Overview
- Editors:
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M. Z. Atassi
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Mayo Clinic, Rochester, USA
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Table of contents (13 chapters)
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Front Matter
Pages i-viii
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Molecular Aspects of T- and B-Cell Recognition of Protein Antigens
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- Robert H. Swanborg, James H. Holda, Joyce A. Killen
Pages 3-22
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- N. R. Rose, M. Accavitti, E. F. Pydyn, M. A. Leon, R. K. Brown
Pages 23-35
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- Charles Hannum, Michiel Ultee, Louis A. Matis, Ronald H. Schwartz, E. Margoliash
Pages 37-51
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- Charles A. Janeway Jr., Kim Bottomly, Barry Jones, Patricia P. Jones, Ethan A. Lerner, Louis A. Matis et al.
Pages 53-71
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- Colin R. Young, M. Zouhair Atassi
Pages 73-93
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Genetic Control of the Immune Response to Proteins and Peptides
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- Chella S. David, M. Zouhair Atassi
Pages 97-125
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- Christopher J. Krco, A. Latif Kazim, M. Zouhair Atassi, Chella S. David
Pages 127-140
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- Alan M. Solinger, John D. Stobo
Pages 141-155
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Regulation of the Immune Response
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Front Matter
Pages 157-157
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- A. J. Infante, M. Z. Atassi, C. G. Fathman
Pages 159-167
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- Neal Roehm, John Kappler, Philippa Marrack
Pages 169-182
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- David W. Scott, P. S. Pillai, Scott J. Anderson, Ronald B. Corley
Pages 183-200
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- Donna M. Rennick, Philip R. Morrow, Eli Benjamini
Pages 201-218
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- Joel W. Goodman, Danute E. Nitecki, Sherman Fong, Zehra Kaymakcalan
Pages 219-225
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Back Matter
Pages 227-230
About this book
The immune response is largely dependent on molecular inter actions involving proteins. The recognition of antigen molecules, whether they are proteins or non-proteins, whether they are self or non-self, takes place at the molecular-cellular interface through membrane receptor molecules that are proteins. The initial step of recognition activates a complex series of cellular events requiring some mechanism of cell-cell interactions and communi cations, eventually leading to antibody production. This biolo gical cascade is controlled at several positions along its con secutive pathways by protein molecules, either in the free form or as receptors on membranes of cells committed to this activity. Clearly, then, the proper understanding of the response by cells of the immune system will depend, to a great measure, on the definition of the molecular events involving protein interactions. Obviously, cells work via molecules and molecules work via cells and, at this level of functional resolution, molecular immunology and cellular immunology will merge and will depend heavily on protein chemistry.
Editors and Affiliations
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Mayo Clinic, Rochester, USA
M. Z. Atassi