Summary
A case of hepatotoxicity secondary to propoxyphene is presented. A cholestatic hepatitis was found on liver biopsy, and the clinical and chemical picture was reproduced promptly by rechallenge with the drug.
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References
McCarthy WH, Keenan RL: Propoxyphene hydrochloride poisoning. Report of first fatality. JAMA 187:460–461, 1964
Frasier S, Crudo FS, Johnson DH: Dextropropoxyphene hydrochloride poisoning in two children. J Pediat 63:158–159, 1963
Karliner JS: Propoxyphene hydrochloride poisoning. JAMA 199:1006–1008, 1967
Gary NE, Maher JF, Demyttenaere MH, et al: Acute propoxyphene hydrochloride intoxication. Arch Intern Med 121:453–457, 1968
Wolfe RC, Reidenberg M, Vispo RH: Propoxyphene (Darvon) addiction and with-drawal syndrome. Ann Intern Med 70:773–776, 1969
Robbins EB: The pharmacologic effects of a new analgesic. J Amer Pharm Ass 44:497–500, 1955
Emmerson JL, Welles JS, Anderson RC: Studies on the tissue distribution ofd-propoxyphene. Toxic Appl Pharmacol 11:482–488, 1967
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The authors wish to thank the Medlars Search Center, 10 Shattuck St, Boston, Mass for its aid in the literature review.
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Klein, N.C., Magida, M.G. Propoxyphene (Darvon) hepatotoxicity. Digest Dis Sci 16, 467–469 (1971). https://doi.org/10.1007/BF02235094
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DOI: https://doi.org/10.1007/BF02235094