Abstract
Diethylstilbestrol and trans-4-dimethylaminostilbene are metabolically activated and several of their metabolites are able to react with cellular macromolecules. Some of the problems are discussed which are encountered in linking a particular metabolite with the mutagenic and carcinogenic properties of these compounds.
Zusammenfassung
Diäthylstilböstrol und trans-4-Dimethylaminostilben werden im Stoffwechsel in zahlreiche reaktionsfähige Metaboliten übergeführt, die mit zellulären Makromolekülen reagieren können. Einige der Probleme, die sich bei dem Versuch ergeben, die Produkte bestimmter Stoffwechselwege mit den mutagenen und carcinogenen Eigenschaften der Ausgangsverbindungen zu verknüpfen, werden diskutiert.
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Neumann, H.G., Metzler, M. & Töpner, W. Metabolic activation of diethylstilbestrol and aminostilbene-derivatives. Arch. Toxicol. 39, 21–30 (1977). https://doi.org/10.1007/BF00343272
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DOI: https://doi.org/10.1007/BF00343272