisner, S. H., Wybregt, S. H., and Crane, R. K., Hereditary fructose intolerance, M Engl J Med., 269, 1271, 1963.
Levin, B., Snodgrass, G. J. A. I., Oberholzer, V. G., Burgess, E. A., and Dobbs, R. H., Fructosaemia: Observations on seven cases, Am. J. Med., 45, 826, 1968.
Swales, J. D., and Smith, A. D. M., Adult fructose intolerance, Q. J. Med., 35, 455, 1966.
Morris, R. C., Ueki, I., and Wegienka, E., An experimental renal acidification defect in patients with hereditary fructose intolerance. I. Its resemblance to renal tubular acidosis, J. Clin. Invest., 47, 1389, 1968.
McKusick, V. A., Kaplan, D., Wise, D., Hanley, W. B., Suddarth, S. B., Sevick, M. E., and Maumanee, A. E., The genetic mucopolysaccharidoses, Medicine (Baltimore), 44, 445, 1965.
McKusick, V. A., The nosology of the mucopolysaccharidoses, Am. J. Med., 47, 730, 1969.
Dorfman, A., and Matalon, R., The mucopolysaccharidoses, in: The Metabolic Basis of Inherited Disease, 3rd ed. (Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., eds.), p. 1218, McGraw-Hill, New York, 1972.
McKusick, V. A., Howell, R. R., Hussels, I. E., Neufeld, E. F., and Stevenson, R. E., Allelism, non-allelism, and genetic compounds among the mucopolysaccharidoses, Lancet, 1, 933, 1972.
Parsons, V., Walker, R. J., and Howorth, P. J. N., Serum 5,-nucleotidase and alkaline phosphatase isoenzymes in diagnosis, with special reference to haemochromatosis, Ann. Clin. Bio- chem., 10, 179, 1973.
Finch, S. C., and Finch, C. A., Idiopathic hemochromatosis, an iron storage disease, Medicine (Baltimore), 34, 381, 1955.
Williams, R., Smith, P. M., Spicer, E. J. F., Barry, M., and Sherlock, S., Venesection therapy in idiopathic haemochromatosis: An analysis of 40 treated and 18 untreated patients, Q. J. Med., 38, 1, 1969.
Dymock, I. W., Hamilton, E. B. D., Laws, J. W., and Williams, R., Arthropathy of haemochromatosis: Clinical and radiological analysis of 63 patients with iron overload, Ann. Rheum. Dis., 29, 469, 1970.
Greene, L. S., and Schiff, L., Primary carcinoma of the liver: A plea for earlier diagnosis with emphasis on the serum alkaline phosphatase values, Gastroenterology, 40, 219, 1961.
Powell, L. W., and Kerr, J. F. R., Reversal of “cirrhosis” in idiopathic haemochromatosis following long-term, intensive venesection therapy, Australas. Ann. Med., 19, 54, 1970.
Urbanska-Bonenberg, L., and Smigla, K., Evaluation of effect of lead upon the liver in clinical and experimental investigations, in: Proceedings of the International Symposium on the Environmental Health Aspects of Lead (Amsterdam, Oct. 2–6,1972), pp. 487–500, Centre for Information and Documentation of the Commission of the European Communities, Luxembourg, 1973.
Cooper, W. C., Tabershaw, I. R., and Nelson, K. W., Laboratory studies of workers in lead smelting and refining, in: Proceedings of the International Symposium on the Environmental Health Aspects of Lead (Amsterdam, Oct. 2-6, 1972), p. 517, Centre for Information and Documentation of the Commission of the European Communities, Luxembourg, 1973.
Kosmider, S., Das Verhalten der alkalischen Phosphatase in Serum bei gewerblichen chronischen Bleivergiftung, Int. Arch. Gewerbepathol. Gewerbehyg., 20, 11, 1963.
Redeker, A. G., and Yamahiro, H. S., Viral hepatitis: Current concepts, Postgrad. Med., 41, 21, 1967.
Goldberg, D. M., Diagnosis of infectious hepatitis in general practice, Lancet, 1, 641, 1971.
Carlstrom, E., Edlund, Y., Hansen, H. A., Hugosson, K., and Werdinius, B., Hepatic tests in the differential diagnosis of jaundice: A statistical multivariate evaluation of combined tests, Scand. J. Clin. Lab. Invest., 15,Suppl. 73, 1963.
Chung, W. K., Moon, S. K., and Popper, H., Anicteric hepatitis in Korea: Comparative studies of asymptomatic and symptomatic series, Gastroenterology, 48, 1, 1965.
Schmidt, W., and Gros, H., Normotest in acute viral hepatitis, Scand. J. Gastroenterol., 19 (Suppl.), 143, 1973.
Wacker, W. E. C., Riordan, J. F., Snodgrass, P. J., Chang, L. W., Morse, L. J., O’Brien, T. F., and Reddy, W. J., The Holy Cross hepatitis outbreak: Clinical and chemical abnormalities, Arch. Intern. Med., 130, 355, 1972.
Goldberg, D. M., and Campbell, D. R., Biochemical investigation of outbreak of infectious hepatitis in a closed community, Br. Med. J., 2, 1435, 1962.
Cooper, W. C., Gershon, R. K., Sun, S. C., and Fresh, J. W., Anicteric viral hepatitis: A clinic-pathological follow-up study in Taiwan, N. Engl. J. Med., 274, 585, 1966.
Overholt, E. L., and Hardin, E. B., Cholangiolitic hepatitis: Clinical-pathologic studies and response to steroid therapy in four cases, Arch. Intern. Med., 103, 859, 1959.
Case records of the Massachusetts General Hospital, Case 80–1961,N. Engl J. Med., 265, 953, 1961.
McSwain, B., Herrington, J. L., Jr., Edwards, W. H., Sawyers, J. L., and Cate, W. R., Jr., Intrahepatic cholangiolitic hepatitis: Its surgical significance, Ann. Surg., 147, 805, 1958.
Scaldon, S., and Sherlock, S., Virus hepatitis with features of prolonged bile retention, Br. Med. J., 2, 734, 1957.
Gudmand-Hoyer, E., and Soeberg, B., Jejunal brush-border disaccharidase and alkaline phosphatase activity in acute viral hepatitis, Scand. J. Gastroenterol., 8, 377, 1973.
Kindmark, C.-O., and Laurell, C.-B., Sequential changes of the plasma protein pattern in inoculation hepatitis, Scand. J. Clin. Lab. Invest., 29, 105, 1972.
Hawkes, R. A., Australia antigen and viral hepatitis in Sydney: A hospital series, Med. J. Aust., 2, 519, 1970.
Blum, A. L., Stutz, R., Haemmerli, U. P., Schmid, P., and Grady, G. F., A fortuitously controlled study of steroid therapy in acute viral hepatitis. I. Acute disease, Am. J. Med., 47, 82, 1969.
Gregory, P. B., Knauer, C. M., Kempson, R. L., and Miller, R., Steroid therapy in severe viral hepatitis: A double-blind, randomized trial of methyl-prednisolone versus placebo, N. Engl. J. Med., 294, 681, 1976.
Becker, M. D., Baptista, A., Scheuer, P. J., and Sherlock, S., Prognosis of chronic persistent hepatitis, Lancet, 1, 53, 1970.
Cucinell, S. A., Evaluation of hepatotoxicity of a drug in prison inmates, J. Clin. Pharmacol., 14, 58, 1974.
Ireton, H. J. C., Gust, I. D., Moon, W. J., Lehmann, N., Stening, G. F., and Smallwood, R. A., The covert liver disease of drug addicts, Aust. N. Z. J. Med., 4, 444, 1974.
Klatskin, G., Subacute hepatic necrosis and postnecrotic cirrhosis due to anicteric infections with hepatitis virus, Am. J. Med., 25, 333, 1958.
McCarty, D. J., and Ormiste, V., Arthritis and HB Ag-positive hepatitis, Arch. Intern. Med., 132, 264, 1973.
Cook, G. C., Mulligan, R., and Sherlock, S., Controlled prospective trial of corticosteroid therapy in active chronic hepatitis, Q. J. Med., 40, 159, 1971.
Jordan, M. C., Rousseau, W. E., Stewart, J. A., Noble, G. R., and Chin, T. D. Y., Spontaneous cytomegalovirus mononucleosis: Clinical and laboratory observations in nine cases, Ann. Intern. Med., 79, 153, 1973.
Lang, D. J., and Hanshaw, J. B., Cytomegalovirus infection and the postperfusion syndrome: Recognition of the primary infections in four patients, W. Engl J. Med., 280, 1145, 1969.
Weller, T. H., The cytomegaloviruses: Ubiquitous agents with protean clinical manifestations, N. Engl. J. Med., 285, 267, 1971.
Klemola, E., and Kaariainer, L., Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis, Med. J., 2, 1099, 1965.
Emanuel, I., and Kenny, G. E., Cytomegalic inclusion disease of infancy, Pediatrics, 38, 957, 1966.
Toghill, P. J., Bailey, M. E., Williams, R., Zeegen, R., and Bown, R., Cytomegalovirus hepatitis in the adult, Lancet, 1, 1351, 1967.
Lamb, S. G., and Stern, H., Cytomegalovirus mononucleosis with jaundice as presenting sign, Lancet, 2, 1003, 1966.
Hanshaw, J. B., Betts, R. F., Simon, G., and Boynton, R. C., Acquired cytomegalovirus infection: Association with hepatomegaly and abnormal liver-function tests, N. Engl J. Med., 272, 602, 1965.
Sobell, J. D., and Fanaroff, A. A., Cytomegalovirus infection with raised alkaline phosphatase, Lancet, 2, 689, 1968.
Swan, C., Tostevin, A. L., Mayo, H., and Black, G. H. B., Further observations on congenital defects in infants following infectious diseases during pregnancy, with special reference to rubella, Med. J. Aust., 1, 409, 1944.
Korones, S. B., Ainger, L. E., Monif, G. R. G., Roane, J., Sever, J. L., and Fuste, F., Congenital rubella syndrome: Study of 22 infants; Myocardial, damage and other new clinical aspects, Am. J. Dis. Child., 110, 434, 1965.
Esterly, J. R., Slusser, R. J., and Ruebner, B. H., Hepatic lesions in the congential rubella syndrome, J. Pediatr., 71, 675, 1967.
Bird, T., Ennis, J. E., Wort, A. J., and Gardner, P. S., Disseminated herpes simplex in newborn infants, J. Clin. Pathol., 16, 423, 1963.
Sun, N. C., and Smith, V. M., Hepatitis associated with myocarditis: Unusual manifestation of infection with Coxsackie virus, Group B, Type 3, N. Engl. J Med., 274, 190, 1966.
Derrick, E. H., “Q” fever, a new fever entity: Clinical features, diagnosis and laboratory investigation, Med. J. Aust., 2, 281, 1937.
Gerstl, B., Movitt, E. R., and Skahen, J. R., Liver function and morphology in “Q” fever, Gastroenterology, 30, 813, 1956.
Bernstein, M., Edmondson, H. A., and Barbour, B. H., The liver lesion in Q fever: Clinical and pathologic features, Arch. Intern. Med., 116, 491, 1965.
Alkan, W. J., Evenchik, Z., and Eshchar, J., Q fever and infectious hepatitis, Am. J. Med., 38, 54, 1965.
Picchi, J., Nelson, A. R., Waller, E. E., Razavi, M., and Clizer, E. E., Q fever associated with granulomatous hepatitis, Ann. Intern. Med., 53, 1065, 1960.
Powell, O. W., Liver involvement in “Q” fever, Australas. Ann. Med., 10, 52, 1961.
Doherty, R. L., A clinical study of scrub typhus in North Queensland, Med. J. Aust., 2, 212, 1956.
de la Maza, L. M., Naeim, F., and Berman, L. D., The changing etiology of liver abscess, J. Am. Med. Assoc., 227, 161, 1974.
Pyrtek, L. J., and Bartus, S. A., Hepatic pyemia, N. Engl J. Med., 272, 551, 1965.
Butler, T. J., and McCarthy, C. F., Pyogenic liver abscess, Gut, 10, 389, 1969.
Hinchey, E. J., and Couper, C. E., Acute obstructive suppurative cholangitis, Ann. J. Surg., 117, 62, 1969.
Neale, G., Gaughey, D. E., Mollin, D. L., and Booth, C. C., Effects of intrahepatic infection on liver function, Med. J., 1, 382, 1966.
Green, M., and Richmond, J. B., Pediatric Diagnosis, p. 367, W. B. Saunders, Philadelphia, 1954.
Thaler, M. M., Neonatal hyperbilirubinemia, Semin. Hematol., 9, 107, 1972.
Fahrlander, H., Huber, F., and Gloor, F., Intrahepatic retention of bile in severe bacterial infections, Gastroenterology, 47, 590, 1964.
Anonymous, The cholestatic jaundice of severe infection (editorial), Lancet, 1, 36, 1966.
Eley, A., Gargreaves, T., and Lambert, H. P., Jaundice in severe infections, Br. Med. J., 2, 75, 1965.
Vermillion, S. E., Gregg, J. A., Baggenstoss, A. H., and Bartholomew, L. G., Jaundice associated with bacteremia, Arch. Intern. Med., 124, 611, 1969.
Fishbein, W. N., Jaundice as an early manifestation of scarlet fever, Ann. Intern. Med., 57, 60, 1962.
Klatskin, G., and Yesner, R., Hepatic manifestations of sarcoidosis and other granulomatous diseases: A study based on histological examination of tissue obtained by needle biopsy of the liver, Yale J. Biol Med., 23, 207, 1950.
Joske, R. A., and Finckh, E. S., Hepatic changes in human brucellosis, Med. J. Aust., 1, 266, 1955.
Buchanan, T. M., Faber, L. C., and Feldman, R. A., Brucellosis in the United States, 1960–1972: An abattoir-associated disease, Medicine (Baltimore), 53, 403, 1974.
Leonard, J. J., Katz, S., and McCormick, G., Recurrent miliary tuberculosis, W. Engl J. Med., 256, 435, 1957.
Guckian, J. C., and Perry, J. E., Granulomatous hepatitis: An analysis of 63 cases and review of the literature, Ann. Intern. Med., 65, 1081, 1966.
Munt, P. W., Miliary tuberculosis in the chemotherapy era: With a clinical review in 69 American adults, Medicine (Baltimore), 51, 139, 1972.
Sataline, L. R., and Matre, W. J., Significance of hyperphosphatasemia in alcoholics with liver disease, Am. J. Med., 35, 323, 1963.
Hurst, A., Maier, H. M., and Lough, S. A., Studies of hepatic function in pulmonary tuberculosis, Am. J. Med. Sci., 214, 431, 1947.
Ross, H., Serum phosphatase in leprosy, Int. J. Lepr., 9, 57, 1941.
Lee, R. U., Thornton, G. F., and Conn, H. O., Liver disease associated with secondary syphilis, N. Engl J. Med., 284, 1423, 1971.
McCracken, J. D., Hall, W. H., and Pierce, H. I., Nephrotic syndrome and acute hepatitis in secondary syphilis,Mil Med., 134, 682, 1969.
Baker, A. L., Kaplan, M. M., Wolfe, H. J., and McGowen, J. A., Liver disease associated with early syphilis, N. Engl J. Med., 284, 1422, 1971.
Heath, C. W., Jr., Alexander, A. D., and Galton, M. M., Leptospirosis in the United States: Analysis of 483 Cases in man, 1949-1961,M Engl J. Med., 273, 857, 1965.
McCrumb, F. R., Stockard, J. L., Robinson, C. R., Turner, L. H., Levis, D. G., Maisey, C. W., Kelleher, M. F., Gleiser, C. A., and Smadel, J. E., Leptospirosis in Malaya. I. Sporadic cases among military and civilian personnel, Am. J. Trop. Med. Hyg., 6, 238, 1957.
Health, C. W., Jr., Alexander, A. D., and Galton, M. M., Leptospirosis in the United States (concluded): Analysis of 483 cases in man, 1949-1961, N. Engl J. Med., 273, 915, 1965.
Chinn, A. B., Roth, H. P., and Moore, R. D., Hepatic function tests in Weil’s disease, Am. J. Med. Sci., 222, 530, 1951.
Edwards, G. A., and Domm, B. M., Human leptospirosis, Medicine (Baltimore), 39, 117, 1960.
Bain, B. J., Ribush, N. T., Nicol, P., Whitshed, H. M., and Morgan, T. O., Renal failure and transient paraproteinemia due to Leptospira pomona, Arch. Intern. Med., 131, 740, 1973.
Holmes, K. K., Counts, G. W., and Beaty, M. N., Disseminated gonococcal infection,, Ann. Intern. Med., 74, 919, 1971.
Butler, T., A clinical study of the bubonic plague: Observations of the 1970 Vietnam epidemic with emphasis on coagulation studies, skin histology and electrocardiograms, Am. J. Med., 53, 268, 1972.
Saphra, I., and Winter, J. W., Clinical manifestations of salmonellosis in man: Evaluation of 7779 human infections identified at New York Salmonella Center, N. Engl J. Med., 256, 1128, 1957.
Dinbar, A., Altmann, G., and Tulcinsky, D. B., The treatment of chronic biliary Salmonella carriers, Am. J. Med., 47, 236, 1969.
Cohen, R. A., Geraci, J. E., Dearing, W. H., and Needham, G. M., Salmonellosis: Observations of 94 patients,Mayo Clin. Proc., 39, 401, 1964.
Black, P. H., Kunz, L. J., and Swartz, M. N., Salmonellosis-A review of some unusual aspects, N. Engl J. Med., 262, 864, 1960.
Havens, W. P., Jr., and Wenner, H. A., Infectious hepatitis complicated by secondary invasion with Salmonella, J. Gin. Invest., 25, 45, 1946.
Erlik, D., and Reitler, R., Intrahepatic typhoid infection as cause of the carrier state, Lancet, 1, 1216, 1960.
Miller, D. F., and Irvine, R. W., Jaundice in acute appendicits, Lancet, 1, 321, 1969.
Rubin, R. H., Swartz, M. N., and Malt, R., Hepatic abscess: Changes in clinical bacteriologic and therapeutic aspects, Am. J. Med., 57, 601, 1974.
Ribaudo, J. M., and Ochsner, A., Intrahepatic abscesses: Amebic and pyogenic, Am. J. Surg., 125, 510, 1973.
Deller, J. J., Cifarelli, P. S., Berque, S., and Buchanan, R., Malaria hepatitis, Mil Med., 132, 614, 1967.
Goldstein, E., A clinical study of falciparum and vivax malaria in Vietnam servicemen, Mil Med., 133, 991, 1968.
Glor, B. A. K., Falciparum malaria in Vietnam: Clinical manifestations and nursing care requirements, Mil Med., 134, 181, 1969.
Khan, M. Y., Zinneman, H. H., and Hall, W. H., Vietnam malaria: Clinical experience with 50 patients,Minn. Med., 53, 331, 1970.
Srichaikul, T., Wasanasomsithi, M., Poshyachinda, V., Panikbutr, N., and Rabieb, T., Fer- rokinetic studies and erythropoiesis in malaria, Arch. Intern. Med., 124, 623, 1969.
Mallory, J. P., Brooks, M. H., and Barry, K. G., Pathophysiology of acute falciparum malaria. II. Fluid compartmentalization,yAm. J. Med., 43, 745, 1967.
Kuvin, S. F., Beye, H. K., Stohlman, F., Jr., Contacos, P. G., and Coatney, G. R., Clinical and physiological responses in sporozoite-induced B strain Plasmodium cynomolgi and Plasmodium vivax infections in normal volunteers, Trans. R. Soc. Trop. Med. Hyg., 56, 371, 1962.
Sadun, E. H., Williams, J. S., and Martin, L. K., Serum biochemical changes in malarial infections in men, chimpanzees and mice, Mil. Med., 131, 1094, 1966.
Remington, J. S., Jacobs, L., and Kaufman, H. E., Toxoplasmosis in the adult, N. Engl. J. Med., 262, 237, 1960.
Kass, E. H., Andrus, S. B., Adams, R. D., Turner, F. C., and Feldman, H. A., Toxoplasmosis in the human adult, Arch. Intern. Med., 89, 159, 1952.
Kayhoe, D. E., Jacobs, L., Beye, H. K., and McClullough, N. B., Acquired toxoplasmosis: Observations on two parasitologically proved cases treated with pyrimethamine and triple sulfonamides, N. Engl. J. Med., 257, 1247, 1957.
Antani, J., and Srinivas, H. V., Clinical evaluation of metronidazole in hepatic amebiasis, Am. J. Trop. Med., 19, 762, 1970.
