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Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice

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Abstract

This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation.

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Abbreviations

AA:

Arachidonic acid

ANOVA:

Analysis of variance

CEUA:

Commission of Ethics in Research in Animals

COX:

Cyclooxygenase

CNS:

Central nervous system

DZP:

Diazepam

GC–MS:

Gas chromatography-mass spectrometry

HCDAL:

Herbarium Caririense Dárdano de Andrade Lima

IL-1β:

Interleukin-1 β

IL-8:

Interleukin-8

LOX:

Lipoxygenase LTB4, leukotriene B4

MPO:

Myeloperoxidase

OECD:

Organization for Economic Cooperation and Development

OEFLM:

Essential oil of leaves of Lantana montevidensis

PAF:

Platelet activating factor

PBS:

Phosphate buffered saline

PGE2 :

Prostaglandin E2

p.i.:

Per os (intraperitoneal administration)

p.o.:

Per os (oral administration)

TNF-α:

Tumor necrosis factors alpha

SEM:

Standard error of the mean

URCA:

Regional University of Cariri

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Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)—Finance Code BPI and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Financiadora de Estudos e Projetos—Brasil (FINEP).

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Authors and Affiliations

  1. Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Brazil, Pimenta, Crato-Ceará, CEP 63.100-000, Brazil

    Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Isabel Sousa Alcântara, Jaime Ribeiro Filho, Anita Oliveira Brito Pereira Bezerra Martins, Renata Torres Pessoa & Irwin Rose Alencar de Menezes

  2. Laboratory of Pharmacotoxicological Prospecting of Bioactive Products, Department of Antibiotics, Federal University of Pernambuco-UFPE, Av. Dos Economistas, Cidade Universitária, Recife, 52171-011, Brazil

    Cícera Datiane de Morais Oliveira Tintino

  3. Laboratory of Bioprospecting of Natural Products and Biotechnology (LBPNB), State University of Ceará, Center of Education, Sciences and Technology of the Inhamuns Region-CECITEC, Tauá, Ceará, CEP 63660-000, Brazil

    Francisco Ernani Alves Magalhães

  4. Department of Biological Sciences, Center for Biological and Health Sciences-CCBS, Pimenta, Crato-Ceará, CEP 63.100-000, Brazil

    Antonia Eliene Duarte

  5. Laboratory of Prospecting of Natural Products, Department of Biological Chemistry, Regional University of Cariri-URCA, Brazil, Pimenta, Crato-Ceará, CEP 63.100-000, Brazil

    José Galberto Martins da Costa

  6. Laboratory of Organic Geochemistry, Center for Natural Sciences - Petrônio Portella, Federal University of Piauí-UFPI, Brazil, Piauí Campus, Teresina, CEP 64049-550, Brazil

    Sidney Gonçalo de Lima

  7. Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri-URCA, Brazil, Pimenta, Crato-Ceará, CEP 63.100-000, Brazil

    Henrique Douglas Melo Coutinho

  8. Department of Agricultural Sciences, University of Naples Federico II, 80055, Portici, Italy

    Raffaele Capasso

Authors
  1. Maria Rayane Correia de Oliveira
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  2. Maria Gabriely de Lima Silva
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  3. Isabel Sousa Alcântara
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  4. Jaime Ribeiro Filho
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  5. Cícera Datiane de Morais Oliveira Tintino
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  6. Francisco Ernani Alves Magalhães
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  7. Anita Oliveira Brito Pereira Bezerra Martins
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  8. Renata Torres Pessoa
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  9. Antonia Eliene Duarte
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  10. José Galberto Martins da Costa
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  11. Sidney Gonçalo de Lima
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  12. Henrique Douglas Melo Coutinho
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  13. Raffaele Capasso
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  14. Irwin Rose Alencar de Menezes
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Corresponding authors

Correspondence to Henrique Douglas Melo Coutinho, Raffaele Capasso or Irwin Rose Alencar de Menezes.

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de Oliveira, M.R.C., de Lima Silva, M.G., Alcântara, I.S. et al. Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice. Environ Dev Sustain 23, 14958–14981 (2021). https://doi.org/10.1007/s10668-021-01281-8

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