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  • Open Access
  • © 2022

Prevention and Treatment of Atherosclerosis

Improving State-of-the-Art Management and Search for Novel Targets

  • Summarizes the latest studies on the management of cardiovascular risk factors

  • Reviews exhaustively the key recent research into the pathogenesis of atherosclerotic cardiovascular diseases

  • Outlines various strategies of identifying and validating novel targets for prevention and treatment of atherosclerosis

  • This book is open access, which means that you have free and unlimited access

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 270)

Buying options

Softcover Book USD 49.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
  2. Improving the Treatment of Established Targets

    1. Front Matter

      Pages 1-1
    2. Diet, Lifestyle, Smoking

      • Lale Tokgozoglu, Vedat Hekimsoy, Giuseppina Costabile, Ilaria Calabrese, Gabriele Riccardi
      Pages 3-24Open Access
    3. Blood Pressure-Lowering Therapy

      • Isabella Sudano, Elena Osto, Frank Ruschitzka
      Pages 25-45Open Access
    4. Glycaemic Control in Diabetes

      • D. Müller-Wieland, J. Brandts, M. Verket, N. Marx, K. Schütt
      Pages 47-71Open Access
    5. LDL-Cholesterol-Lowering Therapy

      • Angela Pirillo, Giuseppe D. Norata, Alberico L. Catapano
      Pages 73-101Open Access
    6. Antithrombotic Therapy: Prevention and Treatment of Atherosclerosis and Atherothrombosis

      • R. H. Olie, P. E. J. van der Meijden, H. M. H. Spronk, H. ten Cate
      Pages 103-130Open Access
  3. Novel Drug Developments Addressing Predefined Targets

    1. Front Matter

      Pages 131-131
    2. Metabolism of Triglyceride-Rich Lipoproteins

      • Jan Borén, Marja-Riitta Taskinen
      Pages 133-156Open Access
    3. High Density Lipoproteins: Is There a Comeback as a Therapeutic Target?

      • Arnold von Eckardstein
      Pages 157-200Open Access
    4. Lipoprotein(a)

      • Florian Kronenberg
      Pages 201-232Open Access
    5. Nonalcoholic Fatty Liver Disease

      • Lingling Ding, Yvonne Oligschlaeger, Ronit Shiri-Sverdlov, Tom Houben
      Pages 233-269Open Access
  4. Hypothesis Based Approaches to Unravel Novel Targets

    1. Front Matter

      Pages 287-287
    2. Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis

      • Ludger Scheja, Joerg Heeren
      Pages 289-310Open Access
    3. Microbiome and Cardiovascular Disease

      • Hilde Herrema, Max Nieuwdorp, Albert K. Groen
      Pages 311-334Open Access
    4. Smooth Muscle Cell-Proteoglycan-Lipoprotein Interactions as Drivers of Atherosclerosis

      • Sima Allahverdian, Carleena Ortega, Gordon A. Francis
      Pages 335-358Open Access
    5. Anti-inflammatory and Immunomodulatory Therapies in Atherosclerosis

      • Justine Deroissart, Florentina Porsch, Thomas Koller, Christoph J. Binder
      Pages 359-404Open Access
    6. Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis

      • Thomas M. Hofbauer, Anna S. Ondracek, Irene M. Lang
      Pages 405-425Open Access
  5. Hypothesis-free Approaches to Unravel Novel Targets

    1. Front Matter

      Pages 427-427

About this book

This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs'  reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets. 


  • open access
  • prevention and treatment of atherosclerosis
  • cardiovascular disease
  • cardiovascular risk factors
  • vascular biology
  • diet and drugs
  • systems biology
  • lipoproteins
  • inflammation
  • thrombosis
  • lifestyle

Editors and Affiliations

  • Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland

    Arnold von Eckardstein

  • Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

    Christoph J. Binder

About the editors

Previous publications in the Handbook of Experimental Pharmacology series co-edited by Prof. ​Arnold von Eckardstein : Atherosclerosis: Diet and Drugs, 2005, Arnold von Eckardstein; High Density Lipoproteins, 2015, Arnold von Eckardstein, Dimitris Kardassis (eds.), Open Access

Bibliographic Information

  • Book Title: Prevention and Treatment of Atherosclerosis

  • Book Subtitle: Improving State-of-the-Art Management and Search for Novel Targets

  • Editors: Arnold von Eckardstein, Christoph J. Binder

  • Series Title: Handbook of Experimental Pharmacology

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2022

  • License: CC BY

  • Hardcover ISBN: 978-3-030-86075-2Published: 01 February 2022

  • Softcover ISBN: 978-3-030-86078-3Published: 01 February 2022

  • eBook ISBN: 978-3-030-86076-9Published: 31 January 2022

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: X, 538

  • Number of Illustrations: 3 b/w illustrations, 37 illustrations in colour

  • Topics: Internal Medicine, Pharmacology, Internal Medicine, Diseases

Buying options

Softcover Book USD 49.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)