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Biological Treatment Approaches for Degenerative Disc Disease: Injectable Biomaterials and Bioartificial Disc Replacement

  • Living reference work entry
  • First Online:
Handbook of Spine Technology

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Abstract

Degenerative disc disease (DDD) is a major cause of disability in the western world. Current treatment strategies only address the symptoms of DDD. To meet the clinical need of regenerative treatment strategies, biological treatment approaches have become of increasing interest in the past decade. Currently explored treatment strategies involve biomolecular treatments for early-stage degeneration, cell-based therapies involving differentiated cells as well as stem cells for advanced-stage DDD, as well as tissue engineering strategies for total disc replacement in terminal-stage disc degeneration.

The following chapter will provide a comprehensive overview about recent the recent progress in regenerative treatment strategies. This chapter will elucidate experimental in vivo studies as well as published and ongoing clinical trials.

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  1. Department of Neurological Surgery, Weill Cornell Brain and Spine Center, New York–Presbyterian Hospital, New York, NY, USA

    Christoph Wipplinger, Yu Moriguchi, Rodrigo Navarro-Ramirez, Eliana Kim, Farah Maryam & Roger Härtl

  2. Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria

    Christoph Wipplinger

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  1. Christoph Wipplinger
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  2. Yu Moriguchi
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  4. Eliana Kim
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  5. Farah Maryam
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  6. Roger Härtl
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Correspondence to Christoph Wipplinger .

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    Hassan Serhan

  2. Department of Orthopedics, Boston University Medical Center, Boston, MA, USA

    Tony Tannoury

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Wipplinger, C., Moriguchi, Y., Navarro-Ramirez, R., Kim, E., Maryam, F., Härtl, R. (2020). Biological Treatment Approaches for Degenerative Disc Disease: Injectable Biomaterials and Bioartificial Disc Replacement. In: Cheng, B. (eds) Handbook of Spine Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-33037-2_38-1

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