Antigen Bridging in the Interaction of T Helper Cells and B Cells
Antigen-bridging models of the interaction between T and B lymphocytes rose to prominence in the late 1960s, based principally on two different experimental approaches (1–3). One involved the “carrier effect”, in which physical association between hapten and carrier is required for a secondary antihapten antibody response in animals primed separately with hapten and carrier, and the other involved thymus-marrow reconstitution of irradiated animals, demonstrating that hapten and carrier were recognized by different cell types in the anti-hapten antibody response.
KeywordsAntigenic Determinant Proline Residue Nominal Antigen Irradiate Animal Axial Translation
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