Current Trends in Histocompatibility

Volume 2 Biological and Clinical Concepts

  • Ralph A. Reisfeld
  • Soldano Ferrone

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Role of Histocompatibility Antigens in Cell-Cell Interaction

    1. Front Matter
      Pages 1-1
    2. Peter C. Doherty, Jack R. Bennink, Rita B. Effros, Mark Frankel
      Pages 35-57
    3. Christopher S. Henney, Zuhair K. Ballas, Keiko Ozato
      Pages 59-80
    4. E. Thorsby, B. Bergholtz, H. Nousiainen
      Pages 113-141
    5. Rolf M. Zinkernagel
      Pages 143-155
  3. Clinical Aspects of Transplantation: Association with Disease

    1. Front Matter
      Pages 157-157
    2. Kent C. Cochrum, Deanne M. Hanes
      Pages 159-175
    3. Leonard J. Greenberg
      Pages 177-199
    4. Ronald H. Kerman, Barry D. Kahan
      Pages 201-226
    5. Faramarz Naeim, Roy L. Walford
      Pages 227-256
    6. J. J. van Rood, G. G. Persijn, E. Goulmy, B. A. Bradley
      Pages 257-278
    7. Lars P. Ryder, Per Platz, Arne Svejgaard
      Pages 279-301
  4. Back Matter
    Pages 303-311

About this book

Introduction

Information about histocompatibility antigens is expanding so rapidly that of all advances. In these volumes, we have it is difficult to remain abreast made an effort to bring together the most current work on topics that have generated most of the recent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some­ times opposing viewpoints as possible. This approach will, we hope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu­ scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla vii Contents I. Role of Histocompatibility Antigens in Cell-Cell Interaction Chapter 1 Histocompatibility Antigens and the T-Cell Repertoire . . . . . . . . . . . . . . 3 Harald von Boehmer 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. H-2 Restriction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. H-2 Restriction of T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. B Cells Are Not H-2-Restricted . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 1. Influence on the T-Cell Repertoire . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 2. H-2-Gene Complementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 3. The B-Cell Repertoire Is Not Directly Influenced by H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Frequency of Cells Specific for Allogeneic H-2 Antigens . . . . . . . . 12 4. 1. Allospecific T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. 2. Allospecific B Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Keywords

antigen blood cytotoxicity diseases genetics histocompatibility immune response immune system immunization leukemia lymphocytes macrophages resistance transplantation virus

Editors and affiliations

  • Ralph A. Reisfeld
    • 1
  • Soldano Ferrone
    • 1
  1. 1.Scripps Clinic and Research FoundationLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-3761-4
  • Copyright Information Springer-Verlag US 1981
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-3763-8
  • Online ISBN 978-1-4684-3761-4
  • About this book