Advertisement

The Enigma of Good Kidney-Graft Survival in the Face of Poor HLA Matches

HLA Matching for Kidney Transplantation Makes Sense
  • J. J. van Rood
  • G. G. Persijn
  • E. Goulmy
  • B. A. Bradley

Abstract

One of the few facts all those involved in kidney allografting agreed on almost from the beginning is that matching for the HLA system plays an overriding role when donor and recipient are siblings. It was one of the fundamental observations that identified the HLA system as the major histocompatibility complex (MHC).

Keywords

Major Histocompatibility Complex Blood Transfusion Graft Survival Improve Graft Survival Major Histocompatibility Complex Restriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albrechtsen, D., Solheim, B.G., and Thorsby, E., 1977, Antiserum inhibition of the mixed lymphocyte culture (MLC) interaction: Inhibitory effect of antibodies reactive with HLA-D associated determinants, Cell. Immunol. 25:258.CrossRefGoogle Scholar
  2. Albrechtsen, D., Flatmark, A., Jervell, J., Solheim, G., and Thorsby, E., 1978, HLA-DR antigen matching in cadaver renal transplantation, Lancet 1:825.PubMedCrossRefGoogle Scholar
  3. Beizer, F.O., Perkins, H.A., Fortmann, J.L., Kountz, S.L., Salvaterro, O., Cochrum, K.C., and Payne, R., 1974, Is HL-A typing of clinical significance in cadaver renal transplantation?, Lancet 1:774.Google Scholar
  4. Bradley, B.A., and Festenstein, H., 1978, Cellular typing, Br. Med. Bull. 34:223.PubMedGoogle Scholar
  5. Brynger, H., Frisk, B., Ahlmén, J., Blohmé, I., and Sandberg, L., 1977. Blood transfusion and primary graft survival in male recipients, Scand. J. Urol. Nephrol. Suppl. 42:76.PubMedGoogle Scholar
  6. Claas, F.H.J., van Rood, J.J., Warren, R.P., Weiden, P.L., Su., P.J., and Storb, R., 1979, The detection of non-HLA antibodies and their possible role in bone marrow graft rejection, Transplant. Proc. 11:423.PubMedGoogle Scholar
  7. Cochrum, K., Perkins, H.A., Payne, R.O., Kountz, S., and Beizer, F., 1973, The correlation of MLC with graft survival, Transplant. Proc. 5:391.PubMedGoogle Scholar
  8. Dausset, J., Hors, J., Busson, M., Festenstein, H., Oliver, R.T.D., Paris, A.M.I., and Sachs, J.A., 1974, A joint analysis performed by France-Transplant and the London Transplant group, N. Engl. J. Med. 290:979.PubMedCrossRefGoogle Scholar
  9. Diepenhorst, P., Sprokholt, R., and Prins, H.K., 1972, Removal of leukocytes from whole blood and erythrocyte suspensions by filtration through cotton-wool. I. Filtration technique, Vox Sang. 23:308.PubMedCrossRefGoogle Scholar
  10. Festenstein, H., Sachs, J.A., and Paris, A.M.I., 1976, Influence of HLA matching and blood transfusion on outcome of 502 London Transplant group renal-graft recipients, Lancet 1:157.PubMedCrossRefGoogle Scholar
  11. Fotino, M., and Allen, F.H., 1972, A shared HL-A haplotype seems to make a cadaver donor satisfactory for kidney transplantation, Vox Sang. 22:309.PubMedCrossRefGoogle Scholar
  12. Goulmy, E., Bradley, B.A., Lansbergen, Q., and van Rood, J.J., 1978, The importance of H-Y incompatibility in human organ transplantation, Transplantation 25:315.PubMedCrossRefGoogle Scholar
  13. Hamburger, J., Crosnier, J., Descamps, B., and Rowinska, D., 1971, The value of present methods used for the selection of organ donors, Transplant. Proc. 3:260.PubMedGoogle Scholar
  14. Histocompatibility Testing 1977 (W.F. Bodmer et al., eds.), 1978, Munksgaard, Copenhagen.Google Scholar
  15. Hors, J., Busson, M., and Dausset, J., 1974, Rôle des incompatibilités HL-A et de la pre-immunisation en transplantation rénale, in: Proceedings of the 5th International Course on Transplantation, Lyon, 1973 (J.P. Revillard, ed.), pp. 19–30, Simep-Editions, Villeurbanne.Google Scholar
  16. Hurme, M., Hetherington, C.M., Chandler, P.R., and Simpson, E., 1978, Cytotoxic T-cell responses to H-Y: Mapping of the Ir genes, J. Exp. Med. 147:758.PubMedCrossRefGoogle Scholar
