Abstract
As an intracellular polypeptide, heat shock protein 70 (HSP70) can be exposed on the plasma membrane and/or released into the circulation. However, the role of HSP70 in various nondisease and disease conditions remains unknown. Quantitative methods for the detection of HSP70 have been used in clinical studies, revealing that an increase in circulating HSP70 is associated with various types of exercise, elderly patients presenting with inflammation, mobile phones, inflammation, sepsis, chronic obstructive pulmonary disease, asthma, carotid intima-media thickness, glutamine-treated ill patients, mortality, diabetes mellitus, active chronic glomerulonephritis, and cancers. Circulating HSP70 decreases with age in humans and in obstructive sleep apnea, arteriosclerosis, atrial fibrillation (AF) following coronary artery bypass surgery, nonalcoholic fatty liver disease, moderate-to-severe alcoholic fatty liver disease, hepatic steatosis, and Helicobacter pylori infection. In conclusion, quantitative methods can be used to detect HSP70, particularly in determining circulating HSP70 levels, using more convenient and rapid screening methods. Studies have shown that changes in HSP70 are associated with various nondisease and disease conditions; thus, HSP70 might be a novel potential biomarker reflecting various nondisease conditions and also the severity of disease conditions. However, the reliability and accuracy, as well as the underlying mechanism, of this relationship remain poorly understood, and large-sample clinical research must be performed to verify the role.
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Abou El Azm AR, Yousef M, Kobtan A, Awad A, Elkassas G, Elfert A (2015) Colonic mucosal expression of heat-shock proteins may have a potential prognostic value in ulcerative colitis. Arab J Gastroenterol. doi:10.1016/j.ajg.2015.02.005
Agnew LL (2011) Measuring intracellular HSP70 in leukocytes by flow cytometry. Curr Protoc Toxicol Chapter 2(Unit 2.21). doi:10.1002/0471140856.tx0221s49
Almeida J, Polvorosa MA, Gonzalez-Quintela A et al (2013) Decreased peripheral blood CD4þ/CD25þ regulatory T cells in patients with alcoholic hepatitis. Alcohol Clin Exp Res 37:1361–1369
Aschkenasy G, Bromberg Z, Raj N, Deutschman CS, Weiss YG (2011) Enhanced HSP70 expression protects against acute lung injury by modulating apoptotic pathways. PLoS One 6(11):e26956
Assmann G, Gotto AM Jr (2004) HDL cholesterol and protective factors in atherosclerosis. Circulation 109:III8–III14
Balakrishnan K, Murali V, Rathika C, Manikandan T, Malini RP, Kumar RA, Krishnan M (2014) HSP70 is an independent stress marker among frequent users of mobile phones. J Environ Pathol Toxicol Oncol 33(4):339–347
Bao-Ge Q, Wang H, Jia Yi-Guo S, Ji-Liang WZ-D, Wang Y-F, Xing-Hai H, Yuan-Xun L, Pan J-D, Guang-Ying R (2015) Changes in tumor necrosis factor alpha, heat shock protein 70, malondialdehyde and superoxide dismutase in subjects with different severities of alcoholic fatty liver disease: a prospective observational study. Medicine 94(11):e643
Boonjaraspinyo S, Boonmars T, Kaewkes S, Laummaunwai P et al (2012) Down-regulated expression of HSP70 in correlation with clinicopathology of cholangiocarcinoma. Pathol Oncol Res 18(2):227–237
Brit D, Alexander W, Egil L, Flo TH, Anders W, Nilofer Q, Sellevold OFM, Terje E, Anders S (2002) Inflammatory response after open heart surgery release of heat-shock protein 70 and signaling through Toll-like receptor-4. Circulation 105:685–690
Chang CC, Chen SD, Lin TK, Chang WN, Liou CW, Chang AY, Chan SH, Chuang YC (2014) Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-κB activation-induced nitricoxide synthase II expression. Neurobiol Dis 62:241–249
Chebotareva NV, Neprintseva NV, Bobkova IN, Kozlovskaia LV (2014) Investigation of 70-kDa heat shock protein in the serum and urine of patients with chronic glomerulonephritis. Ter Arkh 86(6):18–23
Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86–103
Cui X, Xing J, Liu Y, Zhou Y, Luo X, Zhang Z, Han W, Wu T, Chen W (2015) COPD and levels of HSP70 (HSPA1A) and HSP27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study. Cell Stress Chaperones 20(3):473–481
Di Naso FC, Porto RR, Fillmann HS, Maggioni L, Padoin AV, Ramos RJ, Mottin CC, Bittencourt A, Marroni NA, de Bittencourt PI Jr (2015) Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression. Obesity (Silver Spring) 23(1):120–129
Dulin E, García-Barreno P, Guisasola MC (2010) Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population. Cell Stress Chaperones 15(6):929–937
Dvoriantchikova G, Santos AR, Saeed AM, Dvoriantchikova X, Ivanov D (2014) Putative role of protein kinase C in neurotoxic inflammation mediated by extracellular heat shock protein 70 after ischemia-reperfusion. J Neuroinflammation 11:81. doi:10.1186/1742-2094-11-81
Dzaman-Serafin S, Telatyńska-Mieszek B, Ciechanowski K (2005) Heat shock proteins and their characteristics. Pol Merkur Lekarski 19(110):215–219
Garamvölgyi Z, Prohászka Z, Rigó J Jr, Kecskeméti A, Molvarec A (2015) Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study. Cell Stress Chaperones
Gehrmann M, Cervello M, Montalto G et al (2014a) Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Front Immunol 5:307
Gehrmann M, Specht HM, Bayer C, Brandstetter M, Chizzali B, Duma M, Breuninger S, Hube K, Lehnerer S, van Phi V, Sage E, Schmid TE, Sedelmayr M, Schilling D, Sievert W, Stangl S, Multhoff G (2014b) HSP70—a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck. Radiat Oncol 9:131. doi:10.1186/1748-717X-9-131
Gelain DP, de Bittencourt Pasquali MA, Comim C, Grunwald MS, Ritter C, Tomasi CD, Alves SC, Quevedo J, Dal-Pizzol F, Moreira JC (2011) Serum heat shock protein 70 levels, oxidant status, and mortality in sepsis. Shock 35(5):466–470
Ghayour-Mobarhan M, Lamb DJ, Tavallaie S, Ferns GA (2007) Relationship between plasma cholesterol, von Willebrand factor concentrations, extent of atherosclerosis and antibody titres to heat shock proteins-60, -65 and -70 in cholesterol-fed rabbits. Int J Exp Pathol 88:249–255
Goel G, Guo M, Jamie Ding J, Dornbos D III, Ali A, Shenaq M, Guthikonda M, Ding Y (2010) Combined effect of tumor necrosis factor (TNF)-a and heat shock protein (HSP)-70 in reducing apoptotic injury in hypoxia: a cell culture study. Neurosci Lett 483:162–166
Gómez-Choco M, Doucerain C, Urra X, Planas AM, Chamorro A (2014) Presence of heat shock protein 70 in secondary lymphoid tissue correlates with stroke prognosis. J Neuroimmunol 270(1-2):67–74. doi:10.1016/ j.jne-uroim.2014.03.004
Gómez-Chocoa M (2014) Cedric Doucerain b, c, Xabier Urra a, c, Anna M. Planas b, c, Ángel Chamorroa. Presence of heat shock protein 70 in secondary lymphoid tissue correlates with stroke prognosis. J Neuroimmunol 270:67–74
Gong J, Jing L (2011) Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1. Minerva Anestesiol 77:488–495
González-Ramos M, Calleros L, López-Ongil S, Raoch V, Griera M, Rodríguez-Puyol M, de Frutos S, Rodríguez-Puyol D (2013) HSP70 increases extracellular matrix production by human vascular smooth muscle through TGF-β1 up-regulation. Int J Biochem Cell Biol 45(2):232–242
Gruden G, Barutta F, Pinach S, Lorenzati B, Cavallo-Perin P, Giunti S, Bruno G (2013) Circulating anti-HSP70 levels in nascent metabolic syndrome: the Casale Monferrato Study. Cell Stress Chaperones 18(3):353–357
Gupta A, Cooper ZA, Tulapurkar ME, Potla R, Maity T, Hasday JD, Singh IS (2013) Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release. J Biol Chem 288(4):2756–2766
Heck TG, Schöler CM, de Bittencourt PI (2011) HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain? Cell Biochem Funct 29(3):215–226