Reynolds, T. B., Amoebic abscess of the liver, Gastroenterology, 60, 952, 1911.
Tandon, B. N., Tandon, H. D., Ravi, V. V., and Gandhi, P. C., Diffuse liver injury in amebic abscess of the liver: An electron microscopic study, Exp. Mol. Pathol., 23, 155, 1975.
Lamont, N. McE., and Pooler, N. R., Hepatic amoebiasis: A study of 250 cases, Q. J. Med., 27 (N.S.), 389, 1958.
Aufses, A. H., Schaffner, F., Rosenthal, W. S., and Herman, B. E., Portal venous pressure in “pipestem” fibrosis of the liver due to schistosomiasis, Am. J. Med., 27, 807, 1959.
Garcia-Palmieri, M. R., and Marcial-Rojas, R. A., Portal hypertension due to Schistosomiasis mansoni, Am. J. Med., 27, 811, 1959.
Clark, W. D., Cox, P. M., Jr., Ratner, L. H., and Correa-Coronas, R., Acute schistosomiasis mansoni in 10 boys: An outbreak in Caguas, Puerto Rico, Anna. Intern. Med., 73, 379, 1970.
Barreto, V. S. T., Alkaline phosphatase in schistosomiasis (letter), Ann. Intern. Med., 74, 450, 1971.
Charters, A. D., Jackson, J. M., and Vivian, A. B., A case of severe schistosomiasis (Schistosoma mansoni) in Western Australia,Med. J. Aust., 2, 299, 1969.
Dew, H., Hydatid Disease: Its Pathology, Diagnosis and Treatment, Australian Medical Publishing Co., Sydney, 1928.
Romero-Torres, R., and Campbell, J. R., An interpretive review of the surgical treatment of hydatid disease, Surg. Gynecol. Obstet., 121, 851, 1965.
Judd, E. S., Surgical treatment for echinococcus cysts of the liver: Report of four cases, Proc. Staff Meet. Mayo Clin., 35, 58, 1960.
Harris, J. D., Rupture of hydatid cysts of the liver into the biliary tracts, Br. J. Surg., 52, 210, 1965.
Nyqvist, A., and Tillander, H., Echinococcosis unilocularis hepatis with cyst rupture into the biliary ducts: Report of a case., Acta Chir. Scand., 135, 549, 1969.
Joske, R. A., The changing pattern of hydatid disease with special reference to hydatid of the liver, Med. J. Aust., 1, 129, 1974.
Phills, J. A., Harrold, A. J., Whiteman, G. V., and Perelmutter, L., Pulmonary infiltrates, asthma and eosinophilia due to Ascaris suum infestation in man, N. Engl. J. Med., 286, 965, 1972.
Pfefferman, R., Floman, Y., and Rozin, R. R., Ascariasis of the biliary system, Arch. Surg., 105, 118, 1972.
Guattery, J. M., Milne, J., and House, R. K., Observations on hepatic and renal dysfunction in trichinosis: Anatomic changes in these organs occurring in cases of trichinosis, Am. J. Med., 21, 561, 1956.
Ozere, R. L., Van Rooyen, C. E., Roy, D. L., Cameron, T. W. M., and Tanner, C., Human trichinosis: Studies on eleven cases affecting two families in Nova Scotia, Can. Med. Assoc. J., 87, 1353, 1962.
Hall, W. J., and McCabe, W. R., Trichinosis: Report of a small outbreak with observations of thiabendazole therapy, Arch. Intern. Med., 119, 65, 1967.
Rosenberg, E. B., Polmar, S. H., and Whalen, G. E., Increased circulating IgE in trichinosis, Intern. Med., 75, 515, 1971.
Smith, J. W., and Utz, J. P., Progressive disseminated histoplasmosis: A prospective study of 26 patients, Ann. Intern. Med., 76, 551, 1972.
Edmonson, R. P. S., Eykyn, S., Davies, D. R., Fawcett, I. W., and Phillips, I., Disseminated histoplasmosis successfully treated with Amphotericin B, J. Gin. Pathol, 27, 308, 1974.
Shields, L. H., Disseminated cryptococcosis producing a sarcoid type reaction: The report of a case treated with Amphotericin B., Arch. Intern. Med., 104, 763, 1959.
Yamada, T., Sakai, A., Tonouchi, S., and Kawashima, K., Actinomycosis of the liver: Report of a case with special reference to liver function tests, Am. J. Surg., 121, 341, 1971.
Garb, S., Ginical Guide to Undesirable Drug Interactions and Interferences, Springer, New York, 1971.
Shay, H., Berk, J. E., Sones, M., Aegerter, E. E., Weston, J. K., and Adams, A. B., Liver in sarcoidosis, Gastroenterology, 79, 441, 1951.
Klatskin, G., and Yesner, R., Factors in the treatment of Laennec’s cirrhosis. I. Clinical and histological changes observed during a control period of bed-rest, alcohol withdrawal, and a minimal basic diet, J. Gin. Invest., 28, 723, 1949.
Maddrey, W. C., Johns, C. J., Boitnott, J. K., and Iber, F. L., Sarcoidosis and chronic hepatic disease: A clinical and pathologic study of 20 patients, Medicine (Baltimore), 49, 375, 1970.
Fitzgerald, M. X., Fitzgerald, O., and Towers, R. P., Granulomatous hepatitis of obscure aetiology: Diagnostic contribution of Kveim testing and antituberculous therapy, Q. J. Med., 40, 311, 1971.
Wolff, S. M., Hathaway, B. E., and Laster, L., The gastrointestinal system in familial Mediterranean fever, Arch. Intern. Med., 115, 565, 1965.
Barth, W. F., Willerson, J. T., Waldmann, T. A., and Decker, J. L., Primary amyloidosis: Clinical, immunochemical and immunoglobulin metabolism studies in fifteen patients, Am. J. Med., 47, 259, 1969.
Klatskin, G., Alcohol and its relation to liver damage, Gastroenterology, 41, 443, 1961.
Lieber, C. S., Hepatic and metabolic effects of alcohol, Gastroenterology, 50, 119, 1966.
Rubin, E., and Lieber, C. S., Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates, N. Engl. J. Med., 290, 128, 1974.
Freer, D. E., and Statland, B. E., The effects of ethanol (0.75 g Jkg body weight) on the activities of selected enzymes in sera of healthy young adults. 1. Intermediate term effects, Gin. Chem., 23, 830, 1977.
Ashley, M. J., Olin, J. S., Harding le Riche, W., Kornaczewski, A., Schmidt, W., and Rankin, J. G., Skid row alcoholism: A distinct sociomedical entity, Arch. Intern. Med., 136, 272, 1976.
Erenoglu, E., Edreira, J. G., and Patek, A. J., Observations on patients with Laennec’s cirrhosis receiving alcohol while on controlled diets, Ann. Intern. Med., 60, 814, 1964.
Kater, R. M., Carulli, N., and Iber, F. L., Differences in the rate of ethanol metabolism in recently drinking alcoholic and non-drinking subjects, Am. J. Gin. Nutr., 22, 1608, 1969.
Popper, H., Szanto, P. B., and Parthasarathy, M., Florid cirrhosis: A review of 35 cases, Am, J. Gin. Pathol, 25, 889, 1955.
Schaffner, F., and Popper, H., Alcoholic hepatitis in the spectrum of ethanol-induced liver injury, Scand. J. Gastroentol., 5 (Suppl. 7), 69, 1970.
Zeegen, R., Stansfeld, A. G., Dawson, A. M., and Hurst, A. H., Prolonged survival after portal decompression of patients with non-cirrhotic intraheptic portal hypertension, Gut, 11, 610, 1970.
Harinasuta, U., and Zimmerman, H. J., Alcoholic steatonecrosis. I. Relationship between severity of hepatic disease and presence of Mallory bodies in the liver, Gastroenterology, 60, 1036, 1971.
Green, J., Mistillis, S., and Schiff, L., Acute alcoholic hepatitis: A clinical study of fifty cases, Arch. Intern. Med., 112, 67, 1963.
Bradus, S., Korn, R. J., Chomet, B., West, M., and Zimmerman, H. J., Hepatic function and serum enzyme levels in association with fatty metamorphosis of the liver, Am. J. Med. Sci 246, 35, 1963.
Zieve, L., and Hill, E., An evaluation of factors influencing the discriminative effectiveness of a group of liver function tests. III. Relative effectiveness of hepatic tests in cirrhosis, Gastroenterology, 28, 785, 1955.
Christoffersen, P., Eghoje, J., and Juhl, E., Mallory bodies in liver biopsies from chronic alcoholics: A comparative morphological, biochemical, and clinical study of two groups of chronic alcoholics with and without Mallory bodies, Scand. J. Gastroenterol., 8, 341, 1973.
Toghill, P. J., Knill-Jones, R. P., and Williams, R., A controlled trial of a protein-free, liver extract in the treatment of chronic liver disease, Gut, 10, 882, 1969.
Prytz, H., and Sloth, K., Hepatic coma in cirrhosis of the liver: The course and prognosis of 100 consecutive coma episodes, Scand. J. Gastroenterol., 8, 229, 1973.
Devenyi, P., Rutherdale, J., Sereny, G., and Olin, J. S., Clinical diagnosis of alcoholic fatty liver, Am. J. Gastroenterol., 54, 597, 1970.
Kay, C. J., Primary hepatic cancer, Arch. Intern. Med., 113, 46, 1964.
Popper, H., Schaffner, F., Rubin, E., Barka, T., and Paronetto, F., Mechanisms of intrahepatic cholestasis in drug-induced hepatic injury, Ann. N. Y. Acad. Sci., 104, 988, 1963.
Popper, H., Rubin, E., Gardiol, D., Schaffner, F., and Paronetto, F., Drug-induced liver disease: A penalty for progress, Arch. Intern. Med., 115, 128, 1965.
Zimmerman, H. J., Clinical and laboratory manifestations of hepatotoxicity, Ann N. Y. Acad. Set, 104, 954, 1963.
McGill, D. B., and Motto, J. D., An industrial outbreak of toxic hepatitis due to methylene- dianiline, N. Engl. J. Med., 291, 278, 1974.
Kopelman, H., Scheuer, P. J., and Williams, R., The liver lesion of the Epping jaundice, Q. J. Med., 35, 553, 1966.
Steigmann, F., The early recognition of drug-induced liver disease, Med. Gin. North Am., 44, 183, 1960.
Sherlock, S., Hepatic reactions to therapeutic agents, Annu. Rev. Pharmacol., 5, 429, 1965.
Dawborn, J. K., Ralston, M., and Weiden, S., Acute carbon tetrachloride poisoning: Transaminase and biopsy studies, Br. Med. J., 2, 493, 1961.
Alston, W. C., Hepatic and renal complications arising from accidental carbon tetrachloride poisoning in the human subject, J. Gin. Pathol., 23, 249, 1970.
Greenburger, N. J., Robinson, W. L., and Isselbacher, K. J., Toxic hepatitis after the injestion of phosphorus with subsequent recovery, Gastroenterology, 47, 119, 1964.
Fletcher, G. F., and Galambos, J. T., Phosphorus poisoning in humans, Arch. Intern. Med., 112, 846, 1963.
Wieland, T., and Wieland, O., Chemistry and toxicology of the toxins of Amanita phalloides, Pharmacol. Rev., 11, 87, 1959.
Wieland, O., Changes in liver metabolism induced by the poisons of Amanita phalloides, Gin. Chem., 11, 323, 1965.
Wieland, T., Poisonous principles of mushrooms of the genus Amanita, Science, 159, 946, 1968.
Paaso, B., and Harrison, D. C., A new look at an old problem: Mushroom poisoning; Clinical presentations and new therapeutic approaches, Am. J. Med., 58, 505, 1975.
Harrison, D. C., Coggins, C. H., Welland, F. H., and Nelson, S., Mushroom poisoning in five patients, Am. J. Med., 38, 787, 1965.
Lehmann, V. L., Zur Klinik und Spatprognose der Vergiftung mit Amanita phalloides, Helv. Med. Acta, 30, 30, 1963.
Rosenblum, L. E., Korn, R. J., and Zimmerman, H. J., Hepatocellular jaundice as a complication of iproniazid therapy, Arch. Intern. Med., 105, 593, 1960.
Thompson, D. S., Eason, C. N., and Thompson, B. W., An evaluation of the effect of halothane on liver function and disease, Am. J. Surg., 114, 658, 1967.
Trey, C., Lipworth, L., Chalmers, T. C., Davidson, C. S., Gottlieb, L. S., Popper, H., Saunders, S. J., Fulminant hepatic failure: Presumable contribution of halothane, N. Engl. J. Med., 279, 798, 1968.
Simpson, B. R., Strunin, L., and Walton, B., The halothane dilemma: A case for the defence, Br. Med. J., 4, 96, 1971.
Gopinath, C., Jones, R. S., and Ford, E. J., The effect of the repeated administration of halothane on the liver of the horse, J. Pathol., 102, 107, 1970.
Johnstone, R. E., Kennell, E. M., Brummund, W., Jr., Shaw, L. M., and Ebersole, R. C., Effect of halothane anesthesia on muscle, liver, thyroid and adrenal-function tests in man, Gin. Chem., 22, 217, 1976.
Sherlock, S., Halothane hepatitis, Gut, 12, 324, 1971.
Thompson, D. S., and Greifenstein, F. E., Enzyme patterns reflecting hepatic response to anesthesia and operation, South. Med. J., 67, 69, 1974.
Mason, B., and Davidson, D., Halothane hepatitis, Conn. Med., 38, 162, 1974.
Davis, P., and Holdsworth, D. C., Jaundice after multiple halothane anaesthetics administered during the treatment of carcinoma of the uterus, Gut, 14, 566, 1973.
Klion, F. M., Schaffner, F., and Popper, H., Hepatitis after exposure to halothane, Ann. Intern. Med., 71, 461, 1969.
Klatskin, G., and Kimberg, D. V., Recurrent hepatitis attributable to halothane sensitization in an anaesthetist, N. Engl. J. Med., 280, 515, 1969.
Van der Reis, L., Askin, S. J., Frecker, G. N., and Fitzgerald, W. J., Hepatic necrosis after enflurane anesthesia, J. Am. Med. Assoc., 227, 16, 1974.
Toghill, P. J., Smith, P. G., Benton, P., Brown, R. C., and Matthews, H. L., Methyldopa liver damage, Br. Med. J., 3, 545, 1974.
Reynolds, T. B., Peters, R. L., and Yamada, S., Chronic active and lupoid hepatitis caused by a laxative, oxyphenisatin, N. Engl. J. Med., 285, 813, 1971.
Foss, G. L., and Simpson, S. L., Oral methyl testosterone and jaundice, Br. Med. J., 1, 259, 1959.
Schaffner, F., Popper, H., and Chesrow, E., Cholestasis produced by the administration of norethandrolone, Am. J. Med., 26, 249, 1959.
Davis, M., Mückle, T. J., Cassels-Smith, A., Webster, D., and Kerr, D. N. S., Oxymetholone in the treatment of anaemia in chronic renal failure, Br. J. Urol., 44, 387, 1972.
Hellman, L., Zumoff, B., Fishman, J., and Gallagher, T. F., Estradiol metabolism in total extrahepatic biliary obstruction, J. Clin. Endocrinol., 30, 161, 1970.
Mueller, M. N., and Kappas, A., and Damgaard, E., Estrogen pharmacology. I. The influence of estradiol and estriol on hepatic disposal of sulfobromophthalein (BSP) in man, J. Clin. Invest., 43, 1905, 1964.
Song, C. S., Rifkind, A. B., Gillette, P. N., and Kappas, A., Hormones and the liver: The effect of estrogens, progestins, and pregnancy on hepatic function, Am. J. Obstet. Gynecol., 105, 813, 1969.
Adlercreutz, H., and Tenhunen, R., Some aspects of the interaction between natural and synthetic female sex hormones and the liver, Am. J. Med., 49, 630, 1970.
Eisalo, A., Järvinen, P. A., and Luukkainen, T., Hepatic impairment during the intake of contraceptive pills: Clinical trial with postmenopausal women, Br. Med. J., 2, 426, 1964.
Larsson-Cohn, U., Oral contraception and liver-function tests, Br. Med. J., 1, 1414, 1965.
Thulin, K. E., and Nermark, J., Seven cases of jaundice in women taking an oral contraceptive, Anovlar, Br. Med. J., i, 584, 1966.
Cullberg, G., Lundstrom, R., and Stenram, U., Jaundice during treatment with an oral contraceptive, Lyndiol, Br. Med. J., 1, 695, 1965.
Board, J. A., Continuous norethindrone, 0.35 mg, as an oral contraceptive agent, Am. J. Obstet. Gynecol., 109, 531, 1971.
Wajchenberg, B. L., Urinary calcium and phosphorus homeostasis in hypercortisolism. I. Evaluation by means of calcium infusion test, J. Clin. Endocrinol. Metab., 31, 260, 1970.
Tyler, E. T., Cole, S. L., and Levin, M., A clinical evaluation of long-term continuous use of norethynodrel-mestranol for contraception, Fértil. Steril., 20, 871, 1969.
Schreiner, W. E., Nebenwirkungen der medikamentösen Antikonzeption, Schweiz. Med. Wochenschr., 100, 778, 1970.
Kaffarnik, H., Gassei, W. D., Lehnert, H., Schneider, J., Zöfel, P., Meyer-Bertenrath, J. G., and Karsznia, R., Befunde verschiedener Blutwerte unter Ovulationshemmern, Muench. Med. Wochenschr., 113, 757, 1971.
Carter, A. C., and Feldman, E. B., Metabolie effects of mestranol in high dosage, Steroids, 16, 5, 1970.
Wilbert, L., Severidt, E., Kallmann, L., Hillmer, T., and Creutzfeldt, W., Serum-Enzymak- tivitàten und Bromsulfaleinretention unter Ovulationshemmern, Dtsch. Med. Wochenschr., 93, 2207, 1968.
Caroli, J., Cheverl, B., and Rautureau, M., A propos des anomalies biologiques et histologiques hépatiques liées aux contraceptifs oraux: Note sur le comportement des acides biliaries, de la BSP et du vert d’indocyanine, Pathol Biol. (Pans), 16, 935, 1968.
Dooner, H. P., Hoyl, C., Aliaga, C., and Parada, J., Jaundice and oral contraceptives, Acta Hepato-Splenol., 18, 84, 1971.
Roman, W., and Hecker, R., The liver toxicity of oral contraceptives: A critical review of the literature, Med. J. Aust., 2, 682, 1968.
Pihl, E., Rais, O., and Zeuchner, E., Functional and morphological liver changes in women taking oral contraceptives: A clinical and ultrastructural study with special reference to the occurrence of cholestasis, A eta Chir. Scand., 134, 639, 1968.
Hargreaves, T., Oral contraceptives and liver function, J. Clin. Pathol., 23 (Suppl 3), 1, 1969.
Larsson-Cohn, U., The 2-hour sulfobromphthalein retention test and the transaminase activity during oral contraceptive therapy, Am. J. Obstet. Gynecol., 98, 188, 1967.
Eisalo, A., Járvinen, P. A., and Luukkainen, T., Liver-function tests during intake of contraceptive tablets in premenopausal women, Br. Med. J., 1, 1416, 1965.
Fleisher, G. A., Unpublished materials (personal communication from observations at the Mayo Clinic; letter to G. N. Bowers, Jr., Nov. 19, 1975 ).
Pukkinen, M. O., and Willman, K., The effect of oral contraceptives on serum enzymes, Acta Obstet. Gynecol Scand., 46, 525, 1967.
DeMerre, L. J., and Litofsky, F. S., Alkaline phosphatase activity during menstruation, Fértil Steril, 19, 593, 1968.
Baum, J. K., Holtz, F., Bookstein, J. J., and Klein, E. W., Possible association between benign hepatomas and oral contraceptives, Lancet, 2, 926, 1973.
O’Sullivan, J. P., and Wilding, R. P., Liver hamartomas in patients on oral contraceptives, Br. Med. J., 3, 1, 1974.
Mays, E. T., Christopherson, W. M., Mahr, M. M., and Williams, H. C., Hepatic changes in young women ingesting contraceptive steroids: Hepatic hemorrhage and primary hepatic tumors, J. Am. Med. Assoc., 235, 730, 1976.
Edmondson, H. A., Henderson, B., and Benton, B., Liver-cell adenomas associated with use of oral contraceptives, N. Engl. J. Med., 294, 470, 1976.
Read, A. E., Harrison, C. V., and Sherlock, S., Chronic chlorpromazine jaundice with particular reference to its relationship with primary biliary cirrhosis, Am. J. Med., 31, 249, 1961.
