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  • Conference proceedings
  • Open Access
  • © 2020

Make Life Visible


(view affiliations)
  • Presents recent research outcomes in visualization technology

  • Describes new strategies in the field

  • Examines future prospects

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Softcover Book
USD 59.99
Price excludes VAT (USA)
Hardcover Book
USD 59.99
Price excludes VAT (USA)

Table of contents (29 papers)

  1. Front Matter

    Pages i-ix
  2. Visualizing and Controlling Molecules for Life

    1. Front Matter

      Pages 1-1
    2. Regulatory Mechanism of Neural Progenitor Cells Revealed by Optical Manipulation of Gene Expressions

      • Itaru Imayoshi, Mayumi Yamada, Yusuke Suzuki
      Pages 9-11Open Access
    3. Eavesdropping on Biological Processes with Multi-dimensional Molecular Imaging

      • Andrey Andreev, Scott E. Fraser, Sara Madaan
      Pages 13-29Open Access
    4. Apical Cytoskeletons Help Define the Barrier Functions of Epithelial Cell Sheets in Biological Systems

      • Sachiko Tsukita, Tomoki Yano, Elisa Herawati
      Pages 31-38Open Access
    5. Neural Circuit Dynamics of Brain States

      • Karl Deisseroth
      Pages 39-54Open Access
    6. 19F MRI Probes with Tunable Chemical Switches

      • Kazuya Kikuchi, Tatsuya Nakamura
      Pages 65-77Open Access
    7. Making Life Visible: Fluorescent Indicators to Probe Membrane Potential

      • Parker E. Deal, Vincent Grenier, Rishikesh U. Kulkarni, Pei Liu, Alison S. Walker, Evan W. Miller
      Pages 89-104Open Access
    8. Molecular Dynamics Revealed by Single-Molecule FRET Measurement

      • Tomohiro Shima, Sotaro Uemura
      Pages 105-113Open Access
    9. Comprehensive Approaches Using Luminescence to Studies of Cellular Functions

      • Atsushi Miyawaki, Hiroko Sakurai
      Pages 115-124Open Access
  3. Imaging Disease Mechanisms

    1. Front Matter

      Pages 125-125
    2. Making Chronic Pain Visible: Risks, Mechanisms, Consequences

      • A. Vania Apkarian
      Pages 127-131Open Access
    3. Investigating In Vivo Myocardial and Coronary Molecular Pathophysiology in Mice with X-Ray Radiation Imaging Approaches

      • James T. Pearson, Hirotsugu Tsuchimochi, Takashi Sonobe, Mikiyasu Shirai
      Pages 147-162Open Access
    4. Visualizing the Immune Response to Infections

      • Ulrich H. von Andrian
      Pages 163-168Open Access
    5. Imaging Sleep and Wakefulness

      • Takeshi Kanda, Takehiro Miyazaki, Masashi Yanagisawa
      Pages 169-178Open Access

About this book

This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completely
impossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology in the broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license. 


  • Imaging
  • Open Access
  • Optogenetics
  • Diagnosis and Therapy
  • fluorescent probe



Editors and Affiliations

  • Department of Orthopaedic Surgery, Keio University, School of Medicine, Shinjuku, Japan

    Yoshiaki Toyama, Masaya Nakamura

  • RIKEN, Center for Brain Science, Laboratory for Cell Function Dynamics, Wako, Japan

    Atsushi Miyawaki

  • Department of Diagnostic Radiology, Keio University, School of Medicine, Shinjuku, Japan

    Masahiro Jinzaki

About the editors

Yoshiaki Toyama, MD, PhD, Professor

Department of Orthopaedic Surgery

Keio University, School of Medicine

Tokyo, Japan


Atushi Miyawaki, MD, PhD, Lab Head

Laboratory for Cell Function Dynamics

RIKEN, Center for Brain Science

Saitama, Japan


Masaya Nakamura, MD, PhD, Professor

Department of Orthopaedic Surgery

Keio University, School of Medicine

Tokyo, Japan


Masahiro Jinzaki, MD, PhD, Professor and Chairman

Department of Diagnostic Radiology

Keio University, School of Medicine

Tokyo, Japan

Bibliographic Information

  • Book Title: Make Life Visible

  • Editors: Yoshiaki Toyama, Atsushi Miyawaki, Masaya Nakamura, Masahiro Jinzaki

  • DOI:

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2020

  • License: CC BY

  • Hardcover ISBN: 978-981-13-7907-9

  • Softcover ISBN: 978-981-13-7910-9

  • eBook ISBN: 978-981-13-7908-6

  • Edition Number: 1

  • Number of Pages: IX, 292

  • Number of Illustrations: 31 b/w illustrations, 106 illustrations in colour

  • Topics: Neuroscience, Immunology, Cell Biology

Buying options

Softcover Book
USD 59.99
Price excludes VAT (USA)
Hardcover Book
USD 59.99
Price excludes VAT (USA)