Studies on the Development of Tyrosine Hydroxylase, Monoamine Oxidase and Aromatic-L-Amino Acid Decarboxylase in Several Regions of the Chick Brain
Noradrenergic and dopaminergic neurons are present in the central nervous system and their distribution has been mapped out in considerable detail in rat brain by histochemical fluorescence procedures (Hillarp et al, 1966; Ungerstedt, 1971). Norepinephrine neurons arise in the medulla oblongata and pons and either descend into the spinal cord to terminate in the ventral horn or ascend in the median forebrain bundle to terminate in the lower brain stem, mesencephalon and diencephalon. A second major norepinephrine pathway arises in the locus coeruleus. Some of the axons from this nucleus descend to innervate lower brain stem nuclei. Others either proceed laterally to terminate on the purkinje cells of the cerebellum, or ascend via the median forebrain bundle to terminate in such diverse regions as the hypothalamus, hippocampus, thalamus and cerebral cortex (Ungerstedt, 1971).
KeywordsTyrosine Hydroxylase Monoamine Oxidase Cerebral Hemisphere Acid Decarboxylase Norepinephrine Level
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