Studies of the Metabolic Basis of the ATP-DPG Differences in Genetically Selected High and Low ATP-DPG Rat Strains

  • Nancy A. Noble
  • George J. Brewer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)


Red cell ATP and DPG show considerable quantitative variability in human populations. Because DPG and ATP bind to hemoglobin and affect oxygen transport, quantitative variability in these intermediates may result in functional differences in the red cells of various individuals. Earlier work in our laboratory showing a negative correlation between DPG and hemoglobin levels (Eaton and Brewer, 1968) suggests that this is so.


Glycolytic Intermediate Quantitative Variability Mixed Venous Oxygen Tension Fructose Diphosphate Hereditary Difference 


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Nancy A. Noble
    • 1
  • George J. Brewer
    • 1
  1. 1.Department of Human GeneticsUniversity of MichiganUSA

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