Abstract
In recent years, with the booming economy, the Chinese government has increased its financial input to biotechnology research, which has led to remarkable achievements by China in modern biotechnology. As one of the key parts of modern biotechnology, industrial biotechnology will be crucial for China’s sustainable development in this century. This review presents an overview of Chinese industrial biotechnology in last 10 years. Modern biotechnology had been classified into metabolic engineering and systems biology framework. Metabolic engineering is a field of broad fundamental and practical concept so we integrated the related technology achievements into the real practices of many metabolic engineering cases, such as biobased products production, environmental control and others. Now metabolic engineering is developing towards the systems level. Chinese researchers have also embraced this concept and have contributed invaluable things in genomics, transcriptomics, proteomics and related bioinformatics. A series of advanced laboratories or centers were established which will represent Chinese modern biotechnology development in the near future. At the end of this review, metabolic network research advances have also been mentioned.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Han B, Xue Y, Li J, Deng XW (2007) Phil Trans R Soc B 362:1009
Liao L, Li J, Zhao RC (2007) Phil Trans R Soc B 362:1107
McGovern PE, Zhang J, Tang J, Zhang Z, Hall GR, Moreau RA, Nuñez A, Butrym ED, Richards MP, Wang CS, Cheng G, Zhao Z, Wang C (2004) Proc Natl Acad Sci U S A 101:17953
Marquardt R (1998) Chemie Ingenieur Technik 70:158
Bailey JE (2001) Metab Eng 3:111
Bailey JE (1999) Nat Biotechnol 17:616
Cameron DC, Tong IT (1993) Appl Biochem Biotechnol 38:105
Kong QX, Cao LM, Zhang AL, Chen X (2007) Appl Microbiol Biotechnol 73:1382
Kong QX, Zhang AL, Cao LM, Chen X (2007) Appl Microbiol Biotechnol 75:1361
Zhang A, Kong Q, Cao L, Chen X (2007) Lett Appl Microbiol 44:212–7
Cao L, Zhang A, Kong Q, Xu X, Josine TL, Chen X (2007) Biomol Eng 24:638
Zhang Y, Li Y, Du C, Liu M, Cao Z (2006) Metab Eng 8:578
Du C, Zhang Y, Li Y, Cao Z (2007) Appl Environ Microbiol 73:4515
Yang G, Tian J, Li J (2007) Appl Microbiol Biotechnol 73:1017
Zhang XM, Li Y, Zhuge B, Tang XM, Shen W, Rao ZM, Fang HY, Jian Zhuge J (2006) World J Microbiol Biotechnol 22:945
Cao Y, Xia Q, Fang B (2006) J Chem Technol Biotechnol 81:109
Fenghuan W, Huijin Q, He H, Tan T (2005) Mol Biotechnol 31:211
Cheng KK, Zhang JA, Liu DH, Sun Y, Liu HJ, Yang MD, Xu JM (2007) Process Biochem 42:740
Liu HJ, Zhang DJ, Xu YH, Mu Y, Sun YQ, Xiu ZL (2007) Biotechnol Lett 29:1281
Zou XH, Chen GQ (2007) Macromol Biosci 7:174
Qiu YZ, Ouyang SP, Wu Q, Chen GQ (2004) Macromol Biosci 4:255
Ouyang SP, Han J, Qiu YZ, Qin LF, Chen S, Wu Q, Leski ML, Chen GQ (2005) Macromol Symp 224:21
Qiu YZ, Han J, Chen GQ (2006) Appl Microbiol Biotechnol 69:537
Han J, Qiu YZ, Liu DC, Chen CG (2004) FEMS Microbiol Lett 239:195
Lu XY, Wu Q, Chen GQ (2004) Appl Microbiol Biotechnol 64:41
Lu XY, Zhang JY, Wu Q, Chen GQ (2003) FEMS Microbiol Lett 221:97
Chen JY, Liu T, Zheng Z, Chen JC, Chen GQ (2004) FEMS Microbiol Lett 234:231
Chen JY, Song G, Chen GQ (2006) Antonie Van Leewenhoek 89:157
Ouyang SP, Liu Q, Fang L, Chen GQ (2007) Macromol Biosci 7:227
Li R, Zhang H, Qi Q (2007) Bioresour Technol 98:2313
Li R, Chen Q, Wang PG, Qi Q (2007) Appl Microbiol Biotechnol 75:1103