Kohn, N., and Myerson, R. M., Cholestatic hepatitis associated with trifluoperazine, N. Engl. J. Med., 264, 549, 1961.
Dickes, R., Schenker, V., and Deutsch, L., Serial liver-function and blood studies in patients receiving chlorpromazine, N. Engl. J. Med., 256, 1, 1957.
Breuer, R. I., Chlorpromazine hepatotoxicity manifested by a selective and sustained rise of serum alkaline phosphatase activity, Am. J. Dig. Dis., 10, 727, 1965.
Short, M. H., Burns, J. M., and Harris, M. E., Cholestatic jaundice during imipramine therapy, Am. Med. Assoc., 206, 1791, 1968.
Fries, J., and Siraganian, R., Sulfonamide hepatitis: Report of a case due to sulfamethoxazole and sulfisoxazole, N. Engl. J. Med., 274, 95, 1966.
Physicians Desk Reference, 31st ed. (Huff, B. B., ed.), Medical Economics, Oradell, New Jersey, 1974.
Fischer, H. W., and Hoak, J. C., Mimicry of acute cholecystitis by erythromycin estolate reactions: Report of two cases, Am. J. Med. Sci., 247, 283, 1964.
Johnson, D. F., and Hall, W. H., Allergic hepatitis caused by propionyl erythromycin ester of lauryl sulfate, N. Engl J. Med., 265, 1200, 1961.
Reed, C., and Ritchie, F., Toxic jaundice due to propionyl erythromycin ester lauryl sulfate (“ilosonz”), Med. J. Aust., 1, 810, 1962.
Farmer, C. D., Hoffman, H. W., Shorter, R. G., Thurber, O. L., and Bartholomew, L. G., Intrahepatic cholestasis associated with the ingestion of erythromycin estolate (Ilosone), Gastroenterology, 45, 157, 1963.
Maddrey, W. C., and Boitnott, J. K., Isoniazid hepatitis, Ann. Intern. Med., 79, 1, 1973.
Rossouw, J. E., and Saunders, S. J., Hepatic complications of antituberculous therapy, Q. J. Med., 44, 1, 1975.
Ernaelsteen, D., and Williams, R., Jaundice due to nitrofurantoin, Gastroenterology, 41, 590, 1961.
Jokela, S., Liver disease due to nitrofurantoin, Gastroenterology, 53, 306, 1967.
Cook, G. C., and Sherlock, S., Jaundice and its relation to therapeutic agents, Lancet, 1, 175, 1970.
Engel, J. J., Vogt, T. R., and Wilson, D. E., Cholestatic hepatitis after administration of furan derivatives, Arch. Intern. Med., 135, 733, 1975.
Sessions, J. T., Minkel, H. P., Bullard, J. C., and Ingelfinger, F. J., The effect of barbiturates in patients with liver disease, J. Clin. Invest., 33, 1116, 1954.
Birch, C. A., Jaundice due to phenobarbital, Lancet, 1, 478, 1936.
Daikos, G. K., and Kosmidis, J. C., Propoxyphene jaundice, J. Am Med. Assoc., 232, 835, 1975.
Klein, N. C., and Magida, M. G., Propoxyphene (Darvon) hepatotoxicity, Am. J. Dig. Dis., 16, 467, 1971.
Pagliaro, L., Campesi, G., and Aguglia, F., Barbiturate jaundice: Report of a case due to a barbital-containing drug with positive rechallenge to phenobarbital, Gastroenterology, 56, 938, 1969.
Thurmon, T. F., Robertson, R. T., and Anderson, E. E., Phenobarbital and alkaline phosphatase: A preliminary report, J. Pediatr., 81, 547, 1972.
Conney, A. H., Pharmacological implications of microsomal enzyme induction, Pharmacol. Rev., 19, 317, 1967.
Borden, E. C., and Rostand, S. G., Recovery from massive amitriptyline overdose (letter), Lancet, 1, 1256, 1968.
Cunningham, M. L., Acute hepatic necrosis following treatment with amitriptyline and diazepam, Br. J. Psychiatry, 111, 1107, 1965.
Biagi, R. W., and Bapat, B. N., Intrahepatic obstructive jaundice from amitriptyline, Br. J. Psychiatry, 113, 1113, 1967.
Yon, J., and Anuras, S., Hepatitis caused by amitriptyline therapy, J. Am. Med. Assoc., 232, 833, 1975.
Carney, D. M., Zukoski, C. F., and Ogden, D. A., Massive azathioprine overdose: Case report and review of the literature, Am. J. Med., 56, 133, 1974.
Brown, J. H., and Kennedy, B. J., Mithramycin in the treatment of disseminated testicular neoplasms, N. Engl. J. Med., 272, 111, 1965.
Koons, C. R., Sensenbrenner, L. L., and Owens, A. H., Clinical studies of mithramycin in patients with embryonal cancer, Bull. Johns Hopkins Hosp., 118, 462, 1966.
Ream, N. W., Perlia, C. P., Wolter, J., and Taylor, S. G., Mithramycin therapy in disseminated germinal testicular cancer, J. Am. Med. Assoc., 204, 1030, 1968.
Sherr, H. P., and Cocco, A. E., Comparison of hepatic function before and after pre-medication for gastrointestinal endoscopy, Am. J. Med. Sci., 267, 151, 1974.
Berk, J. E., Harris, H., and Pringle, B., The effect of analgesics on serum enzymatic activity, Gastroenterology, 39, 702, 1960.
Kreek, M. J., Dodes, L., Knobler, J., and Martin, R., Long-term methadone maintenance therapy: Effects on liver function, Ann. Intern. Med., 77, 598, 1972.
Stimmel, B., Vernace, S., and Tobias, H., Hepatic dysfunction in heroin addicts: The role of alcohol, J. Am. Med. Assoc., 222, 811, 1972.
Mossberg, S. M., Bloom, A., Berkowitz, J., and Ross, G., Serum enzyme activities following morphine, Arch. Intern. Med., 109, 429, 1962.
Bridgman, J. F., Rosen, S. M., and Thorp, J. M., Complications during clofibrate treatment of nephrotic-syndrome hyperlipoproteineuria, Lancet, 2, 506, 1972.
Dujovne, C. A., Weiss, P., and Bianchine, J. R., Comparative clinical therapeutic trial with two hypolipidemic drugs: Clofibrate and nafenopin, Clin. Pharmacol. Ther., 12, 117, 1971.
Ferrari, C., Testori, G. P., Scanni, A., Frezzati, S., Bertazzoni, A., and Romussi, M., Reduction of serum alkaline phosphatase and gamma-glutamyl transpeptidase activities by short-term clofibrate (letter to the editor), N. Engl J. Med., 295, 449, 1976.
Schade, R. W. B., Demacker, P. N. M., and van’t Laar, A., Clofibrate effect on alkaline phosphatase: Bone or liver fraction (letter to the editor), N. Engl. J. Med., 297, 669, 1977.
Kijima, Y., Sasaoka, T., and Kanayama, M., Clofibrate effect on alkaline phosphatase in renal failure (letter to the editor), N. Engl J. Med., 297, 113, 1977.
Schade, R. W. B., Demacker, P. N. M., and van’t Laar, A., Reduction of serum-alkaline- phosphatase by clofibrate, Lancet, 1, 862, 1975.
Konttinen, A., and Paloheimo, J., The effects of Atromid on serum lipids, proteins and some liver function tests in hypercholesterolaemic patients, J. Atherscler. Res., 3, 525, 1963.
Miller, N. E., Clifton-Bligh, P., Nestel, P. J., and Whyte, H. M., Controlled clinical trial of a new bile acid-sequestering resin, colestipol, in the treatment of hypercholesterolemia, Med J. Aust., 2, 1223, 1973.
Levy, R. I., Fredrickson, D. S., Shulman, R., Bilheimer, D. W., Breslow, J. L., Stone, N. J., Lux, S. E., Sloan, H. R., Krauss, R. M., and Herbert, P. N., Dietary and drug treatment of primary hyperlipoproteinemia, Intern. Med., 77, 267, 1972.
Trout, H. H., Ill, and Longmire, W. P., Jr., Long-term follow-up study of patients with congenital cystic dilatation of the common bile â\xoX,Am. J. Surg., 121, 68, 1971.
Oviedo, M. A., Volkmer, D., and Scanlon, E. F., Primary sclerosing cholangitis, Arch. Surg., 109, 747, 1974.
Warren, K. W., Athanassiades, S., and Monge, J. I., Primary sclerosing cholangitis: A study of forty-two cases, Am. J. Surg., Ill, 23, 1966.
Armstrong, A. R., King, E. J., and Harris, I., Phosphatase in obstructive jaundice, Can. Med. Assoc. J., 31, 14, 1934.
Klatskin, G., Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis: An unusual tumor with distinctive clinical and pathological features, Am. J. Med., 38, 241, 1965.
Popper, H., Cholestasis,,4«m J. Rev. Med., 19, 39, 1968.
Summerskill, W. H. J., The syndrome of benign recurrent cholestasis, Am. J. Med., 38, 298, 1965.
Ruymann, F. B., Takeuchi, A., and Boyce, H. W., Idiopathic, recurrent cholestasis, Pediatrics, 45, 812, 1970.
Rubin, E., Schaffner, F., and Popper, H., Primary biliary cirrhosis: Chronic non-suppurative destructive cholangitis, Am. J. Pathol., 46, 387, 1965.
Klatskin, G., and Kantor, F. S., Mitochondrial antibody in primary biliary cirrhosis and other diseases, Ann. Intern. Med., 77, 533, 1972.
Foulk, W. T., Baggenstoss, A. H., and Butt, H. R., Primary biliary cirrhosis: Reevaluation by clinical and histologic study of 49 cases, Gastroenterology, 47, 354, 1964.
Paronetto, F., Schaffner, F., and Popper, H., Immunocytochemical and serologic observations in primary biliary cirrhosis, W. Engl J. Med., 271, 1123, 1964.
Walker, J. G., Doniach, D., Roitt, I. M., and Sherlock, S., Serological tests in diagnosis of primary biliary cirrhosis, Lancet, 1, 827, 1965.
Galbraith, R. M., Smith, M., Mackenzie, R. M., Tee, D. E., Doniach, D., and Williams, R., High prevalence of seroimmunologic abnormalities in relatives of patients with active chronic hepatitis or primary biliary cirrhosis, N. Engl. J. Med., 290, 63, 1974.
Sherlock, S., and Scheuer, P. J., The presentation and diagnosis of 100 patients with primary biliary cirrhosis, N. Engl J. Med., 289, 674, 1973.
Fox, R. A., Scheuer, P. J., and Sherlock, S., Asymptomatic primary biliary cirrhosis, Gut, 14, 444, 1973.
Stanley, N. N., Fox, R. A., Whimster, W. F., Sherlock, S., and James, D. G., Primary biliary cirrhosis or sarcoidosis-or both, N. Engl. J. Med., 287, 1282, 1972.
Alarcon-Segovia, D., Diaz-Jouanen, E., and Fishbein, E., Features of Sjogren’s syndrome in primary biliary cirrhosis, Arch. Intern. Med., 79, 31, 1973.
Fischer, J. A., and Schmid, M., Treatment of primary biliary cirrhosis with azathioprine, Lancet, 1, 421, 1967.
Ross, A., and Sherlock, S., A controlled trial of azathioprine in primary biliary cirrhosis, Gut, 12, 770, 1971.
Kantrowitz, P. A., Jones, W. A., Greenberger, N. J., and Isselbacher, K. J., Severe postoperative hyperbilirubinemia simulating obstructive jaundice, N. Engl. J. Med., 276, 591, 1967.
Strasberg, S. M., and Silver, M. D., Postoperative hepatogenic jaundice, Surg. Gynecol. Obstet., 132, 81, 1971.
LaMont, J. T., and Isselbacher, K. J., Postoperative jaundice, N. Engl. J. Med., 288, 305, 1973.
Rangel, D. M., Dinbar, A., Stevens, G. H., Cooper, R., and Fonkalsrud, E. W., The hepatic response to endotoxin shock: Hemodynamic and enzymatic observations, J. Surg. Res., 10, 181, 1970.
Durden, W. D., Jr., Siemsen, A. W., and Briggs, W. A., Exchange transfusions in the treatment of fulminant hepatitis and coma, Am. J. Gastroenterol., 51, 129, 1969.
Berger, R. L., Stanton, J. R., Liversage, R. M., Jr., McGoldrick, D. M., Graham, J. H., and Stohlman, F., Jr., Blood exchange in the treatment of hepatic coma, J. Am. Med. Assoc., 202, 267, 1967.
Parbhoo, S. P., Kennedy, J., James, I. M., Chalstrey, L. J., Ajdukiewicz, A., Brock, P. J., Xanalatos, C., Sayer, P., and Sherlock, S., Extracorporeal pig-liver perfusion in treatment of hepatic coma due to fulminant hepatitis, Lancet, 1, 659, 1971.
Hume, D. M., Gayle, W. E., Jr., and Williams, G. M., Cross circulation of patients in hepatic coma with baboon partners having human blood, Surg. Gynecol. Obstet., 128, 495, 1969.
Grunstein, H. S., Yriberri, J., and Posen, S., Calcitonin’s role, N. Engl. J. Med., 297, 401, 1977.
Mays, E. T., Complex penetrating hepatic wounds, Ann. Surg., 173, 421, 1971.
Yellin, A. E., Chaffee, C. B., and Donovan, A. J., Vascular isolation in treatment of juxtahepatic venous injuries, Arch. Surg., 102, 566, 1971.
Raines, D. R., Van Heertum, R. L., and Johnson, L. F., Intrahepatic hematoma: A complication of percutaneous liver biopsy, Gastroenterology, 67, 284, 1974.
Pack, G. T., and Molander, D. W., Metabolism before and after hepatic lobectomy for cancer: Studies in twenty-three patients, Arch. Surg., 80, 685, 1960.
Fortner, J. G., Shiu, M. H., Howland, W. S., Gaston, J. P., Kunlin, A., Kawano, N., Hattori, T., and Beattie, E. I., A new concept for hepatic lobectomy: Experimental studies and clinical application, Arch. Surg., 102, 312, 1971.
Almersjo, Ö., Bergmark, S., Hafstrom, L. O., and Olsson, R., Enzyme and functional changes after extensive liver resection in man, Ann. Surg., 169, 111, 1969.
Dubois, R. S., Rodgerson, D. O., Martineau, G., Schroter, G., Giles, G., Lilly, J., Halgrimson, C. G., Starzl, T. E., Sternlieb, I., and Scheinberg, I. H., Orthotopic liver transplantation for Wilson’s disease, Lancet, 1, 505, 1971.
Chávez-Peón, F., and Malt, R. A., Histocompatibility in survival of hepatic transplantations, Arch. Surg., 102, 505, 1971.
Evans, D. B., and Lehmann, H., Pseudocholinesterase activity in liver transplantation, Lancet, 1, 1040, 1971.
Beaudoin, J. G., Slapak, M., Phillips, M. J., Chandrasekan, A. K., and MacLean, L. D., Function of auxiliary liver allografts, Surg. Gynecol. Obstet., 130, 622, 1970.
Starzl, T. E., Porter, K. A., Brettschneider, L., Penn, I., Bell, P., Putnam, C. W., and McGuire, R. L., Clinical and pathologic observations after orthotopic transplantation of the human liver, Surg. Gynecol. Obstet., 128, 327, 1969.
Javitt, N. B., Shiu, M. H., and Fortner, J. G., Bile salt synthesis in transplanted human liver, Gastroenterology, 60, 405, 1971.
Williams, R., Calne, R. Y., Ansell, I. D., Ashby, B. S., Collum, P. A., Dawson, J. L., Eddleston, A. L. W. F., Evans, D. B., Flute, P. T., Herbertson, P. M., Joysey, V., McGregor, A. M. C., Millard, P. R., Murray-Lyon, I. M., Pena, J. R., Rake, M. O., and Sells, R. A., Liver transplantation in man. III. Studies of liver function, histology and immunosuppressive therapy, Br. Med. J., 3, 12, 1969.
Knill-Jones, R. P., Buckle, R. M., Parsons, V., Calne, R. Y., and Williams, R., Hypercalcemia and increased parathyroid-hormone activity in primary hepatoma, N. Engl. J. Med., 282, 704, 1970.
Conn, H. O., and Lindenmuth, W. W., Prophylactic portacaval anastomosis in cirrhotic patients with esophageal varices: Interim results, with suggestions for subsequent investigations, N. Engl. J. Med., 279, 725, 1968.
Resnick, R. H., Chalmers, T. C., Ishihara, A. M., Garceau, A. J., Callow, A. D., Schimmel, E. M., O’Hara, E. T., and the Boston Inter-Hospital Liver Group, A controlled study of the prophylactic portacaval shunt: A final report, Ann. Intern. Med., 70, 675, 1969.
Conn, H. O., Lindenmuth, W. W., May, C. J., and Ramsby, G. R., Prophylactic portacaval anastomosis: A tale of two studies, Medicine (Baltimore), 51, 27, 1972.
Hsu, K. Y., Portal systemic shunt for portal hypertension: Importance of bromsulphalein retention for prediction of survival, Ann. Surg., 175, 569, 1972.
Madding, G. F., Kennedy, P. A., and Sogemeier, E., Hepatic artery ligation for metastatic tumor in the liver, Am. J. Surg., 120, 95, 1970.
Kew, M., Bersohn, I., Seftel, H., and Kent, G., Liver damage in heatstroke, Am. J. Med., 49, 192, 1970.
Delores, S. J., Cady, A., West, M., Chomet, B., and Zimmerman, H. J., Primary carcinoma of the liver: Analysis of clinical and biochemical features of 80 cases, Am. J. Dig. Dis., 10, 657, 1965.
MacDonald, R., Primary carcinoma of the liver, Arch. Intern. Med., 99, 266, 1957.
Eppstein, S., Primary carcinoma of the liver, Am. J. Med. Sci., 247, 137, 1964.
Ihde, D. C., Sherlock, P., Winawer, S. J., and Fortner, J. G., Clinical manifestations of hepatoma: A review of 6 years’ experience at a cancer hospital, Am. J. Med., 56, 83, 1974.
Farrell, G. C., Joshua, D. E., Uren, R. F., Baird, P. J., Perkins, K. W., and Kronenberg, H., Androgen-induced hepatoma, Lancet, 1, 430, 1975.
Braunstein, H., Histochemical study of the enzymatic activity of human neoplasms. III. Structural-functional relationships in a hepatoma, Cancer, 19, 939, 1966.
Stitnimankarn, T., and Thakerngpol, K., Enzyme histochemical study of primary hepatic carcinoma in Thailand, Cancer, 24, 1064, 1969.
Pepler, W. J., and Theron, J. J., A histochemical study of some of the hydrolytic enzymes in malignant hepatoma of the South African Bantu, Cancer, 15, 855, 1962.
Warnock, M. L., and Reisman, R., Variant alkaline phosphatase in human hepatocellular cancer, Clin. Chim. Acta, 24, 5, 1969.
Higashino, K., Hashinosume, M., Kang, K.-Y., Takahashi, Y., and Yamamura, Y., Studies on a variant alkaline phosphatase in sera of patients with hepatocellular carcinoma, Clin. Chim. Acta, 40, 61, 1972.
Portugal, M. L., Azevedo, M. S., and Manso, C., Serum alpha-fetoprotein and variant alkaline phosphatase in human hepatocellular carcinoma, Int. J. Cancer, 6, 383, 1970.
Waxman, S., and Gilbert, H. S., A tumor-related vitamin B12 binding protein in adolescent hepatoma, N. Engl. J. Med., 289, 1053, 1973.
Talerman, A., and Magyar, E., Hepatocellular carcinoma presenting with pathologic fracture due to bone metastases, Cancer, 32, 1477, 1973.
Berndt, H., Screening for liver metastases, Digestion, 2, 354, 1969.
Kim, N. K., Yasmineh, W. G., Freier, E. F., Goldman, A. I., and Theologides, A., Value of alkaline phosphatase, 5’-nucleotidase, γ-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver, Clin. Chem., 23, 2034, 1977.
Uren, R. F., Hutcherson, R. J., Stephen, M. S., and Wong, J., Liver scanning in patients with suspected metastatic malignant disease, Med. J. Aust., 2, 477, 1976.
Fee, H. J., Prokop, E. K., Cameron, J. L., and Wagner, H. N., Jr., Liver scanning in patients with suspected abdominal tumor, J. Am. Med. Assoc., 230, 1675, 1974.
