1. Working for Better Asthma Control: How Can We Improve the Dialogue Between Patients and Healthcare Professionals?

   • Kevin Gruffydd-Jones
   • Kjeld Hansen

   Commentary Open access 29 October 2019 Pages: 1 - 9

2. COPD Exacerbations: A Patient and Physician’s Perspective

   • John Linnell
   • John R. Hurst

   Commentary Open access 08 November 2019 Pages: 10 - 16

3. Gathering Structured Patient Insight to Drive the PRO Strategy in COPD: Patient-Centric Drug Development from Theory to Practice

   • Francesco Patalano
   • Florian S. Gutzwiller
   • Nigel S. Cook

   Commentary Open access 09 November 2019 Pages: 17 - 26

   

4. Safety and Efficacy of Enoxaparin in Pregnancy: A Systematic Review and Meta-Analysis

   • Barry Jacobson
   • Virendra Rambiritch
   • Rory Leisegang

   Review Open access 31 October 2019 Pages: 27 - 40

   

5. Dyspnea in COPD: New Mechanistic Insights and Management Implications

   • Denis E. O’Donnell
   • Kathryn M. Milne
   • J. Alberto Neder

   Review Open access 30 October 2019 Pages: 41 - 60

   

6. Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review

   • Giustino Varrassi
   • Joseph V. Pergolizzi
   • Antonella Paladini

   Review Open access 08 November 2019 Pages: 61 - 82

   

7. Current US Food and Drug Administration-Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome with Diarrhea

   • Darren M. Brenner
   • Gregory S. Sayuk

   Review Open access 09 November 2019 Pages: 83 - 96

8. Fatigue in Inflammatory Bowel Diseases: Etiologies and Management

   • Angelica Nocerino
   • Andrew Nguyen
   • Arun Swaminath

   Review Open access 23 November 2019 Pages: 97 - 112

   

9. Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review

   • Martina Rekatsina
   • Antonella Paladini
   • Giustino Varrassi

   Review Open access 28 November 2019 Pages: 113 - 139

   

10. Paraneoplastic Syndromes Associated with Laryngeal Cancer

    • Alessandra Rinaldo
    • Andrés Coca-Pelaz
    • Alfio Ferlito

    Review Open access 04 December 2019 Pages: 140 - 154

    

11. Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review

    • Marcelo Luís Occhiutto
    • Raul C. Maranhão
    • Anastasios G. Konstas

    Review Open access 10 December 2019 Pages: 155 - 199

    

12. The Association Between Potential Opioid-Related Adverse Drug Events and Outcomes in Total Knee Arthroplasty: A Retrospective Study

    • Mark R. Jones
    • MaryJo E. Kramer
    • Richard D. Urman

    Original Research 29 October 2019 Pages: 200 - 212

    

13. Is the Recommendation of a Pelvic Lymphadenectomy in Conjunction with Radical Prostatectomy in Prostate Cancer Patients Justified? Report from a Multidisciplinary Expert Panel Meeting

    • Alexander Winter
    • Rolf Harzmann
    • Lothar Weissbach

    Original Research 02 November 2019 Pages: 213 - 224

    

14. Assessing the Long-Term Effectiveness of Cladribine vs. Placebo in the Relapsing-Remitting Multiple Sclerosis CLARITY Randomized Controlled Trial and CLARITY Extension Using Treatment Switching Adjustment Methods

    • Helen Bell Gorrod
    • Nicholas R. Latimer
    • Schiffon L. Wong

    Original Research 07 November 2019 Pages: 225 - 239

    

15. Real-World Predictors of Major Adverse Cardiovascular Events and Major Adverse Limb Events Among Patients with Chronic Coronary Artery Disease and/or Peripheral Arterial Disease

    • Ariel Berger
    • Alex Simpson
    • Jeffrey Berger

    Original Research 08 November 2019 Pages: 240 - 252

    

16. Pharmacokinetics and Safety of Single-Dose Esaxerenone in Japanese Subjects with Mild to Moderate Hepatic Impairment

    • Akifumi Kurata
    • Takafumi Yoshida
    • Hitoshi Ishizuka

    Original Research Open access 08 November 2019 Pages: 253 - 264

    

