The Dual Specificity of Virus-Immune T Cells

Functional Indications That Virus and H-2 Molecules May Associate on the Cell Membrane
  • Peter C. Doherty
  • Jack R. Bennink
  • Rita B. Effros
  • Mark Frankel


A current obsession of cellular immunology is the definition of the T-cell receptor repertoire. Many of the questions that have been raised derive from experiments with virus systems (Doherty et al., 1976a; Zinkernagel and Doherty, 1979). How do we explain the apparent dual specificity for major histocompatibility (MHC) components and for virus?


Major Histocompatibility Complex Influenza Virus Vaccinia Virus Dual Specificity Lymphocytic Choriomeningitis 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Peter C. Doherty
    • 1
  • Jack R. Bennink
    • 1
  • Rita B. Effros
    • 1
  • Mark Frankel
    • 1
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

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