Castagna, J., Benfleld, J. R., Yamada, H., and Johnson, D. E., The reliability of liver scans and function tests in detecting metastases, Surg. Gynecol. Obstet., 134, 463, 1972.
Fenster, L. F., and Klatskin, G., Manifestations of metastatic tumors of the liver: A study of eighty-one patients subjected to needle biopsy, Am. J. Med., 31, 238, 1961.
Gollin, F. F., Sims, J. L., and Cameron, J. R., Liver scanning and liver function tests: A comparative study, J. Am. Med. Assoc., 187, 111, 1964.
Schaefer, J., and Schiff, L., Liver function test in metastatic tumor of the liver: Study of 100 cases, Gastroenterology, 49, 360, 1965.
Lange, C. E., Juhe, S., and Veltman, G., Uber das Auftreten von Angiosarkomen der Leber bei zwei Arbeitern der PVC-herstellenden Industrie, Dtsch. Med. Wochensehr., 99, 1598, 1974.
Falk, H., Creech, J. L., Heath, C. W., Johnson, M. N., and Key, M. M., Hepatic disease among workers at a vinyl chloride polymerization plant, J. Am. Med. Assoc., 230, 59, 1974.
Lee, F. I., and Harry, D. S., Angiosarcoma of the liver in a vinyl-chloride worker, Lancet, 1, 1316, 1974.
Makk, L., Personal communication, 1976.
Hagerstrand, I., Hepatic alkaline phosphatase activity in malignant diseases, Acta Pathol. Microbiol. Scand., 80, 284, 1972.
Axelsson, U., Hagerstrand, I., and Zettervall, O., Unusual pattern of hepatic alkaline phosphatase activity and renal carcinoma, Acta Med. Scand., 195, 223, 1974.
Brittain, R. S., Marchioro, T. L., Hermann, G., Waddell, W. R., and Starzl, T. E., Accidental hepatic artery ligation in humans, Am J. Surg., 107, 822, 1964.
Edgecombe, P. W., and Gardner, C., Accidental ligation of the hepatic artery and its treatment, Can. Med. Assoc. J., 64, 518, 1951.
Andreassen, M., Lindenberg, J., and Winkler, K., Peripheral ligation of the hepatic artery during surgery in noncirrhotic patients, Gut, 3, 167, 1962.
Smyth, N. P. D., and Teimourian, B., Resection of hepatic arterial aneurysm following intraperitoneal rupture: Report of a case with recovery, Ann. Surg., 160, 61, 1964.
Parker, R. G. F., Occlusion of the hepatic veins in man, Medicine (Baltimore), 38, 369, 1959.
Young, R. C., The Budd-Chiari syndrome caused by Aspergillus: Two patients with vascular invasion of the hepatic veins, Arch. Intern. Med., 124, 754, 1969.
Clain, D., Freston, J., Kreel, L., and Sherlock, S., Clinical diagnosis of the Budd-Chiari syndrome: A report of six cases, Am. J. Med., 43, 544, 1967.
Hoyumpa, A. M., Jr., Schiff, L., and Helfman, E. L., Budd-Chiari syndrome in women taking oral contraceptives, Am. J. Med., 50, 137, 1971.
Stuart, K. L., and Bras, G., Veno-occlusive disease of the liver, Q. J. Med., 26, 291, 1957.
Gupta, P. S., Gupta, G. D., and Sharma, M. L., Veno-occlusive disease of the liver, Br. Med. J., I, 1184, 1963.
Lorentz, K., Niemann, E., Jaspers, G., and Oltmanns, D., Enzyme in der menschlichen Galle. II, Mitteilung: Enzymgehalt von Leber und Blasengalle, Enzymol. Biol. Clin., 10, 528, 1969.
Price, C. P., Hill, P. G., and Sammons, H. G., The nature of the alkaline phosphatase of bile, J Clin. Pathol., 25, 149, 1972.
Allen, H., and Spellberg, M. A., Alkaline phosphatase in bile and urine, Arch. Intern. Med., 120, 667, 1967.
Bode, J. C., Zelder, O., and Neuberger, H. O., Effect of taurocholate, dehydrocholate and secretin on biliary output of alkaline phosphatase and GOT, Helv. Med. Acta, 37, 143, 1973.
Liedberg, G., The effect of insulin hypoglycemia on bile flow and composition, Acta Chir. Scand., 135, 325, 1969.
Smith, R. B., III, Conklin, E. F., and Porter, M. R., A five-year study of choledocholithiasis, Surg. Gynecol. Obstet., 116, 731, 1963.
Adams, J. D., and Haisten, A. S., Operative cholangiography: Its value in the unsuspected choledochal stone, Surg. Clin. North Am., 52, 333, 1972.
Saltzstein, E. C., Evani, S. V., and Mann, R. W., Routine operative cholangiography: Analysis of 506 consecutive cholecystectomies, Arch. Surg., 107, 289, 1973.
Gottfries, A., Bile acid conjugation of liver tissue from patients with acute cholecystitis, Scand. J. Gin. Lab. Invest., 21, 249, 1968.
Schmidt, F. R., and McCarthy, J. D., Variations in total serum bilirubin and alkaline phosphatase in the normal postoperative cholecystectomy course, Am. J. Surg., 124, 794, 1972.
Igini, J. P., and Fox, P. F., Spontaneous perforation of the common bile duct, Am. J. Surg., III, 745, 1966.
Hansen, R. C., Wasnich, R. D., DeVries, P. A., and Sunshine, P., Bile ascites in infancy: Diagnosis with 131I-rose bengal, J. Pediatr., 84, 719, 1974.
McCarthy, J. D., and Picazo, J. G., Bile peritonitis: Diagnosis and course, Am. J. Surg., 116, 664, 1968.
Stathakos, P., Fanska, R., Carbone, J. V., and Grodsky, G. M., Jaundice associated with peritoneal absorption of bilirubin, Gastorenterology, 59, 769, 1970.
Kowlessar, O. D., Haeffner, L. J., Riley, E. M., and Sleisenger, M. H., Comparative study of serum leucine aminopeptidase, 5’-nucleotidase and non-specific alkaline phosphatase in diseases affecting the pancreas, hepatobiliary tree and bone, Am. J. Med., 31, 231, 1961.
Tilney, N. L., Collins, J. J., Jr., and Wilson, R. E., Hemorrhagic pancreatitis: A fatal complication of renal transplantation, N. Engl. J. Med., 274, 1051, 1966.
Wense, V. G., Akute Pankreatitis und Ikterus, Zentralbl. Chirurg., 93, 1401, 1968.
Rasmussen, B. L., Hypothermic peritoneal dialysis in the treatment of acute experimental hemorrhagic pancreatitis, Am. J. Surg., 114, 716, 1967.
Albo, R., Silen, W., and Goldman, L., A critical clinical analysis of acute pancreatitis, Arch. Surg., 86, 1032, 1963.
Snape, W. J., Long, W. B., Trotman, B. W., Marin, G. A., and Czaja, A., Marked alkaline phosphatase elevation with partial common bile duct obstruction due to calcific pancreatitis, Gastroenterology, 70, 70, 1976.
Littenberg, G., Afroudakis, A., and Kaplowitz, N., The value of alkaline phosphatase (AP) as a marker for common bile duct (CBD) stenosis in alcoholic pancreatitis, Gastroenterology, 73, 1232, 1977 (abstract).
DiSant’Agnese, P. A., and Blanc, W. A., A distinctive type of biliary cirrhosis of the liver associated with cystic fibrosis of the pancreas: Recognition through signs of portal hypertension, Pediatrics, 18, 387, 1956.
Hsia, D. Y., Shih, L. Y., Justice, P., and O’Flynn, M. E., Serum-alkaline-phosphatase in cystic fibrosis of the pancreas (letter), Lancet, 1, 106, 1969.
Hosli, P., Personal communication, 1978.
Hosli, P., and Vogt, E., Reliable detection of cystic fibrosis in skin-derived fibroblast cultures, Hum. Genet., 41, 169, 1978.
Hosli, P., and Vogt, E., Cystic fibrosis: Leakage of lysosomal enzymes and of alkaline phosphatase into the extracellular space, Biochem. Biophys. Res. Commun., 79, 741, 1977.
Hosli, P., Erickson, R. P., and Vogt, E., Prospects for prenatal diagnosis of cystic fibrosis: Induction of biochemical abnormalities in fibroblasts from patients with cystic fibrosis by a urinary glycoprotein, Biochem. Biophys. Res. Commun., 73, 209, 1976.
Gullick, H. D., Carcinoma of the pancreas: A review and critical study of 100 cases, Medicine (Baltimore), 38, 47, 1959.
Warnes, T. W., Timperley, W. R., Hine, P., and Kay, G., Pancreatic alkaline phosphatase and a tumour variant, Gut, 13, 513, 1972.
Cha, C. J. M., Mastrofrancesco, B., Cha, S., and Randall, H. T., Electrophoretic patterns of alkaline phosphatase isoenzymes in human sera with abnormally high activity and an unusual band observed in the sera of patients with pancreatic cancer, Clin. Chem., 21, 1067, 1975.
Mann, J. R., Rayner, P. H. W., and Gourevitch, A., Insulinoma in childhood, Arch. Dis. Child., 44, 435, 1969.
Gjone, E., Fretheim, B., Nordoy, A., Jacobsen, C. D., and Elgjo, K., Intractable watery diarrhea, hypocalcemia and achlorhydria associated with pancreatic tumour containing gastric secretory inhibitor, Scand. J. Gastroenterol., 5, 401, 1970.
Lightman, S. L., and Bloom, S. R., Cure of insulin-dependent diabetes mellitus by removal of a glucagonoma, Br. Med. J., 1, 367, 1974.
Wilmer, H. A., Renal phosphatase: The correlation between the functional activity of the renal tubule and its phosphatase content, Arch. Pathol., 37, 227, 1944.
Bonting, S. L., Pollak, V. E., Muehrcke, R. C., and Kark, R. M., Quantitative histochemistry of the nephron. II. Alkaline phosphatase activity in man and other species, J. Clin. Invest., 39, 1372, 1960.
Holmgard, A., Quantitative analysis of enzymes in normal and diseased kidney tissue, Scand. J. Clin. Lab. Invest., 14, 1, 1962.
Wilmer, H. A., The disappearance of phosphatase from the hydronephrotic kidney, J. Exp. Med., 78, 225, 1943.
Spink, W. W., and Landeryou, M. J., Diminution in renal alkaline phosphatase in endotoxin shock, J. Clin. Invest., 39, 302, 1960.
Pollak, V. E., Bonting, S. L., Muehrcke, R. C., and Kark, R. M., Quantitative histochemistry of the nephron. IV. Alkaline phosphatase and lactic dehydrogenase activities in renal tubular disease, J. Clin. Invest., 39, 1386, 1960.
Pollak, V. E., Bonting, S. L., Muehrcke, R. C., and Kark, R. M., Quantitative histochemistry of the nephron. V. Alkaline phosphatase and lactic dehydrogenase activities in lupus nephritis, J. Gin. Invest., 39, 1394, 1960.
Braunstein, H., and Adelman, J. U., Histochemical study of the enzymatic activity of human neoplasms. II. Histogenesis of renal cell carcinoma, Cancer, 19, 935, 1966.
Manheimer, L. H., and Seligman, A. M., Improvement in methods for the histochemical demonstration of alkaline phosphatase and its use in a study of normal and neoplastic tissues, J. Natl. Cancer Inst., 9, 181, 1948.
Raab, W. P., Diagnostic value of urinary enzyme determinations, Clin. Chem., 18, 5, 1972.
Amador, E., Zimmermann, T. S., and Wacker, W. E. C., Urinary alkaline phosphatase activity. II. An analytical validation of the assay method, J. Am. Med. Assoc., 185, 953, 1963.
Hilliard, S. D., O’Donnell, J. F., and Schenker, S., On the nature of the inhibitor of urinary alkaline phosphatase, Clin. Chem., 11, 570, 1965.
Greenberg, W. V., and Temple, T. E., Paradoxical rise in urinary alkaline phosphatase activity during storage: Indirect evidence for a labile inhibitor, Am. J. Clin. Pathol., 37, 133, 1967.
Dmochowski, A., Sur les phosphatases de Furine, C. R. Soc. Biol., 113, 956, 1933.
Huggins, C., and Talalay, P., Sodium Phenolphthalein phosphate as a substrate for phosphatase tests, J. Biol. Chem., 159, 399, 1945.
Amador, E., Zimmerman, T. S., and Wacker, W. E. C., Urinary alkaline phosphatase activity. I. Elevated urinary LDH and alkaline phosphatase activities for the diagnosis of renal adenocarcinomas, J Am. Med. Assoc., 185, 775, 1963.
Wellwood, J. M., Ellis, B. G., Hall, J. H., Robinson, D. R., and Thompson, A. E., Early warning of rejection, Br. Med. J., 2, 261, 1973.
Garner, R. J., Serum alkaline phosphatase in cattle in health and disease, J. Comp. Pathol Ther., 62, 287, 1952.
Abul-Fadl, M. A. M., and Metwalli, O. M., Studies on certain urinary and blood serum enzymes in bilharziasis and their possible relation to bladder cancer in Egypt, Br. J. Cancer, 17, 137, 1963.
Butterworth, P. J., Moss, D. W., Pitkanen, E., and Pringle, A., Patterns of urinary excretion of alkaline phosphatase in acute renal failure, Clin. Chim. Acta, 11, 212, 1965.
Butterworth, P. J., Moss, D. W., Pitkanen, E., and Pringle, A., Some characteristics of alkaline phosphatase in human urine, Clin. Chim. Acta, 11, 220, 1965.
Szasz, G., Baranyai, P., Czirbesz, Z., and Csaki, P., Über die Enzymurie bei nephrotischem Syndrom, Klin. Wochenschr., 43, 783, 1965.
Gault, M. H., Oliver, J. A., Lang, C., Asghar, M. I., and Levy, S. W., Urinary enzymes in benign and malignant urinary tract disorders: Alkaline phosphatase and lactic acid dehydrogenase, Br. J. Urol, 39, 296, 1967.
Burgen, A. S. V., Urinary excretion of phosphatases in man, Lancet, 1, 329, 1947.
Dietz, A. A., and Hodges, L. K., Correlation of activities of the phosphatase of the urine and serum of normal and cirrhotic persons, Clin. Chim. Acta, 15, 393, 1967.
Dubach, Y. C., and Padlina, G., Aktivität der alkalischen Phosphatase im Urin, Klin. Wochenschr., 44, 180, 1966.
Werner, M., Heilbron, D. C., Maruhn, D., and Atoba, M., Patterns of urinary enzyme excretion in healthy subjects, Gin. Chim. Acta, 29, 437, 1970.
Hohenegger, M., and Kaiser, E., Tagesrhythmische Ausscheidung der Alkalischen Harnphos- phatase, Klin. Wochenschr., 45, 1252, 1967.
Miyao, M., Hasegawa, Y., Matsuda, H., Matsumura, I., and Imaoka, M., Urinary alkaline phosphatase level in children, Tokushima J. Exp. Med., 15, 65, 1968.
Bergström, K., Blomstrand, R., Magnusson, G., and Werner, B., Some laboratory data, including enzymatic observations, in human renal homotransplantation,, Acta Chir. Scand., 134, 467, 1968.
Ballantine, B., Wood, W. G., and Meffan, P. M., Sequential analysis of urinary enzymes in early diagnosis of parenchymal damage after renal homotransplantation, Br. Med. J., 2, 667, 1968.
Goldberg, W. M., Chakrabarti, S., and Filipich, R., Urinary lactic dehydrogenase, alkaline phosphatase and lysozyme studies in renal disease, Can. Med. Assoc. J., 94, 1264, 1966.
Amador, E., Dorfman, L. E., and Wacker, W. E. C., Urinary alkaline phosphatase and LDH activities in the differential diagnosis of renal disease, Ann. Intern. Med., 62, 30, 1965.
Butterworth, P. J., and Moss, D. W., Action of neuraminidase on human kidney alkaline phosphatase, Nature (London), 209, 805, 1966.
Maruna, R. F. L., Isoenzyme von Phosphomonoesterasen in Körperflüssigkeiten und Geweben: Untersuchungen von “sauren” und “alkalischen” Phosphatasen im Harn, Clin. Chim. Acta, 25, 133, 1969.
Zinner, G., and Ehrlich, H., Zur Problematik der verminderten alkalischen Serum Phosphatase, Z. Urol., 52, 707, 1959.
Zinner, G., and Ehrlich, H., Die alkalische Phosphatase in der klinischen und experimentellen Nierenpathologie, Z. Vitam., Horm. Ferment forsch., 72, 325, 1963.
Verrilli, R. A., Viek, N. F., and Uhlman, R. C., Studies of alkaline phosphatase in various pathological conditions of the kidney. II. Renal vascular and ureteral obstruction, J. Urol., 86, 525, 1961.
Ettinger, B., and Kolb, F. O., Inorganic phosphatase treatment of nephrolithasis, Am. J. Med., 55, 32, 1973.
Specht, E. E., Rickets following ureterosigmoidostomy and chronic hyperchloremia: A case report, J. Bone Joint Surg., 49A, 1422, 1967.
Urdaneta, L. F., Duffell, D., Cheevy, C. D., and Aust, J. B., Late development of primary carcinoma of the colon following ureterosigmoidostomy: Report of three cases and literature review, Ann. Surg., 164, 503, 1966.
Gyory, A., and Edwards, K. D. G., Renal tubular acidosis: A family with an autosomal dominant genetic defect in renal hydrogen ion transport, with proximal tubular and collecting duct dysfunction and increased metabolism of citrate and ammonia, Am. J. Med., 45, 43, 1968.
Randall, R. E., Jr., and Targgart, W. H., Familial renal tubular acidosis,, Ann Intern. Med., 54, 1108, 1961.
Seedat, Y. K., Some observations of renal tubular acidosis-A family study, S. Afr. Med. J., 38, 606, 1964.
Yaffe, S. J., Craig, J. M., and Fellers, F. X., Studies on renal enzymes in a patient with renal tubular acidosis, Am. J. Med., 29, 168, 1960.
Viek, N. F., Uhlman, R. C., and Verrilli, R. A., Studies on alkaline phosphatase in various pathological conditions of the kidney. 1. Renal injury, J. Urol., 85, 714, 1961.
Highman, B., Thompson, E. C., Roshe, J., and Altland, P. D., Serum alkaline phosphatase in dogs with experimental splenic and renal infarcts and with endocarditis, Proc. Exp. Biol. Med., 95, 109, 1957.
Fotino, S., Elevation of serum alkaline phosphatase in severe pyelonephritis and obstructive nephropathy, Nephron, 12, 197, 1974.
Case records of the Massachusetts General Hospital, Case 33-1970, N. Engl. J. Med., 283, 305, 1970.
Duggan, M. L., Acute renal infarction, J. Urol., 90, 669, 1963.
Case records of the Massachusetts General Hospital, Case 80-1961, N. Engl. J. Med., 265, 953, 1961.
Kiely, J. M., Hypernephroma-The internist’s tumor, Med. Clin. North Am., 50, 1067, 1966.
Walsh, P. N., and Kissane, J. M., Nonmetastatic hypernephroma with reversible hepatic dysfunction, Arch. Intern. Med., 122, 214, 1968.
Shipman, K. H., Downing, S. W., and Bradford, H. A., Hypernephroma presenting as fever of unknown origin associated with elevated serum alkaline phosphatase levels, Urol., 89, 160, 1963.
Linhart, P., Heilmann, K., and Weizel, A., Reversible Leberfunktionsstörung bei Patienten mit Hypernephrom, Dtsch. Med. Wochenschr., 96, 29, 1971.
Durocher, J. R., Alkaline phosphatase and hypernephroma (letter), N. Engl. J. Med., 281, 1369, 1969.
Pochedley, C., Suwansirikul, S., and Penzer, P., Renal-cell carcinoma with extrarenal manifestations in a 10-month-old child, Am. J. Dis. Child., 121, 528, 1971.
Kanis, J. A., Ernshaw, M., Heynen, G., Ledingham, J. G. G., Oliver, D. O., Russell, R. G. G., Woods, C. G., Franchimont, P., and Gaspar, S., Changes in histologic and biochemical indexes of bone turnover after bilateral nephrectomy in patients on hemodialysis, N. Engl. J. Med., 296, 1073, 1977.
Lopatkin, N. A., Lopukhin, Y. M., and Shemetov, V. D., Activity of certain enzymes in cadaver renal transplants, Int. Urol. Nephrol., 3, 61, 1971.
Ballantyne, B., Wood, W. G., and Meffan, P. M., Sequential analysis of urinary enzymes in early diagnosis of parenchymal damage after renal homotransplantation, Br. Med. J., 2, 667, 1968.
