Free Amino Acids in the Developing Brain as Affected by Drugs
As Nyhan (1961) pointed out, the effects of most drugs in children are sufficiently different from those seen at older ages and in the adult to warrant considerable systematic investigation. Not only are the differences between the young and the adult of importance, but the timing and patterns of changes which occur as the animal matures are also of importance. During the period of rapid brain development the free amino acid pool in the brain serves as a source of building material for the brain proteins, and in addition some members such as glutamate are used for energy, while others such as GABA serve as neurotransmitters. Any disturbance of the delicate balance among the free amino acids can be expected to affect many reactions necessary to the unimpeded development of the brain. How serious these may be, we have as yet no means of determining. The data presented below are the result of some of our efforts to study these factors.
KeywordsGlutamic Acid Aspartic Acid Free Amino Acid Caudate Nucleus Amino Acid Level
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