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Multiple forms of cytochrome P450

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Abstract

The microsomal monooxygenase system is characterized by its broad substrate specificity which includes endogenous substrates as well as lipophilic drugs and chemicals. From in vitro investigations it was known that the relative reactivities and the pattern of products varied greatly with species, sex, age, diet or pretreatment with drugs of the animal. The suggestion that this was possibly due to a variety of cytochrome P450 enzymes rather than a single monooxygenase was recently confirmed by the isolation of several cytochrome P450 species with different although overlapping substrate specificities. In view of the consequences of a genetic and environment-dependent pattern of monooxygenases for drug metabolism and drug-mediated toxicity the methods of a quantitative assessment of the various forms are discussed.

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Author notes

  1. Pierre Kremers

    Present address: Institut de Pathologie, Laboratoire de Chimie Medicale, Université de Liège, B-4000, Sart Tilman, Liège, Belgium

Authors and Affiliations

  1. Institut für Physiologische Chemie, Universität des Saarlandes, D-6650, Homburg/Saar, Federal Republic of Germany

    Volker Ullrich & Pierre Kremers

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  1. Volker Ullrich
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  2. Pierre Kremers
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Additional information

This work was in part supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich

This work was in part supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich

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Ullrich, V., Kremers, P. Multiple forms of cytochrome P450. Arch. Toxicol. 39, 41–50 (1977). https://doi.org/10.1007/BF00343274

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  • DOI: https://doi.org/10.1007/BF00343274

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