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The Major B and T Cell Determinant on Pigeon Cytochrome c in B10.A Mice

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Immunobiology of Proteins and Peptides—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 150))

Abstract

The specificities of B10.A B and T cells responding to pigeon cytochrome c have been examined. Proliferating T cells recognize glutamine 100 and lysine 104 and can be stimulated in vitro by either native cytochrome c molecules or certain of their CNBr-cleavage fragments. In contrast only molecules with the native cytochrome c conformation were found to interact with B10.A anti-pigeon cytochrome c antibodies. Antibodies appear to recognize a determinant or determinants which overlaps with that which elicits the T cell proliferative response.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Molecular, and Cell Biology, Northwestern University, Evanston, IL, 60201, USA

    Charles Hannum, Michiel Ultee & E. Margoliash

  2. The Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20205, USA

    Louis A. Matis & Ronald H. Schwartz

Authors
  1. Charles Hannum
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  2. Michiel Ultee
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  3. Louis A. Matis
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  4. Ronald H. Schwartz
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  5. E. Margoliash
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    M. Z. Atassi

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© 1982 Plenum Press, New York

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Hannum, C., Ultee, M., Matis, L.A., Schwartz, R.H., Margoliash, E. (1982). The Major B and T Cell Determinant on Pigeon Cytochrome c in B10.A Mice. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides—II. Advances in Experimental Medicine and Biology, vol 150. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4331-8_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4331-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4333-2

  • Online ISBN: 978-1-4684-4331-8

  • eBook Packages: Springer Book Archive

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