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Uptake and Storage of 3H-Norepinephrine in the Cerebral Hemispheres and Cerebellum of Chicks during Embryonic Development and Early Posthatching

  • Antonia Vernadakis
Part of the Advances in Behavioral Biology book series (ABBI, volume 8)

Abstract

Intercommunication between neurons involves neurotransmitter substances which: (a) are synthesized and stored in the presynaptic neuron, (b) are released by the arrival of the impulse; and (c) act on the postsynaptic neurons. The molecular events occurring presynaptically, at the synaptic cleft, or on the postsynaptic membrane are among the most intensively studied subjects in neurobiology. Whereas considerable knowledge exists about the adult CNS, information concerning the differentiation of neurotransmisstion mechanisms during development has only recently begun to accumulate.

Keywords

Glial Cell Chick Embryo Cerebral Hemisphere Developmental Aspect External Granular Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bayliss, B.J., and Todrick, A., 1956, The use of a selective acetyl-cholinesterase inhibitor in the estimation of pseudocholinesterase activity in rat brain, Biochem. J. 62: 62.PubMedGoogle Scholar
  2. Clark, R.B. and Perkins, J.P., 1971, Regulation of adenosine 3’:5’-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine, Proc. Nat. Acad. Sci. 68: 2757.PubMedCrossRefGoogle Scholar
  3. Corner, M.A. and Bot, A.P.C., 1967, Developmental patterns in the central nervous system of birds. II. Somatic motility during the embryonic period and its relation to behavior after hatching, Progr. Brain Res. 26: 214.CrossRefGoogle Scholar
  4. Corner, M.A., Schadand J.P., Sedlâcek, J., Stoeckart, R., and Bot, A.P.C., 1967, Developmental patterns in the central nervous system of birds. I. Electrical activity in the cerebral hemisphere, optic lobe and cerebellum, Progr. Brain Res. 26: 145.CrossRefGoogle Scholar
  5. Davis, J.M., Goodwin, F.K., Bunney, W.E., Murphy, D.L., and Colburn, R.W., 1967, Effects of ions in uptake of norepinephrine by synaptosomes, Pharmacologist 9: 184.Google Scholar
  6. Dengler, J.J., Michaelson, I.A., Spiegai, H.E. and Titus, E., 1962, The uptake of labelled norepinephrine by isolated brain and other tissues of the cat, Int. J. Neuropharmacol. 1: 23.CrossRefGoogle Scholar
  7. De Vellis, J., Inglish, D., and Galey, F., 1971, Effects of cortisol and epinephrine on glial cells in culture, in: “Cellular Aspects of Neural Growth and Differentiation”, ( D. Pease, ed.) UCLA Forum in Medical Sciences, University of California Press.Google Scholar
  8. Ellman, G.L., Courtney, K.D., Andres, V., and Featherstone, R.M., 1961, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem. Pharmacology 7: 88.CrossRefGoogle Scholar
  9. Filogamo, G. and Marchisio, P.C., 1971, Acetylcholine system and neural development, Neurosciences 4: 29.Google Scholar
  10. Fritz, A.H. and Hamburger, A., 1971, Glial cell function: Uptake of transmitter substances, Proc. Nat. Acad. Sci. 68: 2686.CrossRefGoogle Scholar
  11. Giacobini, E., 1964, Metabolic relations between glia and neurons studied in single cells, in: “Morphological and Biochemical Correlates of Neural Activity,” ( Cohen and Snider, eds.), Hoeber, New York.Google Scholar
  12. Hanaway, J., 1967, Formation and differentiation of the external granular layer of the thick cerebellum, J. Comp. Neurol. 131: 1.PubMedCrossRefGoogle Scholar
  13. Hornykiewicz, O., 1966, Dopamine (3-hydroxytryptamine) and brain function, Pharmacol. Rev. 18: 925.PubMedGoogle Scholar
  14. Iversen, L.L., 1971, Role of transmitter uptake mechanisms in synaptic neurotransmission, Br. J. Pharmacol. 41: 571.PubMedGoogle Scholar
  15. Iversen, L.L. and Salt, P.J., 1970, Inhibition of catecholamine Uptake2 by steroids in the isolated rat heart, Br. J. Pharmacol. 40: 528.PubMedGoogle Scholar
