Collection
Special Issue in honor of Prof. Laurence Hurley
- Submission status
- Closed
We are delighted to announce this special issue of Medicinal Chemistry Research honoring Prof. Laurence Hurley, a respected teacher and a well-known and highly regarded medicinal chemist.
You are invited to submit a review or research article to this special issue under the broad theme of drug design and discovery. The special issue will be guest edited by Dr. Wei Wang, Dr. Myron K. Jacobson and Dr. Elaine L. Jacobson.
Prof. Hurley received his B. Pharm with Honors from University of Bath in England in 1967 and his Ph.D. in Medicinal Chemistry working with Prof. Heinz G. Floss and Ulfert Hornemann at Purdue University in 1970 and conducted his post-doctoral study with Prof. James P. Kutney in Chemistry Department at University of British Columbia, Canada from 1970-1972. He joined the faculty at the University of Maryland, Baltimore in 1972, and worked and was promoted from Assistant to Full Professor at the University of Kentucky from 1973 to 1980. He spent 20 years as faculty in the College of Pharmacy at The University of Texas at Austin and served as the Head of Laboratory for Drug Design from 1981-2000. At UT Austin, he was Henry M. Burlage Centennial Professor of Medicinal Chemistry (1983–1986), James E. Bauerle Professor of Medicinal Chemistry (1986-1988), George Hitchings Professor of Drug Design (1988-1992) and George Hitchings Regents Chair in Drug Design (1992-2000). Since 2000, he had been Howard J. Schaeffer Endowed Chair in Pharmaceutical Sciences at the University of Arizona until his retirement in 2019. He has served as Chair, Chemistry in Cancer Research, American Association for Cancer Research (2009) and Vice-Chair, American Chemical Society Medicinal Chemistry Division (2009). He was the Associate Editor of Current Medicinal Chemistry (2001–2010) and the Senior Editor of Journal of Medicinal Chemistry (1992–2010). He was the Founder and Scientific Director in Cylene Pharmaceuticals, Inc (1997-2006) and TetraGene LLC (2012-2016) and the Founder and CSO in Reglagene (2016-present). He received the Distinguished Alumnus Award from Purdue University School of Pharmacy and Pharmaceutical Sciences (1988), Volwiler Research Achievement Award, American Association of Colleges of Pharmacy (1989), Research Achievement Award in Medicinal Chemistry, American Pharmaceutical Association (1992), George & Christine Sosnovsky Award in Cancer Therapy, Royal Society of Chemistry (2005), and Paul Dawson Biotechnology Award, American Association of Colleges of Pharmacy (2008). He was inducted into the ACS MEDI Hall of Fame (1994) and was elected as a Fellow of the American Association for the Advancement of Science (1990) and a Fellow of National Academy of Inventers (2020). He has published 278 papers (with an H-Index of 92), 3 books, and filed 32 patents.
Editors
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Wei Wang ,
Wei Wang
Co-Director, Arizona Center for Drug Discovery, and Professor, Dept. of Pharmacology and Toxicology, University of Arizona College of Pharmacy
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Myron K. Jacobson
Founding Dean, University of North Texas College of Pharmacy, and former Research Professor, University of Arizona College of Pharmacy
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Elaine Jacobson
Former Research Professor, University of Arizona College of Pharmacy
Articles (14 in this collection)
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Useful preclinical clues that a proposed new therapy would work in the clinic: to make a medicinal chemist’s dreams come true
Authors
- Daniel D. Von Hoff
- Haiyong Han
- Content type: Editorial
- Published: 02 June 2022
- Pages: 1064 - 1067
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Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors
Authors (first, second and last of 11)
- Giri R. Gnawali
- Koichi Okumura
- Andrew S. Kraft
- Content type: Original Research
- Published: 26 May 2022
- Pages: 1154 - 1175
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Special issue in honor of Prof. Laurence H. Hurley
Authors
- Myron K. Jacobson
- Wei Wang
- Elaine L. Jacobson
- Content type: Editorial
- Published: 20 May 2022
- Pages: 1061 - 1063
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Discovery of novel, selective, functionalized 5-(2-(5-arylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)ethyl)-γ-butyrolactone sigma-2 ligands
Authors (first, second and last of 6)
- Benjamin E. Blass
- Kevin M. Blattner
- Daniel J. Canney
- Content type: Original Research
- Published: 18 May 2022
- Pages: 1209 - 1223
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2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities
Authors (first, second and last of 7)
- Ronak Haj Ersan
- Burak Kuzu
- Oztekin Algul
- Content type: Original Research
- Published: 16 May 2022
- Pages: 1192 - 1208
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Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
Authors
- Haozhou Tan
- Chunlong Ma
- Jun Wang
- Content type: Original Research
- Published: 12 May 2022
- Pages: 1147 - 1153
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Molecular glues: enhanced protein-protein interactions and cell proteome editing
Authors (first, second and last of 4)
- Evita G. Weagel
- Jason M. Foulks
- Steven L. Warner
- Content type: Review Article
- Open Access
- Published: 12 May 2022
- Pages: 1068 - 1087
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Synthesis of alamandine glycoside analogs as new drug candidates to antagonize the MrgD receptor for pain relief
Authors (first, second and last of 8)
- Wafaa Alabsi
- Timothy Jaynes
- Robin Polt
- Content type: Original Research
- Published: 08 April 2022
- Pages: 1135 - 1146
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A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants
Authors (first, second and last of 7)
- Zhengwei Zhang
- Jingjie Ge
- Jianhua Zhu
- Content type: original research
- Published: 05 February 2022
- Pages: 1126 - 1134
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A vitamin D C/D ring-derived compound with cytotoxicity
Authors (first, second and last of 9)
- Alaa N. Hassan
- Tsugumasa Toma
- Masami Otsuka
- Content type: Original Research
- Published: 02 February 2022
- Pages: 1120 - 1125
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Synthesis and in silico evaluation of novel uridyl sulfamoylbenzoate derivatives as potential anticancer agents targeting M1 subunit of human ribonucleotide reductase (hRRM1)
Authors (first, second and last of 9)
- Prince J. Salvador
- Heather B. Jacobs
- Ahmed M. Awad
- Content type: Original Research
- Published: 28 January 2022
- Pages: 1109 - 1119
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Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents
Authors
- Zheng-Rong Wu
- Wei Deng
- Dian He
- Content type: Original Research
- Published: 24 January 2022
- Pages: 1099 - 1108
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Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin
Authors (first, second and last of 6)
- Chandrashekhar Madasu
- Ya-Ming Xu
- A. A. Leslie Gunatilaka
- Content type: Original Research
- Published: 17 January 2022
- Pages: 1088 - 1098