Metabolic activations of polycyclic hydrocarbons Roland E. LehrDonald M. Jerina OriginalPaper Pages: 1 - 6
Metabolic activation of chlorinated ethylenes: dependence of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides D. HenschlerG. Bonse OriginalPaper Pages: 7 - 12
Structural modifications in contraceptive steroids altering their metabolism and toxicity H. M. Bolt OriginalPaper Pages: 13 - 19
Metabolic activation of diethylstilbestrol and aminostilbene-derivatives H. -G. NeumannM. MetzlerW. Töpner OriginalPaper Pages: 21 - 30
The significance of covalent binding of catechols to proteins in vivo H. RemmerM. ScheulenH. M. Bolt OriginalPaper Pages: 31 - 39
Some aspects of metabolic activation of chemical carcinogens in relation to their organ specificity H. BartschG. P. MargisonM. Wiessler OriginalPaper Pages: 51 - 63
Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene Philip BentleyFranz OeschHansruedi Glatt OriginalPaper Pages: 65 - 75
Dual role of glucuronyl- and sulfotransferases converting xenobiotics into reactive or biologically inactive and easily excretable compounds K. W. Bock OriginalPaper Pages: 77 - 85
Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization Hansruedi GlattFranz Oesch OriginalPaper Pages: 87 - 96
Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites F. OeschD. RaphaelH. R. Glatt OriginalPaper Pages: 97 - 108
Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus Daniel W. NebertRoy C. LevittJames S. Felton OriginalPaper Pages: 109 - 132
Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool Friedrich J. WiebelStuart BrownJames K. Selkirk OriginalPaper Pages: 133 - 148
Enzymic control of irreversible binding of metabolically activated benzo(a)pyrene in perfused rat liver by monooxygenase activity Georg F. KahlErik KlausRegine Kahl OriginalPaper Pages: 149 - 158
Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites H. GreimD. BimboesMaria Krämer OriginalPaper Pages: 159 - 169