Self-HLA-D-Region Products Restrict Human T-Lymphocyte Activation by Antigen

  • E. Thorsby
  • B. Bergholtz
  • H. Nousiainen


Numerous recent studies in rodents have demonstrated that T-cell immune responses to antigen are restricted by products of the major histocompatibility complex (MHC) of the animal under study [for references, see Paul and Benacerraf (1977) and Thorsby (1978), as well as Chapters 1,3, and 8]. Available data may be summarized as follows:
  1. 1.

    Macrophage-dependent antigen activation of T cells involves corecognition of antigen and products of the MHC immune-response (I) region.

  2. 2.

    T-cell help for B-cell antibody production involves recognition of the MHC I-region products expressed in the B cells.

  3. 3.

    T-cell cytotoxicity against virus-infected or chemically modified target cells, or target cells expressing minor histocompatibility antigens, involves corecognition of the MHC D- or K-region products.



Major Histocompatibility Complex Purify Protein Derivative Major Histocompatibility Complex Allele Mixed Lymphocyte Culture Minor Histocompatibility Antigen 


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • E. Thorsby
    • 1
  • B. Bergholtz
    • 1
  • H. Nousiainen
    • 1
  1. 1.Tissue Typing LaboratoryRikshospitalet (The National Hospital)OsloNorway

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