Effects of Prenatal and Postnatal Nicotine Administration on Biochemical Aspects of Brain Development
It has now been established from a number of studies concerned with the effects of nicotine on the adult brain that, depending on the dose administered, nicotine is capable of facilitating elementary forms of learning (Bovet et al., 1969), stimulating or depressing spontaneous motor activity (Bovet et al., 1967; Larson and Silvetti, 1965), inducing EEG and behavioral arousal (Knapp and Domino, 1962; Yamamoto and Domino, 1965), and inducing seizure discharges (Stümpf, 1965; Stümpf and Gogolák, 1967). Although less work has been conducted on the effects of this noxious agent on the developing brain, work from this laboratory using electroconvulsive tests as a measure of whole brain activity has shown that maturation is delayed in the offspring of nicotine-treated animals and that susceptibility to convulsions is temporarily increased once maturity has been attained (Hudson et al., 1973).
KeywordsCerebral Hemisphere Biochemical Development Early Postnatal Life Postnatal Neurogenesis Tobacco Alkaloid
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