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Guanine Nucleotide Metabolism in Red Blood Cells: The Metabolic Basis for GTP Depletion in HGPRT and PNP Deficiency

  • Y. Sidi
  • I. Gelvan
  • S. Brosh
  • J. Pinkhas
  • O. Sperling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

The salvage cycles of purine bases include the activity of 5′-nucleotidase on IMP and GMP to form the respective nucleosides inosine (Ino) and guanosine (Guo); further degradation of the nucleosides by purine nucleoside phosphorylase (PNP) to Hx and Gu, and the ribophosphorylation of these bases by HGPRT to IMP and GMP, respectively.

Keywords

Metabolic Basis Mycophenolic Acid Purine Nucleotide Purine Base Purine Nucleoside Phosphorylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Y. Sidi
    • 1
    • 2
  • I. Gelvan
    • 1
    • 2
  • S. Brosh
    • 1
    • 2
  • J. Pinkhas
    • 1
    • 2
  • O. Sperling
    • 1
    • 2
  1. 1.Departments of Medicine D and of Clinical BiochemistryBeilinson Medical CenterPetah-TikvaIsrael
  2. 2.Department of Chemical PathologyTel-Aviv University Sackler School of MedicineTel-AvivIsrael

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