Wang QH, He P, Lu DJ, Shen A, Jiang N (2005) Enzyme Microb Technol 36:832
Liu LM, Li Y, Li HZ, Chen J (2004) Lett Appl Microbiol 39:199
Liu L, Li Y, Zhu Y, Du G, Chen J (2007) Metab Eng 9:21
Liu L, Li Y, Shi Z, Du G, Chen J (2006) J Biotechnol 126:173
Wang Q, Wu C, Chen T, Chen X, Zhao X (2006) Biotechnol Lett 28:89
Wang Q, Chen X, Yang Y, Zhao X (2006) Appl Microbiol Biotechnol 73:887
Wu H, Li ZM, Zhou L, Ye Q (2007) Appl Environ Microbiol 73:7837
Hong JH, Zhang L, Shi GY, Wang ZX, Zhang KC (2006) Chin J Appl Environ Biol 12:391
Hong J, Shen Y, Bao XM (2006) Prog Biochem Biophys 31:746
Wei P, Li Z, Lin Y, He P, Jiang N (2007) Biotechnol Lett 29:1501
Lei J, Zhao X, Ge X, Bai F (2007) J Biotechnol 131:270
Liu L, Xu Q, Li Y, Shi Z, Zhu Y, Du G, Chen J (2007) Biotechnol Bioeng 97:825
Ouyang SP, Liu Q, Sun SY, Chen JC, Chen GQ (2007) J Biotechnol 132:246
Xiong X, Xing J, Li X, Bai X, Li W, Li Y, Liu H (2007) Appl Environ Microbiol 73:2394
Yan DZ, Liu H, Zhou NY (2006) Appl Environ Microbiol 72:2283
Zheng T, Luo Y, Cao X, Huang X, Hu Z, Tian Y (2006) Chin J Appl Environ Biol 12:884
Lin B, Van Verseveld HW, Roling WF (2002) Biomed Environ Sci 15:130
Dong QL, Zhao XM, Ma HW, Xing XY, Sun NX (2006) Biotechnol J 1:1283
Zhang D, Wang PG, Qi Q (2007) Biotechnol Lett 29:1729
Zhang DW, Li Z, Wang FH, Shrestha B, Tian PF, Tan TW (2007) Enzyme Microb Technol 41:772
Li FX, Jin ZP, Zhao DX, Cheng LQ, Fu CX, Ma F (2006) Phytochemistry 67:553
Wu QL, Chen T, Gan Y, Chen X, Zhao XM (2007) Appl Microbiol Biotechnol 76:783
Zhu Y, Chen X, Chen T, Zhao X (2007) FEMS Microbiol Lett 266:224.
Zhu Y, Chen X, Chen T, Shi S, Zhao X (2006) Biotechnol Lett 28:1667
Li XJ, Chen T, Chen X, Zhao XM (2006) Appl Microbiol Biotechnol 73:374
Swinbanks D (1998) Nature 394:109
Ren SX, Fu G, Jiang XG, Zeng R, Miao YG (2003) Nature 422:888
Qian W, Jia Y, Ren SX, He YQ, Feng JX, Lu LF, Sun Q, Ying G, Tang DJ, Tang H, Wu W, Hao P, Wang L, Jiang BL, Zeng S, Gu WY, Lu G, Rong L, Tian Y, Yao Z, Fu G, Chen B, Fang R, Qiang B, Chen Z, Zhao GP, Tang JL, He C (2005) Genome Res 15:757
Wei W, McCusker JH, Hyman RW, Jones T, Ning Y, Cao Z, Gu Z, Bruno D, Miranda M, Nguyen M, Wilhelmy J, Komp C, Tamse R, Wang X, Jia P, Luedi P, Oefner PJ, David L, Dietrich FS, Li Y, Davis RW, Steinmetz LM (2007) Proc Natl Acad Sci U S A 104:12825
Nie H, Yang F, Zhang X, Yang J, Chen L, Wang J, Xiong Z, Peng J, Sun L, Dong J, Xue Y, Xu X, Chen S, Yao Z, Shen Y, Jin Q (2006) BMC Genomics 7:173
Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J (2002) Nucleic acids Res 30:4432
Chiu CH, Tang P, Chu C, Hu S, Bao Q, Yu J, Chou YY, Wang HS, Lee YS (2005) Nucleic acids Res 33:1690
Zhang YQ, Ren SX, Li HL, Wang YX, Fu G, Yang J, Qin ZQ, Miao YG, Wang WY, Chen RS, Shen Y, Chen Z, Yuan ZH, Zhao GP, Qu D, Danchin A, Wen YM (2003) Mol Microbiol 49:1577
Song Y, Tong Z, Wang J, Wang L, Guo Z, Han Y, Zhang J, Pei D, Zhou D, Qin H, Pang X, Han Y, Zhai J, Li M, Cui B, Qi Z, Jin L, Dai R, Chen F, Li S, Ye C, Du Z, Lin W, Wang J, Yu J, Yang H, Wang J, Huang P, Yang R (2004) DNA Res 11:179
Feng L, Wang W, Cheng J, Ren Y, Zhao G, Gao C, Tang Y, Liu X, Han W, Peng X, Liu R, Wang L (2007) Proc Natl Acad Sci U S A 104:5602
Yang F, Jia Q, Xiong ZH, Zhang XB, Wu HT, Zhao Y, Yang J, Zhu JP, Dong J, Xue Y, Sun LL, Shen Y, Jin Q (2006) Chin Sci Bulletin 51:941
Bao QY (2002) Institute of Genetics and Developmental Biology, CAS Ph.D thesis
Zhang CT, Wang J (2000) Nucleic Acids Res 28:2804.
