Hereditary Xanthine Oxidase Deficiency Consisting of at least Two Subgroups
Previous studies1–6 indicated that though pyrazinamide was metabolized into 5-hydroxypyrazinamide, its deamidated form, pyrazinoic acid, could not be metabolized into 5-hydroxypyrazinoic acid in a xanthinuric patient and normal subjects pretreated with allopurinol. On the other hand, several studies on the metabolism of allopurinol in xanthinuric patients demonstrated that allopurinol was not converted to oxypurinol 7–10 and yet others demonstrated that allopurinol was converted to oxypurinol in xanthinuric patients 11–13. We were interested in what enzyme other than xanthine oxidase related to human metabolism of pyrazinamide and allopurinol and what caused the discrepancy between these different results in the metabolism of allopurinol in xanthinuric patients. Therefore, we conducted a study on the metabolism of pyrazinamide and allopurinol in two patients from different families.
KeywordsUric Acid Urinary Excretion Xanthine Oxidase Xanthine Oxidase Activity Xanthine Dehydrogenase
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