Abstract
In a study of calcium metabolism in 8 patients with postgastrectomy symptoms, 7 had skeletal pains. The amount of pain was positively correlated with the degree of malnutrition, and the level of serum alkaline phosphatase with diarrhea and steatorrhea. Following treatment with oral calcium (150–550 gm.) for 2–6 months, all except 1 patient had gustatory and/or gastro-intestinal discomfort. Retention of oral47Ca was increased prior to treatment and normal after treatment. The amount of bone salt in the hands and feet was significantly lower in the 65-year-old postgastrectomy patients than in the 24-year-old controls and slightly lower than that in the 80-year-old controls. Treatment with oral calcium did not result in an increase in the amount of measurable bone salt.
Similar content being viewed by others
References
Bauer, G. C. H. Tracer techniques for the study of bone metabolism in man.Advances Biol Med Phys 10:227, 1965.
Heaney, R. P. Evaluation and interpretation of calcium-kinetic data in manClin Orthop 31:153, 1963.
Wendeberg, B. Bone salt accretion and exchangeable calcium spaces in man measured with47Ca and85Sr.Clin Orthop 40:162, 1965.
Bauer, G. C. H., Carlsson, A., andLindquist, B. “Use of Isotopes in Clinical Studies of Skeletal Metabolism.” InRadioaktive Isotope in Klinik und Forschung (Vol. 3), Fellinger, K., and Vetter, H., Eds. Urban, München, 1958, p. 25.
Bauer, G. C. H. “Skelettundersökningar.” InNuklear Medicin, en nordisk lœrebog, Cederquist, E., Devik, F., Hammer-Jacobsen, E., Munkner, T., and Waldeskog, B., Eds. Munksgaard, Copenhagen, 1967, p. 326.
Dymling, J.-F. Calcium kinetics in osteopenia and parathyroid disease.Acta Med Scand 408:175, 1964.
Heaney, R. P., andWhedon, G. D. Radiocalcium studies of bone formation rate in human metabolic bone disease.J Clin Endocr 18:1246, 1958.
Nordin, B. E. C. Osteomalacia, osteoporosis and calcium deficiency.Clin Orthop 17:235, 1960.
Frost, H. M. Postmenopausal osteoporosis: a disturbance in osteoclasia.J Amer Geriat Soc 9:1078, 1961.
Jowsey, J. Age changes in human bone.Clin Orthop 17:210, 1960.
Frost, H. M., andVillanueva, A. R. Human osteoblastic activity. Part I. A comparative method of measurement with some results.Henry Ford Hosp Med Bull 9:76, 1961.
Riggs, B. L., Jowsey, J., Kelly, P. J., andKeating, F. R. Bone remodeling in metabolic diseases assessed by quantitative microradiography.Clin Res 12:356, 1964.
Whedon, G. D. Effects of high calcium intakes on bones, blood and soft tissue: relationship of calcium intake to balance in osteoporosis.Fed Proc 18:1112, 1959.
Gershon-Cohen, J., andJowsey, J. The relationship of dietary calcium to osteoporosis.Metabolism 13:221, 1964.
Lutwak, L., andWhedon, G. D. Osteoporosis.DM (April) :1, 1963.
Schwarz, G. Intestinal calcium transport in osteoporosis.Sandorama (Dec.)16, 1965.
Sjöberg, H. E., Reizenstein, P., andArman, E. Retention of orally administered47Ca as measured in the whole-body counter. Unpublished data.
Deller, D. J. Radiocalcium absorption after partial gastrectomy.Amer J Dig Dis 11:10, 1966.
Jacobson, B. X-ray spectrophotometry in vivo.Amer J Roentgen 91:202, 1964.
Arne, L., Mouton, M., andSeilhean, A. A propos d'un syndrome douloureux des membres inférieurs d'origine ostéomalacique secondaire à une gastrectomie.J Méd Bordeaux 7:720, 1960.
Baird, McLean, andOleesky, S. Osteomalacia following gastric surgery.Gastroenterology 33:284, 1957.
Baronchelli, A., andD'Antuono, G. Sulle alterazioni ossee del gastroresecato per malattia ulcerosa.Arch Ital Mal Appar Dig 24:21, 1958.
Bordier, P. “Ostéoporoses Survenant chez des Gastrectomisés ou des Cirrhotiques.” InL'Ostéoporose. D. J. Hioco, Paris, 1964, p. 149.
Bordier, P., Matrajt, H., Hioco, D., Hepner, G. W., Thompson, G. R., andBooth, C. C. Subclinical vitamin-D deficiency following gastric surgery. Histological evidence in bone.Lancet 1:437, 1968.
