Alterations of Protein Metabolism during Development of the Brain
Clearly development and the metabolism of macromolecules are closely linked phenomena, since growth is necessarily the result of altered protein and nucleic acid synthesis; similarly, mechanisms that control growth and those that control macromolecular metabolism must be closely linked, if not identical. Not surprisingly, this problem has attracted the interest of a number of laboratories during recent years, and many important findings are now available on the nervous system. Nevertheless, details of any mechanisms controlling sequence, regional variations, or functional organization of the development process still escape us. It is timely therefore to briefly discuss our present knowledge on changes in protein turnover during development.
KeywordsProtein Metabolism Biochemical Development Amino Acid Uptake Brain Protein Label Amino Acid
Unable to display preview. Download preview PDF.
- Davis, J.M., and Himwich, W.A., 1973, Amino acids and proteins in the developing brain, in “Biochemistry of the Developing Brain” (W.A. Himwich, ed.) Marcel Dekker, New York.Google Scholar
- Guroff, G., and Udenfriend, S., 1964, The uptake of aromatic amino acids by the brain of mature and newborn rats, in “Progress in Brain Research”, vol. 9, The Developing Brain, (W.A. Himwich and H.A. Himwich, eds.), pp. 187–197, Elsevier, Amsterdam.Google Scholar
- Lajtha, A., 1964, Protein metabolism of the nervous system, in “International Review Neurobiology”, vol. 6, (C.C. Pfeiffer and J.R. Smythies, eds.), pp. 1–98, Academic Press, New York.Google Scholar
- Lajtha, A., and Marks, N., 1971, Protein turnover, in “Handbook of neurochemistry”, vol. 5, (A. Lajtha, ed.), pp. 551–629, Plenum Press, New York.Google Scholar
- Lajtha, A., and Piccoli, F., 1971, Alterations related to the cerebral free amino acid pool during development, in “Cellular Aspects of Neural Growth and Differentiation”, (D.C. Pease, ed.), pp. 419–432, University of California Press, Los Angeles.Google Scholar
- Lajtha, A., and Toth, J., 1966, Instability of cerebral proteins, Biochem. Biophys. Res. Comm. 23: 294–298.Google Scholar
- Lajtha, A., and Toth, J., 1973, Perinatal changes in the free amino acid pool of the brain in mice, Brain Research, in press.Google Scholar
- Levi, G., 1970, Cerebral amino acid transport in vitro during development: a kinetic analysis, Arch. Biochem. Biophys. 138: 347–349.Google Scholar
- Navon, S., and Lajtha, A., 1969, The uptake of amino acids by particulate fractions from brain, Biochim. Biophys. Acta 173: 518–531.Google Scholar
- Roberts, S., 1971, Protein synthesis, in “Handbook of Neurochemistry,” Vol. 5, (A. Lajtha, ed.) pp 1–48, Plenum Press, New York.Google Scholar
- Roberts, S., Zomzely, C.E., and Bondy, S.C., 1971, Developmental alterations in cerebral ribonucleic acid and protein synthesis, in “Cellular aspects of neural growth and differentiation, (D.C. Pease, ed.), pp. 447–471, University of California Press, Los Angeles.Google Scholar