Make Life Visible

1. Front Matter

   Pages i-ix

   PDF

2. Visualizing and Controlling Molecules for Life

   1. Front Matter

      Pages 1-1

      PDF

   2. Photoacoustic Tomography: Deep Tissue Imaging by Ultrasonically Beating Optical Diffusion

      • Lihong V. Wang

      Pages 3-7Open Access

   3. Regulatory Mechanism of Neural Progenitor Cells Revealed by Optical Manipulation of Gene Expressions

      • Itaru Imayoshi, Mayumi Yamada, Yusuke Suzuki

      Pages 9-11Open Access

   4. Eavesdropping on Biological Processes with Multi-dimensional Molecular Imaging

      • Andrey Andreev, Scott E. Fraser, Sara Madaan

      Pages 13-29Open Access

   5. Apical Cytoskeletons Help Define the Barrier Functions of Epithelial Cell Sheets in Biological Systems

      • Sachiko Tsukita, Tomoki Yano, Elisa Herawati

      Pages 31-38Open Access

   6. Neural Circuit Dynamics of Brain States

      • Karl Deisseroth

      Pages 39-54Open Access

   7. Optogenetic Reconstitution: Light-Induced Assembly of Protein Complexes and Simultaneous Visualization of Their Intracellular Functions

      • Tomomi Kiyomitsu

      Pages 55-64Open Access

   8. 19F MRI Probes with Tunable Chemical Switches

      • Kazuya Kikuchi, Tatsuya Nakamura

      Pages 65-77Open Access

   9. Circuit-Dependent Striatal PKA and ERK Signaling Underlying Action Selection

      • Kazuo Funabiki

      Pages 79-87Open Access

   10. Making Life Visible: Fluorescent Indicators to Probe Membrane Potential

       • Parker E. Deal, Vincent Grenier, Rishikesh U. Kulkarni, Pei Liu, Alison S. Walker, Evan W. Miller

       Pages 89-104Open Access

   11. Molecular Dynamics Revealed by Single-Molecule FRET Measurement

       • Tomohiro Shima, Sotaro Uemura

       Pages 105-113Open Access

   12. Comprehensive Approaches Using Luminescence to Studies of Cellular Functions

       • Atsushi Miyawaki, Hiroko Sakurai

       Pages 115-124Open Access

3. Imaging Disease Mechanisms

   1. Front Matter

      Pages 125-125

      PDF

   2. Making Chronic Pain Visible: Risks, Mechanisms, Consequences

      • A. Vania Apkarian

      Pages 127-131Open Access

   3. Visualization of the Pathological Changes After Spinal Cord Injury (-From Bench to Bed Side-)

      • Masaya Nakamura

      Pages 133-139Open Access

   4. Multimodal Label-Free Imaging to Assess Compositional and Morphological Changes in Cells During Immune Activation

      • Nicholas Isaac Smith

      Pages 141-146Open Access

   5. Investigating In Vivo Myocardial and Coronary Molecular Pathophysiology in Mice with X-Ray Radiation Imaging Approaches

      • James T. Pearson, Hirotsugu Tsuchimochi, Takashi Sonobe, Mikiyasu Shirai

      Pages 147-162Open Access

   6. Visualizing the Immune Response to Infections

      • Ulrich H. von Andrian

      Pages 163-168Open Access

   7. Imaging Sleep and Wakefulness

      • Takeshi Kanda, Takehiro Miyazaki, Masashi Yanagisawa

      Pages 169-178Open Access

This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completely
impossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology in
the broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.  

• Imaging
• Open Access
• Optogenetics
• Diagnosis and Therapy
• fluorescent probe

   

• Department of Orthopaedic Surgery, Keio University, School of Medicine, Shinjuku, Japan

  Yoshiaki Toyama, Masaya Nakamura

• RIKEN, Center for Brain Science, Laboratory for Cell Function Dynamics, Wako, Japan

  Atsushi Miyawaki

• Department of Diagnostic Radiology, Keio University, School of Medicine, Shinjuku, Japan

  Masahiro Jinzaki

Yoshiaki Toyama, MD, PhD, Professor

Department of Orthopaedic Surgery

Keio University, School of Medicine

Tokyo, Japan

 

Atushi Miyawaki, MD, PhD, Lab Head

Laboratory for Cell Function Dynamics

RIKEN, Center for Brain Science

Saitama, Japan

 

Masaya Nakamura, MD, PhD, Professor

Department of Orthopaedic Surgery

Keio University, School of Medicine

Tokyo, Japan

 

Masahiro Jinzaki, MD, PhD, Professor and Chairman

Department of Diagnostic Radiology

Keio University, School of Medicine

Tokyo, Japan