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Integrating metabolomics into a systems biology framework to exploit metabolic complexity: strategies and applications in microorganisms

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Abstract

As an important functional genomic tool, metabolomics has been illustrated in detail in recent years, especially in plant science. However, the microbial category also has the potential to benefit from integration of metabolomics into system frameworks. In this article, we first examine the concepts and brief history of metabolomics. Next, we summarize metabolomic research processes and analytical platforms in strain improvements. The application cases of metabolomics in microorganisms answer what the metabolomics can do in strain improvements. The position of metabolomics in this systems biology framework and the real cases of integrating metabolomics into a system framework to explore the microbial metabolic complexity are also illustrated in this paper.

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Acknowledgements

The authors would like to thank National Nature Science Foundation of China (no.20536040) and State Key Development Program for Basic Research of China (no.2003CB716003) for financial support.

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  1. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China

    Qing-zhao Wang, Chan-yuan Wu, Tao Chen, Xun Chen & Xue-ming Zhao

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Wang, Qz., Wu, Cy., Chen, T. et al. Integrating metabolomics into a systems biology framework to exploit metabolic complexity: strategies and applications in microorganisms. Appl Microbiol Biotechnol 70, 151–161 (2006). https://doi.org/10.1007/s00253-005-0277-2

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