Chromogranins and Neurotransmitter Retention During Development of the Adrenergic Neuron

  • Bernard L. Mirkin
Part of the Advances in Behavioral Biology book series (ABBI, volume 8)


Functional maturation within the sympathetic nervous system is reflected by the ability of the neuron to synthesize, retain, release and metabolize adrenergic neurotransmitter. The ontogenetic patterns of catecholamine biosynthesis (Friedman et al., 1968; Friedman, 1969; Ignarro and Shideman, 1968a, 1968b), uptake (Iversen et al., 1967; Mirkin, 1972), release (Iversen et al., 1967) and metabolism (Brunjes et al., 1964; Glowinski et al., 1964; Ignarro and Shideman, 1968b) have been reasonably well, if not completely, defined. A major unresolved question is how adrenergic neurotransmitter is bound and retained within the neuron ready to be released in an active form upon neuronal activation. The relationship between neuronal binding of catecholamines and the presence of specific soluble proteins in the adrenergic vesicle has been studied in the developing adrenergic neuron. Data derived from these investigations will be presented in this report.


Adrenal Medulla Sucrose Density Gradient Developmental Aspect Adrenergic Neuron Precipitin Line 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Bernard L. Mirkin
    • 1
  1. 1.Division of Clinical Pharmacology, Departments of Pharmacology and PediatricsUniversity of MinnesotaMinneapolisUSA

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