Hom LL, Lee EC, Apicella JM, Wallace SD, Emmanuel H, Klau JF, Poh PY, Marzano S, Armstrong LE, Casa DJ, Maresh CM (2012) Eleven days of moderate exercise and heat exposure induces acclimation without significant HSP70 and apoptosis responses of lymphocytes in college-aged males. Cell Stress Chaperones 17(1):29–39
Horn P, Kalz A, Lim CL, Pyne D, Saunders P, Mackinnon L, Peake J, Suzuki K (2007) Exercise-recruited NK cells display exercise-associated eHSP-70. Exerc Immunol Rev 13:100–111
Hou C, Zhao H, Li W, Liang Z, Zhang D, Liu L, Tong W, Cai SX, Zou F (2011) Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients. Cell Stress Chaperones 16(6):663–671
Jenei ZM, Gombos T, Förhécz Z, Pozsonyi Z, Karádi I, Jánoskuti L, Prohászka Z (2013a) Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure. Cell Stress Chaperones 18(6):809–813
Jenei ZM, Széplaki G, Merkely B, Karádi I, Zima E, Prohászka Z (2013b) Persistently elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker in post-cardiac-arrest patients. Cell Stress Chaperones 18(4):447–454
Jordan I, Balaguer M, Esteban ME, Cambra FJ, Felipe A, Hernández L, Alsina L, Molero M, Villaronga M, Esteban E (2015) Glutamine effects on heat shock protein 70 and interleukines 6 and 10: randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children. Clin Nutr. doi:10.1016/j.clnu.2015. 01.019
Kavanagh K, Zhang L, Wagner JD (2009) Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. Cell Stress Chaperones 14(3):291–299
Kavanagh K, Flynn DM, Jenkins KA, Zhang L, Wagner JD (2011) Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. Am J Physiol Endocrinol Metab 300(5):E894–901
Kornej J, Reinhardt C, Kosiuk J, Arya A, Hindricks G, Adams V, Husser D, Bollmann A (2013) Response of circulating heat shock protein 70 and anti-heat shock protein 70 antibodies to catheter ablation of atrial fibrillation. J Transl Med 11:49
Krepuska M, Szeberin Z, Sótonyi P, Sarkadi H, Fehérvári M, Apor A, Rimely E, Prohászka Z, Acsády G (2011) Serum level of soluble HSP70 is associated with vascular calcification. Cell Stress Chaperones 16(3):257–265
Lagana SM, Moreira RK, Remotti HE et al (2013) Glutamine synthetase, heat shock protein-70, and glypican-3 in intrahepatic cholangiocarcinoma and tumors metastatic to liver. Appl Immunohistochem Mol Morphol 21(3):254–257
Laso FJ, Vaquero JM, Almeida J et al (2007) Production of inflammatory cytokines by peripheral blood monocytes in chronic alcoholism: relationship with ethanol intake and liver disease. Cytometry B Clin Cytom 72:408–415
Lavie L, Dyugovskaya L, Golan-Shany O, Lavie P (2010) Heat-shock protein 70: expression in monocytes of patients with sleep apnoea and association with oxidative stress and tumour necrosis factor-alpha. J Sleep Res 19(1 Pt 2):139–147
Lee J, Park S, Kim WK (2013) Exercise preconditioning reduces acute ischemic renal injury in HSP70.1 knockout mouse. Histol Histopathol 28(9):1223–1233
Li Y, Kang X, Wang Q (2011) HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-β-induced epithelial-mesenchymal transition. J Genet Genomics 38(3):111–116
Liu W, Chen Y, Lu G, Sun L, Si J (2011) Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori. BMC Gastroenterol 11:146. doi:10.1186/1471-230X-11
Lollo PC, Moura CS, Morato PN, Amaya-Farfan J (2013) Differential response of heat shock proteins to uphill and downhill exercise in heart, skeletal muscle, lung and kidney tissues. J Sports Sci Med 12(3):461–466
Ma L, Sato F, Sato R, Matsubara T, Hirai K, Yamasaki M, Shin T, Shimada T, Nomura T, Mori K, Sumino Y, Mimata H (2014) Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder. Oncol Rep 31(6):2482–2492
Marotta F, Koike K, Lorenzetti A, Naito Y, Fayet F, Shimizu H, Marandola P (2007) Nutraceutical strategy in aging: targeting heat shock protein and inflammatory profile through understanding interleukin-6 polymorphism. Ann N Y Acad Sci 1119:196–202
