Fundamentals of Protein Structure and Function

  • Engelbert Buxbaum

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Proteins

    1. Front Matter
      Pages 1-1
    2. Engelbert Buxbaum
      Pages 3-13
    3. Engelbert Buxbaum
      Pages 15-64
    4. Engelbert Buxbaum
      Pages 65-93
  3. Enzymes

    1. Front Matter
      Pages 95-95
    2. Engelbert Buxbaum
      Pages 97-110
    3. Engelbert Buxbaum
      Pages 111-140
    4. Engelbert Buxbaum
      Pages 141-161
    5. Engelbert Buxbaum
      Pages 163-184
    6. Engelbert Buxbaum
      Pages 185-191
    7. Engelbert Buxbaum
      Pages 193-199
  4. Special Proteins

    1. Front Matter
      Pages 201-201
    2. Engelbert Buxbaum
      Pages 203-224
    3. Engelbert Buxbaum
      Pages 225-285
    4. Engelbert Buxbaum
      Pages 287-304
    5. Engelbert Buxbaum
      Pages 305-322
    6. Engelbert Buxbaum
      Pages 323-341
  5. Membrane Transport

    1. Front Matter
      Pages 361-361

About this book

Introduction

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion of how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological, and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments, and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of  the purification and determination of proteins, as well as their characterisation for size and shape, structure, and molecular interactions. The book emphasises the link between protein structure, physiological function, and medical significance.

This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine, and related courses.

About the author:

Dr. Buxbaum is a biochemist with an interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

Keywords

Cell-cell interactions Enzyme kinetics Fractionisation of cells Hemoglobin diseases Homogenisation of cells Inactivation of enzymes Inhibition of enzymes Levinthal's paradox Membrane proteins Molecular mechanism of Serine-proteases Morpheeins Motor proteins and movement Multiple phosphorylation Prion diseases Protein transport across membranes Structure of immunoglobulins Transport of solutes across membranes Vesicular transport in eukaryotic cells

Authors and affiliations

  • Engelbert Buxbaum
    • 1
  1. 1.KevelaerGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-19920-7
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-19919-1
  • Online ISBN 978-3-319-19920-7
  • About this book