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Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research

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Abstract

Ribosome-inactivating proteins (RIPs) are enzymes which depurinate ribosomal RNA (rRNA), thus impeding the process of translation resulting in inhibition of protein synthesis. They are produced by various organisms including plants, fungi and bacteria. RIPs from plants are linked to plant defense due to their antiviral, antifungal, antibacterial, and insecticidal activities in which they can be applied in agriculture to combat microbial pathogens and pests. Their anticancer, antiviral, embryotoxic, and abortifacient properties may find medicinal applications. Besides, conjugation of RIPs with antibodies or other carriers to form immunotoxins has been found useful to research in neuroscience and anticancer therapy.

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Acknowledgments

We gratefully acknowledge the award of HMRF grants (number 12110672 and number 12131221).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK, Leiden, The Netherlands

    Ouafae Akkouh

  2. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

    Tzi Bun Ng, Randy Chi Fai Cheung, Jack Ho Wong, Wenliang Pan, Charlene Cheuk Wing Ng & Wai Yee Chan

  3. School of Medicine, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen, China

    Ou Sha

  4. School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

    Pang Chui Shaw

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  1. Ouafae Akkouh
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  2. Tzi Bun Ng
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  3. Randy Chi Fai Cheung
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  4. Jack Ho Wong
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  5. Wenliang Pan
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  6. Charlene Cheuk Wing Ng
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  7. Ou Sha
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  9. Wai Yee Chan
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Correspondence to Tzi Bun Ng or Wai Yee Chan.

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Akkouh, O., Ng, T.B., Cheung, R.C.F. et al. Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research. Appl Microbiol Biotechnol 99, 9847–9863 (2015). https://doi.org/10.1007/s00253-015-6941-2

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  • DOI: https://doi.org/10.1007/s00253-015-6941-2

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