Overview
- Editors:
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George J. Brewer
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Department of Human Genetics and Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, USA
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About this book
Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.
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Table of contents (38 papers)
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Front Matter
Pages i-xxxii
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Hemoglobin Structure and Function
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- M. F. Perutz, P. D. Pulsinelli, Helen M. Ranney
Pages 3-18
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- O. Brenna, M. Luzzana, M. Pace, M. Perrella, F. Rossi, L. Rossi-Bernardi et al.
Pages 19-40
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- Austen Riggs, Takashi Imamura
Pages 55-63
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- Chien Ho, Ted R. Lindstrom
Pages 65-76
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Red Cell Metabolism and Function
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- R. T. Jones, R. D. Koler, M. Duerst, Z. Stocklen
Pages 79-98
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- George J. Brewer, Fred J. Oelshlegel Jr., Eric B. Schoomaker, Conrad A. Knutsen
Pages 99-119
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- John W. Eaton, Martin Boraas, Nina L. Etkin
Pages 121-131
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- Harry Jacob, Yoshihito Yawata, Robert Howe
Pages 133-143
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- Michael C. Brain, Robert T. Card
Pages 145-154
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- Nancy A. Noble, George J. Brewer
Pages 155-164
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Carbonic Anhydrase and Carbon Dioxide Transport
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Front Matter
Pages 165-165
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- Ivar Waara, Seved Lövgren, Anders Liljas, K. K. Kannan, Per-Christer Bergstén
Pages 169-187
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- Richard E. Tashian, Ya-Shiou L. Yu
Pages 209-213
Editors and Affiliations
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Department of Human Genetics and Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, USA
George J. Brewer