Merchant S, Korbelik M (2011) Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy. Cell Stress Chaperones 16(2):153–162
Morteza A, Nakhjavani M, Larry M, Nargesi AA, Esteghamati A (2013) Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study. Cell Stress Chaperones 18(6):815–9. doi:10.1007/s12192-013-0435-x
Müller GJ, Lassmann H, Johansen FF (2007) Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus. Neurobiol Dis 25(3):582–93
Nakhjavani M, Morteza A, Asgarani F et al (2012) The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes [J]. Gene 498(1):107–111
Nakhjavani M, Morteza A, Nargesi AA, Mostafavi E, Esteghamati A (2013) Appearance of leptin-HSP70 correlation, in type 2 diabetes. Meta Gene 1:1–7. doi:10.1016/j.mgene.2013.09.002. eCollection 2013
Njemini R, Demanet C, Mets T (2004) Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging. Biogerontology 5(1):31–38
Njemini R, Bautmans I, Onyema OO, Van Puyvelde K, Demanet C, Mets T (2011a) Circulating heat shock protein 70 in health, aging and disease. BMC Immunol 12:24
Njemini R, Smitz J, Demanet C, Sosso M, Mets T (2011b) Circulating heat shock protein 70 (HSP70) in elderly members of a rural population from Cameroon: association with infection and nutrition. Arch Gerontol Geriatr 53(3):359–363
Oc M, Ucar HI, Pinar A, Akbulut B, Oc B, Akyon Y, Kanbak M, Dogan R (2008) Heat shock protein70: a new marker for subsequent atrial fibrillation development? Artif Organs 32(11):846–850
Omar R, Pappolla M, Saran B (1990) Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver disease. Arch Pathol Lab Med 114(6):589–592
Oyake J, Otaka M, Matsuhashi T et al (2006) Over-expression of 70-kDa heat shock protein confers protection against monochloramine-induced gastric mucosal cell injury [J]. Life Sci 79(3):300–305
Petrof EO, Ciancio MJ, Chang EB (2004) Role and regulation of intestinal epithelial heat shock proteins in health and disease. Chin J Dig Dis 5:45–50
Pierzchalski P, Jastrzebska M, Link-Lenczowski P et al (2014) The dynamics of heat shock system activation in Monomac-6 cells upon Helicobacter pylori infection [J]. J Physiol Pharmacol 65(6):791–800
Pimentel-Nunes P, Roncon-Albuquerque R Jr, Gonçalves N et al (2010) Attenuation of toll-like receptor 2-mediated innate immune response in patients with alcoholic chronic liver disease. Liver Int 30:1003–1011
Pockley AG, Georgiades A, Thulin T, de Faire U, Frostegård J (2003) Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension. Hypertension 42(3):235–238
Rejdak K, Kuhle J, Üegg SR, Lindberg RLP et al (2012) Neurofilament heavy chain and heat shock protein 70 as markers of seizure-related brain injury. Epilepsia 53(5):922–927
Rokutan K (2000) Role of heat shock proteins in gastric mucosal protection [J]. J Gastroenterol Hepatol 15(Suppl):D12–19
Rozenberg P, Kocsis J, Saar M, Prohászka Z, Füst G, Fishelson Z (2013) Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer. Int J Cancer 133(2):514–518
Sandström ME, Siegler JC, Lovell RJ, Madden LA, McNaughton L (2008) The effect of 15 consecutive days of heat-exercise acclimation on heat shock protein 70. Cell Stress Chaperones 13(2):169–175
Schett G, Tohidast-Akrad M, Steiner G, Smolen J (2001) The stressed synovium. Arthritis Res 3:80–86
Schroeder S, Lindemann C, Hoeft A, Putensen C, Decker D, von Ruecker AA, Stüber F (1999) Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis. Crit Care Med 27(6):1080–1084
Sedlackova L, Spacek M, Holler E, Imryskova Z, Hromadnikova I (2011) Heat-shock protein expression in leukemia. Tumour Biol 32(1):33–44
Singh K, Agrawal NK, Gupta SK, Mohan G, Chaturvedi S, Singh K (2015) Decreased expression of heat shock proteins may lead to compromised wound healing in type 2 diabetes mellitus patients. J Diabetes Complications. doi:10.1016/j.jdiacomp.2015.01.007
Srivastava P (2002) Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2(3):185–194