17. Clinical Analysis of 122 Cases with Mycoplasma Pneumonia Complicated with Atelectasis: A Retrospective Study

    • De-Quan Su
    • Jin-Fan Li
    • Zhi-Qiang Zhuo

    Original Research 09 November 2019 Pages: 265 - 271

18. Epidural Corticosteroids, Lumbar Spinal Drainage, and Selective Hemodynamic Control for the Prevention of Spinal Cord Ischemia in Thoracoabdominal Endovascular Aortic Repair: A New Clinical Protocol

    • Alberto Pasqualucci
    • Ayman Al-Sibaie
    • Giustino Varrassi

    Original Research Open access 12 November 2019 Pages: 272 - 287

    

19. Cancer-Specific Loss of Urocortin 3 in Human Renal Cancer

    • Pouriya Faraj Tabrizi
    • Anahit Mohebbi Tafrechi
    • Hossein Tezval

    Original Research Open access 13 November 2019 Pages: 288 - 299

    

20. Real-World Effectiveness and Real-World Cost-Effectiveness of Intravitreal Aflibercept and Intravitreal Ranibizumab in Neovascular Age-Related Macular Degeneration: Systematic Review and Meta-Analysis of Real-World Studies

    • Joao Carrasco
    • Georg-Alexander Pietsch
    • Jisu Yoon

    Original Research Open access 14 November 2019 Pages: 300 - 315

    

21. Prospective, Multicenter, Cross-Sectional Survey on Dry Eye Disease in Japan

    • Jun Shimazaki
    • Yuya Nomura
    • Yoshiaki Yamada

    Original Research 14 November 2019 Pages: 316 - 328

    

22. Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

    • Martin Kallab
    • Stephan Szegedi
    • Gerhard Garhöfer

    Original Research Open access 18 November 2019 Pages: 329 - 341

    

23. Correction to: Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

    • Martin Kallab
    • Stephan Szegedi
    • Gerhard Garhöfer

    Correction Open access 10 December 2019 Pages: 342 - 343

24. Cost-Effectiveness of Treating Early to Moderate Stage Knee Osteoarthritis with Intra-articular Hyaluronic Acid Compared to Conservative Interventions

    • Jeffrey Rosen
    • Faizan Niazi
    • Stan Dysart

    Original Research Open access 18 November 2019 Pages: 344 - 352

    

25. The Long-Term Effectiveness and Safety of Omalizumab on Patient- and Physician-Reported Asthma Control: A Three-Year, Real-Life Observational Study

    • Jens Schreiber
    • Inessa Schwab Sauerbeck
    • Claudia Mailänder

    Original Research Open access 18 November 2019 Pages: 353 - 363

    

26. Long-Term Safety of Adalimumab in 29,967 Adult Patients From Global Clinical Trials Across Multiple Indications: An Updated Analysis

    • Gerd R. Burmester
    • Kenneth B. Gordon
    • Remo Panaccione

    Original Research Open access 20 November 2019 Pages: 364 - 380

    

27. The Relationship Between Homocysteine, Blood Pressure Variability, and Left Ventricular Hypertrophy in Patients with Essential Hypertension: An Observational Study

    • Bei-You Lin
    • Ping Li
    • Zhi-Yu Zeng

    Original Research 21 November 2019 Pages: 381 - 389

    

28. Expression of HSPA8 in Nucleus Pulposus of Lumbar Intervertebral Disc and Its Effect on Degree of Degeneration

    • Yong Liu
    • Hua-Cong Wang
    • Bo-Hua Chen

    Original Research 21 November 2019 Pages: 390 - 401

    

29. Comparing the Treatment of Congenital Spine Deformity Using Freehand Techniques In Vivo and 3D-Printed Templates In Vitro (Prospective–Retrospective Single-Center Analytical Single-Cohort Study)

    • Sergey V. Vissarionov
    • Dmitriy N. Kokushin
    • Gjumrakch Aliev

    Original Research 21 November 2019 Pages: 402 - 419

    

30. Influence of Direct Thrombin Inhibitor and Low Molecular Weight Heparin on Platelet Function in Patients with Coronary Artery Disease: A Prospective Interventional Trial

    • Flávia B. B. Arantes
    • Fernando R. Menezes
    • José C. Nicolau

    Original Research Open access 22 November 2019 Pages: 420 - 430

    

31. Cost-Effectiveness of Reimbursing Infliximab for Moderate to Severe Crohn’s Disease in China

    • Haotian Chen
    • Jihao Shi
    • Qian Cao

    Original Research 03 December 2019 Pages: 431 - 449

    