Maltry, E., Carcinoma of the bladder, J. Urol., 99, 165, 1968.
Gomori, G., Distribution of acid phosphatase in the tissues under normal and under pathological conditions, Arch. Pathol., 32, 189, 1941.
Rossi, F., Pescetto, G., and Reale, E., Enzymatic activities in human ontogenesis: First synoptic tables on histochemical research, J. Histochem. Cytochem., 5, 221, 1957.
Aso, Y., Hoshino, Y., Okada, K., Murahashi, I., and Takayasu, H., Histochemical changes of phosphatases in the prostatic gland, Invest. Urol., 6, 304, 1968.
Wachstein, M., and Meisel, E., The histochemical distribution of 5’-nucleotidase and unspecific alkaline phosphatase in the testicle of various species and in two human seminomas, J. Histochem., 2, 137, 1954.
Kirchheim, D., Gyorkey, F., Brandes, D., and Scott, W. W., Histochemistry of the normal hyperplastic and neoplastic human prostate glands, Invest. Urol., 1, 403, 1964.
Reis, J. L., The specificity of phosphomonesterase in human tissues, Biochem. J., 48, 548, 1951.
Gutman, E. B., Sproul, E. E., and Gutman, A. B., Significance of increased phosphatase activity of bone at the site of osteoplastic metastases secondary to carcinoma of the prostate gland, Am. J. Cancer, 28, 485, 1936.
Gutman, A. B., and Gutman, E. B., An “acid” phosphatase occurring in the serum of patients with metastasizing carcinoma of the prostate gland, J. Clin. Invest., 17, 473, 1938.
Robinson, J. N., Gutman, E. B., and Gutman, A. B., Clinical significance of increased serum “acid” phosphatase in patients with bone metastases secondary to prostatic carcinoma, J. Urol., 42, 602, 1939.
Woodard, H. Q., and Dean, A. L., The significance of phosphatase findings in carcinoma of the prostate, J. Urol., 57, 158, 1947.
Nesbit, R. M., and Baum, W. C., Serum phosphatase determinations in diagnosis of prostatic cancer: A review of 1,150 cases, J. Am. Med. Assoc., 145, 1321, 1951.
Wray, S., The significance of the blood acid and alkaline phosphatase values in cancer of the prostate, J Clin. Pathol., 9, 341, 1956.
Goldberg, D. M., and Ellis, G., An assessment of acid and alkaline phosphatase determinations in the diagnosis of prostatic cancer, J. Clin. Pathol., 26, 387, 1973.
Huggins, C., and Hodges, C. V., Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate, Cancer Res., 1, 293, 1941.
Huggins, C., Stevens, R. E., Jr., and Hodges, C. V., Studies on prostatic cancer. II. The effect of castration on advanced carcinoma of the prostate gland, Arch. Surg., 43, 209, 1941.
Morales, A., Burr, R. C., and Bruce, A. W., The use of radioactive phosphorus to treat bone pain in metastatic carcinoma of the prostate, Can. Med. Assoc. J., 103, 372, 1970.
Tong, E. C., Parathormone and 32P therapy in prostatic cancer with bone metastases, Radiology, 98, 343, 1971.
Murphy, G. P., Reynoso, G., Schoonees, R., Gailani, S., Bourke, R., Kenny, G. M., Mirand, E. A., and Schalch, D. S., Hypophysectomy and adrenalectomy for disseminated prostatic carcinoma, J. Urol., 105, 817, 1971.
Prout, G. R., Jr., Chemical tests in the diagnosis of prostatic carcinoma, J. Am. Med. Assoc., 209, 1699, 1969.
Bisson, J., Vickers, M., Jr., and Fagan, W. T., Jr., Bone scan: In clinical perspective, J. Urol., 777, 665, 1974.
Kontturi, M., and Sotaniemi, E., Effect of oestrogen on liver function of prostatic cancer patients, Br. Med. J., 4, 204, 1969.
Kothari, L. K., and Mishra, P., Histochemical changes in the testis and epididymis after vasectomy, Int. J. Fertil., 18, 119, 1973.
Skinner, D. G., Leadbetter, W. F., and Wilkins, E. W., Jr., The surgical management of testis tumors metastatic to the lung: A report of 10 cases with subsequent resection of from one to seven pulmonary metastases, J. Urol., 105, 275, 1971.
Kennedy, B. J., Mithramycin therapy in advanced testicular neoplasms, Cancer, 26, 755, 1970.
Short, M., and Coe, J. I., Malignant interstitial cell tumor of the testis: A case report, J. Urol., 89, 851, 1963.
Wilson, J. M., and Woodhead, D. M., Prognostic and therapeutic implications of urinary gonadotrophin levels in the management of testicular neoplasia, J. Urol, 108, 754, 1972.
Haahr, J., and Sparrevohn, S., Epididymitis in children: A brief review together with reports of six cases, Acta Paediatr. Scand., 60, 216, 1971.
Hall, J. E., Alkaline phosphatase in human endometrium, Am. J. Obstet. Gynecol., 60, 212, 1950.
McKay, D. G., Hertig, A. T., Bardawil, W. A., and Velardo, J. T., Histochemical observations on the endometrium. I. Normal endometrium, Obstet. Gynecol., 8, 22, 1956.
Gautray, J. P., Couderc, P., Colomb, M. C., Sibut, H., and Maurel, C., Biochemical determination of alkaline phosphatase activity in the human endometrium during the menstrual cycle, Am. J. Obstet. Gynecol., 104, 818, 1969.
Wilson, E. W., Alkaline phosphatase in pre-decidual cells of the human endometrium, J. Reprod. Fertil., 19, 567, 1969.
Flowers, C. E., Jr., Vorys, N., Stevens, V., Miller, A. T., and Jensen, L., The effects of suppression of menstruation with ethynodiol diacetate upon the pituitary, ovary and endometrium, Am. J. Obstet. Gynecol., 96, 784, 1966.
Grant, E. C. G., and Pryse-Davies, J., Effect of oral contraceptives on depressive mood changes and on endometrial monoamine oxidase and phosphatase, Br. Med. J., 3, 111, 1968.
Fishman, W. H., Mitchell, G. W., Jr., Borges, P. R. F., Ladue, K. T., and Hayashi, M., Enzy- morphology of cancer of the cervix: β-Glucuronidase, a-naphthyl esterase, alkaline phosphatase, acid phosphatase, and reduced diphosphopyridine nucleotide (DPNH) diaphorase, Cancer, 16, 118, 1963.
Jones, H. W., McKusick, V. A., Harper, P. S., and Wuu, K. D., George Otto Gey (1899–1970): The HeLa cell and a reappraisal of its origin, Obstet. Gynecol., 38, 945, 1971.
Atkinson, W. B., and Gusberg, S. B., Histochemical studies on abnormal growth of human endometrium. 1. Alkaline phosphatase in hyperplasia and adenocarcinoma, Cancer, 7, 248, 1948.
Gross, S. J., Histochemistry of normal and abnormal endometrium: Non-specific esterase, acid phosphatase and alkaline phosphatase, Am. J. Obstet. Gynecol., 88, 647, 1964.
Pfleiderer, A., Jr., and Braun, R., Histochemical study of endometrial carcinoma: Systemic investigations of enzymes in infiltrating regions of tumors and interrelations with infiltrated connective tissue, Am. J. Obstet. Gynecol., 104, 823, 1969.
McKay, D. G., Hertig, A. T., Adams, E. C., and Danziger, S., Histochemical observations on the germ cells of human embryos, Anat. Ree. 77 7, 201, 1953.
Busse, O., Beiträge zur Kenntnis der Stoffwechselvorgange in der menschlichen Placenta, Z. Physiol. Chem., 242, 171, 1936.
Lobel, B. D., Deane, H. W., and Romney, S. L., Enzymic histochemistry of the villous portion of the human placenta from six weeks of gestation to term, Am. J. Obstet. Gynecol., 83, 295, 1962.
Ahmed, Z., and King, E. J., Purification of placental alkaline phosphatase, Biochim. Biophys. Acta, 40, 320, 1960.
Ghosh, N. K., and Fishman, W. H., Purification and properties of molecular weight variants of human placental alkaline phosphatase, Biochem. J., 108, 779, 1968.
Harkness, D. R., Studies on human placental alkaline phosphatase. I. Purification and crystallization, Arch. Biochem. Biophys., 126, 503, 1968.
Sussman, H. H., and Gottlieb, A. J., Human placental alkaline phosphatase. II. Molecular and subunit properties of the enzyme, Biochim. Biophys. Acta, 194, 170, 1969.
France, J. T., and Liggins, G. C., Placental sulfatase deficiency, J. Clin. Endocrinol. Metab., 29, 138, 1969.
France, J. T., Seddon, R. J., and Liggins, G. C., A study of pregnancy with low estrogen production due to placental sulfatase deficiency, J. Gin. Endocrinol., 36, 1, 1973.
France, J. T., Personal communication, 1976.
Coryn, G., Les phosphatases du sang dans le diagnostic des affections osseuses, J. Chir. (Paris), 33, 213, 1934.
Cayla, J., and Fabre, P., La phosphatase sérique pendant la gestation, C. R. Soc. Biol., 120, 748, 1935.
Bodansky, M., Campbell, K., and Ball, E., Changes in serum calcium, inorganic phosphate, and phosphatase activity in the pregnant woman, Am. J. Clin. Pathol., 9, 36, 1939.
deKerleau, J. C., and Cayla, J., Recherches sur la phosphatasémie sérique au cours de la grossesse, Gynecol. Obstet., 39, 112, 1939.
Ebbs, J. H., and Scott, W. A., Blood phosphatase in pregnancy an indication of twins: Preliminary report, Am. J. Obstet. Gynecol., 39, 1043, 1940.
Young, J., King, E. J., Wood, E., and Wootton, I. D. P., A nutritional survey among pregnant women, J. Obstet. Gynaecol. Br. Commonw., 53, 251, 1946.
Hoch, H., Marrack, J. R., Ruse, R. H., and Hoch, R., The composition of the blood of women during pregnancy and after delivery, J. Obstet. Gynaecol. Brit. Commonw., 55, 1, 1948.
Beck, E., and Clark, L. C., Jr., Plasma alkaline phosphatase. II. Normative data for pregnancy, Am. J. Obstet. Gynecol., 60, 731, 1950.
Klees, E., and Frenzel, G., Zur Problematik der Erhöhung der alkalischen Serumphosphatase Aktivität unter der Geburt und im Wochenbett, Klin. Wochenschr., 38, 540, 1960.
Miller, Z. B., Naor, E., Milkovich, L., and Schmidt, W. M., Serum levels of cystine amino- peptidase, leucine aminopeptidase, and alkaline phosphatase in single and twin pregnancies, Obstet. Gynecol., 24, 707, 1964.
Shaper, A. G., and Patel, H. A., Heat-stable alkaline phosphatase of pregnancy in African women, Am. J. Clin. Pathol., 51, 393, 1969.
Szekely, J. A., and Fritzsch, W., Serumaktivität der alkalischen und sauren Phosphatase in der Schwangerschaft und unter der Geburt, Zentralbl. Gynaekol., 92, 1209, 1970.
Iyengar, L., and Srikantia, S. G., Serum alkaline phosphatase in pregnancy, Am. J. Clin. Nutr., 23, 68, 1970.
Elliott, J. R., and O’Kell, R. T., Normal clinical chemical values for pregnant women at term, Gin. Chem., 17, 156, 1971.
Thorling, L., Jaundice in pregnancy: A clinical study, Acta. Med. Scand. Suppl., 302, 1, 1955.
Aguzzi, F., and Maierna, M., Significato della determinazione delle attività enzimatiche fosfatasi alcalina, leucinaminopeptidasi e 7-glutamiltranspeptidasi in gravidanze, Lab, III, 1, 1976.
McMaster, Y., Tennant, R., Clubb, J. S., Neale, F. C., and Posen, S., The mechanism of the elevation of serum alkaline phosphatase in pregnancy, J. Obstet. Gynaecol. Br. Commonw., 71, 135, 1964.
Watson, D., Weston, W., and Porter, R., Plasma alkaline phosphatases in normal and abnormal terminal pregnancy, Enzymol. Biol. Gin., 5, 25, 1965.
Meade, B. W., and Rosalki, S. B., The origin of increased maternal serum enzyme activity in pregnancy and labor, J. Obstet. Gynaecol. Br. Commonw., 70, 862, 1963.
Boyer, S. H., Alkaline phosphatase in human sera and placentae, Science, 134, 1002, 1961.
Boyer, S. H., Human organ alkaline phosphatases: Discrimination by several means including starch gel electrophoresis of antienzyme-enzyme supernatant fluids, Ann. N. Y. Acad. Sci., 103, 938, 1963.
Robinson, J. C., Pierce, J. E., and Blumberg, B. S., The serum alkaline phosphatase of pregnancy, Am. J. Obstet. Gynecol., 94, 559, 1966.
Sussman, H. H., Bowman, M., and Lewis, J. L., Jr., Placental alkaline phosphatase in maternal serum during normal and abnormal pregnancy, Nature (London), 218, 359, 1968.
Ghosh, N. K., and Fishman, W. H., Characterization of placental isoenzyme of alkaline phosphatase in human pregnancy serum, Can. J. Biochem., 47, 147, 1969.
Lee, A. B., and Lewis, P. L., Alkaline phosphatase activity in normal and toxemic pregnancies, Am. J. Obstet. Gynecol., 87, 1071, 1963.
Birkett, D. J., Done, J., Neale, F. C., and Posen, S., Serum alkaline phosphatase in pregnancy: An immunological study, Br. Med. J., 1, 1210, 1966.
Sadovsky, E., and Zuckerman, H., An alkaline phosphatase specific to normal pregnancy, Obstet. Gynecol., 26, 211, 1965.
Neale, F. C., Clubb, J. S., Hotchkis, D., and Posen, S., Heat stability of human placental alkaline phosphatase, J. Clin. Pathol., 18, 359, 1965.
Fishman, W. H., Anstiss, C. L., Prinik, M. P., and Driscoll, S. G., The exponential growth curve for the placental isoenzyme of alkaline phosphatase in sera of normal and diabetic pregnancies, Am J. Clin. Pathol, 60, 353, 1973.
Curzen, P., and Morris, I., Serum alkaline phosphatase in the hypertensive disorders of pregnancy, J. Obstet. Gynaecol Br. Commonw., 72, 397, 1965.
Baycu, T., Alkaline phosphatase activity of the placenta in normal and pathologic pregnancy, Ankara Univ. Tip Fak. Mecm., 18, 511, 1965 (cited from Chem. Abstr., 65, 4346d, 1966 ).
Bagga, O. P., Mullick, V. D., Madan, P., and Dewan, S., Total serum alkaline phosphatase and its isoenzymes in normal and toxemic pregnancies, Am. J. Obstet. Gynecol., 104, 850, 1969.
Chaudhuri, S. K., Role of nutrition in the etiology of toxemia of pregnancy, Am. J. Obstet. Gynecol, 110, 46, 1971.
Levine, B., and Wood, W. A., Jr., Maternal serum alkaline phosphatase and placental function, Am J. Obstet. Gynecol., 91, 961, 1965.
Biswas, S., Hindocha, P., and Dewhurst, C. J., Human chorionic somatomammotrophin in serum and urine in various stages of pregnancy: Its correlation with enzymes and oestrogens, J. Endocrinol., 54, 251, 1972.
Spellacy, W. N., Teoh, E. S., Buhi, W. C., Birk, S. A., and McCreary, S. A., Value of human chorionic somatomammotropin in managing high-risk pregnancies, Am. J. Obstet. Gynecol., 109, 588, 1971.
Leroux, M., and Perry, W. F., Serum heat-stable alkaline phosphatase in pregnancy, Am. J. Obstet. Gynecol., 108, 235, 1970.
Elder, M. G., Serum heat stable alkaline phosphatase levels and their relationship to urinary oestrogen output and fetal and placental weights, J. Obstet. Gynaecol Br. Commonw., 78, 123, 1971.
Curzen, P., and Hensel, H., Serum heat-stable alkaline phosphatase and its relation to urinary oestrogen output, fetal and placental weight, and placental enzyme content, J. Obstet. Gynaecol Br. Commonw., 79, 23, 1972.
Petrucco, O. M., Cellier, K., and Fishtail, A., Diagnosis of intrauterine fetal growth retardation by serial serum oxytocinase, urinary oestrogen and serum heat stable alkaline phosphatase (HSAP) estimations in uncomplicated and hypertensive pregnancies, J. Obstet. Gynaecol Br. Commonw., 80, 499, 1973.
Hunter, R. J., Pinkerton, J. H. M., and Johnston, H., Serum placental alkaline phosphatase in normal pregnancy and preeclampsia, Obstet. Gynecol, 36, 536, 1970.
Levine, B., Ely, C. W., Jr., and Wood, W. A., Jr., Assessment of fetal maturity by maternal serum alkaline phosphatase analysis, Am. J. Obstet. Gynecol., 96, 1155, 1966.
Messer, R. H., Heat-stable alkaline phosphatase as an index of placental function, Am. J. Obstet. Gynecol., 98, 459, 1967.
Slotnick, E. A., Alkaline phosphatase as a measure of fetal maturity, J. Am. Osteopath. Assoc., 68, 180, 1968.
Quigley, G. J., Richards, R. T., and Shier, K. J., Heat-stable alkaline phosphatase: A parameter of placental function, Am J. Obstet. Gynecol., 106, 340, 1970.
Houston, R. G., Biochemical determination of fetal maturity, Med. Lab., 24, 159, 1971.
Nadler, H. L., and Gerbie, A. B., Enzymes in noncultured amniotic fluid cells, Am. J. Obstet. Gynecol, 103, 710, 1969.
Stenback, F., and Ojala, A., Determination of fetal maturity by means of amniotic fluid cells, Acta Cytoi., 14, 439, 1970.
Wolf, P. L., Bloch, D., and Tsudaka, T., Biochemical profile of amniotic fluid to assess fetal maturity, Gin. Chem., 16, 843, 1970.
Geyer, H., and Schneider, I., Enzyme im Fruchtwasser, Z. Klin. Chem., 8, 141, 1970.
Geyer, H., Die Herkunft der Fruchtwasser-Enzyme, Z. Klin. Chem., 8, 145, 1970.
Galerne, D., Jouanel, P., Baudon, J., and Dastugue, G., De quelques activités enzymatiques (amylasique, phosphatasique acide et alcaline et 7-glutamyl transpeptidasique) du liquide amniotique dans l’espèce humaine, C. R. Soc. Biol., 164, 319, 1970.
Kellen, J. A., Kaspar, D., and Leung, K. K. Y., Alkaline phosphatases from amniotic fluid, Enzymol. Biol. Clin., 11, 429, 1970.
Hahnemann, N., and Sorensen, S. A., Studies on alkaline phosphatase in amniotic fluid, Acta Obstet. Gynecol. Scand. Suppl., 29, 15, 1974.
Moore, H. C., Recurrent jaundice of pregnancy, Lancet, 2, 57, 1963.
Simmons, S. C., Recurrent jaundice of pregnancy, Lancet, 2, 60, 1963.
Calandra, S., Cristini, G., and Zeneroli, M. L., Enzimi plasmatici in corso di nefropatia ed ittero in gravidanza, Minerva Ginecol., 20, 1852, 1968.
Wójcicka, J., and Chojnowska, I., Wplyw wewnatrzwatrobowej cholestazy przebiegajacej z zoltaczka na sklad bialek surowicy kobiet ciezarnych, Ginekal. Pol., 40, 1293, 1969.
Kahl, M. E., Fred, H. L., Brown, H., and Davis, J. S., Acute fatty liver of pregnancy, Arch. Intern. Med., 113, 63, 1964.
Reyes, H., Gonzalez, M. C., Ribalta, J., Aburto, H., Matus, C., Schramm, G., Katz, R., and Medina, E., Prevalence of intrahepatic cholestasis of pregnancy in Chile, Ann. Intern. Med., 88, 4S I, 1978.
Biswas, S., and Hindocha, P., Serum heat labile alkaline phosphatase activity during pregnancy, Clin. Chim. Acta, 38, 455, 1972.
Haemmerli, V. P., and Wyss, H. I., Recurrent intrahepatic cholestasis of pregnancy, Medicine (Baltimore), 46, 299, 1967.
Wood, E. E., A case of acute fatty liver of pregnancy, J. Obstet. Gynaecol. Br. Commonw., 77, 337, 1970.
