Effect of Inorganic Phosphate on Red Cell Metabolism: In Vitro and In Vivo Studies
The oxygen dissociation curve of whole blood is influenced by pH and the levels of 2,3-DPG and ATP in the red cells. The levels of these compounds are closely related to red cell metabolism which is determined by a number of factors including pH, temperature, Pi concentration, pO2 and pCO2. A left shift in the hb-O2 dissociation curve has been correlated to low levels of ATP and 2,3-DPG in hypophosphatemic states (Lichtman et al, 1971), conversely, a right shift in the curve has been observed with high levels of ATP and 2,3-DPG in association with the hyperphosphatemia of renal disease (Lichtman and Miller, 1970). These observations suggest that the metabolism of the red cell is influenced by relatively minor variations in Pi concentration.
KeywordsPlasma Phosphate Oxygen Dissociation Curve Adenine Phosphoribosyltransferase Vivo Study Fresh Human Blood
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