HLA-Linked Regulation of Immune Responsiveness in Man

Role of I-Region-Gene Products
  • Leonard J. Greenberg


During the past decade, there has been an ever-increasing interest in the interaction between the immune system and the major histocompatibility complex (MHC) of the species. The impetus for this intense scientific focus derives for the most part from the discovery that immune responsiveness is genetically controlled by genes mapping in the H-2 complex of the mouse, i.e., the observation of linkage between the Ir-1 locus and H-2 (McDevitt and Chinitz, 1969). Since that time, many associations between immune-response (Ir) genes and the MHC have been detected in inbred strains of mice (Martin et al., 1971; Vaz and Levine, 1970; McDevitt et al., 1969) and guinea pigs (Green and Benacerraf, 1971; Ellman et al., 1970; Green et al., 1970). This subject has been extensively reviewed in several books (McDevitt, 1978; Sercarz et al., 1977; Snell et al., 1976; Klein, 1975) and will not be dealt with in any detail in this chapter.


Major Histocompatibility Complex Twin Pair Purify Protein Derivative Mixed Lymphocyte Culture Streptococcal Antigen 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Leonard J. Greenberg
    • 1
  1. 1.Department of Laboratory Medicine and PathologyUniversity of Minnesota Medical SchoolMinneapolisUSA

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