Bur, G. E., Hertig, A. T., McKay, D. G., and Adams, E. C., Histochemical aspects of hydatidi- form mole and choriocarcinoma, Obstet. Gynaecol., 19, 156, 1962.
Cohen, J. D., and Utiger, R. D., Metastatic choriocarcinoma associated with hyperthyroidism, J. Gin. Endocrinol. Metab., 30, 423, 1970.
Bark, C. J., Artifactual elevations of serum alkaline phosphatase following albumin infusions, Am. J. Clin. Pathol., 52, 466, 1969.
Mackie, J. A., Jr., Arvan, D. A., Mullen, J. L., Jr., and Rawnsley, H. M., Elevated serum alkaline phosphatase levels after the administration of certain preparations of human albumin, Am. J. Surg., 121, 57, 1971.
Wilkins, D. T., Albumin-induced elevation of alkaline phosphatase (letter), J. Am. Med. Assoc., 275, 486, 1971.
Schiffner, J. H., Artificially elevated serum alkaline phosphatase (letter), N. Engl. J. Med., 282, 631, 1970.
Stocks, A. E., and Martin, F. I. R., Pituitary function in haemochromatosis, Am. J. Med., 45, 839, 1968.
Selenkow, H. A., Tyler, H. R., Matson, D. D., and Nelson, D. H., Hypopituitarism due to hypothalamic sarcoidosis, Am. J. Med. Sci., 238, 456, 1959.
Shealy, C. N., Kahana, L., Engel, F. L., and McPherson, H. T., Hypothalamic-pituitary sarcoidosis: A report on four patients, one with prolonged remission of diabetes insipidus following steroid therapy, Am. J. Med., 30, 46, 1961.
Rabin, D., Spitz, I., Bercovici, B., Bell, J., Laufer, A., Benveniste, R., and Polishuk, W., Isolated deficiency of follicle-stimulating hormone: Clinical and laboratory features, N. Engl. J. Med., 287, 1313, 1972.
Odell, W. D., Isolated deficiencies of anterior pituitary hormones: Symptoms and diagnosis, J. Am. Med. Assoc., 197, 1006, 1966.
Raben, M. S., Growth hormone (concluded). 2. Clinical use of human growth hormone, N. Engl. J. Med., 266, 82, 1962.
Reinfrank, R. F., and Nichols, F. L., Hypogonadotrophic hypogonadism in the Laurence- Moon syndrome, J. Clin. Endocrinol. Metab., 24, 48, 1964.
Riggs, B. L., Randall, R. V., Wahner, H. W., Jowsey, J., Kelley, P. J., and Singh, M., The nature of the metabolic bone disorder in acromegaly, J. Clin. Endocrinol. Metab., 34, 911, 1972.
Gordon, D. A., Hill, F. M., and Ezrin, C., Acromegaly: A review of 100 cases, Can. Med. Assoc. J., 87, 1106, 1962.
Sotos, J. F., Dodge, P. R., Muirhead, D., Crawford, J. D., and Talbot, N. B., Cerebral gigantism in childhood: A syndrome of excessively rapid growth with acromegalic features and a nonprogressive neurologic disorder, N. Engl. J. Med., 271, 109, 1964.
Cohen, M. I., Cerebral gigantism in childhood (letter), N. Engl. J. Med., 271, 635, 1964.
Milunsky, A., Cowie, V. A., and Donoghue, E. C., Cerebral gigantism in childhood: A report of two cases and a review of the literature, Pediatrics, 40, 395, 1967.
Ott, J. E., and Robinson, A., Cerebral gigantism, Am. J. Dis. Child., 117, 357, 1969.
Cassar, J., and Joseph, S., Alkaline phosphatase levels in thyroid disease, Clin. Chim. Acta, 23, 33, 1969.
Langer, B., Les troubles du métabolisme osseux dans l’hyperthyroidie, Praxis, 56, 1018, 1967.
Green, W., Wessler, S., and Avioli, L. V., Management of juvenile hyperthyroidism, J. Am. Med. Assoc., 213, 1652, 1970.
Huther, K. J., and Scholz, H. R., Die Serumaktivitâten der alkalischen Phosphatase und der Transaminasen bei Schilddriisen-iiberfunktion, Dtsch. Med. Wochenschr., 95, 498, 1970.
Hackenberg, K., Reinwein, D., Franken, F. H., Bach, I., and Irmscher, K., Alkalische Phosphatase und 7-Glutamyl-Transpeptidase bei Hyperthyreosen unter thyreostatischer Behand- lung, Acta Endocrinol. Suppl., 152, 83, 1971 (abstract).
Epstein, F. H., Freedman, L. R., and Levitin, H., Hypercalcemia, nephrocalcinosis and reversible renal insufficiency associated with hyperthyroidism, N. Engl. J. Med., 258, 782, 1958.
Parfitt, A. M., and Dent, C. E., Hyperthyroidism and hypercalcaemia, Q. J. Med., 39, 171, 1970.
Wilkin, T. J., Isles, T. E., Peterson, C. R., Crooks, J., and Swanson-Beck, J., Post-thyroidectomy hypocalcaemia: A feature of the operation or the thyroid disorder?, Lancet 1, 621, 1977.
Richter, J., and Ohlen, J., Hyperthyreose and die Isoenzyme der alkalischen Phosphatase, Dtsch. Med. Wochenschr., 96, 195, 1971.
Gerlach, U., Paul, L., and Latzel, H., Isoenzyme der alkalischen Phosphatase bei Hyperthyreose, Enzymol. Biol. Clin., 11, 251, 1970.
Greenberger, N. J., Milligan, F. D., DeGroot, L. J., and Isselbacher, K. J., Jaundice and thyrotoxicosis in the absence of congestive heart failure: A study of four cases, Am. J. Med., 36, 840, 1964.
Fedotin, M. S., and Lefer, L. G., Liver disease caused by propylthiouracil, Arch. Inter. Med., 135, 319, 1975.
Richter, J., Ohlen, J., Pause, H., and Pabst, H. W., The effect of methimazole treatment on alkaline phosphatase in hyperthyroidism, Scand. J. Clin. Invest., 27, 116, 1971.
Chertow, B. S., Motto, G. S., and Shah, J. H., A biochemical profile of abnormalities in hypo-thyroidism, Am. J. Clin. Pathol., 61, 785, 1974.
Posen, S., Unpublished.
Kleerekoper, M., Basten, A., Penny, R., and Posen, S., Idiopathic hypoparathyroidism with primary ovarian failure: Report of a case with detailed immunological studies, Arch. Intern. Med., 134, 944, 1974.
Chaykin, L. B., Frame, B., and Sigler, J. W., Spondylitis: A clue to hypoparathyroidism, Ann Intern. Med., 70, 995, 1969.
Morse, W. I., Cochrane, W. A., and Landrigan, P. L., Familial hypoparathyroidism with pernicious anemia, steatorrhea and adrenocortical insufficiency, N. Engl. J. Med., 264, 1021, 1961.
Kunin, A. S., Mackay, B. R., Burns, S. L., and Halberstam, M. J., The syndrome of hypo- parathyroidism and adrenocortical insufficiency, a possible sequel of hepatitis: Case report and review of the literature, Am. J. Med., 34, 856, 1963.
Nichols, F. L., Holdsworth, D. E., and Reinfrank, R. F., Familial hypocalcaemia, latent tetany and calcification of the basal ganglia: Report of a kindred, Am. J. Med., 30, 518, 1961.
Rodriguez, H. J., Villareal, H., Jr., Klahr, S., and Slatopolsky, E., Pseudohypoparathyroidism Type II: Restoration of normal renal responsiveness to parathyroid hormone by calcium administration, J. Clin. Endocrinol. Metab., 39, 693, 1974.
O’Neal, L. W., Pathologic anatomy in Cushing’s syndrome, Ann. Surg., 160, 860, 1964.
O’Riordan, J. L. H., Blanshard, G. P., Moxham, A., and Nabarro, J. D. N., Corticotrophin- secreting carcinomas, Q. J. Med., 35, 137, 1966.
Liddle, G. W., Nicholson, W. E., Island, D. P., Orth, D. N., Abe, K., and Lowder, S. C., Clinical and laboratory studies of ectopic humoral syndromes, Recent Prog. Horm. Res., 25, 283, 1969.
Orth, D. N., and Liddle, G. W., Results of treatment in 108 patients with Cushing’s syndrome, N. Engl. J. Med., 285, 243, 1971.
Hutter, A. M., Jr., and Kayhoe, D. E., Adrenal cortical carcinoma: Clinical features of 138 patients, Am. J. Med., 41, 572, 1966.
Nichols, F., Bower, B., Williams, H., and Martin, R., Adrenocortical carcinoma in the adult: Re-emphasis and new aspects, Abstract, Meeting of the Endocrine Society, Chicago, June 20-22 1966, p 107.
Iannaccone, A., Gabrilove, J. L., Brahms, S. A., and Soffer, L. J., Osteoporosis in Cushing’s syndrome, Ann. Intern. Med., 52, 570, 1960.
Haas, H. G., Canary, J. J., Kyle, L. H., Meyer, R. J., and Schaaf, M., Skeletal calcium retention in osteoporosis and in osteomalacia, J. Clin. Endocrinol. Metab., 23, 605, 1963.
Mertz, D. P., Über die Wirkung von Prednison und Testosteron auf die Aktivität der alkalischen Serumphosphatase, Z. Klin. Med., 155, 329, 1958.
Irvine, W. J., and Barnes, E. W., Adrenocortical insufficiency, Clin. Endocrinol. Metab., 1, 549, 1972.
Bongiovanni, A. M., and Root, A. W., The adrenogenital syndrome, N. Engl. J. Med., 268, 1283, 1342, 1391, 1963.
Brook, C. G. D., Zachman, M., Prader, A., and Mürset, G., Experience with long-term therapy in congenital adrenal hyperplasia, J. Pediatr., 85, 12, 1974.
Earll, J. M., Newman, S. G., and DiRaimondo, V. C., Bilateral testicular tumors in untreated congenital adrenocortical hyperplasia, J. Am. Med. Assoc., 209, 937, 1969.
Fore, W. W., Bledsoe, T., Weber, D. M., Akers, R., and Brooks, R. T., Jr., Cortisol production by testicular tumors in adrenogenital syndrome, Arch. Intern. Med., 130, 59, 1972.
Posner, J. B., and Jacobs, D. R., Isolated analdosteronism. 1. Clinical entity, with manifestations of persistent hyperkalemia, periodic paralysis, salt losing tendency, and acidosis, Metabolism, 13, 513, 1964.
Marieb, N. J., Melby, J. C., and Lyall, S. S., Isolated hypoaldosteronism associated with idiopathic hypoparathyroidism, Arch. Intern. Med., 134, 424, 1974.
Kutscher, W., and Wust, H., Nebennierenrinde und alkalische Phosphatasen, Z. Physiol. Chem., 273, 235, 1942.
Waters, M. D., and Summer, G. K., Prednisolone induction of alkaline phosphatase inhuman skin fibroblasts, Biochim. Biophys. Acta, 177, 650, 1969.
Cox, R. P., and McLeod, C. M., Hormonal induction of alkaline phosphatase in human cells in tissue culture, Nature (London), 190, 85, 1961.
Moog, F., Etzler, M. E., and Grey, R. D., The differentiation of alkaline phosphatase in the small intestine, Ann. N. Y. Acad. Sci., 166, 447, 1969.
Hugon, J. S., Charuel, C., and Laurendeau, D., Circadian rhythm of alkaline phosphatase activity in the Golgi zone of mouse duodenal enterocytes, Histochemie, 35, 263, 1973.
Highman, B., Maling, H. M., and Thompson, E. C., Serum transaminase and alkaline phosphatase levels after large doses of norepinephrine and epinephrine in dogs, Am. J. Physiol., 196, 436, 1959.
Gifford, R. W., Kvale, W. F., Mäher, F. T., Roth, G. M., and Priestley, J. T., Clinical features, diagnosis and treatment of pheochromocytoma: A review of 76 cases, Mayo Gin. Proc., 39, 281, 1964.
Sheps, S. G., Tyce, G. M., Flock, E. V., and Maher, F. T., Current experience in the diagnosis of pheochromocytoma, Circulation, 34, 473, 1966.
Sipple, J. H., The association of pheochromocytoma with carcinoma of the thyroid gland, Am. J. Med., 31, 163, 1961.
Minno, A. M., Bennett, W. A., and Kvale, W. F., Pheochromocytoma: A study of 15 cases diagnosed at autopsy, N. Engl. J. Med., 251, 959, 1954.
James, R. E., Baker, H. L., Jr., and Scanlon, P. W., The roentgenologic aspects of metastatic pheochromocytoma, Am. J. Roentgenol., 775, 783, 1972.
Paloyan, E., Scanu, A., Straus, F. H., Pickleman, J. R., and Paloyan, D., Familial pheochromocytoma, medullary thyroid carcinoma, and parathyroid adenomas, J. Am. Med. Assoc., 214, 1443, 1970.
Swinton, N. W., Jr., Clerkin, E. P., and Flint, L. D., Hypercalcemia and familial pheochromocytoma: Correction after adrenalectomy, Ann. Intern. Med., 76, 455, 1972.
Brackett, N. C., Jr., Koppel, M., Randall, R. E., Jr., and Nixon, W. P., Hyperplasia of the juxtaglomerular complex with secondary aldosteronism without hypertension (Bartter’s syndrome), Am. J. Med., 44, 803, 1968.
Arant, B. S., Brackett, N. C., Jr., Young, R. B., and Still, W. J. S., Case studies of siblings with juxtaglomerular hyperplasia and secondary aldosteronism with severe azotemia and renal rickets-Bartter’s syndrome or disease?, Pediatrics, 46, 344, 1970.
White, M. G., Bartter’s syndrome: A manifestation of renal tubular defects, Arch. Intern. Med., 129, 41, 1972.
Conn, J. W., Cohen, E. L., Lucas, C. P., McDonald, W. J., Mayor, G. H., Blough, W. M., Eve- land, W. C., Bookstein, J. J., and Lapides, J., Primary reninism: Hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors, Arch. Intern. Med., 130, 682, 1972.
Blackard, W. G., Garcia, A. R., and Brown, C. L., Effect of streptozotocin on qualitative aspects of plasma insulin in a patient with a malignant islet cell tumor, J. Clin. Endocrinol., 31, 215, 1970.
Belfiore, F., Romeo, F., Furno, C., and LoVecchio, L., L’attivita fosfatasica del siero nel diabete mellito, Metabolismo, 4, 359, 1968.
Goldberg, D. M., Martin, J. V., and Knight, A. H., Elevation of serum alkaline phosphatase activity and related enzymes in diabetes mellitus, Clin. Biochem., 10, 8, 1977.
Frankel, J. J., Ashbury, Jr., C. E., and Baker, L. A., Hepatic insufficiency and cirrhosis in diabetes mellitus, Arch. Intern. Med., 86, 376, 1950.
Bogoch, A., Casselman, W. G. B., Kaplan, A., and Bockus, H. L., Studies of hepatic function in diabetes mellitus, portal cirrhosis and other liver diseases: A correlation of clinical biochemical and liver needle biopsy findings, Am. J. Med., 18, 354, 1955.
Camerini-Davalos, R., Marble, A., and Muench, H., Liver function in diabetes millitus, N. Engl. J. Med., 266, 1349, 1962.
Bronstein, H. D., Kantrowitz, P. A., and Schaffner, F., Marked enlargement of the liver and transient ascites associated with the treatment of diabetic acidosis, N. Engl. J. Med., 261, 1314, 1959.
Caspary, W. F., Winckler, K., and Creutzfeldt, W., Intestinal brush border enzyme activity in juvenile and maturity onset diabetes mellitus,Diabetologia, 10, 353, 1974.
Humphery, T. J., Posen, S., and Casey, J. H., Klinefelter’s syndrome: Experiences with 24 patients, Med. J. Aust., 2, 779, 1976.
Jackson, A. W., Muldal, S., Ockey, C. H., and O’Connor, P. J., Carcinoma of male breast in association with Klinefelter syndrome,Br. Med. J., 7, 223, 1965.
Robson, M. C., Santiago, Q., and Huang, T. W., Bilateral carcinoma of the breast in a patient with Klinefelter’s syndrome, J. Clin. Endocrinol., 28, 897, 1968.
Brown, D. M., Jowsey, J., and Bradford, D. S., Osteoporosis in ovarian dysgenesis, J. Pediatr., 84, 816, 1914.
Elliott, G. A., Sandler, A., and Rabinowitz, D., Gonadal dysgenesis in three sisters, J. Clin. Endocrinol. Metab., 19, 995, 1959.
Espiner, E. A., Veale, A. M. O., Sands, V. E., and Fitzgerald, P. H., Familial syndrome of streak gonads and normal male karyotype in five phenotypic females, N. Engl. J. Med., 283, 6, 1970.
Meyerson, L., and Gwinup, G., Turner’s syndrome in the male, Arch. Intern. Med., 116, 125, 1965.
Zeuthen, E., Nielsen, J., and Yde, H., XYY males found in a general male population: Cytogenetic and physical examination, Her editas, 74, 283, 1973.
Gutman, A. B., and Gutman, E. B., Adult phosphatase levels in prepubertal rhesus prostatic tissue after testosterone propionate, Proc. Soc. Exp. Biol. Med., 41, 211, 1939.
Pritchard, J. E., Fibrous dysplasia of the bones, Am. J. Clin. Sci., 222, 313, 1951.
Liu, N., Grumbach, M. M., deNapoli, R. A., and Moroshima, A., Prevalence of electroen- cephalographic abnormalities in idiopathic precocious puberty and premature pubarche: Bearing on pathogenesis and neuroendocrine regulation of puberty, J. Clin. Endocrinol. Metab., 25, 1296, 1965.
Hung, W., Blizzard, R. M., Migeon, C. J., Comacho, A. M., and Nyhan, W. L., Precocious puberty in a boy with hepatoma and circulating gonadotropin, Pediatr., 63, 895, 1963.
Kosenow, W., Feil, G., von Torne, H. V., Bierich, J. R., and Apostolakis, M., Sexuelle Frühreife durch primäres Leberkarcinom: “Hepatogenitales Syndrom,” Monatschr. Kinderheilkd., 115, 37, 1967.
Ferrier, P., Shepard, T. H., and Smith, E. K., Growth disturbances and values for hormone excretion in various forms of precocious sexual development, Pediatrics, 28, 258, 1961.
Sigurjonsdottir, T. J., and Hayles, A. B., Precocious puberty: A report of 96 cases, Am. J. Dis. Child., 115, 309, 1968.
Mandell, G. H., Floyd, W. S., Cohn, S. L., and Goodman, P. A., Luteoma of pregnancy: A pseudotumor, Am. J. Clin. Pathol., 47, 148, 1967.
Landow, H., Kabat, E. A., and Newman, W., Distribution of alkaline phosphatase in normal and in neoplastic tissues of the nervous system: A histochemical study, Arch. Neurol. Psychiatry,48,51%, 1942.
Nandy, K., and Bourne, G. H., Alkaline phosphatases in brain and spinal cord, Nature (London), 200, 1216, 1963.
Buckell, M., and Robertson, M. C., Enzyme studies in cerebral tumors, Br. J. Cancer, 19, 83, 1965.
Klingon, G. H., The Guillain-Barré syndrome associated with cancer, Cancer, 18, 157, 1965.
Preswick, G., and Jeremy, D., Subclinical polyneuropathy in renal insufficiency, Lancet, 2, 731, 1964.
Benson, M. D., Cohen, A. S., Brandt, K. D., and Cathcart, E. S., Neuropathy, M components, and amyloid, Lancet, 1, 10, 1975.
Austin, J. H., Observations on the syndrome of hypertrophic neuritis (the hypertrophic interstitial radiculo-neuropathies), Medicine (Baltimore), 35, 187, 1956.
Knill-Jones, R. P., Goodwill, C. J., Dayan, A. D., and Williams, R., Peripheral neuropathy in chronic liver disease: Clinical, electrodiagnostic, and nerve biopsy findings, J. Neurol. Neuro- surg. Psychiatry, 35, 22, 1972.
Kaplan, M. S., Opitz, J. M., and Gösset, F. R., Noonan’s syndrome: A case with elevated serum alkaline phosphatase levels and malignant schwannoma of the left forearm, Am. J. Dis. Child., 116, 359, 1968.
Guzowski, K., and Knobloch, J., Disorders of the nervous system: Activity of acid and alkaline phosphatase in the cerebrospinal fluid, Arch. Neurol., 8, 105, 1963.
Colling, K., and Rossiter, R., Alkaline and acid phosphatase in cerebrospinal fluid, Can. J. Res., 28, 56, 1950.
