Overview
- Editors:
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Kiyonobu Mikanagi
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Mikanagi Gotanda Hospital, Tokyo, Japan
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Kusuki Nishioka
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Tokyo Women’s Medical College, Tokyo, Japan
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William N. Kelley
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University of Michigan Medical Center, Ann Arbor, USA
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Table of contents (89 chapters)
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Front Matter
Pages i-xiii
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Human Diseases and Enzyme Abnormalities
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- Vanna Micheli, H. Anne Simmonds
Pages 1-7
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- Manuel L. Jiménez, Juan G. Puig, Felícitas A. Mateos, Teresa H. Ramos, Juan S. Melián, Victor G. Nieto et al.
Pages 9-13
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- Michael A. Becker, Juan G. Puig, Felicitas A. Mateos, Manuel L. Jimenez, Mitchel Kim, H. Anne Simnonds
Pages 15-22
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- Bruce A. Barshop, Arthur S. Alberts, Paul K. Laikind, Harry E. Gruber
Pages 23-30
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- M. M. Żydowo, J. Purzycka-Preis, N. Ogasawara
Pages 31-34
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- Fujio Takeuchi, Naoyuki Kamatani, Yutaro Nishida, Terumasa Miyamoto
Pages 35-41
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- Yuji Hidaka, Susan A. Tarle, Naoyuki Kamatani, William N. Kelley, Thomas D. Palella
Pages 43-49
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- Naoyuki Kamatani, Shoko Kuroshima, Chihiro Terai, Masayuki Hakoda, Kusuki Nishioka, Kiyonobu Mikanagi
Pages 51-58
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- Toshihiro Nishina, Ryozo Sakuma, Tsukasa Kojima, Motoshi Kiyamura, Naoyuki Kamatani, Kusuki Nishioka
Pages 59-65
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- Y. Sidi, I. Gelvan, S. Brosh, J. Pinkhas, O. Sperling
Pages 67-71
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- Takeshi Sakiyama, Munenori Iwase, Kenichi Horinouchi, Akira Akatsuka, Yasuyoshi Yoshida, Takanobu Kikuchi et al.
Pages 73-79
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- Robert L. Wortmann, Majeedul Chowdhury, John W. Rachow
Pages 81-85
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- Kazuya Higashino, Tetsuya Yamamoto, Toshikazu Hada, Norio Kono, Masanori Kawachi, Masahisa Nanahoshi et al.
Pages 87-91
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- Masanori Kawachi, Norio Kono, Ikuo Mineo, Naoko Hara, Seiichi Himeno, Yuya Yamada et al.
Pages 93-96
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- H. Anne Simmonds, Vanna Micheli, John A. Duley, Lynette D. Fairbanks, David A. Hopkinson, Roland J. Levinsky
Pages 97-102
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- Geert van Waeg, Frank Niklasson, Åke Ericson, Carl-Henric de Verdier
Pages 103-110
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- Albert H. van Gennip, Nico G. Abeling, Lida Elzinga-Zoetekouw, Liny G. Scholten, Arno van Cruchten, Henk D. Bakker
Pages 111-118
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- Kazuki Okajima, Takaharu Yamamoto, Mariko Suchi, Yoshiro Wada
Pages 119-122
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- Y. Nishida, F. Takeuchi, T. Miyamoto
Pages 123-127
About this book
These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.
Editors and Affiliations
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Mikanagi Gotanda Hospital, Tokyo, Japan
Kiyonobu Mikanagi
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Tokyo Women’s Medical College, Tokyo, Japan
Kusuki Nishioka
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University of Michigan Medical Center, Ann Arbor, USA
William N. Kelley