Bussabarger, R. A., Freeman, S., andIvy, I. C. The experimental production of severe homogeneous osteoporosis by gastrectomy in puppies.Amer J Physiol 121:137, 1938.
Bonorino Udaondo, C., andCastex, M. R. Le trophisme osseux chez les gastrectomisés.Presse Med 73:847, 1947.
Caniggia, A., Gennari, C., andCesari, L. Intestinal absorption of45Ca and dynamics of45Ca in gastrectomy osteoporosis.Acta Med Scand 176:599, 1964.
Clark, C. C. Postgastrectomy bone disease.Proc Roy Soc Med 57:580, 1964.
Clark, C. G., andCrooks, J. Osteomalacia after gastrectomy.Lancet 2:1347, 1965.
Clark, C. G., Crooks, J., Dawson, A. A., andMitchell, P. E. G. Disordered calcium metabolism after polya partial gastrectomy.Lancet 1:734, 1964.
Deller, D. J., andBegley, M. D. Calcium metabolism and the bones after partial gastrectomy. I. Clinical features and radiology of the bones.Austral Ann Med 12:282, 1963.
Deller, D. J., Edwards, R. G., andAddison, M. Calcium metabolism and the bones after partial gastrectomy. II. The nature and cause of the bone disorder.Austral Ann Med 12:295, 1963.
Deller, D. J., Begley, M. D., Edwards, R. G., andAddison, M. Metabolic effects of partial gastrectomy with special reference to calcium and folic acid. I. Changes in calcium metabolism and the bones.Gut 5:218, 1964.
Ekbom, K., andHed, R. Calcium studies in partially gastrectomized patients with special reference to the oral intake of calcium.Acta Med Scand 178:193, 1965.
Ekbom, K., andHed, R. Disordered calcium metabolism after partial gastrectomy.Surg Dig 2:9, 1967.
Ellman, P., andIrwin, D. B. Osteomalacia following gastrectomy.Postgrad Med J 35:358, 1959.
Fischermann, K., Harly, S., Worning, H., andZacho, A. Pancreatic function and the absorption of fat, iron, vitamin B12 and calcium after total gastrectomy for gastric cancer.Gut 8:260, 1967.
Hall, G. H., andNeale, G. Bone rarefaction after partial gastrectomy.Ann Intern Med 59:455, 1963.
Harvald, B., Krogsgaard, A. R., andLous, P. Calcium deficiency following partial gastrectomy.Nord Med 68:1060, 1962.
Higgins, P. McR., andPride, R. B. Postgastrectomy osteomalacia: incidence after the no-loop and other types of gastrectomy.Brit J Surg 53:881, 1966.
Hillemand, P., Mialaret, J., andBoutelier, D. A propos d'une ostéomalacie après gastrectomie partielle avec anastomose gastrojéjunale. Transformation par rétablissement du circuit duodénale.Arch Mal Appar Dig 49:489, 1960.
Hillemand, P., Mialaret, J., andBoutelier, D. Exclusion duodénale et ostéomalacie des gastrectomisés.Presse Med 69:627, 1961.
Jones, C. T., Williams, J. A., Cox, E. V., Meynell, M. J., Cooke, W. T., andStammers, F. A. R. Peptic ulceration. Some haematological and metabolic consequences of gastric surgery.Lancet 2:425, 1962.
Jones, C. T., Williams, J. A., andNicholson, G. “Disturbances of Bone Metabolism after Partial Gastrectomy.” InPartial Gastrectomy, Complications and Metabolic Consequences, Stammers, F. A. R., and Williams, J. A., Eds. Butterworths, London, 1963, p. 190.
Kothe, W. Der Kalzium- und Phosphatstoffwechsel nach totaler Gastrektomie.Z Chir 91:112, 1966.
Lever, J. V., Paterson, C. R., andMorgan, D. B. Calcium infusion test in osteomalacia: an appraisal.Brit Med J 3:281, 1967.
Lichtwitz, A., de Seze, S., Cachin, M., Guillaumat, M., Hioco, D., andPergola, F. Les troubles du métabolisme phosphocalcique chez les gastrectomisés.Sem Hôp Paris 37:3391, 1961.
Lichtwitz, A., de Sèze, S., Cachin, M., Guillaumat, M., Hioco, D., andPergola, F. Physiopathologie des modifications du métabolisme phosphocalcique chez les gastrectomisés avec exclusion du duodénum.Sem Hôp Paris 37:3401, 1961.
Lods, J.-C. Les déminéralisations osseuses post-gastrectomies.Rev Prat 11:1273, 1961.
