Self-HLA-D-Region Products Restrict Human T-Lymphocyte Activation by Antigen

  • E. Thorsby
  • B. Bergholtz
  • H. Nousiainen


Numerous recent studies in rodents have demonstrated that T-cell immune responses to antigen are restricted by products of the major histocompatibility complex (MHC) of the animal under study [for references, see Paul and Benacerraf (1977) and Thorsby (1978), as well as Chapters 1,3, and 8]. Available data may be summarized as follows:
  1. 1.

    Macrophage-dependent antigen activation of T cells involves corecognition of antigen and products of the MHC immune-response (I) region.

  2. 2.

    T-cell help for B-cell antibody production involves recognition of the MHC I-region products expressed in the B cells.

  3. 3.

    T-cell cytotoxicity against virus-infected or chemically modified target cells, or target cells expressing minor histocompatibility antigens, involves corecognition of the MHC D- or K-region products.



Major Histocompatibility Complex Purify Protein Derivative Major Histocompatibility Complex Allele Mixed Lymphocyte Culture Minor Histocompatibility Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • E. Thorsby
    • 1
  • B. Bergholtz
    • 1
  • H. Nousiainen
    • 1
  1. 1.Tissue Typing LaboratoryRikshospitalet (The National Hospital)OsloNorway

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