  17. Iwaki, Y., Terasaki, P.I., Park, M.S., and Billing, R., 1978, Enhancement of human kidney allografts by cold B-lymphocyte cytotoxins, Lancet 1:1228.PubMedCrossRefGoogle Scholar
  18. Jeannet, M., 1970, Histocompatibility testing using leukocyte typing and mixed lymphocyte culture in kidney transplants, Helv. Med. Acta 35:168.PubMedGoogle Scholar
  19. Jonker, M., and van Rood, J.J., 1978, Can anti-HLA-A and-B antigens inhibit the MLC test?, Tissue Antigens 11:251.PubMedCrossRefGoogle Scholar
  20. Martins-da-Silva, B., Vassalli, P., and Jeannet, M., 1978, Matching renal grafts, Lancet 1:1047 (letter to the editor).Google Scholar
  21. Moraes, J.R., and Stastny, P., 1977, A new antigen system expressed in human endothelial cells, J. Clin. Invest. 60:449.PubMedCrossRefGoogle Scholar
  22. Morris, P.J., Bishop, M., Fellows, G., Ledingham, J.G., Ting, A., Oliver, D., Cullen, P., French, M., Smith, J.C., and Williams, K., 1978, Results from a new renal transplantation unit, Lancet 2:1353.PubMedCrossRefGoogle Scholar
  23. Oliver, R.T.D., Sachs, J.A., Festenstein, H., Pegrum, G.D., and Moorhead, J.F., 1972, Influence of HL-A matching antigenic strength and immune responsiveness on the outcome of 349 cadaver renal grafts, Lancet 2:381.Google Scholar
  24. Opelz, G., and Terasaki, P.I., 1978, Improvement of kidney-graft survival with increased numbers of blood transfusions, N. Engl. J. Med. 299:799.PubMedCrossRefGoogle Scholar
  25. Opelz, G., Sengar, D.P., Mickey, M.R., and Terasaki, P.I., 1973, Effect of blood transfusions on subsequent kidney transplants, Transplant. Proc. 5:253.PubMedGoogle Scholar
  26. Oriol, R., Cartron, J., Yvart, J., Bedrossian, J., Duboust, A., Bariety, J., Gluckman, J.C., and Gagnadoux, M.F., 1978, The Lewis system: New histocompatibility antigens in renal transplantation, Lancet 1:574.PubMedCrossRefGoogle Scholar
  27. Paul, L.C., van Es, L.A., van Leeuwen, A., van Rood, J.J., de Graeff, J., and Brutel de la Rivière, G., 1979, Antibodies directed against antigens on the endothelium of peritubular capillaries in patients rejecting renal allografts, Transplantation 27:175.PubMedCrossRefGoogle Scholar
  28. Persijn, G.G., van Hooff, J.P., Kalff, M.W., Lansbergen, Q., and van Rood, J.J., 1977, Effect of blood transfusion and HLA matching on renal transplantation in the Netherlands, Transplant. Proc. 9:503.PubMedGoogle Scholar
  29. Persijn, G.G., Gabb, B.W., van Leeuwen, A., Nagtegaal, A., Hoogeboom, J., and van Rood, J.J., 1978, Matching for HLA antigens of A, B and DR loci in renal transplantation by Eurotransplant, Lancet 1:1278.PubMedCrossRefGoogle Scholar
  30. Persijn, G.G., Cohen, B., and van Rood, J.J., 1979, Eurotransplant: Improved graft survival through HLA-A,-B and-DR matching and prospective blood transfusion policy, Dialysis Transplant. 8:493.Google Scholar
  31. Shearer, G.M., 1974, Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes, Eur. J. Immunol. 4:527.PubMedCrossRefGoogle Scholar
  32. Solheim, B., Flatmark, A., Jervell, J., and Arnesen, E., 1977, Influence of blood transfusions on kidney transplant and uremic patient survival, Scand. J. Urol. Nephrol. Suppl. 42:65.PubMedGoogle Scholar
  33. Starzl, T.E., Marchioro, T.L., Hermann, G., Brittain, R.S., and Waddell, W.R., 1964, Renal homografts in patients with major donor-recipient blood group incompatibilities, Surgery 55:195.PubMedGoogle Scholar
  34. Stenzel, K.H., Shitsell, J.C., Cheigh, J.S., Riggio, R.R., Stubenborg, W.T., Sullivan, J.F., Rubin, A.L., and Fotino, M., 1974, Effects of HL-A matching and immune responsiveness on cadaver kidney graft survival, Transplant. Proc. 6:89.PubMedGoogle Scholar
  35. Stiller, C.R., Sinclair, N.R., Sheppard, R.R., Lockwood, B.L., Ulan, R.A., Sharpe, J.A., and Hayman, P., 1978, Beneficial effect of operation-day blood transfusions on human renal-allograft survival, Lancet 1:169.PubMedCrossRefGoogle Scholar
  36. Storb, R., Prentice, R.L., and Thomas, E.D., 1977, Treatment of aplastic anemia by marrow transplantation from HLA identical siblings: Prognostic factors associated with graft-versus-host disease and survival, J. Clin. Invest. 59:625.PubMedCrossRefGoogle Scholar
