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Hepatitis after konyne administrationne administration

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Abstract

Konyne concentrate of Factors II, VII, IX and X has been utilized in the management of a variety of coagulation disorders. Our experience with this product is described, and the high incidence of subsequent hepatitis is emphasized. Based on present data, we feel that Konyne should be restricted to certain patients with Christmas disease, selected patients with inherited Factor II, VII or X deficiency, and Coumadin overdosage only when life-threatening bleeding supervenes. Liver disease appears to contraindicate the use of Konyne. The recently introduced screening program and elimination of Australia antigen positive donors might alter this situation in the future.

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References

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Authors and Affiliations

  1. From the Gastroenterology and Hematology Service, William Beaumont General Hospital, El Paso, Tex.

    Martin M. Oken MD (Major MC), Lawrence Hootkin MD (Major MC) & Robert L. DeJager MD (Major MC)

Authors
  1. Martin M. Oken MD
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  2. Lawrence Hootkin MD
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  3. Robert L. DeJager MD
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Additional information

This material has been reviewed by the Commander, William Beaumont General Hospital, El Paso, Texas, and there is no objection to its presentation and/or publication. This review does not imply any indorsement of the opinions advanced or any recommendation of such products as may be named.

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Oken, M.M., Hootkin, L. & DeJager, R.L. Hepatitis after konyne administrationne administration. Digest Dis Sci 17, 271–274 (1972). https://doi.org/10.1007/BF02232302

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  • DOI: https://doi.org/10.1007/BF02232302

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