Zhang R, Zhang CT (2004) J Mol Evol 59:227
Zhang R, Zhang CT (2005) Archaea 1:335
Zhang R, Zhang CT (2005) Appl Environ Microbiol 71:3126
Wu J, Mao X, Cai T, Luo J, Wei L (2006) Nucleic Acids Res 34(Web Server issue):W720
Yang J, Wang J, Yao ZJ, Jin Q, Shen Y, Chen R (2003) J Microbiol Methods 54:423
Han ZG, Zhao GP, Chen Z (2003) C R Biol 326:949
Zhou D, Han Y, Qiu J, Qin L, Guo Z, Wang X, Song Y, Tan Y, Du Z, Yang R (2006) Microbes Infect 8:2669
Qiu J, Zhou D, Qin L, Han Y, Wang X, Du Z, Song Y, Yang R (2006) FEMS Microbiol Lett 263:26
Xu Z, Zhang LX, Zhang JD, Cao YB, Yu YY, Wang DJ, Ying K, Chen WS, Jiang YY (2006) Int J Med Microbiol 296:421
Yu L, Zhang W, Wang L, Yang J, Liu T, Peng J, Leng W, Chen L, Li R, Jin Q (2006) Antimicrob Agents Chemother 51:44
Liu X, Zhang X, Wang C, Liu L, Lei M, Bao X (2007) Curr Microbiol 54:325
Zhang L, Zhang Y, Zhou Y, Zhao Y, Zhou Y, Cheng J (2002) Int J Antimicrob Agents 20:444
Zhang L, Zhang Y, Zhou Y, An S, Zhou Y, Cheng J (2002) J Antimicrob Chemother 49:905
Gu X, Zhang Z, Huang W (2005) Proc Natl Acad Sci U S A 102:707
Chen Z, Wang W, Ling XB, Liu JJ, Chen L (2006) BMC Bioinformatics 7:72
Wilkins MR, Sanchez JC, Gooley AA, Appel RD, Humphery-Smith I, Hochstrasser DF, Williams KL (1996) Biotechnol Genet Eng Rev 13:19
Xi J, Wang X, Li S, Zhou X, Yue L, Fan J, Hao D (2006) Phytochemistry 67:2341
Zhang X, Shi L, Shu S, Wang Y, Zhao K, Xu N, Liu S, Roepstorff P (2007) Proteomics 7:2340
Jiang X, Ye M, Jiang X, Liu G, Feng S, Cui L, Zou H (2007) J Proteome Res 6:2287
Jiang X, Jiang X, Feng S, Tian R, Ye M, Zou H (2007) J Proteome Res 6:1038
Jiang X, Feng S, Tian R, Han G, Jiang X, Ye M, Zou H (2007) Proteomics 7:528
Gu X, Deng C, Yan G, Zhang X (2006) J Proteome Res 5:3186
Xie C, Ye M, Jiang X, Jin W, Zou H (2006) Mol Cell Proteomics 5:454
Zhang C, Liu P, Wang N, Li Y, Wang L (2007) Mol Vis 13:1873
Yan H, Row KH (2006) Anal Chim Acta 566:147
Yan L, Zhang JD, Cao YB, Gao PH, Jiang YY (2007) Acad J Second Mil Med Univ 28:438
Wang X, Li X, Li Y (2007) Biotechnol Lett 29:1599
Jiang X, Jiang X, Han G, Ye M, Zou H (2007) BMC Bioinformatics 8:323
Zhang Y, Yin Y, Chen Y, Gao G, Yu P, Luo J, Jiang Y (2003) BMC Genomics 4:42
Mao Y, Li Y, Zhang X (2006) Proteomics 6:420
Mao Y, Li Y, Zhang X (2007) Proteomics 7:1409
Wang YX, Yuan YJ (2005) J Proteome Res 4:1999
Cheng JS, Yuan YJ (2006) Proteomics 6:2199
Wang S, Zhu R, Peng B, Liu M, Lou Y, Ye X, Xu Z, Liu D, Peng X (2006) Proteomics 6:5212
Huang CZ, Lin XM, Wu LN, Zhang DF, Liu D, Wang SY, Peng XX (2006) J Proteome Res 5:3268
Liang Y, Chen H, Tang M, Shen S (2007) Mycol Res 111:939
