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Drugs and the Developing Brain

  • Book
  • © 1974

Overview

Editors:
  1. Antonia Vernadakis

    1. Department of Psychiatry and Pharmacology, University of Colorado, School of Medicine, Denver, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Norman Weiner

    1. Department of Pharmacology, University of Colorado, School of Medicine, Denver, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Behavioral Biology (ABBI, volume 8)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xii
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  5. Drug Actions: Biochemical Development

    1. Front Matter

      Pages 213-213
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    2. Alterations of Protein Metabolism during Development of the Brain

      • Abel Lajtha, David Dunlop
      Pages 215-229

    3. Free Amino Acids in the Developing Brain as Affected by Drugs

      • Williamina A. Himwich, Jimmie M. Davis
      Pages 231-241

    4. Effects of Prenatal and Postnatal Nicotine Administration on Biochemical Aspects of Brain Development

      • Doherty B. Hudson, Beverly J. Merrill, Laurie A. Sands
      Pages 243-256

  6. Drug Actions: Biochemical Development

    1. Front Matter

      Pages 257-257
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    2. Maturation of the Blood-Brain and Blood-CSF Barriers

      • Dixon M. Woodbury
      Pages 259-280
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Keywords

About this book

The thalidomide tragedy which occurred slightly more than a decade ago made public officials and the general public acutely aware of the teratogenic potential of drugs. Although specialists in pharmacology and developmental biology had been studying this problem many years before, this catastrophic episode triggered the passage of legislation which required that information about the teratogenicity of drugs be produced before the drugs could be available to the general public. Gross deformities in man produced by drugs are frequently difficult to reproduce in experimental animals and the changes which are produced in other animals are frequently not translatable to humans. The problem of evaluating the potential that drugs have to produce gross malformations is small, however, compared to the evaluation of subtle but permanent behavioral effects which drugs may exert upon the developing organism. Nevertheless, many experimental studies in recent years indicate that subtle biochemical changes produced by drugs on brain tissue during critical periods of fetal or early post­ natal maturation may become manifest subsequently as behavioral deviations in early childhood or adolescence. Hyperkinetic disorders, epilepsies and other developmental disabilities may have a subtle biochemical imbalance, perhaps drug induced, as an underlying factor. This symposium was organized with the intent of bringing to­ gether prominent investigators who are working in different aspects of brain development and who are interested in the effects of drugs on the developing brain in order to discuss their findings, pro­ pose new theories, and open new avenues for future research.

Editors and Affiliations

  • Department of Psychiatry and Pharmacology, University of Colorado, School of Medicine, Denver, USA

    Antonia Vernadakis

  • Department of Pharmacology, University of Colorado, School of Medicine, Denver, USA

    Norman Weiner

Bibliographic Information

  • Book Title: Drugs and the Developing Brain

  • Editors: Antonia Vernadakis, Norman Weiner

  • Series Title: Advances in Behavioral Biology

  • DOI: https://doi.org/10.1007/978-1-4684-3063-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1974

  • Softcover ISBN: 978-1-4684-3065-3Published: 25 February 2012

  • eBook ISBN: 978-1-4684-3063-9Published: 06 December 2012

  • Series ISSN: 0099-6246

  • Edition Number: 1

  • Number of Pages: XII, 538

  • Topics: Public Health

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