Advertisement

Immune Response Gene Control of T Dependent Reactivity to Collagen in Man

  • Alan M. Solinger
  • John D. Stobo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 150)

Abstract

T dependent reactivity controlled by immune response (Ir) genes in rodents exhibits the following three characteristics. (1–3) First, it is dependent on interactions between T cells and antigen presenting accessory cells (conveniently referred to here as MØ). Second, the reactivity is directed against determinants inherent in either synthetic polypeptides or limited regions of globular proteins. Third, the reactivity is controlled by genes present in the immune response (Ir) locus of the major histocompatibility complex.

Keywords

Rheumatoid Arthritis Peripheral Blood Mononuclear Cell Collagen Reactivity Dependent Reactivity Synthetic Polypeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. Rosenthal, M. Barginski, and L. Rosenwasser. Immune response gene control of determinant selection. J. Immunol. 123: 471 (1979)PubMedGoogle Scholar
  2. 2.
    W. Paul and B. Benacerraf. Functional specificity of thymus dependent lymphocytes. Science 195: 1293 (1977)PubMedCrossRefGoogle Scholar
  3. 3.
    H. McDevitt and A. Chinitz. Genetic control of antibody response: Relationship between immune response and histocompatability (H-2) type. Science 163: 1207 (1969)Google Scholar
  4. 4.
    R. Winchester and H. Kunkel. The human la system. In: Advances in Immunology, F. Dixon and H. Kunkel eds., Academic Press, New York, 28: 222 (1979)Google Scholar
  5. 5.
    T. Sasazuki, N. Ohta, R. Kaneoka, and S. Kojima. Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man. J. Exp. Med. 152: 3145 (1980)Google Scholar
  6. 6.
    W. Griffin, S. Moore, H. Luthra, C. McKenna, and C. Fathman. Association of antibodies to native DNA with HLA-DRw3. A possible major histocompatability complex-linked human immune response gene. J. Exp. Med. 152: 3195 (1980)CrossRefGoogle Scholar
  7. 7.
    D. Trentham, R. Dynesius, R. Rocklin, and J. David. Cellular sensitivity to collagen in rheumatoid arthritis. New Eng. J. Med. 299: 327 (1978)Google Scholar
  8. 8.
    J. Stuart, A. Postlethwaite, A. Townes, and A. Kang. Cell mediated immunity to collagen and collagen chains in rheumatoid arthritis and other rheumatic diseases. Amer. J. Med. 69: 13 (1980)PubMedCrossRefGoogle Scholar
  9. 9.
    J. Smolen, E. Menzel, 0. Scherak, M. Kojer, G. Kolarz, C. Steffen, and W. Mayr. Lymphocyte transformation to denatured type I collagen and B lymphocyte alloantigens in rheumatoid arthritis. Arth. and Rheum. 23: 424 (1980)CrossRefGoogle Scholar
  10. 10.
    A. Gibofsky, R. Winchester, E. Yunis, and H. Kunkel. Contrast- ing patterns of newer histocompatibility determinants in patients with rheumatoid arthritis and systemic lupus erythematosus. Arth. and Rheum. 21: 1345 (1978)CrossRefGoogle Scholar
  11. 11.
    P. Stastny. HLA-D and la antigens in rheumatoid arthritis and systemic lupus erythematosus. Arth. and Rheum. 21: 1395 (1978)CrossRefGoogle Scholar
  12. 12.
    R. Rocklin. Products of activated lymphocytes: Leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF). J. Immunol. 112: 1461 (1974)PubMedGoogle Scholar
  13. 13.
    L. Rosenwasser, R. Bhatnagar, and J. Stobo. Genetic control of the murine T lymphocyte proliferative response to collagen: Analysis of the molecular and cellular contributions to immunogenicity. J. Immunol. 124: 2854 (1980)PubMedGoogle Scholar
  14. 14.
    P. Hausman, H. Raff, R. Gilbert, L. Picker, and J. Stobo. T cells and macrophages involved in the autologous mixed lymphocyte reaction are required for the response to conventional antigen. J. Immunol. 125: 1374 (1980)PubMedGoogle Scholar
  15. 15.
    H. Raff, L. Picker, and J. Stobo. Macrophage heterogeneity in man. J. Exp. Med. 152: 581 (1980)CrossRefGoogle Scholar
  16. 16.
    B. Benacerraf and R. Germain. Specific suppressor responses to antigen under I region control. Fed. Proc. 38: 2053 (1979)Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Alan M. Solinger
    • 1
  • John D. Stobo
    • 1
  1. 1.Section of Rheumatology/Clinical Immunology Dept. of Medicine and The Howard Hughes Medical InstituteUniversity of California, San FranciscoSan FranciscoUSA

Personalised recommendations