Müller WE, Brümmer F, Batel R, Müller IM, Schröder HC (2003) Genomics 90:103
Zhang Y, Fan XG, Chen R, Liu JP, Li N (2004) World Chin J Digestology 12:1325
Kan B, Habibi H, Schmid M, Liang W, Wang R, Wang D, Jungblut PR (2004) Proteomics 4:3061
Peng X, Xu C, Ren H, Lin X, Wu L, Wang S (2005) J Proteome Res 4:2257
Wang QZ, Wu CY, Chen T, Chen X, Zhao XM (2006) Appl Microbiol Biotechnol 70:151
Yang S, Qiao B, Lu SH, Yuan YJ (2007) Biochim Biophys Acta 1771:600
Chen W, Yu FM, Yuan YJ (2007) J Chem Industry Eng 58:2336
Gao P, Shi C, Tian J, Shi X, Yuan K, Lu X, Xu G (2007) J Pharm Biomed Anal 44:180
Jia L, Tanaka N, Terabe S (2005) Electrophoresis 26:3468
Chen H, Wortmann A, Zenobi R (2007) J Mass Spectrom 42:1123
Xia JM, Wu XJ, Yuan YJ (2007) Metabolomics 3:531
Li J, Wu XJ, Liu CX, Yuan YJ (2006) Yaoxue Xuebao 41:47
Ni Y, Su M, Qiu Y, Chen M, Liu Y, Zhao A, Jia W (2007) FEBS Lett 581:707
Rathsam C, Eaton RE, Simpson CL, Browne GV, Valova VA, Harty DW, Jacques NA (2005) J Proteome Res 6:2161
Sun Y, Qian SJ (2002) Biotechnol Lett 24:1525
Ma H, Zeng AP (2003) Bioinformatics 19:270
Ma HW, Zhao XM, Yuan YJ, Zeng AP (2004) Bioinformatics 20:1870
Jiang D, Wang YH, Li Y, Zhang SW, Yang SL, Yang L (2006) Chem J Chin Universi 27:1683
124. Luo YE, Fan DD, Shang LA, Shi HJ, Ma XX, Mi Y, Zhao GF (2008) Biotechnol Lett 30:637
Gao HJ, Du GC, Chen J (2006) World J Microbiol Biotechnol 22:399
Bai DM, Zhao XM, Li XG, Xu SM (2004) Biotechnol Bioeng 88:681
Bai DM, Zhao XM, Li XG, Xu SM (2004) Biochem Eng J 18:41
Zhang HM, Shimizu K, Yao SJ (2003) Biochem Eng J 16:211
Li M, Ho PY, Yao SJ, Shimizu K (2006) Biochem Eng J 30:286
Zhang HM, Yao SJ (2007) Chin J Chem Eng 15:150
González-Díaz H, Agüero-Chapin G, Varona J, Molina R, Delogu G, Santana L, Uriarte E, Podda G (2007) Bioinformatics 23:1049
Luo RY, Liao S, Zeng SQ, Li YX, Luo QM (2006) Chin Sci Bull 51:689
Acknowledgments
This work was partly supported by National Natural Science Foundation of China (20536040) and State Key Development Program for Basic Research of China (2003CB716003 and 2007CB707802).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wang, QZ., Zhao, XM. (2009). Modern Biotechnology in China. In: Tsao, G., Ouyang, P., Chen, J. (eds) Biotechnology in China II. Advances in Biochemical Engineering / Biotechnology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2008_17
Download citation
DOI: https://doi.org/10.1007/10_2008_17
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-14994-8
Online ISBN: 978-3-642-14995-5
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)