Bobrowski, H., Zachowanie sie alkalicznej fosfatazy: W plynie mozgowo-rdzeniowym I W surowicy; W niektorych zespolach neuroinfekcyjnych, Prze. Epidemiol., 25, 141, 1971.
Palva, T., Raunio, V., and Nousiainen, R., Alkaline and acid phosphatase activity in post- auricular skin and cholesteatoma epithelium,,Acta Otolaryngol., 75, 221, 1973.
Carpenter, R. R., and Petersdorf, R. G., The clinical spectrum of bacterial meningitis, Am. J. Med., 33, 262, 1962.
Duma, R. J., Rosenblum, W. I., McGhee, R. F., Jones, M. M., and Nelson, E. C., Primary amoebic meningoencephalitis caused by Naegleria: Two new cases, response to Amphotericin B, and a review, Ann. Intern. Med., 74, 923, 1971.
Ainslie, J. D., Stumpf, P. K., and Francis, T., Serum alkaline phosphatase in monkeys and man during poliomyelitis, Am. J. Hyg., 53, 58, 1951.
Whedon, G. D., and Shorr, E., Metabolic studies in paralytic acute anterior poliomyelitis. II. Alterations in calcium and phosphorus metabolism, J. Clin. Invest., 36, 966, 1957.
Fredrickson, D. S., and Sloan, H. R., Sphingomyelin lipidoses: Niemann-Pick disease, in: The Metabolic Basis of Inherited Disease, 3rd ed. ( Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., eds.), McGraw-Hill, New York, 1972.
Crocker, A. C., and Farber, S., Niemann-Pick disease: A review of eighteen patients, Medicine (Baltimore), 37, 1, 1958.
Fischer, M. H., Fortune, J. S., and Gerritsen, T., Serum proteins and alkaline phosphatase levels in patients with tuberous sclerosis, Am. J. Ment. Defic., 78, 674, 1974.
Golji, H., Tuberous sclerosis and renal neoplasms, J. Urol., 85, 919, 1961.
Hernberg, C. A., and Edgren, W., Looser-Milkman syndrome with neurofibromatosis Recklinghausen and general decalcification of the skeleton, Acta Med. Scand., 136, 26, 1949.
Saville, P. D., Nassim, J. R., Stevenson, F. H., Mulligan, L., and Carey, M., Osteomalacia in Von Recklinghausen’s neurofibromatosis: Metabolic study of a case, Br. Med. J., 1, 1311, 1955.
Levene, L. J., Bone changes in neurofibromatosis: Report of a case with coincidental osteitis deformans and review of the literature, Arch. Intern. Med., 103, 570, 1959.
Barron, K. D., and Bernsohn, J., Brain esterases and phosphatases in multiple sclerosis, Ann. N. Y. Acad. Sci., 122, 369, 1965.
Jones, H. H., Jones, H. H., Jr., and Bunch, L. D., Biochemical studies in multiple sclerosis, Ann. Intern. Med., 33, 831, 1950.
Papiha, S. S., and Roberts, D. F., Serum alkaline phosphatase in patients with multiple sclerosis, Clin. Genet., 7, 11, 1975.
Bistrian, B. R., Blackburn, G. L., and Stanbury, J. B., Metabolic aspects of a protein-sparing modified fast in the dietary management of Prader-Willi obesity, N. Engl. J. Med., 296, 11A, 1977.
Dukes, M. N. G., Meyler’s Side Effects of Drugs: A Survey of Unwanted Effects of Drugs Reported in 1972–1975, Vol. 8, Excerpta Medica, Amsterdam, 1975.
Klatskin, G., Toxic and drug-induced hepatitis, in: Diseases of the Liver, 4th ed. ( Schiff, L., ed.), Lippincott, Philadelphia, 1975.
American Hospital Formulary Service, American Society of Hospital Pharmacists, Washington, D.C. (inserts 1959-1977).
Schwartz, M. K., Interferences in diagnostic biochemical procedures, Adv. Clin. Chem., 16, 1, 1973.
Tietz, N. W., Fundamentals of Clinical Chemistry, W. B. Saunders, Philadelphia, 1970.
Martin, E. W., Hazards of Medication: A Manual on Drug Interactions, Incompatibilities, Con-traindications and Adverse Effects, Lippincott, Philadelphia, 1971.
Garb, S., Clinical Guide to Undesirable Drug Interactions and Interferences, Springer, New York, 1971.
Iber, F. L., Cholestasis, Postgrad. Med., 41, 30, 1967.
Bauer, J. D., Ackermann, P. G., and Toro, G., Brady’s Clinical Laboratory Methods, 7th ed., C. V. Mosby, St. Louis, 1968.
Hussar, D. A., The new drugs of 1971, Am. J. Pharm., 144, 5, 1972.
Goodman, L. S., and Gilman, A., The Pharmacological Basis of Therapeutics, 5th ed., Mac- millan, New York, 1975.
Thienes, C. H., and Haley, T. J., Clinical Toxicology, 5th ed., Lea and Febiger, Philadelphia, 1972.
Wilkinson, J. H., An Introduction to Diagnostic Enzymology, Arnold, London, 1962.
Batsakis, J. G., and Briere, R. O., Interpretive Enzymology, C. C. Thomas, Springfield, Illinois, 1967.
O’Kell, R. T., Knepper, L., Mantzey, L., and Elliott, J. R., Effect of drugs on results of laboratory tests, Clin. Chem., 18, 1039, 1972.
Philip, Jr., J. R., Untoward effects of antimicrobial drugs: Prevention and control, Postgrad. Med., 50, 193, 1971.
Lubran, M., The effects of drugs on laboratory values, Med. Clin. North Am., 53, 211, 1969.
Schoental, R., Liver disease and “natural” hepatotoxins, Bull. W. H. O., 29, 823, 1963.
Jadin-Starodoubsky, A., Delwaide, P. A., Penders, C., Collard, J., and Heusghem, A., Psychotropic drug interferences with clinical chemistry determination, in: Reference Values in Human Chemistry (Siest, G., ed.), p. 299, S. Karger, Basel, 1973.
Caraway, W. T., Chemical and diagnostic specificity of laboratory tests: Effect of hemolysis, lipemia, anticoagulants, medications, contaminants, and other variables, Am. J. Clin. Pathol., 37, 445, 1962.
Caraway, W. T., and Kammeyer, C. W., Chemical interference by drugs and other substances with chemical laboratory test procedures, Clin. Chim. Acta, 41, 395, 1972.
Gutman, A. B., Drug reactions characterized by cholestasis associated with intrahepatic biliary tract obstruction, Am. J. Med., 23, 841, 1957.
Schaffner, F., Iatrogenic jaundice, J. Am. Med. Assoc., 174, 1690, 1960.
Demetriou, J. A., Drews, P. A., and Gin, J. B., Enzymes, in: Clinical Chemistry: Principles and Techniques, 2nd ed. (Henry, R. J., Cannon, D. C., and Winkelman, J. W., eds.), p. 815, Harper and Row, Hagerstown, Maryland, 1974.
Christian, D. G., Drug interference with laboratory blood chemistry determinations, Am. J. Clin. Pathol., 54, 118, 1970.
Meyler, L., and Herxheimer, A., Side effects of drugs, Vol. 5, in: Excerpta Medica Foundation, Morton and Co., The Hague, 1968.
Anonymous, FDA drug efficacy study implementation,Drug Ther., 7, 81, 1971.
Stewart, M. J., and Simpson, E., Prognosis in paracetamol self-poisoning: The use of plasma paracetamol concentration in a region without a poisoning treatment center, Ann. Clin. Biochem., 10, 173, 1973.
Davidson, D. G. D., and Eastham, W. N., Acute liver necrosis following overdose of paracetamol, Br. Med. J., 2, 497, 1966.
Proudfoot, A. T., and Wright, N., Acute paracetamol poisoning, Br. Med. J., 3, 551, 1970.
Field, J. B., and Tyroler, S.A., Clinical evaluation of acetohexamide, a new sulfonylurea agent, Diabetes, 12, 252, 1963.
Montgomery, D. A. D., Rastogi, G. K., and Weaver, J. A., Acetohexamide in treatment of diabetes mellitus, Br. Med. J., 1, 868, 1964.
Lee-Jones, M., Serum transaminase during salicylate therapy, Br. Med. J., 2, 772, 1971.
Seaman, W. E., and Plötz, P. H., Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers, Arthritis Rheum., 19, 155, 1976.
Tulpule, P. G., Madhavan, T. V., and Gopalan, C., Effect of feeding aflatoxin to young monkeys, Lancet, 1, 962, 1964.
Beermann, B., Ericsson, J. L. E., Hellstrom, K., Wengle, B., and Werner, B., Transient cholestasis during treatment with ajmaline and chronic xanthomatous cholestasis after administration of ajmaline, methyltestosterone and ethinylestradiol Acta Med. Scand., 190, 241, 1971.
Simmons, F., Feldman, B., and Gerety, D., Granulomatous hepatitis in a patient receiving allopurinol, Gastroenterology, 62, 101, 1972.
Schwab, R. S., Poskanzer, D. C., England, A. C., Jr., and Young, R. R., Amantadine in Parkinson’s disease, J. Am. Med. Assoc., 222, 792, 1972.
Scholz, H., and Meyer, W., Akute Agranulozytose und intrahepatische Cholestase nach Amino- phenazon bei einem 12-jährigen Mädchen,Dsch. Gesundheitswes., 27, 205, 1972.
Paine, D., Fatal hepatic necrosis associated with aminosalicylic acid: Review of the literature and report of a case, J. Am. Med Assoc.. 167, 285, 1958.
Watts, C., and Griffiths, H. E. D., Biochemical studies of severe liver damage caused by p-aminosalicylic acid, Gastroenterology, 46, 311, 1964.
Weinstein, L., and Weinstein, A. J., The pathophysiology and pathoanatomy of reactions to antimicrobial agents, Adv. Intern. Med., 19, 109, 1974.
Spingarn, C. L., Edelman, M. H., Waye, J. D., Donoso, E., and Gregory, C., Observations on the treatment of Schistosomiasis mansoni with antimony dimercaptosuccinaté (TWSb), Am. J. Med., 34, 477, 1963.
Hanger, F. M., Jr., and Gutman, A. B., Post-arsphenamine jaundice apparently due to obstruction of the intrahepatic biliary tract, J. Am. Med. Assoc., 115, 263, 1940.
Haskell, C. M., Canellos, G. P., Leventhal, B. G., Carbone, P. P., Block, J. B., Serpick, A. A., and Selawry, O. S., L-Asparaginase: Therapeutic and toxic effects in patients with neoplastic disease, N. Engl. J. Med., 281, 1028, 1969.
Haxhe, J. J., Alexandre, G. P. J., and Kestens, P. J., The effect of Imuran and Azaserine on liver function tests in the dog, Arch. Intern. Pharmacodyn., 168, 366, 1967.
Tsuchiya, K., Causation of ouch ouch disease (itai-itai byo): An introductory review. Part I. Nature of the disease, Keijo J. Med., 18, 181, 1969.
Kazantzis, G., Flynn, G. V., Spowage, J. S., and Trott, D. G., Renal tubular malfunction and pulmonary emphysema in cadmium pigment workers, Q. J. Med., 32, 165, 1963.
Payne, R. J., and Brand, S. N., The toxicity of intravenously used marihuana, J. Am. Med. Assoc., 233, 351, 1975.
Drug Commentary Evaluation of a new antituberculous agent: Capreomycin sulfate (Capastat sulfate), J. Am. Med. Assoc., 223, 179, 1973.
Browning, R. H., and Donnerberg, R. L., Capreomycin: Experiences in patient acceptance and toxicity, Ann. N. Y. Acad. Sci., 135, 1057, 1966.
Ramsay, I. D., Carbamazepine-induced jaundice, Br. Med. J., 4, 155, 1967.
Nelson, R. S., Hepatitis due to carbarsone, J. Am. Med. Assoc., 166, 764, 1956.
Wilson, F. M., Delamaric, J., Lanter, C. B., and Lerner, A. M., Anicteric carbenicillin hepatitis: Eight episodes in four patients, J. Am. Med. Assoc., 232, 818, 1975.
Rees, K. R., and Sinha, K. P., Blood enzymes in liver injury, J. Pathol. Bacteriol., 80, 297, 1960.
Illig, H., Cholostatische Hepatose nach Carbutamid-Behandlung,Med. Welt, 48, 2543, 1961.
Pauvert, R., Benhamou, J. P., Oudea, P., Berthelot, P., and Viallet, A., Hepatite cholestatique due a la carbutamide,Presse Med., 77, 1287, 1963.
Danzinger, R. G., Hofmann, A. F., Schoenfield, L. J., and Thistle, J. L., Dissolution of cholesterol gallstones by chenodeoxycholic acid, N. Engl. J. Med., 286, 1, 1972.
Bell, G. D., Whitney, B., and Dowling, R. H., Gallstone dissolution in man using chenodeoxycholic acid, Lancet, 2, 1213, 1972.
Thistle, J. L., and Hofmann, A. F., Efficacy and specificity of chenodeoxycholic acid therapy for dissolving gallstones, N. Engl. J. Med., 289, 655, 1973.
Foot, E. C., and Thomson, W. B., Cholestatic jaundice after chloramphenicol, Br. Med. J., 7, 403, 1963.
Amromin, G. D., Deliman, R. M., and Shanbrom, E., Liver damage after chemotherapy for leukemia and lymphoma, Gastroenterology, 42, 401, 1962.
Lo, K. J., Eastwood, I. R., and Eidelman, S., Cholestatic jaundice associated with chlordi- azepoxide hydrochloride (Librium) therapy: Report of a case and review of the literature, Am. J. Dig. Dis., 12, 845, 1967.
Schroeder, H. G., Acute and delayed chloroform poisoning, Br. J. Anaesth., 37, 972, 1965.
Bogusz, M., Influence of insecticides on the activity of some enzymes contained in human serum, Clin. Chim. Acta, 19, 367, 1968.
Sell, J. L., and Davison, K. L., Changes in the activities of hepatic microsomal enzymes caused by DDT and dieldrin, Fed. Proc. Fed. Am. Soc. Exp. Biol., 32, 2003, 1973.
Drerup, A. L., Alexander, W. A., Lumb, G. D., Cummins, A. J., and Clark, G. M., Jaundice occurring in a patient treated with chlorothiazide, N. Engl. J. Med., 259, 534, 1958.
Shay, H., and Siplet, H., Study of chlorpromazine jaundice, its mechanism and prevention: Special reference to serum alkaline phosphatase and glutamic oxalacetic transaminase, Gastroenterology, 32, 571, 1957.
Whitfield, A. G. W., Chlorpromazine jaundice, Br. Med. J., 1, 784, 1955.
Brown, G., Zoidis, J., and Spring, M., Hepatic damage during chlorpropamide therapy, J Am. Med. Assoc., 170, 2085, 1959.
Reichel, J., Goldberg, S. B., Ellenberg, M., and Schaffner, F., Intrahepatic cholestasis following administration of chlorpropamide, Am. J. Med., 28, 654, 1960.
Ruddock, D. G. S., and Hoenig, J., Chlorprothixene and obstructive jaundice, Br. Med. J., 7, 231, 1973.
Tesarova, O., Molcan, J., and Jenca, G., Zmeny hepatalnej funkcie v priebehu liecby chlorpro- thixenom,y4ci. Nerv. Super., 5, 204, 1963.
Leppex, M. H., Wolfe, C. K., Zimmerman, H. J., Caldwell, E. R., Spies, H. W., and Dowling, H. F., Effect of large doses of aureomycin on human liver, Arch. Intern. Med., 88, 271, 1951.
Bateman, J. C., Barberio, J. R., Cromer, J. K., and Klopp, C. T., Investigation of mechanism and type of jaundice produced by large doses of parenterally administed Aureomycin, Antibiot. Chemother. (Washington,D. C.). 3, 1, 1953.
Jones, M. F., and Caldwell, J. R., Acute hemorrhagic pancreatitis associated with administration of chlorthalidone, N. Engl. J. Med., 267, 1029, 1962.
Pascale, L. R., Waldstein, S. S., Engbring, G., Dubin, A., and Szanto, P. B., Chromium intoxication: With special reference to hepatic injury, J. Am. Med. Assoc., 149, 1385, 1952.
Sternlieb, P., and Eisman, S. H., Toxic hepatitis and agranulocytosis due to cinchopen, Ann. Intern. Med., 47, 826, 1957.
Babior, B. M., and Davidson, C. S., Hepatitis: Drug or viral (editorial), Am. J. Med., 41, 491, 1966.
Elmore, M., Rissing, J. P., Rink, L., and Brooks, G. F., Clindamycin-associated hepatotoxicity, Am. J. Med., 57, 627, 1974.
Phillips, I., Clinical uses and control of rifampicin and clindamycin, J. Clin. Pathol., 24, 410, 1971.
Orgain, E. S., Bogdonoff, M. D., and Cain, C., Clofibrate and androsterone effect on serum lipids, Arch. Intern. Med., 119, 80, 1967.
Gifford, R. W., Clonidine in the management of mild hypertension in twenty-two patients, Cleveland Gin. Q., 36, 173, 1969.
Carr, A. A., Colchicine toxicity, Arch. Intern. Med., 115, 29, 1965.
Fellin, R., Briani, G., Balestrieri, P., Baggio, G., Baiocchi, M. R., and Crepaldi, G., Long-term effects of colestipol (U-26,597A) on plasma lipids in familial type II hyperbetalipoproteinemia, Atherosclerosis, 22, 431, 1975.
Holtzman, N. A., Elliott, D. A., and Heller, R. H., Copper intoxication: Report of a case with observations on ceruloplasmin, N. Engl. J. Med., 275, 347, 1966.
French, A. B., Barss, T. P., Fairlie, C. S., Bengle, A. L., Jones, C. M., Linton, R. R., and Beecher, H. K., Metabolic effects of anesthesia in man. V. A comparison of the effects of ether and cyclopropane anesthesia on the abnormal liver, Ann. Surg., 135, 145, 1952.
Bennike, K. A., and Hagelsten, J. O., Cyclopropane hepatitis: A Danish disease?, Lancet, 2, 255, 1964.
Chyatte, S. B., and Basmajian, J. V., Dantrolene sodium: Long-term effects in severe spasticity, Arch. Phys. Med. Rehabil., 54, 311, 1973.
Schneider, R., and Mitchell, D., Dantrolene hepatitis, J. Am. Med. Assoc., 235, 1590, 1976.
Powell, W. J., Koch-Weser, J., and Williams, R. A., Lethal hepatic necrosis after therapy with imipramine and desipramine, J. Am. Med. Assoc., 206, 642, 1968.
Kopelman, H., Robertson, M. H., Sanders, P. G., and Ash, I., The Epping jaundice, Br. Med. J., 7, 514, 1966.
Millikan, L. E., and Harrell, E. R., Drug reactions to the sulfones, Arch. Dermatol, 102, 220, 1970.
Breinstrup, H., and Sogaard-Andersen, J., Cholestasis intrahepatica efter griseofulvinbehan- dling, Ugeskr. Laeg., 128, 145, 1966.
Kasich, A. M., Chlorazepate dipotassium in the treatment of anxiety associated with chronic gastrointestinal disease, Curr. Ther. Res., 15, 83, 1973.
Harinasuta, U., and Zimmerman, H. J., Diphenylhydantoin sodium hepatitis, J. Am. Med. Assoc., 203, 1015, 1968.
Weedon, A. P., Diphenylhydantoin sensitivity: A syndrome resembling infectious mononucleosis with a morbilliform rash and cholestatic hepatitis, Aust. N. Z. J. Med., 5, 561, 1975.
Eisen, H. J., and Ginsberg, A. L., Disulfiram hepatotoxicity, Ann. Intern. Med., 83, 673, 1975.
Hochman, R., and Robbins, J. J., Jaundice due to ectylurea,7V. Engl. J. Med., 259, 1, 1958.
Cooksley, W. G. E., and Powell, L. W., Erythromycin jaundice: Diagnosis by an in vitro challenge test,Aust. N. Z. J. Med., 7, 291, 1977.
Mäher, J. F., and Schreiner, G. E., Studies on ethacrynic acid in patients with refractory edema, Ann. Intern. Med., 62, 15, 1965.
Datey, K. K., Deshmukh, S. N., Dalvi, S. P., and Purandare, N. M., Hepatocellular damage with ethacrynic acid,Br. Med. J., 3, 152, 1967.
Clarke, G. B. M., and O’Hea, A. J., Chronic pulmonary tuberculosis: Treatment with ethionamide combined with cycloserine or Oxytetracycline,Br Med. J., 1, 636, 1961.
