Studies of the Metabolic Basis of the ATP-DPG Differences in Genetically Selected High and Low ATP-DPG Rat Strains
Red cell ATP and DPG show considerable quantitative variability in human populations. Because DPG and ATP bind to hemoglobin and affect oxygen transport, quantitative variability in these intermediates may result in functional differences in the red cells of various individuals. Earlier work in our laboratory showing a negative correlation between DPG and hemoglobin levels (Eaton and Brewer, 1968) suggests that this is so.
KeywordsGlycolytic Intermediate Quantitative Variability Mixed Venous Oxygen Tension Fructose Diphosphate Hereditary Difference
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