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The pharmacology of arachidonic acid-induced rat paw edema

  • Models of Inflammation and Arthritis
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Abstract

Arachidonic acid (AA) injected into hindpaws of Lewis rats produces a severe edematous response. Treatment with corticosteroids (dexamethasone, prednisolone), dual inhibitors of arachidonate metabolism (phenidone, SK & F 86002), anti-histamine/serotonin agents (chlorpheniramine, cyproheptadine) and a gold compound (auranofin) inhibited AA-induced edema. In contrast, administration of high doses of cyclooxygenase inhibitors (indomethacin, piroxicam, naproxen, ibuprofen, meclofenamic acid and tiflamizole) did not affect AA-induced hind paw edema. The involvement of lipoxygenase products and mast cell mediators in the edematous response to arachidonic acid render this model potentially useful for studying antiinflammatory agents with a mechanism of action different from that of cyclooxygenase inhibitors.

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Authors and Affiliations

  1. Smith Kline & French Laboratories, 709 Swedeland Road, 19479, Swedeland, PA, USA

    M. J. DiMartino, G. K. Campbell Jr., C. E. Wolff & N. Hanna

Authors
  1. M. J. DiMartino
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  2. G. K. Campbell Jr.
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  3. C. E. Wolff
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  4. N. Hanna
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DiMartino, M.J., Campbell, G.K., Wolff, C.E. et al. The pharmacology of arachidonic acid-induced rat paw edema. Agents and Actions 21, 303–305 (1987). https://doi.org/10.1007/BF01966498

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  • DOI: https://doi.org/10.1007/BF01966498

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