Conn, H. O., Binder, H. J., and Orr, H. D., Ethionamide-induced hepatitis: A review with a report of an additional case, Am. Rev. Respir. Dis., 90, 542, 1964.
Steer, P. L., Marks, M. I., Klite, P. D., and Eickhoff, T. C., 5-Fluorocytosine: An oral antifungal compound; A report on clinical and laboratory experience, Ann. Intern. Med., 76, 15, 1972.
Naeim, F., Copper, P. H., and Semion, A. A., Peliosis hepatis: Possible etiologic role of anabolic steroids, Arch. Pathol., 95, 284, 1973.
Bartholomew, A. A., and Holt, N. F., A long-acting phenothiazine (fluphenazine enanthate): A preliminary communication, Med. J. Aust., 1, 12, 1966.
Klein, J. O., Eickhoff, T. C., and Finland, M., Gentamicin: Activity in vitro and observations in 26 patients, Am. J. Med. Set, 248, 528, 1964.
Bhatia, S. K., Hadden, D. R., Montgomery, D. A. D., and Weaver, J. A., Glibenclamide therapy in diabetes mellitus, Br. Med. J., 2, 570, 1970.
Anonymous, Glibenclamide: A review, Drugs, 1, 116, 1971.
Greenwood, R. H., Prunty, F. T. G., and Silver, J., Osteomalacia after prolonged glutethimide administration, Br. Med. J., 1, 643, 1973.
Ghisolfi, J., Rumeau, J.-L., Rolland, M., and Dalous, A., Syndrome cholestatique secondaire a une chrysotherapie massive, Arch. Fr. Pediatr., 29, 1097, 1972.
Simon, N., Berko, G., Polay, A., and Kocsis, G., Der Einfluss der Griseofulvin-Therapie auf die Leberfunktion und den Porphyrin-Stoffwechsel, Arch. Dermatol. Forsch., 241, 148, 1971.
Cotton, S. G., Lovel, T. W. L., and Montuschi, E., The treatment of hypertension: An extended clinical trial of guanoxan, Clin. Trials J., 4, 707, 1967.
Montuschi, E., and Lovel, T. W. I., Guanoxan in hypertension, Lancet, 1, 1339, 1964.
Walton, B., Simpson, B. R., Strumin, L., Doniach, D., Perrin, J., and Appleyard, A. J., Unexplained hepatitis following halothane, Br. Med. J., 1, 1171, 1976.
Tornetta, I. J., and Tamaki, H. T., Halothane jaundice and hepatotoxicity, J. Am. Med. Assoc., 184, 658, 1963.
Jori, G. P., and Peschle, C., Hydralazine disease associated with transient granulomas in the liver: A case report, Gastroenterology, 64, 1163, 1973.
Weisburst, M., Self, T., Peace, R., and Cooper, J., Jaundice and rash associated with the use of phenobarbital and hydrochlorothiazide, South. Med. J., 69, 126, 1976.
Heikel, T., Knight, B. C., and Rimington, C., Studies on biliary excretion in the rabbit. 1. The effect of icterogenic and rehmannic acid on bile flow and the excretion of bilirubin, phylloerythrin, coproporphyria, alkaline phosphatase and bromsulphalein, Proc. R. Soc. (London), 153, 47, 1960.
Arias, I. M., Effects of plant acid (icterogenin) and certain anabolic steroids on hepatic metabolism of bilirubin and sulfobromophthalein (BSP), Ann. N. Y. Acad. Sei., 104, 1014, 1963.
Dayan, A. D., and Lewis, P. D., Idoxuridine and jaundice, Lancet, 2, 1073, 1969.
Karkalas, Y., and Lai, H., Jaundice following therapy with imipramine and cyproheptadine, Clin. Toxicol., 4, 47, 1971.
Fenech, F. F., Bannister, W. H., and Grech, J. L., Hepatitis with biliverdinaemia in association with indomethacin therapy,Br. Med. J., 3, 155, 1967.
Kelsey, W. M., and Scharyi, M., Fatal hepatitis probably due to indomethacin, J. Am. Med. Assoc., 199, 586, 1967.
Van Dyk, J. J., Falkson, H. C., Van Der Merwe, A. M., and Falkson, G., Unexpected toxicity in patients with iphosphamide, Cancer Res., 32, 921, 1972.
Ajdukiewicz, A. B., Grainger, J., Scheuer, P. J., and Sherlock, S., Jaundice due to iprindole, Gut, 12, 705, 1971.
Benack, R. T., and Lynch, V., Jaundice associated with isocarboxazid therapy, N. Engl. J. Med., 264, 294, 1961.
Black, M., Mitchell, J. R., Zimmerman, H. J., Ishak, K. G., and Elper, G. R., Isoniazid associated hepatitis in 114 patients, Gastroenterology, 69, 289, 1975.
Barbeau, A., L-Dopa therapy in Parkinson’s disease: A critical review of nine years experience, Can. Med. Assoc. J., 101, 791, 1969.
Langrall, H. M., and Joseph C., Status of the clinical evaluation of levodopa in the treatment of Parkinson’s disease and syndrome, Gin. Pharmacol. Ther., 12, 323, 1971.
Mena, I., Marin, O., Fuenzalida, S., and Cotzias, G. C., Chronic manganese poisoning: Clinical picture and manganese turnover, Neurology, 2 7, 128, 1967.
Einhorn, M., and Davidsohn, I., Hepatotoxicity of mercaptopurine, J. Am. Med. Assoc., 188, 802. 1964.
Urban, E., Frank, B. W., and Kern, F., Liver dysfunction with mestranol but not with nor- ethynodrel in a patient with Enovid-induced jaundice,, Ann. Intern. Med., 68, 598, 1966.
Mach, B., Field, R. A., and Taft, E. B., Metahexamide jaundice: Report of a case,iV. Engl. J. Med., 261, 438, 1959.
Kaupp, H. A., and Preston, F. W., Jaundice due methandrostenolone therapy, J. Am. Med. Assoc., 180, 411, 1962.
Fischer, M. G., Nayer, H. R., and Miller, A., Methimazole-induced jaundice, J. Am. Med. Assoc., 223, 1028, 1973.
Judson, J. A., DeJongh, H. J., and Walmsley, J. B. W., Possible cross-sensitivity between halothane and methoxyflurane: Report of a case. Anesthesiology, 35, 521, 1971.
Maddrey, W. C., and Boitnott, J. K., Severe hepatitis from methyldopa, Gastroenterology, 68, 351, 1975.
Elkington, S. G., Schreiber, W. M., and Conn, H. O., Hepatic injury cased by L-alpha- methyldopa, Gradation, 40, 589, 1969.
Sataline, L., and Lowell, D., Delayed hepatotoxicity from methyldopa, Conn. Med., 39, 115, 1975.
Convery, F. R., Gunn, D. R., Hughes, J. D., and Martin, W. E., The relative safety of poly-methylmethacrylate, J. Bone Joint Surg., 57A, 51, 1975.
Goodman, C. R., Hepatotoxicity due to methylphenidate hydrochloride, N. Y. State J. Med., 72, 2339, 1972.
Heaney, R. P., and Whedon, G. D., Impairment of hepatic bromosulphalein clearance by two 17-substituted testosterones, J. Lab. Gin. Med., 52, 169, 1958.
Anonymous, Minocycline (minocin), Med. Lett., 14, 9, 1912.
Bass, B. H., Jaundice associated with naproxen, Lancet, 1, 998, 1974.
Holdsworth, C. D., Atkinson, M., and Goldie, W., Hepatitis caused by the newer amine-oxidase- inhibiting drugs, Lancet, 2, 621, 1961.
Rivin, A. U., Jaundice occurring during nicotinic acid therapy for hypercholesteremia, J. Am. Med. Assoc., 170, 2088, 1959.
Winter, S. L., and Boyer, J. L., Hepatic toxicity from large doses of vitamin B3 (nicotinamide), N. Engl. J. Med., 289, 1180, 1973.
Kohn, R. M., and Monies, M., Hepatic fibrosis following long acting nicotinic acid therapy: A case report, Am. J. Med. Sci., 258, 94, 1969.
Pardue, W. O., Severe liver dysfunction during nicotinic acid therapy, J. Am. Med. Assoc., 175, 137, 1961.
MacBeth, W. A., Blennerhassett, J. B., and Nye, E. R., Liver toxicity with betapyridyl carbinol, N. Z.Med. J., 74, 382, 1971.
Somayaji, B. N., Paton, A., Price, J. H., Harris, A. W., and Flewett, T. H., Norethisterone jaundice in two sisters, Br. Med. J., 2, 281, 1968.
Schoenfeld, L. J., Sulfobromophthalein transport and metabolism, Gastroenterology, 48, 530. 1965.
Cox, R. P., Foltz, E. L., Raymond, S., and Drewyer, R., Novobiocin jaundice, N. Engl. J. Med., 262, 139, 1959.
Ten Pas, A., and Quinn, E. L., Cholestatic hepatitis following the administration of sodium oxacillin, J. Am. Med. Assoc., 191, 674, 1965.
Dismukes, W. E., Oxacillin-induced hepatic dysfunction, J. Am. Med. Assoc., 226, 861, 1973.
Elking, M. P., and Kabat, H. F., Drug induced modifications of laboratory test values, Am. J. Hosp. Pharm., 25, 485, 1968.
Young, G. P., Bhathal, P. S., Sullivan, J. R., Wall, A. J., Fone, D. J., and Hurley, T. H., Fatal hepatic coma complicating oxymetholone therapy in multiple myeloma, Aust. N. Z. J. Med., 7, 47, 1977.
Pearson, A. J. G., Grainger, J. M., Scheuer, P. J., and Mclntyre, N., Jaundice due to oxy- phenisatin, Lancet, i, 994, 1971.
Rønnov-Jessen, V., and Tjernlund, A., Hepatotoxicity due to treatment with papaverine: Report of four cases, N. Engl. J. Med., 281, 1333, 1969.
Hayward, J. N., and Boshell, B. R., Paraldehyde intoxication with metabolic acidosis: Report of two cases, experimental data and a critical review of the literature, Am. J. Med., 23, 965, 1957.
Rau, R., Weber, S., and Boni, A., Allergisch-toxische Leberschàdigung durch D-Penizillamin, Schweiz. Med. Wochenschr., 102, 1226, 1972.
Waugh, D., Myocarditis, arteritis, and focal hepatic, splenic and renal granulomas apparently due to penicillin sensitivity, Am. J. Pathol., 28, 437, 1952.
Hoekenga, M. T., Bunde, C. A., Cho, Y. W., and Kuzma, R. J., Double blind multicenter evaluation of a new antianginal drug: Perhexiline maleate, Clin. Pharmacol., Ther., 13, 140, 1972 (abstract).
Newberne, J. W., Assessment of safety data from patients on short and long-term perhexiline therapy,Postgrad. Med. J., 49, 125, 1973.
Cook, G. C., and Sherlock, S., Jaundice and its relation to therapeutic agents, Lancet, 1, 175, 1965.
Tyler, M. W., and King, E. Q., Phenacemide in treatment of epilepsy, J. Am. Med. Assoc., 147, 17, 1951.
Goldflnger, S. E., and Marx, S., Hypersensitivity hepatitis due to phenazopyridine hydrochloride, N. Engl. J. Med., 286, 1090, 1972.
Vas, C. J., and Parsonage, M. J., Treatment of intractable temporal lobe epilepsy with pheneturidq, Acta Neurol. Scand., 43, 580, 1967.
Perkins, J., Phenindione jaundice, Lancet, 1, 125, 1962.
Beer, D. T., and Schaffner, F., Fatal jaundice after administration of beta-phenylisopropyl- hydrazine, J. Am. Med. Assoc.,171, 887, 1959.
Goldstein, G., Sarcoid reaction associated with phenylbutazone hypersensitivity, Ann. Intern. Med., 59, 97, 1963.
Muscat-Baron, J. M., and Freeman, D. M., Toxic hepatitis following phenylbutazone therapy, Br. J. Clin. Pract., 20, 437, 1966.
Greenberger, N. J., Robinson, W. L., and Isselbacher, K. J., Toxic hepatitis after the ingestion of phosphorus with subsequent recovery, Gastroenterology, 47, 179, 1964.
Hamlyn, A. N., Morris, J. S., Sarkany, I., and Sherlock, S., Piperazine hepatitis, Gastroenterology,70, 1144, 1976.
Reynolds, E. S., Schlant, R. C., Gonick, H. C., and Dammin, G. J., Fatal massive necrosis of the liver as a manifestation of hypersensitivity to probenecid, N. Engl. J. Med., 256, 592, 1957.
Farber, H. I., Fever, vomiting and liver dysfunction with procainamide therapy, Postgrad. Med., 56, 155, 1974.
Weinstein, A., Alper, B. J., and Dade, J. R., Cholestasis due to prochlorperazine, J. Am. Med. Assoc., 170, 1663, 1959.
Kent, J. A., Jaundice occurring during administration of promazine, Gastroenterology, 32, 937, 1957.
Stephen, S. A., Unwanted effects of propranolol, Am. J. Cardiol., 18, 463, 1966.
Touloukian, R. J., and Downing, S. E., Cholestasis associated with long-term parenteral hyper-alimentation, Surg., 106, 58, 1973.
Oken, M. M., Hootkin, L., and Dejager, R. L., Hepatitis after koyne administration, Am. J. Digest. Diseases, 17, 271, 1972.
Anonymous, Intravenous feeding with amino acids and fats, Drug Ther. Bull., 10, 49, 1972.
Deisseroth, A., Morganroth, J., and Winokur, S., Quinidine-induced liver disease, Ann. Intern. Med., 77, 595, 1972.
Murphy, P. J., and Rymer, W., Quinidine-induced liver disease,, Ann. Intern. Med., 78, 785, 1973.
Lees, A. W., Allan, G. W., Smith, J., Tyrrell, W. F., and Fallon, R. J., Toxicity from rifampicin plus isoniazid and rifampicin plus ethambutol therapy, Tubercle, 52, 182, 1971.
Scheuer, P. J., Summerfleld, J. A., Lai, S., and Sherlock, S., Rifampicin hepatitis: A clinical and histological study, Lancet, 1, 421, 1974.
Slater, S. D., Davidson, J. F., and Patrick, R. S., Jaundice induced by stanozolol hypersensitivity, Postgrad. Med. J., 52, 229, 1976.
Schmidt, E., Poliwoda, H., Buhl, V., Alexander, K., and Schmidt, F. W., Observations of enzyme elevations in the serum during streptokinase treatment, J. Gin. Pathol., 25, 650, 1972.
Espiritu, C. R., Kim, T. S., and Levine, R. A., Granulomatous hepatitis associated with sulfa- dimethoxine hypersensitivity, J. Am. Med. Assoc., 202, 985, 1967.
Koch-Weser, J., Sidei, V. W., Dexter, M., Parish, C., Finer, D. C., and Kanarek, P., Adverse reactions to sulfisoxazole, sulfamethoxazole and nitrofurantoin, Arch. Intern. Med., 128, 399, 1971.
Dujovne, C. A., Chan, C. H., and Zimmerman, H. J., Sulfonamide hepatic injury: Review of the literature and report of a case due to sulfamethoxazole, N. Engl. J. Med., 277, 785, 1967.
Tisdale, W. A., Focal hepatitis, fever and skin rash following therapy with sulfamethoxypyri- dazine, a long-acting sulfonamide, N. Engl. J. Med., 258, 687, 1958.
Garvin, C. F., Toxic hepatitis due to sulfanilamide, J. Am. Med. Assoc., Ill, 2283, 1938.
Kemp Harper, R. A., Pemberton, J., and Tobias, J. S., Serial liver function studies following barium enemas containing 1% tannic acid, Gin. Radiol., 24, 315, 1973.
Lucke, H. H., Hodge, K. E., and Patt, N. L., Fatal liver damage after barium enemas containing tannic acid, Can. Med. Assoc. J., 89, 765, 1963.
McAlister, W. H., Anderson, M. S., Bloomberg, C. R., and Margulis, A. R., Lethal effects of tannic acid in barium enema: Report of three fatalities and experimental studies, Radiology, 80, 765, 1963.
Faierman, D., and Jacobs, S., Liver injury from elixir of terpin hydrate with codeine, Mt. Sinai J. Med., 40, 56, 1973.
Robinson, M. J., and Rywlin, A. M., Tetracycline associated fatty liver in the male: Report of an autopsied case, Am. J. Dig. Dis., 15, 857, 1970.
Schultz, J. C., Adamson, J. S., Workman, W. W., and Norman, T. D., Fatal liver disease after intravenous administration of tetracycline in high dosage, N. Engl J. Med., 269, 999, 1963.
Dowling, H. F., and Lepper, M. H., Hepatic reactions to tetracycline, J. Am. Med. Assoc., 188, 307, 1964.
Pflug, G. R., Toxicities associated with tetracyline therapy, Am. J. Pharm., 135, 438, 1963.
Barancik, M., Brandborg, L. L., and Albion, M. J., Thioridazine-induced cholestasis, J. Am. Med. Assoc., 200, 175, 1967.
Kane, F. J., Jr., and Moore, L. P., Hepatotoxicity occuring with thioridazine therapy, South. Med. J., 64, 573, 1971.
Gargill, S. L., and Lesses, M. F., Toxic reactions to thiouracil: Report of cases with one fatality, J. Am. Med. Assoc., 127, 890, 1945.
Janower, M. L., Sidei, V. W., Baker, W. H., Fitzpatrick, D. E. P., Guarino, F. I., and Flynn, M. J., Late clinical and laboratory manifestations of Thorotrast administration in cerebral arteriography: A follow up study of thirty patients, Engl. J. Med.. 279, 186, 1968.
Saragoca, A., Tavares, M. H., Barros, F. B., and Da Silva Horta, J., Some clinical and laboratory findings in patients injected with thorium dioxide, Am. J. Gastroenterol, 57, 301, 1972.
Van Thiel, D. H., DeBelle, R., Mellow, M., Widerlite, L., and Philipps, E., Tolazamide hepatotoxicity: A case report, Gastroenterology, 67, 506, 1974.
Baird, R. W., and Hull, J. G., Cholestatic jaundice from tolbutamide, Ann. Intern. Med., 53, 194, 1960.
O’Brien, E. T., Yeoman, W. B., and Hobby, J. A. E., Hepatorenal damage from toluene in a “glue-sniffer,” Br. Med. J., 2, 29, 1971.
Baerg, R. D., and Kimberg, D. V., Centrilobular hepatic necrosis and acute renal failure in “solvent-sniffers,” Ann. Intern. Med.. 73, 713, 1970.
Bandt, C., and Hoffbauer, F. W., Liver injury associated with tranylcypromine therapy, J. Am. Med. Assoc., 188, 752, 1964.
Ticktin, H. E., and Zimmerman, H. J., Hepatic dysfunction and jaundice in patients receiving triacetyloleandomycin, N. Engl. J. Med., 267, 964, 1962.
Bankier, R. G., A comparison of fluspirilene and trifluoperazine in the treatment of acute schizophrenic psychosis, J. Gin. Pharmacol., 13, 44, 1973.
Meacham, G. C., Tillotson, F. W., and Meinle, R. W., Liver damage after prolonged urethane therapy, Am. J. Gin. Pathol., 22, 22, 1952.
Carr, H. J., and Knauer, Q. F., Death due to hepatic necrosis in a patient receiving zoxazol- amine: Report of a case and review of the literature, N. Engl. J. Med., 264, 977, 1961.
Cooper, D. S., Kaplan, M. M., Ridgway, E. C., Maloof, F. and Daniels, G. H., Alkaline phosphatase isoenzyme patterns in hyperthyroidism, Ann. Intern. Med., 90, 164, 1979.
DeBroe, M. E., Mets, T. E., Leroux-Roels, G. G., and Wieme, R. J., Occurrence of immunoglobulin G-alkaline phosphatase complexes in human serum, Ann. Inter. Med., 90, 30, 1979.
Stephan, J., Marek, J., Havranek, T., Dolezal, V., and Pacovsky, V., Bone isoenzymes of serum alkaline phosphatase in acromegaly, Gin. Glim. Acta, 93, 355, 1979.
Cherian, A. G., and Hill, J. G., Age dependence of serum enzymatic activities (alkaline phosphatase, aspartate aminotransferase and creatine kinase) in healthy children and adolescents, Am. J. Gin. Pathol., 70, 783, 1978.
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McComb, R.B., Bowers, G.N., Posen, S. (1979). Clinical Utilization of Alkaline Phosphatase Measurements. In: Alkaline Phosphatase. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2970-1_9
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