Human Ia-like Alloantigens and Their Medical Significances

  • Faramarz Naeim
  • Roy L. Walford


The major histocompatibility complex (MHC) represents one of the so-called multigene families, and as such is characterized by multiplicity, close linkage, sequence homology, and related or overlapping phenotypic functions. Multigene families are thought to be composed of units of chromosomal organization encompassing a number of genes coding for simple and complex but related traits (Hood et al., 1975). The MHCs in all vertebrate species so far investigated are strikingly homologous and involved in controlling a wide array of biological activities, including allograft survival, immune responsiveness, and susceptibility to disease. The mouse MHC, the H-2 system, has been extensively studied and more completely mapped than the corresponding HLA system in man, largely because of availability of congenic strains differing only in the MHC region.


Systemic Lupus Erythematosus Major Histocompatibility Complex Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia Cell Tissue Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Faramarz Naeim
    • 1
  • Roy L. Walford
    • 1
  1. 1.Department of PathologyUniversity of CaliforniaLos AngelesUSA

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