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Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential

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Abstract

Myrciaria floribunda is a plant that is distributed across different Brazilian biomes such as the Amazon, Caatinga, Cerrado, and Atlantic Forest, and it possesses antioxidant, antimicrobial, and anticancer properties. The antinociceptive and anti-inflammatory properties of the essential oil from M. floribunda leaves (MfEO) were examined in this study using mouse models. Gas chromatography–mass spectrometry was employed to describe the oil, and the results revealed that δ-cadinene, bicyclogermacrene, α-cadinol, and epi-α-muurolol predominated in the chemical profile. The oil stimulated a decrease in nociception in the chemical and thermal models used to evaluate acute antinociceptive activity. Findings from the use of pain pathway blockers to study the presumed underlying mechanism indicated opioid pathway activity. The anti-edematogenic effect, decreased cell migration, and generation of pro-inflammatory cytokines provided evidence of the anti-inflammatory potential of the essential oil from M. floribunda. According to this research, the essential oil from M. floribunda can effectively alleviate acute pain and inflammation.

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Authors and Affiliations

  1. Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil

    Priscilla Glazielly dos Santos de Moraes, Izabelly Bianca da Silva Santos, Valquíria Bruna Guimarães Silva, Alisson Macário de Oliveira, Maria Tereza dos Santos Correia, Wêndeo Kennedy Costa & Márcia Vanusa da Silva

  2. Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil

    Júlio César Ribeiro dede Oliveira FariasAguiar & Daniela Maria do Amaral Ferraz Navarro

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  1. Priscilla Glazielly dos Santos de Moraes
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  2. Izabelly Bianca da Silva Santos
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Correspondence to Wêndeo Kennedy Costa.

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dos Santos de Moraes, P.G., da Silva Santos, I.B., Silva, V.B.G. et al. Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential. Inflammopharmacol 31, 3143–3151 (2023). https://doi.org/10.1007/s10787-023-01300-2

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