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  • © 2018

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection


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  • Summarizes and enriches understanding of the novel aspects of nicotinic acetylcholine receptor (nAChR) functions in the CNS

  • Professionals and scholars alike will find it a handy up-to-date overview of basic and clinical studies of nAChRs for the treatment of neurodegenerative diseases

  • This Open Access Book has an interdisciplinary appeal and will engage scholars in field of drug innovation

Buying options

Softcover Book
USD 59.99
Price excludes VAT (USA)
Hardcover Book
USD 59.99
Price excludes VAT (USA)

Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
  2. Overview

    • Akinori Akaike, Yasuhiko Izumi
    Pages 1-15Open Access
  3. In Vivo Imaging of Nicotinic Acetylcholine Receptors in the Central Nervous System

    • Masashi Ueda, Yuki Matsuura, Ryosuke Hosoda, Hideo Saji
    Pages 17-44Open Access
  4. A New Aspect of Cholinergic Transmission in the Central Nervous System

    • Ikunobu Muramatsu, Takayoshi Masuoka, Junsuke Uwada, Hatsumi Yoshiki, Takashi Yazama, Kung-Shing Lee et al.
    Pages 45-58Open Access
  5. Nicotinic Acetylcholine Receptor Signaling: Roles in Neuroprotection

    • Toshiaki Kume, Yuki Takada-Takatori
    Pages 59-71Open Access
  6. Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection

    • Norimitsu Morioka, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
    Pages 73-88Open Access
  7. Shati/Nat8l and N-acetylaspartate (NAA) Have Important Roles in Regulating Nicotinic Acetylcholine Receptors in Neuronal and Psychiatric Diseases in Animal Models and Humans

    • Atsumi Nitta, Hiroshi Noike, Kazuyuki Sumi, Hajime Miyanishi, Takuya Tanaka, Kazuya Takaoka et al.
    Pages 89-111Open Access
  8. Nicotinic Acetylcholine Receptors in Regulation of Pathology of Cerebrovascular Disorders

    • Hiroshi Katsuki, Kosei Matsumoto
    Pages 113-136Open Access
  9. SAK3-Induced Neuroprotection Is Mediated by Nicotinic Acetylcholine Receptors

    • Kohji Fukunaga, Yasushi Yabuki
    Pages 159-171Open Access
  10. Removal of Blood Amyloid As a Therapeutic Strategy for Alzheimer’s Disease: The Influence of Smoking and Nicotine

    • Nobuya Kitaguchi, Kazunori Kawaguchi, Kazuyoshi Sakai
    Pages 173-191Open Access

About this book

This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

This book is published with open access under a CC BY 4.0 license.


  • Alzheimer’s disease
  • Neurodegenerative diseases
  • Nicotine
  • Transporter
  • Glia
  • Open Access

Editors and Affiliations

  • Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    Akinori Akaike

  • Department of Neurology, School of Medicine, Sapporo Medical University, Sapporo, Japan

    Shun Shimohama

  • Graduate School of Medicine, Yokohama City University, Yokohama, Japan

    Yoshimi Misu

About the editors

Akinori Akaike

Department of Pharmacology, Kyoto University, Japan


Shun Shimohama

Department of Neurology, Sapporo Medical University School of Medicine, Japan


Yoshimi Misu

Graduate School of Medicine, Yokohama City University, Japan

Bibliographic Information

  • Book Title: Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

  • Editors: Akinori Akaike, Shun Shimohama, Yoshimi Misu

  • DOI:

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2018

  • License: CC BY

  • Hardcover ISBN: 978-981-10-8487-4

  • Softcover ISBN: 978-981-13-4166-3

  • eBook ISBN: 978-981-10-8488-1

  • Edition Number: 1

  • Number of Pages: X, 191

  • Number of Illustrations: 38 b/w illustrations, 24 illustrations in colour

  • Topics: Neuroscience, Neurology, Pharmacology

Buying options

Softcover Book
USD 59.99
Price excludes VAT (USA)
Hardcover Book
USD 59.99
Price excludes VAT (USA)