  37. Termijtelen, A., Bradley, B.A., and van Rood, J.J., 1977, The influence of HLA-A and-B associated gene products on typing for HLA-D by the HTC and PLT methods, Tissue Antigens 10:161.Google Scholar
  38. Thomas, J., Thomas, F., and Lee, H.M., 1977, Why do HLA-nonidentical renal allografts survive 10 years or more?, Transplant. Proc. 9:85.PubMedGoogle Scholar
  39. Thompson, J.S., Jackson, D., Greazel, N.A., Parmely, M.J., and Severson, C.D., 1976, Antileukocyte antibody in postpartum and renal transplant subjects: A comparison of capillary agglutination and lymphocytotoxicity reactions, Transplantation 21:85.PubMedCrossRefGoogle Scholar
  40. Thompson, J.S., Corry, R.J., Lawton, R.L., Bonney, W.W., and Kaloyanides, G.J., 1977a, Effect of prospective HLA-haplotype matching on renal transplantation, Transplant. Proc. 9:205.PubMedGoogle Scholar
  41. Thompson, J.S., Severson, C.D., Greazel, N.A., and Ferrone, S., 1977b, Detection of HLA (Ia) and non-HLA specificities by “B-cell” antisera, Transplant. Proc. 9:597.PubMedGoogle Scholar
  42. Ting, A., and Morris, P.J., 1978, Matching for B-cell antigens of the HLA-DR series in cadaver renal transplantation, Lancet 1:575.PubMedCrossRefGoogle Scholar
  43. Transplantation Proceedings, 1977, Vol. 9.Google Scholar
  44. Troup, G.M., Jameson, J., Thomsen, M., Svejgaard, A., and Walford, R.L., 1978, Studies of HLA alloantigens of the Navajo Indians of North America. I. Variance of association between HLA-DRw (WIA) and HLA-DW specificities, Tissue Antigens 12:44.PubMedGoogle Scholar
  45. van Es, A.A., Marquet, R.L., van Rood, J.J., Kalff, M.W., and Balner, H., 1977, Blood transfusions induce prolonged kidney allograft survival in rhesus monkeys, Lancet 1:506.PubMedGoogle Scholar
  46. van Hooff, J.P., Hendriks, G.F.J., Schippers, H.M.A., and van Rood, J.J., 1974, The influence of possible HL-A haploidentity on renal graft survival in Eurotransplant, Lancet 1:1130.PubMedCrossRefGoogle Scholar
  47. van Hooff, J.P., Kalff, M.W., van Poelgeest, A.E., Persijn, G.G., and van Rood, J.J., 1976, Blood transfusions and kidney transplantation, Transplantation 22:306.CrossRefGoogle Scholar
  48. van Rood, J.J., 1967, A proposal for international cooperation in organ transplantation: Eurotransplant, in: Histocompatibility Testing 1967 (E.S. Curtoni, P.L. Mattiuz, and R.M. Tosi, eds.), pp. 451–458, Munksgaard, Copenhagen.Google Scholar
  49. van Rood, J.J., van Leeuwen, A., and Bruning, J.W., 1967, The relevance of leucocyte antigens for allogenic renal transplantation, J. Clin. Pathol. Suppl. 20:504.Google Scholar
  50. van Rood, J.J., van Leeuwen, A., Termijtelen, A., and Bradley, B.A., 1978, HLA-D rally won by serology, in: Histocompatibility Testing 1977 (W.F. Bodmer, J.R. Batchelor, J.G. Bodmer, H. Festenstein, and P.J. Morris, eds.), p. 403, Munksgaard, Copenhagen.Google Scholar
  51. van Rood, J.J., Persijn, G.G., van Leeuwen, A., Goulmy, E., and Gabb, B.W., 1979, A new strategy to improve kidney graft survival: The induction of CML non-responsiveness, Transplant. Proc. 11:736.PubMedGoogle Scholar
  52. von Boehmer, H., Fathman, C.G., and Haas, W., 1977, H-2 gene complementation in cytotoxic T cell responses of female against male cells, Eur. J. Immunol. 7:443.CrossRefGoogle Scholar
  53. Wonigeit, K., and Pichlmayr, R., 1977, Specific defect in the capability to generate cytotoxic effector cells in vitro after organ transplantation in man, Dialysis Transplant. 6:58.Google Scholar
  54. Zinkernagel, R.M., and Doherty, P.C., 1974, Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system, Nature (London) 248:701.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • J. J. van Rood
    • 1
  • G. G. Persijn
    • 2
  • E. Goulmy
    • 1
  • B. A. Bradley
    • 1
  1. 1.Department of ImmunohaematologyUniversity Medical CenterLeidenThe Netherlands
  2. 2.Eurotransplant FoundationUniversity Medical CenterLeidenThe Netherlands

Personalised recommendations