Fundamentals of Protein Structure and Function

1. Membrane Transport

   1. Protein Transport Across Membranes

      • Engelbert Buxbaum

      Pages 363-391

   2. Vesicular Transport in Eukaryotic Cells

      • Engelbert Buxbaum

      Pages 393-420

   3. Transport of Solutes Across Membranes

      • Engelbert Buxbaum

      Pages 421-468

2. Back Matter

   Pages 469-521

   PDF

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance.

This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses.

About the author:

Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

• Cell-cell interactions
• Enzyme kinetics
• Fractionisation of cells
• Hemoglobin diseases
• Homogenisation of cells
• Inactivation of enzymes
• Inhibition of enzymes
• Levinthal's paradox
• Membrane proteins
• Molecular mechanism of Serine-proteases
• Morpheeins
• Motor proteins and movement
• Multiple phosphorylation
• Prion diseases
• Protein transport across membranes
• Structure of immunoglobulins
• Transport of solutes across membranes
• Vesicular transport in eukaryotic cells

• Kevelaer, Germany

  Engelbert Buxbaum

Dr. Buxbaum is a biochemist with interests in enzymology and protein science. He has special experience with isolation of soluble and membrane proteins, assay development, enzyme kinetics, binding, and transport studies. Dr. Buxbaum has taught courses in biochemistry, protein science, and molecular medicine at various universities.

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