Louyot, P., Mathieu, J., andGaucher, A. Ostéomalacie et fonction gastrique.Rev Rhum 26:438, 1959.
Louyot, P., Mathieu, J., andGaucher, A. L'ostéose raréfiante des gastrectomisés. Étude de 50 sujets gastrectomisés avec anastomose gastro-jéjunale.Arch Mal Appar Dig 50:20, 1961.
Melick, R. A., andBenson, J. A. Osteomalacia following partial gastrectomy.New Eng J Med 260:976, 1959.
Milhaud, G., Vesin, P., Bourichon, J., Roberti, A., andViguié, R. Ètude du métabolisme de la sérumalbumine et du calcium chez le gastrectomisé.Sem Hôp Paris 41:1207, 1965.
Morgan, D. B., Paterson, C. R., Woods, C. G., Pulvertaft, C. N., andFourman, P. Search for osteomalacia in 1228 patients after gastrectomy and other operations on the stomach.Lancet 2:1085, 1965.
Morgan, D. B., Paterson, C. R., Woods, C. G., Pulvertaft, C. N., andFourman, P. Osteomalacia after gastrectomy. A response to very small doses of vitamin D.Lancet 2:1089, 1965.
Morgan, D. B., Pulvertaft, C. N., andFourman, P. Effects of age on the loss of bone after gastric surgery.Lancet 2:772, 1966.
Nicolaysen, R., andRagård, R. The calcium and phosphorus metabolism in gastrectomized patients.Scand J Clin Lab Invest 7:298, 1955.
Nikkilä, E. A. Late metabolic consequences of partial gastrectomy.Nord Med 78:1220, 1967.
Pyrah, L. N., andSmith, I. B. Osteomalacia following gastrectomy.Lancet 1:935, 1956.
Sarasin, C. Osteomalacie und hypochrome Anämie nach Magenresektion.Gastroenterologia (Basel) 66:182, 1941/1942.
Sataline, L. R., Buch, P., andFoxman, D. Osteomalacia following partial gastrectomy: pathophysiologic and therapeutic considerations. Report of a case.Amer J Dig Dis 12:1160, 1967.
Simon, L. Ostéoporose des affections digestives.Sem Hôp Paris 42:22, 1966.
Sjöberg, H. E., andReizenstein, P. Nutritional studies in the dumping syndrome. III. Retention of orally administered47calcium in patients after gastrectomy.Amer J Dig Dis 12:1156, 1967.
Thompson, G. R., Lewis, B., andBooth, C. C. Vitamin-D absorption after partial gastrectomy.Lancet 1:457, 1966.
Thompson, G. R., Neale, G., Watts, J. M., andBooth, C. C. Detection of vitamin-D deficiency after partial gastrectomy.Lancet 1:623, 1966.
Williams, J. A. Effects of upper gastro-intestinal surgery on blood formation and bone metabolism.Brit J Surg 51:125, 1964.
Williams, J. A. Partial gastrectomy. The late nutritional and metabolic effects.Amer J Proctol 17:288, 1966.
Yong, J. M. Cause of raised serum-alkaline-phosphatase after partial gastrectomy and in other malabsorption states.Lancet 1:1132, 1966.
Ask-Upmark, E. Osteomalacia hepatica.Acta Med Scand 99:204, 1939.
Hanngren, Å., Hedenstedt, S., andReizenstein, P. Nutritional studies in dumping syndrome. I. Subjects with postcibal symptoms.Amer J Dig Dis 12:71, 1967.
Reizenstein, P. Errors and artefacts in serum folic acid assays.Acta Med Scand 178:133, 1965.
Reizenstein, P. Radio-B12 in the diagnosis of pernicious anemia. (Abst.)Nord Med 61:65, 1959.
Zackrisson, L., andReizenstein, P. “Mapping of Correlation between Clinical Variables.”Int Congr Med, Warsaw, 1958.
Reizenstein, P., andHöglund, S. “Absorption and Excretion of Iron Measured by Whole-Body Counting.” InClinical Uses of Whole-Body Counting. Proceedings of a Panel. IAEA, Vienna, 1965, p. 255.
Author information
Authors and Affiliations
Additional information
Supported by Sandoz Inc., Basle, Switzerland and Ekhaga Foundation, Stockholm, Sweden.
Rights and permissions
About this article
Cite this article
Arman, E., Reizenstein, P. Studies in the dumping syndrome. Digest Dis Sci 14, 153–162 (1969). https://doi.org/10.1007/BF02235876
Issue Date:
DOI: https://doi.org/10.1007/BF02235876