Structure of Haemoglobin M Milwaukee, A Mutant Form Exhibiting Interaction Between Ferrous and Ferric Subunits
There are five different abnormal haemoglobins which cause methaemoglobinaemia. In four of these the action of methaemoglobin reductase is ineffective because either the proximal or the distal haem-linked histidines in one pair of subunits have been replaced by tyrosines, and in the fifth, known as haemoglobin M Milwaukee (Hb Mil), because valines Ell(67) β have been replaced by glutamic acids (Gerald and Efron, 1961).
KeywordsIron Atom Difference Spectrum Oxygen Affinity Ferrous Citrate Porphyrin Ring
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