  16. Kellogg, C., Vernadakis, A. and Rutledge, C.O., 1971, Uptake and metabolism of 3H-norepinephrine in the cerebral hemispheres of chick embryos, J. Neurochem. 18: 1931.PubMedCrossRefGoogle Scholar
  17. Maickel, R.P., Cox, R.H., Jr., Sailant, J. and Miller, F.P., 1968, A method for the determination of serotonin and norepinephrine in discrete areas of rat brain, Int. J. Neuropharmacol. 7: 275.PubMedCrossRefGoogle Scholar
  18. Renson, J., 1971, Development of monaminergic transmission in the rat brain in “Chemistry and Brain Development”, (Paoletti and Davison, eds.), Plenum Press, New York.Google Scholar
  19. Rutledge, C.O., 1970, The mechanisms by which amphetamine inhibits oxidative deamination of norepinephrine in brain, J. Pharmacol. Exp. Ther. 171: 188.PubMedGoogle Scholar
  20. Rutledge, C.O. and Jonason, J., 1967, Metabolic pathways of dopamine and norepinephrine in rabbit brain in vitro, J. Pharmacol. Exp. Ther. 157: 493.PubMedGoogle Scholar
  21. Snyder, S.H. and Coyle, J.T., 1969, Regional differences in 3Hnorepinephrine and 3H-dopamine uptake into rat brain homogenates, J. Pharmacol. Exp. Ther. 165: 78.PubMedGoogle Scholar
  22. Snyder, S.H., Green, A.I. and Hendley, E.D., 1968, Kinetics of 3Hnorepinephrine accumulation into slices from different regions of rat brain, J. Pharmacol. Exp. Ther. 164: 90.PubMedGoogle Scholar
  23. Vernadakis, A., 1973a, Comparative studies of neurotransmitter substances in the maturing and aging central nervous system of the chicken, in “Neurobiological Aspects of Maturation and Aging,” (Ford, ed.), Elsevier, Amsterdam, in press.Google Scholar
  24. Vernadakis, A., 1973b, Changes in nucleic acid content and butyrylcholinesterase activity in CNS structures during the life-span of the chicken, J. Gerontology: 28: 281.Google Scholar
  25. Vernadakis, A. and Burkhalter, A., 1965, Convulsive responses in developing chickens, Proc. Soc. Exper. Biol. & Med. 119: 512.Google Scholar
  26. Vernadakis, A. and Burkhalter, B., 1967, Acetylcholinesterase activity in optic lobes of chicks at hatching, Nature 214: 594.CrossRefGoogle Scholar
  27. Vernadakis, A. and Gibson, D.A., 1973a, Role of neurotransmitter sub- stances in neural growth, in “Conference on The Problems and Priorities in Perinatal Pharmacology” sponsored by National Institute of Child Health, April 12–14, 1973, Raven Press, in press.Google Scholar
  28. Vernadakis, A. and Gibson, D.A., 1973b, Chemical properties of neuronal and glial fractions isolated from chicks early post-hatching. Abstract of paper presented at the 4th Inter. Meeting of the Inter. Soc. for Neurochemistry, Aug. 26–31, 1973, Tokyo, Japan.Google Scholar
  29. Vernadakis, A. and Woodbury, D.M., 1971a, Influence of cortisol on brain and spinal cord excitability in developing rats, in “Steroid Hormones and Brain Function”, (Sawyer and Gorski, eds.) UCLA Forum in Medical Sciences, University of California Press.Google Scholar
  30. Vernadakis, A. and Woodbury, D.M., 1971b, Effects of cortisol on maturation of the central nervous system, in “Influence of Hormones on the Nervous System”, (Ford, ed.), Proc. Intern. Soc. of Psychoneuroendocrinology, S. Karger, Basel, New York.Google Scholar
  31. Vos, J., Schadé, J.P., and Van Der Helm, 1967, Developmental patterns in the central nervous system of birds. II. Some biochemical parameters of embryonic and post-embryonic maturation, Progr. Brain Res. 26: 193.CrossRefGoogle Scholar
  32. Ziance, R.H. and Rutledge, C.O., 1972, A comparison of the effects of fenfluramine and amphetamine on uptake, release and catabolism of norepinephrine in brain, J. Pharmacol. Exp. Ther. 180: 118.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Antonia Vernadakis
    • 1
  1. 1.Departments of Psychiatry and PharmacologyUniversity of Colorado School of MedicineDenverUSA

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