32. Validation of Waste Anaesthetic Gas Exposure Limits When Using a Closed Vaporizer Filling System: A Laboratory-Based Study

    • Shane Varughese
    • H. Peter Bacher

    Original Research Open access 04 December 2019 Pages: 450 - 456

    

33. A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan

    • Isao Kawaguchi
    • Kazuaki Chayama
    • Hiromitsu Kumada

    Original Research Open access 05 December 2019 Pages: 457 - 476

    

34. Economic Value of Adjunctive Brivaracetam Treatment Strategy for Focal Onset Seizures in Finland

    • Saku Väätäinen
    • Erkki Soini
    • Reetta Kälviäinen

    Original Research Open access 05 December 2019 Pages: 477 - 500

    

35. Matching-Adjusted Indirect Comparison of the Efficacy of Apalutamide and Enzalutamide with ADT in the Treatment of Non-Metastatic Castration-Resistant Prostate Cancer

    • Simon Chowdhury
    • Stéphane Oudard
    • Boris A. Hadaschik

    Original Research Open access 07 December 2019 Pages: 501 - 511

    

36. Matching-Adjusted Indirect Comparison of Health-Related Quality of Life and Adverse Events of Apalutamide Versus Enzalutamide in Non-Metastatic Castration-Resistant Prostate Cancer

    • Simon Chowdhury
    • Stéphane Oudard
    • Boris A. Hadaschik

    Original Research Open access 07 December 2019 Pages: 512 - 526

    

37. Factors Determining the Choice of Spinal Versus General Anesthesia in Patients Undergoing Ambulatory Surgery: Results of a Multicenter Observational Study

    • Xavier Capdevila
    • Christophe Aveline
    • Francis Bonnet

    Original Research Open access 11 December 2019 Pages: 527 - 540

    

38. Impact of Chloroprocaine on the Eligibility for Hospital Discharge in Patients Requiring Ambulatory Surgery Under Spinal Anesthesia: An Observational Multicenter Prospective Study

    • Xavier Capdevila
    • Christophe Aveline
    • Francis Bonnet

    Original Research Open access 11 December 2019 Pages: 541 - 551

    

39. Survival, Chemotherapy Treatments, and Health Care Utilization Among Patients with Advanced Small Cell Lung Cancer: An Observational Study

    • Jinghua He
    • Changxia Shao
    • Fan Jin

    Original Research 11 December 2019 Pages: 552 - 565

    

40. Surgery for Idiopathic Epimacular Membrane: Morpho-Functional Outcomes Based on the Preoperative Macular Integrity of the Photoreceptoral Junction. A Prospective Pilot Study

    • Giulio Ruberto
    • Vincenzo Parisi
    • Luciano Quaranta

    Original Research 11 December 2019 Pages: 566 - 577

    

41. Integrating Duodenal Sampling in a Human Mass Balance Study to Quantify the Elimination Pathways of JNJ-53718678, a Respiratory Syncytial Virus Fusion Protein Inhibitor

    • Bart Remmerie
    • Maarten van den Boer
    • Marita Stevens

    Original Research 12 December 2019 Pages: 578 - 591

    

42. Application of Dried Human Amnion Graft to Improve Post-Prostatectomy Incontinence and Potency: A Randomized Exploration Study Protocol

    • Dimitri Barski
    • Holger Gerullis
    • Thomas Otto

    Study Protocol Open access 28 November 2019 Pages: 592 - 602

    

43. Recognising Skin Cancer in Primary Care

    • Owain T. Jones
    • Charindu K. I. Ranmuthu
    • Fiona M. Walter

    Practical Approach Open access 16 November 2019 Pages: 603 - 616

    

44. Stepwise Decreasing of Vitreous Pressure by Anterior Vitrectomy: A Novel Method for Preventing Positive Vitreous Pressure During Penetrating Keratoplasty

    • Xinyu Huang
    • Qi Zhou
    • Yanlong Bi

    Case Series Open access 15 November 2019 Pages: 617 - 629

    

45. Methylmalonic Acidemia Complicated by Homocystinuria Diseases: a Report of Three Cases

    • Ya-Nan Zhang
    • Ya-Lei Pi
    • Hui-Feng Zhang

    Case Series 22 November 2019 Pages: 630 - 636