Stocki P, Wang XN, Dickinson AM (2012) Inducible heat shock protein 70 reduces T cell responses and stimulatory capacity of monocyte-derived dendritic cells. J Biol Chem 287(15):12387–12394
Tamási L, Bohács A, Tamási V, Stenczer B, Prohászka Z, Rigó J Jr, Losonczy G, Molvarec A (2010) Increased circulating heat shock protein 70 levels in pregnant asthmatics. Cell Stress Chaperones 15(3):295–300
Tarantino G, Finelli C, Colao A, Capone D, Tarantino M, Grimaldi E, Chianese D, Gioia S, Pasanisi F, Contaldo F, Scopacasa F, Savastano S (2012) Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase? J Transl Med 10:50. doi:10.1186/1479-5876-10-50
Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, Asea A (2004) Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N Y Acad Sci 1019:502–505
Tiss A, Khadir A, Abubaker J, Abu-Farha M, Al-Khairi I, Cherian P, John J, Kavalakatt S, Warsame S, Al-Ghimlas F, Elkum N, Behbehani K, Dermime S, Dehbi M (2014) Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue. Lipids Health Dis 13:106
Tsan MF, Gao B (2009) Heat shock proteins and immune system. J Leukoc Biol 85:905–910
Van Herwijnen MJ, Van Der Zee R, Van Eden W, Broere F (2013) Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis. Int J Hyperthermia 29(5):448–454
Vinokurov M, Ostrov V, Yurinskaya M, Garbuz D, Murashev A, Antonova O, Evgen’ev M (2012) Recombinant human HSP70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels. Cell Stress Chaperones 17(1):89–101
Wachstein J, Tischer S, Figueiredo C, Limbourg A, Falk C, Immenschuh S, Blasczyk R, Eiz-Vesper B (2012) HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells. PLoS One 7(12):e51747. doi:10.1371/journal.pone.0051747
Yadav AK, Kumar V, Jha V (2013) Heat shock proteins 60 and 70 specific proinflammatory and cytotoxic response of CD4+CD28null cells in chronic kidney disease. Mediators Inflamm 2013:384807. doi:10.1155/2013/384807
Yang X, He H, Yang W, Song T, Guo C, Zheng X, Liu Q (2010) Effects of HSP70 antisense oligonucleotide on the proliferation and apoptosis of human hepatocellular carcinoma cells. J Huazhong Univ Sci Technolog Med Sci 30(3):337–343
Yeh CH, Tseng R, Hannah A, Estrov Z, Estey E, Kantarjian H, Albitar M (2010) Clinical correlation of circulating heat shock protein 70 in acute leukemia. Leuk Res 34(5):605–609
Yeo M, Park HK, Kim DK et al (2004) Restoration of heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase expression induced by Helicobacter pylori [J]. Proteomics 4(11):3335–3342
Yuan ZQ, Zhang Y, Li XL, Peng YZ, Huang YS, Yang ZC (2010) HSP70 protects intestinal epithelial cells from hypoxia/reoxygenation injury via a mechanism that involves the mitochondrial pathways. Eur J Pharmacol 643(2-3):282–288
Yun CH, Yoon SY, Nguyen TT, Cho HY, Kim TH, Kim ST, Kim BC, Hong YS, Kim SJ, Lee HJ (2010) Geldanamycin inhibits TGF-beta signaling through induction of Hsp70. Arch Biochem Biophys 495(1):8–13
Zhao B, Sun G, Feng G, Duan W, Zhu X, Chen S, Hou L, Jin Z, Yi D (2012) Carboxy terminus of heat shock protein (HSP) 70-interacting protein (CHIP) inhibits HSP70 in the heart. J Physiol Biochem 68(4):485–491
Zhao JH, Meng XL, Zhang J, Li YL, Li YJ, Fan ZM (2014) Oxygen glucose deprivation post-conditioning protects cortical neurons against oxygen-glucose deprivation injury: role of HSP70 and inhibition of apoptosis. J Huazhong Univ Sci Technol Med Sci 34(1):18–22
Ziegler TR, Ogden LG, Singleton KD, Luo M, Fernandez-Estivariz C, Griffith DP, Galloway JR, Wischmeyer PE (2005) Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 31(8):1079–1086
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Qu, B., Jia, Y., Liu, Y. et al. The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review. Cell Stress and Chaperones 20, 885–892 (2015). https://doi.org/10.1007/s12192-015-0618-8
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DOI: https://doi.org/10.1007/s12192-015-0618-8